Details for: CL0002365

Cell ID: CL0002365

Cell Name: medullary thymic epithelial cell

Marker Score Threshold: 1,640
(Derived using integrated single-cell and genomic data)

Description: An epithelial cell of the medullary thymus. This cell type expresses a diverse range of tissue-specific antigens. This promiscuous gene expression is a cell-autonomous property of medullary epithelial cells and is maintained during the entire period of thymic T cell output.

Synonyms: mTEC

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 4.63
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.71
    Ensembl ID: ENSG00000075624
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 3.69
    Ensembl ID: ENSG00000087086
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 3.68
    Ensembl ID: ENSG00000156508
  • Gene Symbol: H3 3B (ENSG00000132475)
    Fold Change: 3.68
    Ensembl ID: ENSG00000132475
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.67
    Ensembl ID: ENSG00000166710
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 3.67
    Ensembl ID: ENSG00000167996
  • Gene Symbol: FAU (ENSG00000149806)
    Fold Change: 3.63
    Ensembl ID: ENSG00000149806
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 3.58
    Ensembl ID: ENSG00000111640
  • Gene Symbol: HSP90AA1 (ENSG00000080824)
    Fold Change: 3.56
    Ensembl ID: ENSG00000080824
  • Gene Symbol: HSP90AB1 (ENSG00000096384)
    Fold Change: 3.54
    Ensembl ID: ENSG00000096384
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.52
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.49
    Ensembl ID: ENSG00000184009
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 3.48
    Ensembl ID: ENSG00000167658
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 3.48
    Ensembl ID: ENSG00000099622
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 3.44
    Ensembl ID: ENSG00000131143
  • Gene Symbol: RPSA (ENSG00000168028)
    Fold Change: 3.44
    Ensembl ID: ENSG00000168028
  • Gene Symbol: HSPB1 (ENSG00000106211)
    Fold Change: 3.43
    Ensembl ID: ENSG00000106211
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 3.42
    Ensembl ID: ENSG00000101439
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 3.4
    Ensembl ID: ENSG00000104529
  • Gene Symbol: HMGB1 (ENSG00000189403)
    Fold Change: 3.39
    Ensembl ID: ENSG00000189403
  • Gene Symbol: H3 3A (ENSG00000163041)
    Fold Change: 3.38
    Ensembl ID: ENSG00000163041
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 3.37
    Ensembl ID: ENSG00000127184
  • Gene Symbol: HNRNPA2B1 (ENSG00000122566)
    Fold Change: 3.35
    Ensembl ID: ENSG00000122566
  • Gene Symbol: HNRNPA1 (ENSG00000135486)
    Fold Change: 3.34
    Ensembl ID: ENSG00000135486
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 3.31
    Ensembl ID: ENSG00000135404
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 3.29
    Ensembl ID: ENSG00000108654
  • Gene Symbol: HLA A (ENSG00000206503)
    Fold Change: 3.29
    Ensembl ID: ENSG00000206503
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 3.28
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 3.28
    Ensembl ID: ENSG00000160213
  • Gene Symbol: GSTP1 (ENSG00000084207)
    Fold Change: 3.28
    Ensembl ID: ENSG00000084207
  • Gene Symbol: HINT1 (ENSG00000169567)
    Fold Change: 3.26
    Ensembl ID: ENSG00000169567
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 3.24
    Ensembl ID: ENSG00000172757
  • Gene Symbol: KRT5 (ENSG00000186081)
    Fold Change: 3.24
    Ensembl ID: ENSG00000186081
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 3.23
    Ensembl ID: ENSG00000114942
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.23
    Ensembl ID: ENSG00000135390
  • Gene Symbol: HLA B (ENSG00000234745)
    Fold Change: 3.22
    Ensembl ID: ENSG00000234745
  • Gene Symbol: KRT19 (ENSG00000171345)
    Fold Change: 3.21
    Ensembl ID: ENSG00000171345
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 3.2
    Ensembl ID: ENSG00000185650
  • Gene Symbol: JUNB (ENSG00000171223)
    Fold Change: 3.18
    Ensembl ID: ENSG00000171223
  • Gene Symbol: GPX4 (ENSG00000167468)
    Fold Change: 3.17
    Ensembl ID: ENSG00000167468
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 3.16
    Ensembl ID: ENSG00000130303
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 3.15
    Ensembl ID: ENSG00000143933
  • Gene Symbol: JUN (ENSG00000177606)
    Fold Change: 3.12
    Ensembl ID: ENSG00000177606
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 3.08
    Ensembl ID: ENSG00000067560
  • Gene Symbol: HMGN2 (ENSG00000198830)
    Fold Change: 3.08
    Ensembl ID: ENSG00000198830
  • Gene Symbol: HLA C (ENSG00000204525)
    Fold Change: 3.07
    Ensembl ID: ENSG00000204525
  • Gene Symbol: DNAJB1 (ENSG00000132002)
