Details for: CL0002329

Cell ID: CL0002329

Cell Name: basal epithelial cell of tracheobronchial tree

Marker Score Threshold: 1133
(Derived using integrated single-cell and genomic data)

Description: An epithelial cell type that lacks the columnar shape typical for other respiratory epithelial cells. This cell type is able to differentiate into other respiratory epithelial cells in response to injury.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 4.99
    Ensembl ID: ENSG00000151150
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 4.22
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 4.19
    Ensembl ID: ENSG00000156110
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 3.93
    Ensembl ID: ENSG00000053254
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 3.52
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CA12 (ENSG00000074410)
    Fold Change: 3.51
    Ensembl ID: ENSG00000074410
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 3.4
    Ensembl ID: ENSG00000151914
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 3.4
    Ensembl ID: ENSG00000198589
  • Gene Symbol: CRYBG1 (ENSG00000112297)
    Fold Change: 3.34
    Ensembl ID: ENSG00000112297
  • Gene Symbol: COL7A1 (ENSG00000114270)
    Fold Change: 3.13
    Ensembl ID: ENSG00000114270
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 2.93
    Ensembl ID: ENSG00000278540
  • Gene Symbol: CDH13 (ENSG00000140945)
    Fold Change: 2.82
    Ensembl ID: ENSG00000140945
  • Gene Symbol: CACNB4 (ENSG00000182389)
    Fold Change: 2.77
    Ensembl ID: ENSG00000182389
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 2.7
    Ensembl ID: ENSG00000069849
  • Gene Symbol: JAG1 (ENSG00000101384)
    Fold Change: 2.67
    Ensembl ID: ENSG00000101384
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 2.39
    Ensembl ID: ENSG00000072210
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 2.37
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.33
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.32
    Ensembl ID: ENSG00000185650
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.31
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 2.19
    Ensembl ID: ENSG00000153113
  • Gene Symbol: KLF5 (ENSG00000102554)
    Fold Change: 2.18
    Ensembl ID: ENSG00000102554
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.18
    Ensembl ID: ENSG00000099622
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 2.08
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 2.06
    Ensembl ID: ENSG00000164904
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 2.03
    Ensembl ID: ENSG00000173575
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.03
    Ensembl ID: ENSG00000077549
  • Gene Symbol: RCC1 (ENSG00000180198)
    Fold Change: 2.02
    Ensembl ID: ENSG00000180198
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.98
    Ensembl ID: ENSG00000198363
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.97
    Ensembl ID: ENSG00000156273
  • Gene Symbol: CREBBP (ENSG00000005339)
    Fold Change: 1.92
    Ensembl ID: ENSG00000005339
  • Gene Symbol: CDR2 (ENSG00000140743)
    Fold Change: 1.9
    Ensembl ID: ENSG00000140743
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.9
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.89
    Ensembl ID: ENSG00000182718
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.87
    Ensembl ID: ENSG00000157764
  • Gene Symbol: BCL6 (ENSG00000113916)
    Fold Change: 1.85
    Ensembl ID: ENSG00000113916
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.85
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.81
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.8
    Ensembl ID: ENSG00000174437
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 1.72
    Ensembl ID: ENSG00000163697
  • Gene Symbol: LTB4R (ENSG00000213903)
    Fold Change: 1.71
    Ensembl ID: ENSG00000213903
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.69
    Ensembl ID: ENSG00000145349
  • Gene Symbol: COL17A1 (ENSG00000065618)
    Fold Change: 1.66
    Ensembl ID: ENSG00000065618
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.62
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ATR (ENSG00000175054)
    Fold Change: 1.6
    Ensembl ID: ENSG00000175054
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.59
    Ensembl ID: ENSG00000159842
  • Gene Symbol: CDH3 (ENSG00000062038)
    Fold Change: 1.57
    Ensembl ID: ENSG00000062038
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 1.56
    Ensembl ID: ENSG00000010278
  • Gene Symbol: ALDH3A1 (ENSG00000108602)
    Fold Change: 1.55
    Ensembl ID: ENSG00000108602
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.53
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.51
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.5
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ADARB2 (ENSG00000185736)
    Fold Change: 1.47
    Ensembl ID: ENSG00000185736
  • Gene Symbol: CAPN1 (ENSG00000014216)
    Fold Change: 1.43
    Ensembl ID: ENSG00000014216
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.43
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.42
    Ensembl ID: ENSG00000097007
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 1.42
    Ensembl ID: ENSG00000165272
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.39
    Ensembl ID: ENSG00000058668
  • Gene Symbol: CDC27 (ENSG00000004897)
    Fold Change: 1.38
    Ensembl ID: ENSG00000004897
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.38
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: 1.36
    Ensembl ID: ENSG00000165029
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.35
    Ensembl ID: ENSG00000013441
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.35
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ACVR2A (ENSG00000121989)
    Fold Change: 1.33
    Ensembl ID: ENSG00000121989
  • Gene Symbol: ADH7 (ENSG00000196344)
    Fold Change: 1.31
    Ensembl ID: ENSG00000196344
  • Gene Symbol: CDK6 (ENSG00000105810)
    Fold Change: 1.31
    Ensembl ID: ENSG00000105810
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.3
    Ensembl ID: ENSG00000140836
  • Gene Symbol: CDH1 (ENSG00000039068)
    Fold Change: 1.3
    Ensembl ID: ENSG00000039068
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.29
    Ensembl ID: ENSG00000166710
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 1.29
    Ensembl ID: ENSG00000107779
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.29
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.26
