Details for: CL0002325

Cell ID: CL0002325

Cell Name: lactocyte

Marker Score Threshold: 16057
(Derived using integrated single-cell and genomic data)

Description: A milk-producing glandular epithelial cell that is part of a mammary gland alveolus and differentiates from a luminal adaptive secretory precursor cell during secretory differentiation (also termed lactogenesis I). Following secretory activation (also termed lactogenesis II), a lactocyte is involved in the synthesis and/or transport of milk constituents including proteins, oligosaccharides, lactose, micronutrients, fat, hormones, immunoglobulins, and cytokines into the lumen of the lactating mammary gland.

Synonyms: mammary alveolar cell, epithelial cell of lactiferous gland, lactaction-associated mammary epithelial cell, lactation-derived mammary cell, luminal cell of alveolus of lactiferous gland, mammary alveolar epithelial cell, mammary gland alveolar epithelial cell, LMC

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.22
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.96
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 2.84
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.81
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.67
    Ensembl ID: ENSG00000182718
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.66
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 2.6
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ABCA3 (ENSG00000167972)
    Fold Change: 2.58
    Ensembl ID: ENSG00000167972
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.56
    Ensembl ID: ENSG00000163399
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.53
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.44
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 2.42
    Ensembl ID: ENSG00000198363
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 2.41
    Ensembl ID: ENSG00000151914
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 2.36
    Ensembl ID: ENSG00000145349
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.32
    Ensembl ID: ENSG00000185650
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 2.18
    Ensembl ID: ENSG00000157764
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 2.14
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 2.13
    Ensembl ID: ENSG00000162909
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 2.1
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 2.1
    Ensembl ID: ENSG00000196975
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.1
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 2.09
    Ensembl ID: ENSG00000058668
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.08
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.92
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.91
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.9
    Ensembl ID: ENSG00000143761
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.89
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.79
    Ensembl ID: ENSG00000143153
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.78
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.77
    Ensembl ID: ENSG00000164111
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.73
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.72
    Ensembl ID: ENSG00000111275
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.72
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.71
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.67
    Ensembl ID: ENSG00000162104
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.65
    Ensembl ID: ENSG00000122359
  • Gene Symbol: C4BPA (ENSG00000123838)
    Fold Change: 1.64
    Ensembl ID: ENSG00000123838
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.58
    Ensembl ID: ENSG00000168374
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.57
    Ensembl ID: ENSG00000172270
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.56
    Ensembl ID: ENSG00000090013
  • Gene Symbol: AQP4 (ENSG00000171885)
    Fold Change: 1.56
    Ensembl ID: ENSG00000171885
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.56
    Ensembl ID: ENSG00000133639
  • Gene Symbol: AK1 (ENSG00000106992)
    Fold Change: 1.56
    Ensembl ID: ENSG00000106992
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.55
    Ensembl ID: ENSG00000127022
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.54
    Ensembl ID: ENSG00000171552
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.53
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.53
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.52
    Ensembl ID: ENSG00000100852
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.49
    Ensembl ID: ENSG00000149131
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.48
    Ensembl ID: ENSG00000170634
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 1.47
    Ensembl ID: ENSG00000107779
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.47
    Ensembl ID: ENSG00000183255
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.47
    Ensembl ID: ENSG00000156273
  • Gene Symbol: ALPL (ENSG00000162551)
    Fold Change: 1.44
    Ensembl ID: ENSG00000162551
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.44
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ANXA3 (ENSG00000138772)
    Fold Change: 1.43
    Ensembl ID: ENSG00000138772
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.43
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.41
    Ensembl ID: ENSG00000087274
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 1.4
    Ensembl ID: ENSG00000165272
