Details for: CL0002375

Cell ID: CL0002375

Cell Name: Schwann cell precursor

Marker Score Threshold: 249
(Derived using integrated single-cell and genomic data)

Description: A multipotent progenitor cell that develops from a migratory neural crest cell. The schwann cell precursor is embedded among axons, with minimal extracellular space separating them from nerve cell membranes. This cell lacks a basal lamina, which distinguishes it from more mature Schwann cells. In rodents, cadherin-19 (Cdh19) serves as a specific marker for this developmental stage.

Synonyms: Schwann cell precursor cell, SCP

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.98
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.89
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.19
    Ensembl ID: ENSG00000184009
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.11
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 3.09
    Ensembl ID: ENSG00000172757
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.96
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.87
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.81
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.65
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.59
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.57
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.51
    Ensembl ID: ENSG00000070831
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.36
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.28
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.25
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.24
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.18
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.12
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.09
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 2.08
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.06
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.03
    Ensembl ID: ENSG00000143761
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.99
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.89
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.84
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.84
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.83
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.82
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.81
    Ensembl ID: ENSG00000099624
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.8
    Ensembl ID: ENSG00000005022
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.78
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.77
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.75
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.71
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.71
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.7
    Ensembl ID: ENSG00000196776
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.7
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.7
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.65
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.64
    Ensembl ID: ENSG00000128272
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.63
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.62
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.62
    Ensembl ID: ENSG00000085224
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.61
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.61
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.6
    Ensembl ID: ENSG00000152234
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.56
    Ensembl ID: ENSG00000100300
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.54
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.53
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.52
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.51
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.5
    Ensembl ID: ENSG00000182718
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.48
    Ensembl ID: ENSG00000053254
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.46
    Ensembl ID: ENSG00000173575
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.45
    Ensembl ID: ENSG00000084234
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.44
    Ensembl ID: ENSG00000161203
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.44
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.42
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.4
    Ensembl ID: ENSG00000141522
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.4
    Ensembl ID: ENSG00000085063
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.39
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.38
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.37
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CEBPB (ENSG00000172216)
    Fold Change: 1.34
    Ensembl ID: ENSG00000172216
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.34
    Ensembl ID: ENSG00000070961
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.33
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.32
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.32
    Ensembl ID: ENSG00000168374
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.32
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.31
    Ensembl ID: ENSG00000165527
  • Gene Symbol: AP3S1 (ENSG00000177879)
    Fold Change: 1.29
    Ensembl ID: ENSG00000177879
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.28
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.28
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.25
    Ensembl ID: ENSG00000069849
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.25
    Ensembl ID: ENSG00000153922
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.25
    Ensembl ID: ENSG00000042753
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.24
    Ensembl ID: ENSG00000134480
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.23
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.2
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.18
    Ensembl ID: ENSG00000131100
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.17
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.15
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.15
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.12
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.12
    Ensembl ID: ENSG00000126247
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.11
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.11
    Ensembl ID: ENSG00000213465
  • Gene Symbol: LYST (ENSG00000143669)
    Fold Change: 1.09
    Ensembl ID: ENSG00000143669
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.08
    Ensembl ID: ENSG00000006125
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.08
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.07
    Ensembl ID: ENSG00000087274
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.07
    Ensembl ID: ENSG00000146731
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.07
    Ensembl ID: ENSG00000115307
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.06
    Ensembl ID: ENSG00000087088
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.05
    Ensembl ID: ENSG00000110330
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.05
    Ensembl ID: ENSG00000155366
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.03
    Ensembl ID: ENSG00000164615
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.03
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.01
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: N/A
    Ensembl ID: ENSG00000177556
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Multipotent Progenitor Cell**: SCPs are a type of multipotent progenitor cell that can differentiate into various cell types, including Schwann cells, fibroblasts, and glial cells. 2. **Lack of Basal Lamina**: SCPs do not have a basal lamina, allowing them to migrate closely to axons and interact with surrounding cells. 3. **Expression of Cadherin-19 (Cdh19)**: SCPs express cadherin-19 in rodents, which serves as a specific marker for this developmental stage. 4. **Cytoskeleton Organization**: SCPs are involved in the organization of the cytoskeleton, particularly in the formation of actin filaments and adherens junctions. 5. **Cell-Extracellular Matrix Interactions**: SCPs interact with the extracellular matrix, influencing cell migration, adhesion, and differentiation. **Clinical Significance** 1. **Peripheral Nervous System Disorders**: SCPs play a crucial role in the development and maintenance of the peripheral nervous system, making them a target for the treatment of disorders such as peripheral neuropathy, multiple sclerosis, and Guillain-Barré syndrome. 2. **Neurodegenerative Diseases**: SCPs have been implicated in various neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Cancer**: SCPs have been shown to contribute to cancer development and progression, particularly in the context of neural crest-derived malignancies. 4. **Regenerative Medicine**: SCPs hold promise as a source of cells for regenerative medicine, particularly in the context of neural tissue engineering and repair. In conclusion, SCPs are a critical component of the peripheral nervous system, playing a key role in cell-cell communication, cytoskeleton organization, and cell-extracellular matrix interactions. Understanding the biology of SCPs is essential for the development of novel therapeutic strategies for various neurological disorders and diseases.