    Ensembl ID: ENSG00000196975
  • Gene Symbol: MAPK14 (ENSG00000112062)
    Fold Change: 1.25
    Ensembl ID: ENSG00000112062
  • Gene Symbol: RUNX1 (ENSG00000159216)
    Fold Change: 1.23
    Ensembl ID: ENSG00000159216
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 1.23
    Ensembl ID: ENSG00000083123
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.21
    Ensembl ID: ENSG00000122786
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 1.21
    Ensembl ID: ENSG00000148090
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.2
    Ensembl ID: ENSG00000087274
  • Gene Symbol: PARP4 (ENSG00000102699)
    Fold Change: 1.15
    Ensembl ID: ENSG00000102699
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.14
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.11
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.11
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CD58 (ENSG00000116815)
    Fold Change: 1.07
    Ensembl ID: ENSG00000116815
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.07
    Ensembl ID: ENSG00000070831
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.07
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 1.07
    Ensembl ID: ENSG00000114423
  • Gene Symbol: CSE1L (ENSG00000124207)
    Fold Change: 1.07
    Ensembl ID: ENSG00000124207
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.05
    Ensembl ID: ENSG00000162909
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.05
    Ensembl ID: ENSG00000149311
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 1.04
    Ensembl ID: ENSG00000131143
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.04
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.03
    Ensembl ID: ENSG00000162104
  • Gene Symbol: CLTC (ENSG00000141367)
    Fold Change: 1.03
    Ensembl ID: ENSG00000141367
  • Gene Symbol: KRIT1 (ENSG00000001631)
    Fold Change: 1.03
    Ensembl ID: ENSG00000001631
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.03
    Ensembl ID: ENSG00000104964
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.02
    Ensembl ID: ENSG00000166747
  • Gene Symbol: CBFB (ENSG00000067955)
    Fold Change: 1.02
    Ensembl ID: ENSG00000067955
  • Gene Symbol: ATF6B (ENSG00000213676)
    Fold Change: 1.02
    Ensembl ID: ENSG00000213676
  • Gene Symbol: BMP7 (ENSG00000101144)
    Fold Change: 1
    Ensembl ID: ENSG00000101144
  • Gene Symbol: BCR (ENSG00000186716)
    Fold Change: 1
    Ensembl ID: ENSG00000186716
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** * Lack of columnar shape, unlike other respiratory epithelial cells * Ability to differentiate into other respiratory epithelial cells in response to injury * Express ANK3, CD44, ADK, FOXN3, RERE, CA12, and DST genes, which are involved in various cellular processes * Involved in cell adhesion, migration, and differentiation * Found in the tracheobronchial tree, including the trachea, bronchi, and bronchioles **Clinical Significance** * Basal epithelial cells of the tracheobronchial tree play a crucial role in maintaining the integrity of the respiratory epithelium and are involved in the repair of damaged epithelial tissues. * Dysregulation of ANK3, CD44, ADK, FOXN3, RERE, CA12, and DST genes has been implicated in various respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cancer. * Understanding the function and regulation of basal epithelial cells of the tracheobronchial tree is essential for the development of novel therapeutic strategies for respiratory diseases. * Further research is needed to elucidate the mechanisms by which these cells differentiate and respond to injury, and to explore the potential of these cells as a source of stem cells for tissue repair. **Gene Expression** * ANK3: involved in cell adhesion and migration * CD44: involved in cell adhesion and migration * ADK: involved in nucleotide salvage and metabolism * FOXN3: involved in transcriptional regulation and cell differentiation * RERE: involved in transcriptional regulation and cell differentiation * CA12: involved in chloride ion homeostasis and metabolism * DST: involved in collagen formation and degradation **Pathways and Ontologies** * Asparagine n-linked glycosylation * Axon guidance * Axon initial segment * Axonogenesis * Basal plasma membrane * Basolateral plasma membrane * Bicellular tight junction * Cadherin binding * Cell surface * Cellular response to magnesium ion * Copi-mediated anterograde transport * Costamere * Cytoskeletal anchor activity * Cytoskeletal protein binding * Cytoskeleton organization * Cytosol * Dendrite * Developmental biology * Endoplasmic reticulum * Er to golgi anterograde transport * Establishment of protein localization * Golgi apparatus * Golgi to plasma membrane protein transport * Interaction between l1 and ankyrins * Intercalated disc * L1cam interactions * Lateral plasma membrane * Lysosome * Magnesium ion homeostasis * Maintenance of protein location in plasma membrane * Membrane assembly * Membrane trafficking * Metabolism of proteins * Mitotic cytokinesis * Negative regulation of delayed rectifier potassium channel activity * Nervous system development * Neuromuscular junction * Neuromuscular junction development * Neuronal action potential * Neuron projection * Node of ranvier * Plasma membrane * Plasma membrane organization * Positive regulation of cation channel activity * Positive regulation of cell communication by electrical coupling * Positive regulation of gene expression * Positive regulation of homotypic cell-cell adhesion * Positive regulation of membrane depolarization during cardiac muscle cell action potential * Positive regulation of membrane potential * Positive regulation of protein targeting to membrane * Positive regulation of sodium ion transmembrane transporter activity * Positive regulation of sodium ion transport * Post-translational protein modification * Postsynaptic membrane * Protein-macromolecule adaptor activity * Protein binding * Protein localization to axon * Protein localization to plasma membrane * Regulation of potassium ion transport * Sarcolemma * Sarcoplasmic reticulum * Signal transduction * Spectrin-associated cytoskeleton * Spectrin binding * Structural constituent of cytoskeleton * T-tubule * Transmembrane transporter binding * Transport to the golgi and subsequent modification * Vesicle-mediated transport * Z disc **References** * [Insert references here] Note: The information provided is based on the data available in the provided text and may not be comprehensive or up-to-date.