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: 1.38
    Ensembl ID: ENSG00000165029
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.38
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.37
    Ensembl ID: ENSG00000128272
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.36
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.33
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.31
    Ensembl ID: ENSG00000097007
  • Gene Symbol: BCL6 (ENSG00000113916)
    Fold Change: 1.3
    Ensembl ID: ENSG00000113916
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.3
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.29
    Ensembl ID: ENSG00000069849
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.28
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.27
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.26
    Ensembl ID: ENSG00000159842
  • Gene Symbol: KLF5 (ENSG00000102554)
    Fold Change: 1.23
    Ensembl ID: ENSG00000102554
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 1.21
    Ensembl ID: ENSG00000148090
  • Gene Symbol: ARRB1 (ENSG00000137486)
    Fold Change: 1.2
    Ensembl ID: ENSG00000137486
  • Gene Symbol: BMP1 (ENSG00000168487)
    Fold Change: 1.2
    Ensembl ID: ENSG00000168487
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.2
    Ensembl ID: ENSG00000106546
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.18
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.16
    Ensembl ID: ENSG00000033627
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.16
    Ensembl ID: ENSG00000070961
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.15
    Ensembl ID: ENSG00000122786
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.15
    Ensembl ID: ENSG00000183020
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.13
    Ensembl ID: ENSG00000174437
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 1.13
    Ensembl ID: ENSG00000130208
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 1.12
    Ensembl ID: ENSG00000175899
  • Gene Symbol: C1R (ENSG00000159403)
    Fold Change: 1.12
    Ensembl ID: ENSG00000159403
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.11
    Ensembl ID: ENSG00000138279
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.1
    Ensembl ID: ENSG00000166747
  • Gene Symbol: PARP4 (ENSG00000102699)
    Fold Change: 1.09
    Ensembl ID: ENSG00000102699
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.08
    Ensembl ID: ENSG00000143322
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.07
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 1.06
    Ensembl ID: ENSG00000072210
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.06
    Ensembl ID: ENSG00000198931
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.06
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.06
    Ensembl ID: ENSG00000128595
  • Gene Symbol: ACADL (ENSG00000115361)
    Fold Change: 1.05
    Ensembl ID: ENSG00000115361
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.05
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.04
    Ensembl ID: ENSG00000141522
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.02
    Ensembl ID: ENSG00000101966
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.01
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1
    Ensembl ID: ENSG00000075239
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Cellular Differentiation**: Lactocytes differentiate from luminal adaptive secretory precursor cells during secretory differentiation (lactogenesis I) and undergo further differentiation during lactogenesis II. 2. **Milk Production**: Lactocytes synthesize and transport milk constituents, including proteins, oligosaccharides, lactose, micronutrients, fat, hormones, immunoglobulins, and cytokines, into the lumen of the lactating mammary gland. 3. **Adaptive Immune System**: Lactocytes participate in antigen processing and presentation via MHC class I and II molecules, playing a crucial role in the adaptive immune system. 4. **Secretory Activation**: Lactocytes undergo secretory activation during lactogenesis II, allowing them to synthesize and transport milk constituents. 5. **Gene Expression**: Lactocytes express genes involved in milk production, such as lactation-associated genes, and genes involved in the adaptive immune system, such as MHC class I and II molecules. **Clinical Significance** 1. **Lactation-Related Disorders**: Abnormalities in lactocyte function or differentiation can lead to lactation-related disorders, such as galactorrhea or oligomenorrhea. 2. **Immunological Disorders**: Abnormalities in lactocyte function or differentiation can also lead to immunological disorders, such as autoimmune diseases or immunodeficiency. 3. **Mammary Gland Disorders**: Abnormalities in lactocyte function or differentiation can also lead to mammary gland disorders, such as mastitis or breast cancer. 4. **Nutritional Disorders**: Abnormalities in lactocyte function or differentiation can also lead to nutritional disorders, such as lactose intolerance or protein deficiency. 5. **Reproductive Disorders**: Abnormalities in lactocyte function or differentiation can also lead to reproductive disorders, such as polycystic ovary syndrome (PCOS) or infertility. In conclusion, lactocytes play a crucial role in milk production and the adaptive immune system, and abnormalities in lactocyte function or differentiation can lead to various clinical disorders. Further research is needed to understand the mechanisms underlying lactocyte function and differentiation and to develop effective treatments for lactation-related disorders.