Details for: CL0002338

Cell ID: CL0002338

Cell Name: CD56-positive, CD161-positive immature natural killer cell, human

Marker Score Threshold: 329
(Derived using integrated single-cell and genomic data)

Description: A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-positive, CD117-positive, CD122-positive,and CD161-positive.

Synonyms: p-NK

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.19
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.19
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CD7 (ENSG00000173762)
    Fold Change: 3.17
    Ensembl ID: ENSG00000173762
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 3.12
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 3.07
    Ensembl ID: ENSG00000172757
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.06
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.06
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.04
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.01
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 2.88
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.86
    Ensembl ID: ENSG00000135404
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.83
    Ensembl ID: ENSG00000122545
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.83
    Ensembl ID: ENSG00000070831
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.76
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CD52 (ENSG00000169442)
    Fold Change: 2.69
    Ensembl ID: ENSG00000169442
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.66
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.65
    Ensembl ID: ENSG00000019582
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.64
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.63
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 2.51
    Ensembl ID: ENSG00000104894
  • Gene Symbol: CD48 (ENSG00000117091)
    Fold Change: 2.39
    Ensembl ID: ENSG00000117091
  • Gene Symbol: CD247 (ENSG00000198821)
    Fold Change: 2.35
    Ensembl ID: ENSG00000198821
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 2.34
    Ensembl ID: ENSG00000026508
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.32
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CD2 (ENSG00000116824)
    Fold Change: 2.32
    Ensembl ID: ENSG00000116824
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.32
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.3
    Ensembl ID: ENSG00000099624
  • Gene Symbol: RUNX3 (ENSG00000020633)
    Fold Change: 2.22
    Ensembl ID: ENSG00000020633
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 2.2
    Ensembl ID: ENSG00000149311
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.18
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.13
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.1
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CDKN2D (ENSG00000129355)
    Fold Change: 2.07
    Ensembl ID: ENSG00000129355
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 2.05
    Ensembl ID: ENSG00000110848
  • Gene Symbol: CD3E (ENSG00000198851)
    Fold Change: 2.03
    Ensembl ID: ENSG00000198851
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.02
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 2.02
    Ensembl ID: ENSG00000112576
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 2
    Ensembl ID: ENSG00000143119
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.97
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.95
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.94
    Ensembl ID: ENSG00000165527
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.94
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.91
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.91
    Ensembl ID: ENSG00000153113
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.89
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.85
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.81
    Ensembl ID: ENSG00000241837
  • Gene Symbol: FMNL1 (ENSG00000184922)
    Fold Change: 1.81
    Ensembl ID: ENSG00000184922
  • Gene Symbol: ADGRE5 (ENSG00000123146)
    Fold Change: 1.8
    Ensembl ID: ENSG00000123146
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.79
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.75
    Ensembl ID: ENSG00000197043
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.71
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.71
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.7
    Ensembl ID: ENSG00000141522
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.65
    Ensembl ID: ENSG00000134825
  • Gene Symbol: AREG (ENSG00000109321)
    Fold Change: 1.65
    Ensembl ID: ENSG00000109321
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.62
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.62
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.62
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.56
    Ensembl ID: ENSG00000110955
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.56
    Ensembl ID: ENSG00000136717
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.56
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.55
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.54
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CTSC (ENSG00000109861)
    Fold Change: 1.53
    Ensembl ID: ENSG00000109861
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.51
    Ensembl ID: ENSG00000196954
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.46
    Ensembl ID: ENSG00000122359
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.45
    Ensembl ID: ENSG00000108561
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.43
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.4
    Ensembl ID: ENSG00000148700
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.39
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.39
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.38
    Ensembl ID: ENSG00000173575
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.37
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CASP8 (ENSG00000064012)
    Fold Change: 1.35
    Ensembl ID: ENSG00000064012
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.31
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.29
    Ensembl ID: ENSG00000126247
  • Gene Symbol: CAPG (ENSG00000042493)
    Fold Change: 1.29
    Ensembl ID: ENSG00000042493
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 1.29
    Ensembl ID: ENSG00000114423
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.27
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.25
    Ensembl ID: ENSG00000117410
  • Gene Symbol: GRK2 (ENSG00000173020)
    Fold Change: 1.21
    Ensembl ID: ENSG00000173020
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.2
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.17
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.17
    Ensembl ID: ENSG00000143727
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.17
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.15
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.13
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CHD4 (ENSG00000111642)
    Fold Change: 1.1
    Ensembl ID: ENSG00000111642
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.09
    Ensembl ID: ENSG00000104763
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.08
    Ensembl ID: ENSG00000149823
  • Gene Symbol: CENPC (ENSG00000145241)
    Fold Change: 1.07
    Ensembl ID: ENSG00000145241
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.07
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.07
    Ensembl ID: ENSG00000138279
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.05
    Ensembl ID: ENSG00000146731
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.03
    Ensembl ID: ENSG00000107262
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.01
    Ensembl ID: ENSG00000198898
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: N/A
    Ensembl ID: ENSG00000185650
Hovered Details

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Hovered Details

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**Key Characteristics** * **Surface Markers:** + CD34-negative + CD56-positive + CD117-positive + CD122-positive + CD161-positive * **Function:** + Recognition and elimination of infected cells and tumor cells + Production of cytokines and chemokines to recruit immune cells to the site of infection or inflammation + Expression of activating receptors such as NKG2D, which recognizes stress-induced ligands on tumor cells * **Developmental Stage:** + Immature natural killer cells + Not yet fully matured * **Cytoskeletal Organization:** + Actin cytoskeleton involved in cell movement and phagocytosis + Actin filaments involved in cell signaling and regulation of cell cycle **Clinical Significance** * **Immune System Disorders:** + Impaired natural killer cell function has been associated with various immune system disorders, including cancer, autoimmune diseases, and chronic infections + Dysregulation of natural killer cell function can lead to impaired immune response and increased susceptibility to infections * **Cancer:** + Natural killer cells play a crucial role in the recognition and elimination of tumor cells + Impaired natural killer cell function has been associated with poor prognosis and reduced survival rates in various types of cancer * **Infectious Diseases:** + Natural killer cells are involved in the recognition and elimination of infected cells + Impaired natural killer cell function can lead to increased susceptibility to infections and impaired immune response **Pathways and Ontologies** * **Actin Cytoskeleton:** + Involved in cell movement and phagocytosis + Regulates cell signaling and cell cycle * **Adherens Junctions:** + Involved in cell-cell adhesion and signaling + Regulates cell migration and invasion * **Apoptosis:** + Involved in programmed cell death + Regulates cell cycle and tissue homeostasis * **Cytokine Signaling:** + Involved in immune response and inflammation + Regulates cell signaling and tissue homeostasis * **DNA Damage Response:** + Involved in DNA repair and maintenance + Regulates cell cycle and tissue homeostasis Overall, the CD56-positive, CD161-positive immature natural killer cell is an essential component of the immune system, and its dysfunction can have significant clinical implications. Further research is needed to fully understand the role of this cell type in immune responses and to develop therapeutic strategies to restore natural killer cell function in individuals with impaired immune system disorders.