CL0002351 - progenitor cell of endocrine pancreas details

Details for: CL0002351

Cell ID: CL0002351

Cell Name: progenitor cell of endocrine pancreas

Marker Score Threshold: 217
(Derived using integrated single-cell and genomic data)

Description: A progenitor cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1.

Synonyms: pancreatic endocrine progenitor, pancreatic islet progenitor cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Gene Symbol: B2M (ENSG00000166710)
Fold Change: 3.99
Ensembl ID: ENSG00000166710
Gene Symbol: ACTB (ENSG00000075624)
Fold Change: 3.92
Ensembl ID: ENSG00000075624
Gene Symbol: CFL1 (ENSG00000172757)
Fold Change: 3.04
Ensembl ID: ENSG00000172757
Gene Symbol: ACTG1 (ENSG00000184009)
Fold Change: 2.99
Ensembl ID: ENSG00000184009
Gene Symbol: SLC25A6 (ENSG00000169100)
Fold Change: 2.96
Ensembl ID: ENSG00000169100
Gene Symbol: CALM1 (ENSG00000198668)
Fold Change: 2.86
Ensembl ID: ENSG00000198668
Gene Symbol: BTF3 (ENSG00000145741)
Fold Change: 2.67
Ensembl ID: ENSG00000145741
Gene Symbol: CDC42 (ENSG00000070831)
Fold Change: 2.56
Ensembl ID: ENSG00000070831
Gene Symbol: ATP5MC2 (ENSG00000135390)
Fold Change: 2.53
Ensembl ID: ENSG00000135390
Gene Symbol: BTG1 (ENSG00000133639)
Fold Change: 2.48
Ensembl ID: ENSG00000133639
Gene Symbol: ATP5F1E (ENSG00000124172)
Fold Change: 2.47
Ensembl ID: ENSG00000124172
Gene Symbol: RHOA (ENSG00000067560)
Fold Change: 2.4
Ensembl ID: ENSG00000067560
Gene Symbol: SEPTIN7 (ENSG00000122545)
Fold Change: 2.4
Ensembl ID: ENSG00000122545
Gene Symbol: CAPZB (ENSG00000077549)
Fold Change: 2.35
Ensembl ID: ENSG00000077549
Gene Symbol: ZFP36L1 (ENSG00000185650)
Fold Change: 2.32
Ensembl ID: ENSG00000185650
Gene Symbol: ZFP36L2 (ENSG00000152518)
Fold Change: 2.2
Ensembl ID: ENSG00000152518
Gene Symbol: CALM2 (ENSG00000143933)
Fold Change: 2.15
Ensembl ID: ENSG00000143933
Gene Symbol: CD74 (ENSG00000019582)
Fold Change: 2.14
Ensembl ID: ENSG00000019582
Gene Symbol: CALR (ENSG00000179218)
Fold Change: 2.08
Ensembl ID: ENSG00000179218
Gene Symbol: CD63 (ENSG00000135404)
Fold Change: 2.05
Ensembl ID: ENSG00000135404
Gene Symbol: TSPO (ENSG00000100300)
Fold Change: 2.01
Ensembl ID: ENSG00000100300
Gene Symbol: ARF1 (ENSG00000143761)
Fold Change: 2
Ensembl ID: ENSG00000143761
Gene Symbol: ATP5ME (ENSG00000169020)
Fold Change: 1.99
Ensembl ID: ENSG00000169020
Gene Symbol: CD44 (ENSG00000026508)
Fold Change: 1.99
Ensembl ID: ENSG00000026508
Gene Symbol: CAST (ENSG00000153113)
Fold Change: 1.95
Ensembl ID: ENSG00000153113
Gene Symbol: CD47 (ENSG00000196776)
Fold Change: 1.84
Ensembl ID: ENSG00000196776
Gene Symbol: ALDOA (ENSG00000149925)
Fold Change: 1.82
Ensembl ID: ENSG00000149925
Gene Symbol: ATP5F1D (ENSG00000099624)
Fold Change: 1.79
Ensembl ID: ENSG00000099624
Gene Symbol: CAPZA1 (ENSG00000116489)
Fold Change: 1.79
Ensembl ID: ENSG00000116489
Gene Symbol: ATP5PF (ENSG00000154723)
Fold Change: 1.77
