Details for: CL0002355

Cell ID: CL0002355

Cell Name: primitive red blood cell

Marker Score Threshold: 750
(Derived using integrated single-cell and genomic data)

Description: A large nucleated basophilic erythrocyte found in mammalian embryos. This cell type arises from the blood islands of yolk sacs and expresses different types of hemoglobins (beta-H1, gamma-1 and zeta) than adult erythrocytes. Considered a type of erythroblast as this cell type can enucleate in circulation.

Synonyms: primitive erythroblast, primitive erythrocyte, primitive erythroid cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.02
    Ensembl ID: ENSG00000169100
  • Gene Symbol: AMT (ENSG00000145020)
    Fold Change: 2.53
    Ensembl ID: ENSG00000145020
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.34
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 2
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.97
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.94
    Ensembl ID: ENSG00000198668
  • Gene Symbol: SCARB1 (ENSG00000073060)
    Fold Change: 1.92
    Ensembl ID: ENSG00000073060
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.9
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ALDH3B1 (ENSG00000006534)
    Fold Change: 1.81
    Ensembl ID: ENSG00000006534
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.78
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.78
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.76
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.76
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.75
    Ensembl ID: ENSG00000124172
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.71
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.7
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.69
    Ensembl ID: ENSG00000153113
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.69
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.69
    Ensembl ID: ENSG00000152234
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.68
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.67
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.66
    Ensembl ID: ENSG00000099624
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.66
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.65
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.63
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.63
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.61
    Ensembl ID: ENSG00000146731
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.61
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.6
    Ensembl ID: ENSG00000165629
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.6
    Ensembl ID: ENSG00000134825
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.59
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.59
    Ensembl ID: ENSG00000135404
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.55
    Ensembl ID: ENSG00000122545
  • Gene Symbol: AK1 (ENSG00000106992)
    Fold Change: 1.53
    Ensembl ID: ENSG00000106992
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.52
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.51
    Ensembl ID: ENSG00000149925
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.47
    Ensembl ID: ENSG00000176171
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.45
    Ensembl ID: ENSG00000143799
  • Gene Symbol: CD36 (ENSG00000135218)
    Fold Change: 1.45
    Ensembl ID: ENSG00000135218
  • Gene Symbol: BLVRA (ENSG00000106605)
    Fold Change: 1.43
    Ensembl ID: ENSG00000106605
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.43
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CA2 (ENSG00000104267)
    Fold Change: 1.4
    Ensembl ID: ENSG00000104267
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.4
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ADSL (ENSG00000239900)
    Fold Change: 1.4
    Ensembl ID: ENSG00000239900
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.39
    Ensembl ID: ENSG00000085224
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.39
    Ensembl ID: ENSG00000101444
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.38
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.36
    Ensembl ID: ENSG00000168374
  • Gene Symbol: APEH (ENSG00000164062)
    Fold Change: 1.33
    Ensembl ID: ENSG00000164062
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.32
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.32
    Ensembl ID: ENSG00000198898
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.31
    Ensembl ID: ENSG00000004455
  • Gene Symbol: CASP8 (ENSG00000064012)
    Fold Change: 1.3
    Ensembl ID: ENSG00000064012
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.3
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.27
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.27
    Ensembl ID: ENSG00000163399
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.26
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.26
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.25
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.24
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.24
