Details for: CL0002363

Cell ID: CL0002363

Cell Name: keratocyte

Marker Score Threshold: 230
(Derived using integrated single-cell and genomic data)

Description: A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic morphology; located between the lamellae with a large flattened nucleus, and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratan sulfate.

Synonyms: corneal fibroblast, corneal keratocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.63
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.54
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.43
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.38
    Ensembl ID: ENSG00000124172
  • Gene Symbol: APOD (ENSG00000189058)
    Fold Change: 2.36
    Ensembl ID: ENSG00000189058
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.35
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.31
    Ensembl ID: ENSG00000135046
  • Gene Symbol: AEBP1 (ENSG00000106624)
    Fold Change: 2.21
    Ensembl ID: ENSG00000106624
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.19
    Ensembl ID: ENSG00000142192
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.18
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.16
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 2.16
    Ensembl ID: ENSG00000148700
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.15
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.13
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.08
    Ensembl ID: ENSG00000169020
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.01
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 2.01
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ADH1B (ENSG00000196616)
    Fold Change: 1.98
    Ensembl ID: ENSG00000196616
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.98
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.96
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.95
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.93
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.88
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.82
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.78
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.77
    Ensembl ID: ENSG00000165092
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.76
    Ensembl ID: ENSG00000115963
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.74
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.73
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.73
    Ensembl ID: ENSG00000111275
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.72
    Ensembl ID: ENSG00000198931
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.72
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.71
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.7
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.68
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: 1.67
    Ensembl ID: ENSG00000165029
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.66
    Ensembl ID: ENSG00000168374
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.61
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.6
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.59
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.59
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.58
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.57
    Ensembl ID: ENSG00000122359
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.56
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.49
    Ensembl ID: ENSG00000104763
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.49
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.48
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.48
    Ensembl ID: ENSG00000165629
  • Gene Symbol: AOX1 (ENSG00000138356)
    Fold Change: 1.47
    Ensembl ID: ENSG00000138356
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.46
    Ensembl ID: ENSG00000141522
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.46
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.45
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.44
    Ensembl ID: ENSG00000197043
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.43
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.4
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.4
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.39
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.39
    Ensembl ID: ENSG00000177556
  • Gene Symbol: AXL (ENSG00000167601)
    Fold Change: 1.39
    Ensembl ID: ENSG00000167601
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.38
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.37
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 1.33
    Ensembl ID: ENSG00000047648
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.33
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.31
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ANG (ENSG00000214274)
    Fold Change: 1.31
    Ensembl ID: ENSG00000214274
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.29
    Ensembl ID: ENSG00000058668
  • Gene Symbol: ADM (ENSG00000148926)
    Fold Change: 1.28
    Ensembl ID: ENSG00000148926
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.26
    Ensembl ID: ENSG00000160710
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.26
    Ensembl ID: ENSG00000107262
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.25
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.22
    Ensembl ID: ENSG00000120805
  • Gene Symbol: JAG1 (ENSG00000101384)
    Fold Change: 1.22
    Ensembl ID: ENSG00000101384
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.21
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.16
    Ensembl ID: ENSG00000097007
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.16
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.15
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.15
    Ensembl ID: ENSG00000072778
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.15
    Ensembl ID: ENSG00000115307
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 1.14
    Ensembl ID: ENSG00000130203
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.14
    Ensembl ID: ENSG00000069849
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.13
    Ensembl ID: ENSG00000002330
  • Gene Symbol: AR (ENSG00000169083)
    Fold Change: 1.13
    Ensembl ID: ENSG00000169083
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.13
    Ensembl ID: ENSG00000071553
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.11
    Ensembl ID: ENSG00000164904
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.11
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1.1
    Ensembl ID: ENSG00000143149
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.1
    Ensembl ID: ENSG00000101966
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.09
    Ensembl ID: ENSG00000110330
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.09
    Ensembl ID: ENSG00000183020
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.08
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 1.08
    Ensembl ID: ENSG00000145362
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.07
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.07
    Ensembl ID: ENSG00000070961
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.06
    Ensembl ID: ENSG00000085662
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.04
    Ensembl ID: ENSG00000198356
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.03
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 1.01
    Ensembl ID: ENSG00000076555
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1
    Ensembl ID: ENSG00000204574
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: N/A
    Ensembl ID: ENSG00000165527
Hovered Details

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Hovered Details

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**Key Characteristics** * **Cell morphology**: Keratocytes have a flattened, dendritic morphology with a large flattened nucleus and lengthy processes that communicate with neighboring cells. * **Location**: Keratocytes reside in the cornea stroma, which represents approximately 85-90% of corneal thickness. * **Function**: Keratocytes are responsible for synthesizing and maintaining the extracellular matrix components of the cornea, including collagen I, V, and VI, as well as keratan sulfate. * **Gene expression**: Keratocytes express a range of genes involved in cell signaling, adhesion, and migration, including ACTB, B2M, and several genes involved in collagen synthesis. * **Cell-cell interactions**: Keratocytes interact with neighboring cells through gap junctions and adherens junctions, which facilitate communication and coordination of cellular activities. **Clinical Significance** * **Corneal disease**: Keratocytes play a critical role in maintaining corneal transparency and integrity. Dysfunction or damage to keratocytes can lead to corneal disease, including keratoconus, Fuchs' endothelial dystrophy, and corneal ulcers. * **Wound healing**: Keratocytes are involved in the wound healing process, synthesizing and secreting growth factors and extracellular matrix components to promote tissue repair. * **Corneal transplantation**: Keratocytes are essential for the success of corneal transplantation, as they play a key role in maintaining the integrity and transparency of the transplanted tissue. * **Ophthalmic disorders**: Keratocytes have been implicated in various ophthalmic disorders, including glaucoma, age-related macular degeneration, and diabetic retinopathy. In conclusion, keratocytes are specialized fibroblasts that play a critical role in maintaining corneal transparency and integrity. Their dysfunction or damage can lead to corneal disease, and they are essential for the success of corneal transplantation. Further research is needed to understand the mechanisms underlying keratocyte function and to develop new therapeutic strategies for the treatment of corneal disorders.