Ensembl ID: ENSG00000154723
Gene Symbol: ATRX (ENSG00000085224)
Fold Change: 1.73
Ensembl ID: ENSG00000085224
Gene Symbol: CANX (ENSG00000127022)
Fold Change: 1.72
Ensembl ID: ENSG00000127022
Gene Symbol: SLC25A5 (ENSG00000005022)
Fold Change: 1.68
Ensembl ID: ENSG00000005022
Gene Symbol: ATP5F1B (ENSG00000110955)
Fold Change: 1.67
Ensembl ID: ENSG00000110955
Gene Symbol: ATP5MC3 (ENSG00000154518)
Fold Change: 1.67
Ensembl ID: ENSG00000154518
Gene Symbol: TMEM258 (ENSG00000134825)
Fold Change: 1.66
Ensembl ID: ENSG00000134825
Gene Symbol: CCND3 (ENSG00000112576)
Fold Change: 1.62
Ensembl ID: ENSG00000112576
Gene Symbol: ATP1A1 (ENSG00000163399)
Fold Change: 1.6
Ensembl ID: ENSG00000163399
Gene Symbol: CD81 (ENSG00000110651)
Fold Change: 1.59
Ensembl ID: ENSG00000110651
Gene Symbol: BSG (ENSG00000172270)
Fold Change: 1.58
Ensembl ID: ENSG00000172270
Gene Symbol: BST2 (ENSG00000130303)
Fold Change: 1.58
Ensembl ID: ENSG00000130303
Gene Symbol: AMD1 (ENSG00000123505)
Fold Change: 1.57
Ensembl ID: ENSG00000123505
Gene Symbol: ANXA11 (ENSG00000122359)
Fold Change: 1.56
Ensembl ID: ENSG00000122359
Gene Symbol: ATF4 (ENSG00000128272)
Fold Change: 1.56
Ensembl ID: ENSG00000128272
Gene Symbol: APRT (ENSG00000198931)
Fold Change: 1.54
Ensembl ID: ENSG00000198931
Gene Symbol: ARHGDIA (ENSG00000141522)
Fold Change: 1.53
Ensembl ID: ENSG00000141522
Gene Symbol: ANXA5 (ENSG00000164111)
Fold Change: 1.52
Ensembl ID: ENSG00000164111
Gene Symbol: CHD1 (ENSG00000153922)
Fold Change: 1.5
Ensembl ID: ENSG00000153922
Gene Symbol: ATP6V0B (ENSG00000117410)
Fold Change: 1.49
Ensembl ID: ENSG00000117410
Gene Symbol: ANXA2 (ENSG00000182718)
Fold Change: 1.49
Ensembl ID: ENSG00000182718
Gene Symbol: CALM3 (ENSG00000160014)
Fold Change: 1.48
Ensembl ID: ENSG00000160014
Gene Symbol: CD59 (ENSG00000085063)
Fold Change: 1.48
Ensembl ID: ENSG00000085063
Gene Symbol: ATP1B3 (ENSG00000069849)
Fold Change: 1.47
Ensembl ID: ENSG00000069849
Gene Symbol: ACTN4 (ENSG00000130402)
Fold Change: 1.46
Ensembl ID: ENSG00000130402
Gene Symbol: ATP5F1C (ENSG00000165629)
Fold Change: 1.46
Ensembl ID: ENSG00000165629
Gene Symbol: ADAR (ENSG00000160710)
Fold Change: 1.43
Ensembl ID: ENSG00000160710
Gene Symbol: CAPZA2 (ENSG00000198898)
Fold Change: 1.43
Ensembl ID: ENSG00000198898
Gene Symbol: ATP5F1A (ENSG00000152234)
Fold Change: 1.43
Ensembl ID: ENSG00000152234
Gene Symbol: TLE5 (ENSG00000104964)
Fold Change: 1.41
Ensembl ID: ENSG00000104964
Gene Symbol: CAPN2 (ENSG00000162909)
Fold Change: 1.4
Ensembl ID: ENSG00000162909
Gene Symbol: ATM (ENSG00000149311)
Fold Change: 1.39
Ensembl ID: ENSG00000149311
Gene Symbol: ARF4 (ENSG00000168374)
Fold Change: 1.39
Ensembl ID: ENSG00000168374
Gene Symbol: ANXA7 (ENSG00000138279)
Fold Change: 1.36
Ensembl ID: ENSG00000138279
Gene Symbol: CCNH (ENSG00000134480)
Fold Change: 1.34
Ensembl ID: ENSG00000134480
Gene Symbol: ARF6 (ENSG00000165527)
Fold Change: 1.33
Ensembl ID: ENSG00000165527
