Details for: CL0002370

Cell ID: CL0002370

Cell Name: respiratory goblet cell

Marker Score Threshold: 289
(Derived using integrated single-cell and genomic data)

Description: A simple columnar epithelial cell that secretes mucin. Rough endoplasmic reticulum, mitochondria, the nucleus, and other organelles are concentrated in the basal portion. The apical plasma membrane projects microvilli to increase surface area for secretion.

Synonyms: respiratory mucosa goblet cells

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.56
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.55
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.48
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.44
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.39
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 2.36
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.36
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 2.34
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.34
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 2.29
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 2.28
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 2.27
    Ensembl ID: ENSG00000111275
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.27
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.26
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.24
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.23
    Ensembl ID: ENSG00000154518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.23
    Ensembl ID: ENSG00000005022
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 2.22
    Ensembl ID: ENSG00000165272
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.18
    Ensembl ID: ENSG00000143761
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 2.17
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.16
    Ensembl ID: ENSG00000154723
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.16
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.14
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.12
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 2.12
    Ensembl ID: ENSG00000122359
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.11
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.09
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.08
    Ensembl ID: ENSG00000169020
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 2.07
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.05
    Ensembl ID: ENSG00000164111
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.05
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.01
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 2.01
    Ensembl ID: ENSG00000168374
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.99
    Ensembl ID: ENSG00000117410
  • Gene Symbol: AQP5 (ENSG00000161798)
    Fold Change: 1.95
    Ensembl ID: ENSG00000161798
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.94
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.9
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.84
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.74
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.72
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.72
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.72
    Ensembl ID: ENSG00000085224
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.7
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.7
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.7
    Ensembl ID: ENSG00000120805
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.7
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.67
    Ensembl ID: ENSG00000174437
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.61
    Ensembl ID: ENSG00000100823
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.6
    Ensembl ID: ENSG00000115963
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.55
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.54
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.54
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ADH1C (ENSG00000248144)
    Fold Change: 1.53
    Ensembl ID: ENSG00000248144
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.5
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.47
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.46
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.46
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.44
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.44
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.43
    Ensembl ID: ENSG00000143727
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.43
    Ensembl ID: ENSG00000106546
  • Gene Symbol: ASS1 (ENSG00000130707)
    Fold Change: 1.42
    Ensembl ID: ENSG00000130707
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 1.4
    Ensembl ID: ENSG00000072210
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.37
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.36
    Ensembl ID: ENSG00000160710
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.35
    Ensembl ID: ENSG00000004455
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.35
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.32
    Ensembl ID: ENSG00000071553
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.3
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.3
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ARSD (ENSG00000006756)
    Fold Change: 1.3
    Ensembl ID: ENSG00000006756
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.28
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.26
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ALDH1A3 (ENSG00000184254)
    Fold Change: 1.26
    Ensembl ID: ENSG00000184254
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.24
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1.23
    Ensembl ID: ENSG00000143149
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.22
    Ensembl ID: ENSG00000101966
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.21
    Ensembl ID: ENSG00000151729
  • Gene Symbol: ARCN1 (ENSG00000095139)
    Fold Change: 1.19
    Ensembl ID: ENSG00000095139
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.18
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.17
    Ensembl ID: ENSG00000138175
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.17
    Ensembl ID: ENSG00000002330
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.14
    Ensembl ID: ENSG00000134287
  • Gene Symbol: ACAT2 (ENSG00000120437)
    Fold Change: 1.13
    Ensembl ID: ENSG00000120437
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.12
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ATP12A (ENSG00000075673)
    Fold Change: 1.1
    Ensembl ID: ENSG00000075673
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.1
    Ensembl ID: ENSG00000164904
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.09
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ANXA3 (ENSG00000138772)
    Fold Change: 1.09
    Ensembl ID: ENSG00000138772
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.09
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.08
    Ensembl ID: ENSG00000060971
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.07
    Ensembl ID: ENSG00000100412
  • Gene Symbol: AKT1 (ENSG00000142208)
    Fold Change: 1.07
    Ensembl ID: ENSG00000142208
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.06
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.05
    Ensembl ID: ENSG00000149925
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.04
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.02
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1
    Ensembl ID: ENSG00000204574
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1
    Ensembl ID: ENSG00000198356
Hovered Details

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Hovered Details

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**Key Characteristics** Respiratory goblet cells have several key characteristics that distinguish them from other types of epithelial cells: 1. **Mucin production**: Respiratory goblet cells are specialized to produce and secrete mucin, a glycoprotein that is secreted onto the surface of the airway. 2. **Apical microvilli**: The apical surface of respiratory goblet cells is covered with microvilli, which increase the surface area of the cell and allow for more efficient mucin secretion. 3. **Basal nucleus**: The basal portion of respiratory goblet cells contains the nucleus and other organelles, including the rough endoplasmic reticulum and mitochondria, which are involved in protein synthesis and energy production. 4. **Simple columnar epithelium**: Respiratory goblet cells are a type of simple columnar epithelium, which is characterized by a single layer of cells with a simple structure and function. **Clinical Significance** Respiratory goblet cells play a crucial role in the respiratory tract, and their dysfunction can lead to a range of clinical disorders. Some of the clinical significance of respiratory goblet cells includes: 1. **Asthma**: Respiratory goblet cells play a key role in the pathogenesis of asthma, where the overproduction of mucin leads to airway inflammation and hyperresponsiveness. 2. **Chronic obstructive pulmonary disease (COPD)**: Respiratory goblet cells are also involved in the pathogenesis of COPD, where the overproduction of mucin leads to airway obstruction and inflammation. 3. **Cystic fibrosis**: Respiratory goblet cells are affected in cystic fibrosis, a genetic disorder that leads to the production of thick, sticky mucus that clogs the airways. 4. **Allergies**: Respiratory goblet cells are involved in the regulation of immune responses in the respiratory tract, and their dysfunction can lead to allergic disorders such as allergic rhinitis and allergic asthma. In summary, respiratory goblet cells are specialized epithelial cells that play a crucial role in the respiratory tract. Their dysfunction can lead to a range of clinical disorders, and their study is an important area of research in the field of respiratory medicine.