    Fold Change: 3.04
    Ensembl ID: ENSG00000132002
  • Gene Symbol: HNRNPK (ENSG00000165119)
    Fold Change: 3
    Ensembl ID: ENSG00000165119
  • Gene Symbol: FUS (ENSG00000089280)
    Fold Change: 2.99
    Ensembl ID: ENSG00000089280
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.99
    Ensembl ID: ENSG00000019582
  • Gene Symbol: HLA E (ENSG00000204592)
    Fold Change: 2.98
    Ensembl ID: ENSG00000204592
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.97
    Ensembl ID: ENSG00000124172
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 2.96
    Ensembl ID: ENSG00000164919
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 2.96
    Ensembl ID: ENSG00000067082
  • Gene Symbol: FOS (ENSG00000170345)
    Fold Change: 2.95
    Ensembl ID: ENSG00000170345
  • Gene Symbol: EIF3E (ENSG00000104408)
    Fold Change: 2.94
    Ensembl ID: ENSG00000104408
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 2.91
    Ensembl ID: ENSG00000135940
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 2.91
    Ensembl ID: ENSG00000122705
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.9
    Ensembl ID: ENSG00000133639
  • Gene Symbol: HSPA8 (ENSG00000109971)
    Fold Change: 2.9
    Ensembl ID: ENSG00000109971
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.9
    Ensembl ID: ENSG00000182718
  • Gene Symbol: GPX1 (ENSG00000233276)
    Fold Change: 2.89
    Ensembl ID: ENSG00000233276
  • Gene Symbol: CLU (ENSG00000120885)
    Fold Change: 2.85
    Ensembl ID: ENSG00000120885
  • Gene Symbol: IFI27 (ENSG00000165949)
    Fold Change: 2.85
    Ensembl ID: ENSG00000165949
  • Gene Symbol: EIF4A2 (ENSG00000156976)
    Fold Change: 2.85
    Ensembl ID: ENSG00000156976
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.84
    Ensembl ID: ENSG00000179218
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 2.83
    Ensembl ID: ENSG00000126267
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.82
    Ensembl ID: ENSG00000142192
  • Gene Symbol: KRT17 (ENSG00000128422)
    Fold Change: 2.81
    Ensembl ID: ENSG00000128422
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.81
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.8
    Ensembl ID: ENSG00000198668
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 2.8
    Ensembl ID: ENSG00000111775
  • Gene Symbol: HMGN1 (ENSG00000205581)
    Fold Change: 2.8
    Ensembl ID: ENSG00000205581
  • Gene Symbol: H2AZ1 (ENSG00000164032)
    Fold Change: 2.79
    Ensembl ID: ENSG00000164032
  • Gene Symbol: HNRNPC (ENSG00000092199)
    Fold Change: 2.78
    Ensembl ID: ENSG00000092199
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.78
    Ensembl ID: ENSG00000152518
  • Gene Symbol: DNAJA1 (ENSG00000086061)
    Fold Change: 2.78
    Ensembl ID: ENSG00000086061
  • Gene Symbol: HSPA1A (ENSG00000204389)
    Fold Change: 2.78
    Ensembl ID: ENSG00000204389
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 2.76
    Ensembl ID: ENSG00000176340
  • Gene Symbol: DUSP1 (ENSG00000120129)
    Fold Change: 2.73
    Ensembl ID: ENSG00000120129
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.72
    Ensembl ID: ENSG00000110955
  • Gene Symbol: FN1 (ENSG00000115414)
    Fold Change: 2.69
    Ensembl ID: ENSG00000115414
  • Gene Symbol: HSPA5 (ENSG00000044574)
    Fold Change: 2.69
    Ensembl ID: ENSG00000044574
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 2.69
    Ensembl ID: ENSG00000112695
  • Gene Symbol: KRT8 (ENSG00000170421)
    Fold Change: 2.66
    Ensembl ID: ENSG00000170421
  • Gene Symbol: KRT15 (ENSG00000171346)
    Fold Change: 2.64
    Ensembl ID: ENSG00000171346
  • Gene Symbol: GNG5 (ENSG00000174021)
    Fold Change: 2.63
    Ensembl ID: ENSG00000174021
  • Gene Symbol: EIF5 (ENSG00000100664)
    Fold Change: 2.62
    Ensembl ID: ENSG00000100664
  • Gene Symbol: HSPD1 (ENSG00000144381)
    Fold Change: 2.62
    Ensembl ID: ENSG00000144381
  • Gene Symbol: HSPA1B (ENSG00000204388)
    Fold Change: 2.61
    Ensembl ID: ENSG00000204388
  • Gene Symbol: HSPE1 (ENSG00000115541)
    Fold Change: 2.6
    Ensembl ID: ENSG00000115541
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.6
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.6
    Ensembl ID: ENSG00000154723
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.59
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ERH (ENSG00000100632)
    Fold Change: 2.58
    Ensembl ID: ENSG00000100632
  • Gene Symbol: DAD1 (ENSG00000129562)
    Fold Change: 2.57
    Ensembl ID: ENSG00000129562
  • Gene Symbol: CDKN1A (ENSG00000124762)
    Fold Change: 2.57
    Ensembl ID: ENSG00000124762
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 2.57
    Ensembl ID: ENSG00000010278
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 2.57
    Ensembl ID: ENSG00000151914