Gene Symbol: CEBPB (ENSG00000172216)
Fold Change: 1.29
Ensembl ID: ENSG00000172216
Gene Symbol: APLP2 (ENSG00000084234)
Fold Change: 1.28
Ensembl ID: ENSG00000084234
Gene Symbol: BNIP2 (ENSG00000140299)
Fold Change: 1.27
Ensembl ID: ENSG00000140299
Gene Symbol: ATP5PO (ENSG00000241837)
Fold Change: 1.25
Ensembl ID: ENSG00000241837
Gene Symbol: ATP5PB (ENSG00000116459)
Fold Change: 1.23
Ensembl ID: ENSG00000116459
Gene Symbol: RERE (ENSG00000142599)
Fold Change: 1.21
Ensembl ID: ENSG00000142599
Gene Symbol: ADD1 (ENSG00000087274)
Fold Change: 1.2
Ensembl ID: ENSG00000087274
Gene Symbol: ANXA13 (ENSG00000104537)
Fold Change: 1.19
Ensembl ID: ENSG00000104537
Gene Symbol: RHOG (ENSG00000177105)
Fold Change: 1.18
Ensembl ID: ENSG00000177105
Gene Symbol: ACADVL (ENSG00000072778)
Fold Change: 1.18
Ensembl ID: ENSG00000072778
Gene Symbol: ASAH1 (ENSG00000104763)
Fold Change: 1.17
Ensembl ID: ENSG00000104763
Gene Symbol: AP2B1 (ENSG00000006125)
Fold Change: 1.16
Ensembl ID: ENSG00000006125
Gene Symbol: ATP2B1 (ENSG00000070961)
Fold Change: 1.16
Ensembl ID: ENSG00000070961
Gene Symbol: ATP5MC1 (ENSG00000159199)
Fold Change: 1.15
Ensembl ID: ENSG00000159199
Gene Symbol: CD52 (ENSG00000169442)
Fold Change: 1.15
Ensembl ID: ENSG00000169442
Gene Symbol: APEX1 (ENSG00000100823)
Fold Change: 1.15
Ensembl ID: ENSG00000100823
Gene Symbol: CAMLG (ENSG00000164615)
Fold Change: 1.14
Ensembl ID: ENSG00000164615
Gene Symbol: CAPNS1 (ENSG00000126247)
Fold Change: 1.13
Ensembl ID: ENSG00000126247
Gene Symbol: CENPC (ENSG00000145241)
Fold Change: 1.13
Ensembl ID: ENSG00000145241
Gene Symbol: BIRC3 (ENSG00000023445)
Fold Change: 1.13
Ensembl ID: ENSG00000023445
Gene Symbol: ATP6V1E1 (ENSG00000131100)
Fold Change: 1.13
Ensembl ID: ENSG00000131100
Gene Symbol: AUP1 (ENSG00000115307)
Fold Change: 1.13
Ensembl ID: ENSG00000115307
Gene Symbol: ADAM10 (ENSG00000137845)
Fold Change: 1.11
Ensembl ID: ENSG00000137845
Gene Symbol: ADD3 (ENSG00000148700)
Fold Change: 1.11
Ensembl ID: ENSG00000148700
Gene Symbol: APOA1 (ENSG00000118137)
Fold Change: 1.11
Ensembl ID: ENSG00000118137
Gene Symbol: BNIP3L (ENSG00000104765)
Fold Change: 1.11
Ensembl ID: ENSG00000104765
Gene Symbol: BIRC2 (ENSG00000110330)
Fold Change: 1.07
Ensembl ID: ENSG00000110330
Gene Symbol: RHOB (ENSG00000143878)
Fold Change: 1.06
Ensembl ID: ENSG00000143878
Gene Symbol: CCT6A (ENSG00000146731)
Fold Change: 1.05
Ensembl ID: ENSG00000146731
Gene Symbol: ADH5 (ENSG00000197894)
Fold Change: 1.03
Ensembl ID: ENSG00000197894
Gene Symbol: RHOC (ENSG00000155366)
Fold Change: 1.03
Ensembl ID: ENSG00000155366
Gene Symbol: XIAP (ENSG00000101966)
Fold Change: 1.02
Ensembl ID: ENSG00000101966
Gene Symbol: C1QBP (ENSG00000108561)
Fold Change: 1.02
Ensembl ID: ENSG00000108561
Gene Symbol: TMEM50B (ENSG00000142188)
Fold Change: 1.02
Ensembl ID: ENSG00000142188
Gene Symbol: ARF5 (ENSG00000004059)
Fold Change: 1.01
Ensembl ID: ENSG00000004059

