Details for: CL0002365

Cell ID: CL0002365

Cell Name: medullary thymic epithelial cell

Marker Score Threshold: 1640
(Derived using integrated single-cell and genomic data)

Description: An epithelial cell of the medullary thymus. This cell type expresses a diverse range of tissue-specific antigens. This promiscuous gene expression is a cell-autonomous property of medullary epithelial cells and is maintained during the entire period of thymic T cell output.

Synonyms: mTEC

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 4.63
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.71
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.67
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.49
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 3.28
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.23
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 3.2
    Ensembl ID: ENSG00000185650
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 3.08
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.97
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.9
    Ensembl ID: ENSG00000182718
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.82
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.81
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.78
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.72
    Ensembl ID: ENSG00000110955
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.6
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.6
    Ensembl ID: ENSG00000154723
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 2.57
    Ensembl ID: ENSG00000151914
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 2.56
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.5
    Ensembl ID: ENSG00000152234
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.49
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 2.49
    Ensembl ID: ENSG00000185883
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.48
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.44
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 2.37
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 2.31
    Ensembl ID: ENSG00000004059
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 2.3
    Ensembl ID: ENSG00000130203
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.29
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.26
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 2.24
    Ensembl ID: ENSG00000168374
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.24
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.22
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2.21
    Ensembl ID: ENSG00000116459
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.17
    Ensembl ID: ENSG00000104964
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 2.13
    Ensembl ID: ENSG00000165272
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 2.12
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 2.12
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.11
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.09
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 2.07
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 2.01
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.99
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.89
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.87
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.87
    Ensembl ID: ENSG00000138279
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.76
    Ensembl ID: ENSG00000023445
  • Gene Symbol: CCND1 (ENSG00000110092)
    Fold Change: 1.73
    Ensembl ID: ENSG00000110092
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.71
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.71
    Ensembl ID: ENSG00000196975
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.7
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.69
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.69
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.68
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.66
    Ensembl ID: ENSG00000156110
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.61
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.59
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.58
    Ensembl ID: ENSG00000122359
  • Gene Symbol: FAS (ENSG00000026103)
    Fold Change: 1.58
    Ensembl ID: ENSG00000026103
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.57
    Ensembl ID: ENSG00000090013
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.55
    Ensembl ID: ENSG00000160710
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.55
    Ensembl ID: ENSG00000127837
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.53
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ASCL1 (ENSG00000139352)
    Fold Change: 1.52
    Ensembl ID: ENSG00000139352
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.52
    Ensembl ID: ENSG00000115307
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.49
    Ensembl ID: ENSG00000101444
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.48
    Ensembl ID: ENSG00000143727
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.46
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1.46
    Ensembl ID: ENSG00000143149
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.44
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.4
    Ensembl ID: ENSG00000197043
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.39
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.37
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.37
    Ensembl ID: ENSG00000120805
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.36
    Ensembl ID: ENSG00000176171
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.35
    Ensembl ID: ENSG00000002330
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.34
    Ensembl ID: ENSG00000198356
  • Gene Symbol: ACTA2 (ENSG00000107796)
    Fold Change: 1.34
    Ensembl ID: ENSG00000107796
  • Gene Symbol: BLVRA (ENSG00000106605)
    Fold Change: 1.34
    Ensembl ID: ENSG00000106605
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.33
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.32
    Ensembl ID: ENSG00000148700
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.3
    Ensembl ID: ENSG00000151729
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.3
    Ensembl ID: ENSG00000147872
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.26
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.25
    Ensembl ID: ENSG00000071553
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.22
    Ensembl ID: ENSG00000131100
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.21
    Ensembl ID: ENSG00000115963
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.17
    Ensembl ID: ENSG00000164904
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.17
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ANGPT2 (ENSG00000091879)
    Fold Change: 1.08
    Ensembl ID: ENSG00000091879
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 1.07
    Ensembl ID: ENSG00000072210
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.07
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.06
    Ensembl ID: ENSG00000198363
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.05
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.04
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.02
    Ensembl ID: ENSG00000060971
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.02
    Ensembl ID: ENSG00000134287
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.01
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.01
    Ensembl ID: ENSG00000204574
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.01
    Ensembl ID: ENSG00000151150
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.01
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: N/A
    Ensembl ID: ENSG00000072110
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Promiscuous Gene Expression**: MTECs express a wide range of tissue-specific antigens, which is a characteristic feature of these cells. 2. **Cell-Autonomous Property**: The promiscuous gene expression of MTECs is maintained throughout the entire period of thymic T-cell output, indicating a cell-autonomous property. 3. **Location in the Medulla**: MTECs are located in the medulla of the thymus, where they interact with thymocytes (immature T cells). 4. **Role in T Cell Development**: MTECs play a crucial role in the development and selection of T cells, influencing their maturation and function. 5. **Diverse Antigen Expression**: MTECs express a diverse range of antigens, including those specific to different tissues and organs. **Clinical Significance** 1. **Autoimmune Disorders**: Dysfunction of MTECs has been implicated in various autoimmune disorders, such as type 1 diabetes, multiple sclerosis, and rheumatoid arthritis. 2. **Immunodeficiency Disorders**: MTEC dysfunction has also been linked to immunodeficiency disorders, such as severe combined immunodeficiency (SCID) and thymic hypoplasia. 3. **Tumor Immune Evasion**: MTECs have been shown to interact with tumor cells, potentially influencing tumor immune evasion and progression. 4. **Thymic Dysgenesis**: MTEC dysfunction can lead to thymic dysgenesis, a condition characterized by abnormal thymus development and function. 5. **Potential Therapeutic Targets**: Understanding the role of MTECs in T cell development and selection may lead to the identification of potential therapeutic targets for autoimmune and immunodeficiency disorders. In conclusion, medullary thymic epithelial cells (MTECs) are unique cells with promiscuous gene expression, playing a crucial role in the development and selection of T cells. Their dysfunction has been implicated in various autoimmune and immunodeficiency disorders, making them a potential therapeutic target for the treatment of these conditions.