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.24
    Ensembl ID: ENSG00000112576
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.22
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ADD2 (ENSG00000075340)
    Fold Change: 1.22
    Ensembl ID: ENSG00000075340
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.21
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ATIC (ENSG00000138363)
    Fold Change: 1.2
    Ensembl ID: ENSG00000138363
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.2
    Ensembl ID: ENSG00000196776
  • Gene Symbol: CD7 (ENSG00000173762)
    Fold Change: 1.19
    Ensembl ID: ENSG00000173762
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.19
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.19
    Ensembl ID: ENSG00000197894
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.18
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.17
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.16
    Ensembl ID: ENSG00000069849
  • Gene Symbol: CDC5L (ENSG00000096401)
    Fold Change: 1.16
    Ensembl ID: ENSG00000096401
  • Gene Symbol: BIRC5 (ENSG00000089685)
    Fold Change: 1.16
    Ensembl ID: ENSG00000089685
  • Gene Symbol: CCNA2 (ENSG00000145386)
    Fold Change: 1.16
    Ensembl ID: ENSG00000145386
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 1.15
    Ensembl ID: ENSG00000130208
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.15
    Ensembl ID: ENSG00000204574
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.15
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ACTL6A (ENSG00000136518)
    Fold Change: 1.15
    Ensembl ID: ENSG00000136518
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.15
    Ensembl ID: ENSG00000198356
  • Gene Symbol: ACADS (ENSG00000122971)
    Fold Change: 1.13
    Ensembl ID: ENSG00000122971
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.13
    Ensembl ID: ENSG00000138279
  • Gene Symbol: AP2A1 (ENSG00000196961)
    Fold Change: 1.13
    Ensembl ID: ENSG00000196961
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.12
    Ensembl ID: ENSG00000177556
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.11
    Ensembl ID: ENSG00000166710
  • Gene Symbol: TMEM50B (ENSG00000142188)
    Fold Change: 1.09
    Ensembl ID: ENSG00000142188
  • Gene Symbol: CD151 (ENSG00000177697)
    Fold Change: 1.09
    Ensembl ID: ENSG00000177697
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.08
    Ensembl ID: ENSG00000165527
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.08
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CAPN1 (ENSG00000014216)
    Fold Change: 1.07
    Ensembl ID: ENSG00000014216
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.06
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ALAD (ENSG00000148218)
    Fold Change: 1.06
    Ensembl ID: ENSG00000148218
  • Gene Symbol: CCNG1 (ENSG00000113328)
    Fold Change: 1.05
    Ensembl ID: ENSG00000113328
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.03
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.02
    Ensembl ID: ENSG00000087274
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.01
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.01
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CD58 (ENSG00000116815)
    Fold Change: 1
    Ensembl ID: ENSG00000116815
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1
    Ensembl ID: ENSG00000070961
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Large, nucleated, basophilic erythrocyte**: The primitive red blood cell is a large, nucleated cell that is basophilic, meaning it stains with basic dyes. 2. **Expresses different types of hemoglobins**: The primitive red blood cell expresses beta-H1, gamma-1, and zeta hemoglobins, which are different from the hemoglobins expressed in adult erythrocytes. 3. **Considered a type of erythroblast**: The primitive red blood cell is considered a type of erythroblast, which is a cell that is involved in the production of red blood cells. 4. **Can enucleate in circulation**: The primitive red blood cell can enucleate, or lose its nucleus, in circulation, which is a characteristic feature of erythroblasts. **Clinical Significance** 1. **Embryonic development**: The primitive red blood cell is involved in the development of the hematopoietic system in mammals, and its expression of different types of hemoglobins is essential for the development of the blood islands in the yolk sac. 2. **Hematological disorders**: Alterations in the expression of hemoglobins in the primitive red blood cell have been implicated in various hematological disorders, including anemia and leukemias. 3. **HIV infection**: The primitive red blood cell is involved in the pathogenesis of HIV infection, and alterations in its expression of hemoglobins have been associated with HIV-related anemia. 