Gene representation (1565)
Gene/Pathway representation (1565)

Hovered Details

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**Key Characteristics** * Progenitor cell of the endocrine pancreas * Able to differentiate into alpha, beta, and delta endocrine cells * Expresses neurogenin-3 and Isl-1 transcription factors * Involved in the adaptive immune system, amyloid fiber formation, and antigen presentation * Gene Symbol: B2M (beta-2 microglobulin) * Ensembl ID: ENSG00000166710 **Clinical Significance** The pancreatic endocrine progenitor cell plays a crucial role in the development and function of the pancreas, particularly in the regulation of glucose metabolism and insulin production. Abnormalities in this cell type have been implicated in various diseases, including: * Diabetes mellitus type 1 and 2 * Pancreatic cancer * Autoimmune diseases such as type 1 diabetes and rheumatoid arthritis * Inflammatory bowel disease Understanding the biology and function of the pancreatic endocrine progenitor cell is essential for the development of novel therapeutic strategies for these diseases. **Pathways and Ontologies** The cell ID CL0002351 is involved in various pathways and ontologies, including: * Adaptive immune system * Amyloid fiber formation * Antigen presentation: folding, assembly and peptide loading of class I MHC * Antigen processing-cross presentation * Antigen processing and presentation of endogenous peptide antigen via MHC class I * Antigen processing and presentation of exogenous peptide antigen via MHC class II * Antigen processing and presentation of exogenous protein antigen via MHC class Ib, tap-dependent * Bacterial infection pathways * Cellular response to iron(III) ion * Cellular response to iron ion * Cellular response to nicotine * Class I MHC mediated antigen processing & presentation * Cytokine signaling in immune system * Cytosol * Dap12 interactions * Dap12 signaling * Disease * Early endosome lumen * Early endosome membrane * Endoplasmic reticulum * Endoplasmic reticulum lumen * Endosomal/vacuolar pathway * Er-phagosome pathway * Er to Golgi transport vesicle membrane * External side of plasma membrane * Extracellular exosome * Extracellular region * Extracellular space * Focal adhesion * Golgi apparatus * Golgi membrane * Hfe-transferrin receptor complex * Hiv infection * Host interactions of hiv factors * Identical protein binding * Immune system * Immunoregulatory interactions between a lymphoid and a non-lymphoid cell * Infection with mycobacterium tuberculosis * Infectious disease * Innate immune system * Interferon gamma signaling * Interferon signaling * Intracellular iron ion homeostasis * Iron ion transport * Late endosome membrane * Learning or memory * Lysosomal membrane * Membrane * Metabolism of proteins * MHC class II protein complex * MHC class II protein complex binding * MHC class I peptide loading complex * MHC class I protein complex * Modulation by mtb of host immune system * Multicellular organismal-level iron ion homeostasis * Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters * Nef mediated downregulation of MHC class I complex cell surface expression * Negative regulation of epithelial cell proliferation * Negative regulation of forebrain neuron differentiation * Negative regulation of neurogenesis * Negative regulation of neuron projection development * Negative regulation of receptor binding * Neutrophil degranulation * Peptide antigen assembly with MHC class II protein complex * Peptide antigen assembly with MHC class I protein complex * Peptide antigen binding * Phagocytic vesicle membrane * Plasma membrane * Positive regulation of cellular senescence * Positive regulation of ferrous iron binding * Positive regulation of immune response * Positive regulation of protein binding * Positive regulation of receptor-mediated endocytosis * Positive regulation of receptor binding * Positive regulation of T cell activation * Positive regulation of T cell cytokine production * Positive regulation of T cell mediated cytotoxicity * Positive regulation of transferrin receptor binding * Protein binding * Protein homodimerization activity * Protein homotetramerization * Protein refolding * Recycling endosome membrane * Regulation of erythrocyte differentiation * Regulation of iron ion transport * Response to molecule of bacterial origin * SARS-CoV-2 activates/modulates innate and adaptive immune responses * SARS-CoV-2 infection * SARS-CoV-2-host interactions * SARS-CoV infections * Sensory perception of smell * Specific granule lumen * Structural molecule activity * T cell differentiation in thymus * T cell mediated cytotoxicity * Tertiary granule lumen * The role of nef in HIV-1 replication and disease pathogenesis * Viral infection pathways

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.