Details for: CL0002363

Cell ID: CL0002363

Cell Name: keratocyte

Marker Score Threshold: 230
(Derived using integrated single-cell and genomic data)

Description: A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic morphology; located between the lamellae with a large flattened nucleus, and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratan sulfate.

Synonyms: corneal fibroblast, corneal keratocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.63
    Ensembl ID: ENSG00000075624
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 2.56
    Ensembl ID: ENSG00000167996
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 2.55
    Ensembl ID: ENSG00000087086
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 2.54
    Ensembl ID: ENSG00000156508
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.54
    Ensembl ID: ENSG00000166710
  • Gene Symbol: H3 3B (ENSG00000132475)
    Fold Change: 2.51
    Ensembl ID: ENSG00000132475
  • Gene Symbol: HSP90AA1 (ENSG00000080824)
    Fold Change: 2.5
    Ensembl ID: ENSG00000080824
  • Gene Symbol: FAU (ENSG00000149806)
    Fold Change: 2.48
    Ensembl ID: ENSG00000149806
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 2.44
    Ensembl ID: ENSG00000149131
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.43
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 2.42
    Ensembl ID: ENSG00000122786
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.42
    Ensembl ID: ENSG00000135404
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 2.42
    Ensembl ID: ENSG00000108654
  • Gene Symbol: C1R (ENSG00000159403)
    Fold Change: 2.42
    Ensembl ID: ENSG00000159403
  • Gene Symbol: HSP90AB1 (ENSG00000096384)
    Fold Change: 2.42
    Ensembl ID: ENSG00000096384
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 2.42
    Ensembl ID: ENSG00000101439
  • Gene Symbol: HNRNPA2B1 (ENSG00000122566)
    Fold Change: 2.42
    Ensembl ID: ENSG00000122566
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.41
    Ensembl ID: ENSG00000145741
  • Gene Symbol: C1S (ENSG00000182326)
    Fold Change: 2.41
    Ensembl ID: ENSG00000182326
  • Gene Symbol: FBLN1 (ENSG00000077942)
    Fold Change: 2.41
    Ensembl ID: ENSG00000077942
  • Gene Symbol: DCN (ENSG00000011465)
    Fold Change: 2.41
    Ensembl ID: ENSG00000011465
  • Gene Symbol: GSN (ENSG00000148180)
    Fold Change: 2.41
    Ensembl ID: ENSG00000148180
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 2.4
    Ensembl ID: ENSG00000167658
  • Gene Symbol: GNAS (ENSG00000087460)
    Fold Change: 2.39
    Ensembl ID: ENSG00000087460
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 2.38
    Ensembl ID: ENSG00000127184
  • Gene Symbol: IGFBP6 (ENSG00000167779)
    Fold Change: 2.38
    Ensembl ID: ENSG00000167779
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.38
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CEBPD (ENSG00000221869)
    Fold Change: 2.36
    Ensembl ID: ENSG00000221869
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 2.36
    Ensembl ID: ENSG00000111640
  • Gene Symbol: GPX4 (ENSG00000167468)
    Fold Change: 2.36
    Ensembl ID: ENSG00000167468
  • Gene Symbol: APOD (ENSG00000189058)
    Fold Change: 2.36
    Ensembl ID: ENSG00000189058
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.36
    Ensembl ID: ENSG00000099622
  • Gene Symbol: COL6A2 (ENSG00000142173)
    Fold Change: 2.35
    Ensembl ID: ENSG00000142173
  • Gene Symbol: HMGB1 (ENSG00000189403)
    Fold Change: 2.35
    Ensembl ID: ENSG00000189403
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.35
    Ensembl ID: ENSG00000182718
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 2.34
    Ensembl ID: ENSG00000104529
  • Gene Symbol: DUSP1 (ENSG00000120129)
    Fold Change: 2.33
    Ensembl ID: ENSG00000120129
  • Gene Symbol: GLUL (ENSG00000135821)
    Fold Change: 2.33
    Ensembl ID: ENSG00000135821
  • Gene Symbol: H3 3A (ENSG00000163041)
    Fold Change: 2.32
    Ensembl ID: ENSG00000163041
  • Gene Symbol: C3 (ENSG00000125730)
    Fold Change: 2.32
    Ensembl ID: ENSG00000125730
  • Gene Symbol: HLA E (ENSG00000204592)
    Fold Change: 2.32
    Ensembl ID: ENSG00000204592
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.32
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 2.31
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.31
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CLU (ENSG00000120885)
    Fold Change: 2.3
    Ensembl ID: ENSG00000120885
  • Gene Symbol: COL6A1 (ENSG00000142156)
    Fold Change: 2.3
    Ensembl ID: ENSG00000142156
  • Gene Symbol: IGFBP5 (ENSG00000115461)
    Fold Change: 2.29
    Ensembl ID: ENSG00000115461
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.29
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CFH (ENSG00000000971)