4. **Cancer research**: The primitive red blood cell has been used as a model system to study the development and progression of cancer, particularly in the context of hematopoietic malignancies. **Gene Symbol and Ensembl ID** The gene symbol for the primitive red blood cell is SLC25A6, and its Ensembl ID is ENSG00000169100. The gene is involved in various pathways, including apoptotic process, Atp:adp antiporter activity, disease, HIV infection, and host interactions of HIV factors. **Pathways/Ontology** The primitive red blood cell is involved in various pathways, including: 1. **Apoptotic process**: The primitive red blood cell is involved in the regulation of apoptosis, or programmed cell death. 2. **Atp:adp antiporter activity**: The primitive red blood cell is involved in the regulation of ATP and ADP levels in the cell. 3. **Disease**: The primitive red blood cell is involved in the pathogenesis of various diseases, including anemia and leukemias. 4. **HIV infection**: The primitive red blood cell is involved in the pathogenesis of HIV infection, and alterations in its expression of hemoglobins have been associated with HIV-related anemia. 5. **Host interactions of HIV factors**: The primitive red blood cell is involved in the regulation of host interactions with HIV factors, including the production of chemokines and cytokines. **Gene Symbol: AMT** The gene symbol for the primitive red blood cell is AMT, and its Ensembl ID is ENSG00000145020. The gene is involved in various pathways, including: 1. **Aminomethyltransferase activity**: The AMT gene is involved in the regulation of aminomethyltransferase activity. 2. **Glycine catabolic process**: The AMT gene is involved in the regulation of glycine catabolic process. 3. **Glycine decarboxylation via glycine cleavage system**: The AMT gene is involved in the regulation of glycine decarboxylation via glycine cleavage system. 4. **Glycine degradation**: The AMT gene is involved in the regulation of glycine degradation. 5. **Glyoxylate metabolism and glycine degradation**: The AMT gene is involved in the regulation of glyoxylate metabolism and glycine degradation. **Gene Symbol: BTF3** The gene symbol for the primitive red blood cell is BTF3, and its Ensembl ID is ENSG00000145741. The gene is involved in various pathways, including: 1. **Cytoplasm**: The BTF3 gene is involved in the regulation of cytoplasmic processes. 2. **Cytosol**: The BTF3 gene is involved in the regulation of cytosolic processes. 3. **In utero embryonic development**: The BTF3 gene is involved in the regulation of in utero embryonic development. 4. **Nascent polypeptide-associated complex**: The BTF3 gene is involved in the regulation of nascent polypeptide-associated complex. 5. **Negative regulation of protein localization to endoplasmic reticulum**: The BTF3 gene is involved in the regulation of negative protein localization to endoplasmic reticulum. **Gene Symbol: CANX** The gene symbol for the primitive red blood cell is CANX, and its Ensembl ID is ENSG00000127022. The gene is involved in various pathways, including: 1. **Adaptive immune system**: The CANX gene is involved in the regulation of adaptive immune system. 2. **Antigen presentation: folding, assembly and peptide loading of class I MHC**: The CANX gene is involved in the regulation of antigen presentation. 3. **Assembly of viral components at the budding site**: The CANX gene is involved in the regulation of assembly of viral components at the budding site. 4. **Calcium ion binding**: The CANX gene is involved in the regulation of calcium ion binding. 5. **Calnexin/calreticulin cycle**: The CANX gene is involved in the regulation of calnexin/calreticulin cycle. **Gene Symbol: CALM2** The gene symbol for the primitive red blood cell is CALM2, and its Ensembl ID is ENSG00000143933. The gene is involved in various pathways, including: 1. **Adenylate cyclase activator activity**: The CALM2 gene is involved in the regulation of adenylate cyclase activator activity. 2. **Adenylate cyclase binding**: The CALM2 gene is involved in the regulation of adenylate cyclase binding. 3. **Calcium-dependent protein binding**: The CALM2 gene is involved in the regulation of calcium-dependent protein binding. 4. **Calcium channel complex**: The CALM2 gene is involved in the regulation of calcium channel complex. 5. **Calcium channel inhibitor activity**: The CALM2 gene is involved in the regulation of calcium channel inhibitor activity. **Gene Symbol: CALM1** The gene symbol for the primitive red blood cell is CALM1, and its Ensembl ID is ENSG00000198668. The gene is involved in various pathways, including: 1. **Activation of AMPK downstream of NMDARs**: The CALM1 gene is involved in the regulation of activation of AMPK downstream of NMDARs. 2. **Activation of Ca-permeable kainate receptor**: The CALM1 gene is involved in the regulation of activation of Ca-permeable kainate receptor. 3. **Activation of kainate receptors upon glutamate binding**: The CALM1 gene is involved in the regulation of activation of kainate receptors upon glutamate binding. 4. **Activation of NMDA receptors and postsynaptic events**: The CALM1 gene is involved in the regulation of activation of NMDA receptors and postsynaptic events. 5. **Activation of Rac1 downstream of NMDARs**: The CALM1 gene is involved in the regulation of activation of Rac1 downstream of NMDARs.