Details for: CL0002340

Cell ID: CL0002340

Cell Name: luminal cell of prostate epithelium

Marker Score Threshold: 582
(Derived using integrated single-cell and genomic data)

Description: The exocrine cell of the prostate, this epithelial cell secretes prostatic acid phosphotase and PSA, and is dependent on androgen hormones for survival.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.63
    Ensembl ID: ENSG00000166710
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.58
    Ensembl ID: ENSG00000169100
  • Gene Symbol: KLK3 (ENSG00000142515)
    Fold Change: 3.51
    Ensembl ID: ENSG00000142515
  • Gene Symbol: AZGP1 (ENSG00000160862)
    Fold Change: 3.43
    Ensembl ID: ENSG00000160862
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.43
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 3.38
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.19
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ACP3 (ENSG00000014257)
    Fold Change: 3.06
    Ensembl ID: ENSG00000014257
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.02
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.02
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ALDH1A3 (ENSG00000184254)
    Fold Change: 2.91
    Ensembl ID: ENSG00000184254
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.77
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 2.63
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.6
    Ensembl ID: ENSG00000143761
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 2.59
    Ensembl ID: ENSG00000155366
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.48
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 2.46
    Ensembl ID: ENSG00000117410
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.44
    Ensembl ID: ENSG00000067560
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 2.38
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 2.37
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.33
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.33
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 2.32
    Ensembl ID: ENSG00000128272
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 2.18
    Ensembl ID: ENSG00000165272
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.16
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 2.13
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.11
    Ensembl ID: ENSG00000130402
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.04
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.94
    Ensembl ID: ENSG00000170017
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.93
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.91
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.91
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.9
    Ensembl ID: ENSG00000169020
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.9
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.84
    Ensembl ID: ENSG00000154723
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.84
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 1.83
    Ensembl ID: ENSG00000047648
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.82
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CEACAM1 (ENSG00000079385)
    Fold Change: 1.82
    Ensembl ID: ENSG00000079385
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.79
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.77
    Ensembl ID: ENSG00000141522
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.76
    Ensembl ID: ENSG00000176171
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.72
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.7
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.64
    Ensembl ID: ENSG00000140836
  • Gene Symbol: CRYBG1 (ENSG00000112297)
    Fold Change: 1.63
    Ensembl ID: ENSG00000112297
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.59
    Ensembl ID: ENSG00000154518
  • Gene Symbol: AR (ENSG00000169083)
    Fold Change: 1.58
    Ensembl ID: ENSG00000169083
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.57
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.57
    Ensembl ID: ENSG00000085224
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.51
    Ensembl ID: ENSG00000005022
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.48
    Ensembl ID: ENSG00000142599
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.45
    Ensembl ID: ENSG00000171552
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.44
    Ensembl ID: ENSG00000159199
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.43
    Ensembl ID: ENSG00000090013
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.41
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.41
    Ensembl ID: ENSG00000152234
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.38
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.34
    Ensembl ID: ENSG00000100852
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.33
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ANXA3 (ENSG00000138772)
    Fold Change: 1.33
    Ensembl ID: ENSG00000138772
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.33
    Ensembl ID: ENSG00000071553
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.31
    Ensembl ID: ENSG00000023445
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.31
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.29
    Ensembl ID: ENSG00000120805
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 1.29
    Ensembl ID: ENSG00000072210
  • Gene Symbol: BMPR1B (ENSG00000138696)
    Fold Change: 1.28
    Ensembl ID: ENSG00000138696
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.28
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.27
    Ensembl ID: ENSG00000116459
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.25
    Ensembl ID: ENSG00000110330
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.25
    Ensembl ID: ENSG00000060971
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 1.23
    Ensembl ID: ENSG00000107779
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.22
    Ensembl ID: ENSG00000156273
  • Gene Symbol: ARG2 (ENSG00000081181)
    Fold Change: 1.21
    Ensembl ID: ENSG00000081181
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.21
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1.2
    Ensembl ID: ENSG00000143149
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.2
    Ensembl ID: ENSG00000143727
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.18
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ACLY (ENSG00000131473)
    Fold Change: 1.18
    Ensembl ID: ENSG00000131473
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.17
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.17
    Ensembl ID: ENSG00000149925
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.16
    Ensembl ID: ENSG00000101966
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.16
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.13
    Ensembl ID: ENSG00000033627
  • Gene Symbol: ACADL (ENSG00000115361)
    Fold Change: 1.12
    Ensembl ID: ENSG00000115361
  • Gene Symbol: CCND1 (ENSG00000110092)
    Fold Change: 1.11
    Ensembl ID: ENSG00000110092
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.09
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.09
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.09
    Ensembl ID: ENSG00000164904
  • Gene Symbol: ADM (ENSG00000148926)
    Fold Change: 1.06
    Ensembl ID: ENSG00000148926
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.06
    Ensembl ID: ENSG00000111275
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.04
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.04
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.03
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.03
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.02
    Ensembl ID: ENSG00000204574
  • Gene Symbol: ACOX1 (ENSG00000161533)
    Fold Change: 1.01
    Ensembl ID: ENSG00000161533
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 1
    Ensembl ID: ENSG00000278540
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1
    Ensembl ID: ENSG00000197894
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: N/A
    Ensembl ID: ENSG00000004455
Hovered Details

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Hovered Details

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**Key Characteristics** The luminal cell of the prostate epithelium (CL0002340) is a type of exocrine cell that is responsible for the secretion of prostatic acid phosphatase and PSA. The cell is characterized by its dependence on androgen hormones for its survival and growth. The cell's gene expression profile is closely linked to various cellular processes, including: * Adaptive immune responses: The cell is involved in the adaptive immune response, particularly in the processing and presentation of antigens via MHC class II and class I molecules. * Antigen processing and presentation: The cell is responsible for the processing and presentation of antigens via MHC class II and class I molecules. * Metabolism of proteins: The cell is involved in the metabolism of proteins, including the degradation of proteins and the regulation of protein binding and homodimerization. * Cellular senescence: The cell is involved in the regulation of cellular senescence, particularly in the context of androgen deprivation. * Apoptosis: The cell is involved in the regulation of apoptosis, particularly in the context of androgen deprivation. * Angiogenesis: The cell is involved in the regulation of angiogenesis, particularly in the context of prostate cancer. **Clinical Significance** The luminal cell of the prostate epithelium (CL0002340) has significant clinical implications for the diagnosis and treatment of prostate cancer. The cell's ability to secrete PSA makes it a useful marker for prostate cancer diagnosis. Additionally, the cell's dependence on androgen hormones makes it a potential target for androgen deprivation therapy (ADT) in the treatment of prostate cancer. The cell's involvement in adaptive immune responses and antigen processing and presentation also makes it a potential target for immunotherapy in the treatment of prostate cancer. Furthermore, the cell's regulation of cellular senescence and apoptosis makes it a potential target for the development of novel therapeutic strategies for prostate cancer. The cell's involvement in angiogenesis also makes it a potential target for the development of novel therapeutic strategies for prostate cancer. In conclusion, the luminal cell of the prostate epithelium (CL0002340) is a complex cell type that plays a critical role in the development and maintenance of the prostate gland. Its dependence on androgen hormones, involvement in adaptive immune responses and antigen processing and presentation, and regulation of cellular senescence and apoptosis make it a potential target for the diagnosis and treatment of prostate cancer.