    Fold Change: 2.29
    Ensembl ID: ENSG00000000971
  • Gene Symbol: GSTP1 (ENSG00000084207)
    Fold Change: 2.28
    Ensembl ID: ENSG00000084207
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.27
    Ensembl ID: ENSG00000185650
  • Gene Symbol: COL1A2 (ENSG00000164692)
    Fold Change: 2.27
    Ensembl ID: ENSG00000164692
  • Gene Symbol: HINT1 (ENSG00000169567)
    Fold Change: 2.27
    Ensembl ID: ENSG00000169567
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.26
    Ensembl ID: ENSG00000152518
  • Gene Symbol: EIF4A2 (ENSG00000156976)
    Fold Change: 2.26
    Ensembl ID: ENSG00000156976
  • Gene Symbol: HNRNPK (ENSG00000165119)
    Fold Change: 2.26
    Ensembl ID: ENSG00000165119
  • Gene Symbol: TSC22D3 (ENSG00000157514)
    Fold Change: 2.23
    Ensembl ID: ENSG00000157514
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 2.22
    Ensembl ID: ENSG00000153113
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 2.22
    Ensembl ID: ENSG00000114942
  • Gene Symbol: HSPA8 (ENSG00000109971)
    Fold Change: 2.22
    Ensembl ID: ENSG00000109971
  • Gene Symbol: AEBP1 (ENSG00000106624)
    Fold Change: 2.21
    Ensembl ID: ENSG00000106624
  • Gene Symbol: IGFBP7 (ENSG00000163453)
    Fold Change: 2.21
    Ensembl ID: ENSG00000163453
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.2
    Ensembl ID: ENSG00000131143
  • Gene Symbol: FOS (ENSG00000170345)
    Fold Change: 2.2
    Ensembl ID: ENSG00000170345
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.19
    Ensembl ID: ENSG00000142192
  • Gene Symbol: HLA B (ENSG00000234745)
    Fold Change: 2.19
    Ensembl ID: ENSG00000234745
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.19
    Ensembl ID: ENSG00000172757
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.18
    Ensembl ID: ENSG00000084234
  • Gene Symbol: IL6ST (ENSG00000134352)
    Fold Change: 2.18
    Ensembl ID: ENSG00000134352
  • Gene Symbol: CFD (ENSG00000197766)
    Fold Change: 2.18
    Ensembl ID: ENSG00000197766
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.16
    Ensembl ID: ENSG00000164111
  • Gene Symbol: HNRNPU (ENSG00000153187)
    Fold Change: 2.16
    Ensembl ID: ENSG00000153187
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 2.16
    Ensembl ID: ENSG00000148700
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.15
    Ensembl ID: ENSG00000067560
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.15
    Ensembl ID: ENSG00000122545
  • Gene Symbol: EBF1 (ENSG00000164330)
    Fold Change: 2.15
    Ensembl ID: ENSG00000164330
  • Gene Symbol: EPHX1 (ENSG00000143819)
    Fold Change: 2.15
    Ensembl ID: ENSG00000143819
  • Gene Symbol: FGFR1 (ENSG00000077782)
    Fold Change: 2.15
    Ensembl ID: ENSG00000077782
  • Gene Symbol: ITGB1 (ENSG00000150093)
    Fold Change: 2.14
    Ensembl ID: ENSG00000150093
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.13
    Ensembl ID: ENSG00000135390
  • Gene Symbol: HLA A (ENSG00000206503)
    Fold Change: 2.12
    Ensembl ID: ENSG00000206503
  • Gene Symbol: HSPB1 (ENSG00000106211)
    Fold Change: 2.12
    Ensembl ID: ENSG00000106211
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.11
    Ensembl ID: ENSG00000133639
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 2.11
    Ensembl ID: ENSG00000126267
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 2.1
    Ensembl ID: ENSG00000135940
  • Gene Symbol: EFEMP1 (ENSG00000115380)
    Fold Change: 2.1
    Ensembl ID: ENSG00000115380
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 2.09
    Ensembl ID: ENSG00000119138
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 2.09
    Ensembl ID: ENSG00000164919
  • Gene Symbol: CDKN1C (ENSG00000129757)
    Fold Change: 2.09
    Ensembl ID: ENSG00000129757
  • Gene Symbol: GPX3 (ENSG00000211445)
    Fold Change: 2.09
    Ensembl ID: ENSG00000211445
  • Gene Symbol: CYP1B1 (ENSG00000138061)
    Fold Change: 2.09
    Ensembl ID: ENSG00000138061
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.08
    Ensembl ID: ENSG00000169020
  • Gene Symbol: DAD1 (ENSG00000129562)
    Fold Change: 2.08
    Ensembl ID: ENSG00000129562
  • Gene Symbol: ISLR (ENSG00000129009)
    Fold Change: 2.08
    Ensembl ID: ENSG00000129009
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.07
    Ensembl ID: ENSG00000134825
  • Gene Symbol: FUS (ENSG00000089280)
    Fold Change: 2.06
    Ensembl ID: ENSG00000089280
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 2.06
    Ensembl ID: ENSG00000160213
  • Gene Symbol: HMGN1 (ENSG00000205581)
    Fold Change: 2.05
    Ensembl ID: ENSG00000205581
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 2.05
    Ensembl ID: ENSG00000213719
  • Gene Symbol: CRYAB (ENSG00000109846)
    Fold Change: 2.05
    Ensembl ID: ENSG00000109846