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in medullary thymic epithelial cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in medullary thymic epithelial cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** 1. **Promiscuous Gene Expression**: MTECs express a wide range of tissue-specific antigens, which is a unique feature of these cells. 2. **Medullary Thymus Location**: MTECs are found in the medulla of the thymus, where they interact with developing T lymphocytes. 3. **Tissue-Specific Antigens**: MTECs express a diverse range of tissue-specific antigens, which can be used as markers for identifying these cells. 4. **Apoptotic Process**: MTECs are involved in the regulation of the apoptotic process, which is essential for maintaining immune homeostasis. 5. **Gene Expression**: MTECs exhibit complex gene expression patterns, which are influenced by various signaling pathways. **Clinical Significance** 1. **Autoimmune Diseases**: MTECs play a crucial role in regulating the immune system, particularly in the context of autoimmune diseases such as type 1 diabetes and multiple sclerosis. 2. **Cancer**: MTECs can contribute to cancer development by promoting immune evasion and tumor progression. 3. **Thymic Dysplasia**: Abnormalities in MTECs can lead to thymic dysplasia, a condition characterized by impaired thymic function and increased susceptibility to infections. 4. **Immunotherapy**: MTECs are being explored as a potential target for immunotherapy, particularly in the context of cancer treatment. 5. **Vaccine Development**: MTECs can be used as a model system to develop vaccines against infectious diseases, such as HIV and influenza. **Pathways and Ontology** MTECs are involved in various signaling pathways, including: 1. **Apoptotic Process**: MTECs regulate the apoptotic process, which is essential for maintaining immune homeostasis. 2. **ATP:ADP Antiporter Activity**: MTECs exhibit ATP:ADP antiporter activity, which is involved in regulating energy metabolism. 3. **Infectious Disease**: MTECs interact with pathogens and regulate the immune response to infectious diseases. 4. **Host Interactions**: MTECs interact with host cells and regulate various cellular processes, including cell proliferation and differentiation. Overall, MTECs play a critical role in regulating the immune system, and their dysregulation can contribute to various diseases. Further research is needed to understand the complex biology of MTECs and their role in maintaining immune homeostasis.