Details for: CL0002350

Cell ID: CL0002350

Cell Name: endocardial cell

Marker Score Threshold: 565
(Derived using integrated single-cell and genomic data)

Description: An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin.

Synonyms: endocardial endothelial cell, endothelial cell of endocardium

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 5.24
    Ensembl ID: ENSG00000179218
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 5.19
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 3.89
    Ensembl ID: ENSG00000010278
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 3.83
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 3.74
    Ensembl ID: ENSG00000128595
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 3.71
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.69
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.61
    Ensembl ID: ENSG00000075624
  • Gene Symbol: C7 (ENSG00000112936)
    Fold Change: 3.28
    Ensembl ID: ENSG00000112936
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 3.17
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.11
    Ensembl ID: ENSG00000184009
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 3.1
    Ensembl ID: ENSG00000067560
  • Gene Symbol: SERPINH1 (ENSG00000149257)
    Fold Change: 2.99
    Ensembl ID: ENSG00000149257
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.92
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.88
    Ensembl ID: ENSG00000135390
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.84
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 2.72
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.57
    Ensembl ID: ENSG00000099624
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.56
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.54
    Ensembl ID: ENSG00000154723
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.53
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.43
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 2.4
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.38
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.38
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 2.3
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 2.29
    Ensembl ID: ENSG00000153956
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.29
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.23
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.21
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 2.21
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.2
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.19
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.14
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CAV1 (ENSG00000105974)
    Fold Change: 2.08
    Ensembl ID: ENSG00000105974
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.05
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.05
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.94
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.92
    Ensembl ID: ENSG00000122786
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.92
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CAV2 (ENSG00000105971)
    Fold Change: 1.9
    Ensembl ID: ENSG00000105971
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.87
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.85
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.83
    Ensembl ID: ENSG00000159199
  • Gene Symbol: BGN (ENSG00000182492)
    Fold Change: 1.78
    Ensembl ID: ENSG00000182492
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.75
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.75
    Ensembl ID: ENSG00000058668
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.74
    Ensembl ID: ENSG00000155366
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.73
    Ensembl ID: ENSG00000183255
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.73
    Ensembl ID: ENSG00000134825
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.69
    Ensembl ID: ENSG00000133639
  • Gene Symbol: RUNX1T1 (ENSG00000079102)
    Fold Change: 1.64
    Ensembl ID: ENSG00000079102
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.58
    Ensembl ID: ENSG00000005022
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.58
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.58
    Ensembl ID: ENSG00000153113
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.54
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.53
    Ensembl ID: ENSG00000087274
  • Gene Symbol: BMX (ENSG00000102010)
    Fold Change: 1.51
    Ensembl ID: ENSG00000102010
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.51
    Ensembl ID: ENSG00000145349
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 1.48
    Ensembl ID: ENSG00000130203
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.46
    Ensembl ID: ENSG00000164111
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.46
    Ensembl ID: ENSG00000134982
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.46
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.46
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.43
    Ensembl ID: ENSG00000141522
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.41
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.4
    Ensembl ID: ENSG00000143153
  • Gene Symbol: AQP1 (ENSG00000240583)
    Fold Change: 1.35
    Ensembl ID: ENSG00000240583
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.35
    Ensembl ID: ENSG00000162909
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.32
    Ensembl ID: ENSG00000177556
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.3
    Ensembl ID: ENSG00000198898
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.29
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.29
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.24
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.23
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.23
    Ensembl ID: ENSG00000174437
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.23
    Ensembl ID: ENSG00000143878
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.2
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.19
    Ensembl ID: ENSG00000168374
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.19
    Ensembl ID: ENSG00000087088
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.19
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.18
    Ensembl ID: ENSG00000071553
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.18
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.17
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CCND2 (ENSG00000118971)
    Fold Change: 1.16
    Ensembl ID: ENSG00000118971
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.16
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.13
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.11
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.11
    Ensembl ID: ENSG00000116489
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.1
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.1
    Ensembl ID: ENSG00000185883
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.07
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.06
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ARCN1 (ENSG00000095139)
    Fold Change: 1.06
    Ensembl ID: ENSG00000095139
  • Gene Symbol: ACTC1 (ENSG00000159251)
    Fold Change: 1.06
    Ensembl ID: ENSG00000159251
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.05
    Ensembl ID: ENSG00000143727
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.05
    Ensembl ID: ENSG00000101966
  • Gene Symbol: JAG1 (ENSG00000101384)
    Fold Change: 1.02
    Ensembl ID: ENSG00000101384
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.02
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.01
    Ensembl ID: ENSG00000072778
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Location**: Endocardial endothelial cells line the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. 2. **Function**: These cells regulate blood flow, blood pressure, and immune responses, and release vasoactive substances such as prostacyclin, nitrous oxide, and endothelin. 3. **Surface receptors and molecules**: Endocardial endothelial cells express MHC class I and II molecules, as well as other surface receptors and molecules involved in antigen presentation and immune response. 4. **Gene expression**: These cells express a range of genes involved in cell adhesion, migration, and immune response, including CD9, B2M, and CALR. 5. **Cellular responses**: Endocardial endothelial cells respond to various stimuli, including changes in blood pressure, shear stress, and immune responses. **Clinical Significance** 1. **Cardiovascular disease**: Endocardial endothelial cells play a crucial role in maintaining the integrity of the cardiovascular system, and dysfunction of these cells has been implicated in various cardiovascular diseases, including atherosclerosis, hypertension, and heart failure. 2. **Immune response**: Endocardial endothelial cells are involved in the regulation of immune responses, and dysfunction of these cells has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Infectious diseases**: Endocardial endothelial cells are also involved in the regulation of immune responses to infectious diseases, such as HIV and tuberculosis. 4. **Cancer**: Endocardial endothelial cells have been implicated in the development and progression of certain types of cancer, including breast and lung cancer. 5. **Regenerative medicine**: Endocardial endothelial cells have the potential to be used as a source of stem cells for regenerative medicine, particularly in the treatment of cardiovascular disease. **Gene Symbol and Ensembl ID** * Gene Symbol: CALR (Calreticulin) * Ensembl ID: ENSG00000179218 * Gene Symbol: B2M (Beta-2 microglobulin) * Ensembl ID: ENSG00000166710 * Gene Symbol: CD9 (CD9 molecule) * Ensembl ID: ENSG00000010278