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in keratocyte cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in keratocyte cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** 1. **Morphology**: Keratocytes exhibit a flattened, dendritic morphology, with a large flattened nucleus and lengthy processes that communicate with neighboring cells. 2. **Location**: Keratocytes are located in the corneal stroma, a layer of highly regular collagenous lamellae and extracellular matrix components. 3. **Function**: Keratocytes play a crucial role in maintaining the cornea's transparency, facilitating wound healing, and synthesizing its components. 4. **Secretion**: Keratocytes secrete collagen I, V, VI, and keratan sulfate, which are essential for the cornea's structure and function. 5. **Cellular interactions**: Keratocytes communicate with neighboring cells through their lengthy processes, facilitating cellular interactions and maintaining tissue homeostasis. **Clinical Significance** 1. **Corneal diseases**: Keratocytes play a crucial role in maintaining the cornea's transparency, and diseases affecting these cells can lead to corneal dystrophies, such as keratoconus, and other ocular surface disorders. 2. **Wound healing**: Keratocytes are essential for wound healing in the cornea, and their dysfunction can lead to delayed or impaired wound healing. 3. **Corneal transplantation**: Keratocytes are an essential component of corneal tissue, and their preservation and transplantation are critical for successful corneal transplantation. 4. **Ocular surface disorders**: Keratocytes play a crucial role in maintaining the ocular surface, and disorders affecting these cells can lead to ocular surface disorders, such as dry eye and conjunctivitis. 5. **Immunological responses**: Keratocytes can participate in immunological responses, such as the activation of immune cells and the production of cytokines, which can impact ocular health and disease. In conclusion, keratocytes are specialized fibroblasts that play a crucial role in maintaining the cornea's transparency, facilitating wound healing, and synthesizing its components. Their dysfunction can lead to various ocular surface disorders and diseases, highlighting the importance of understanding keratocyte biology and its clinical significance.