Details for: CL0002377

Cell ID: CL0002377

Cell Name: immature Schwann cell

Marker Score Threshold: 462
(Derived using integrated single-cell and genomic data)

Description: A glial cell that develops from a Schwann cell precursor. The immature Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. Immature Schwann cell can be found communally ensheathing large groups of axons.

Synonyms: Schwann cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.49
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.39
    Ensembl ID: ENSG00000166710
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 2.36
    Ensembl ID: ENSG00000156508
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 2.35
    Ensembl ID: ENSG00000167996
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 2.35
    Ensembl ID: ENSG00000087086
  • Gene Symbol: FAU (ENSG00000149806)
    Fold Change: 2.26
    Ensembl ID: ENSG00000149806
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 2.23
    Ensembl ID: ENSG00000111640
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 2.1
    Ensembl ID: ENSG00000108654
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.06
    Ensembl ID: ENSG00000184009
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.04
    Ensembl ID: ENSG00000131143
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.02
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.01
    Ensembl ID: ENSG00000172757
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 2
    Ensembl ID: ENSG00000167658
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 1.99
    Ensembl ID: ENSG00000127184
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 1.96
    Ensembl ID: ENSG00000104529
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 1.93
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.88
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.85
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.77
    Ensembl ID: ENSG00000135390
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 1.74
    Ensembl ID: ENSG00000164919
  • Gene Symbol: EIF4A2 (ENSG00000156976)
    Fold Change: 1.73
    Ensembl ID: ENSG00000156976
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.73
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.72
    Ensembl ID: ENSG00000133639
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 1.72
    Ensembl ID: ENSG00000114942
  • Gene Symbol: GNAS (ENSG00000087460)
    Fold Change: 1.7
    Ensembl ID: ENSG00000087460
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.63
    Ensembl ID: ENSG00000070831
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.62
    Ensembl ID: ENSG00000126267
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.61
    Ensembl ID: ENSG00000067560
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 1.59
    Ensembl ID: ENSG00000112695
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.56
    Ensembl ID: ENSG00000143933
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.56
    Ensembl ID: ENSG00000135940
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.56
    Ensembl ID: ENSG00000135404
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.54
    Ensembl ID: ENSG00000067082
  • Gene Symbol: FUS (ENSG00000089280)
    Fold Change: 1.52
    Ensembl ID: ENSG00000089280
  • Gene Symbol: DUSP1 (ENSG00000120129)
    Fold Change: 1.51
    Ensembl ID: ENSG00000120129
  • Gene Symbol: ENO1 (ENSG00000074800)
    Fold Change: 1.51
    Ensembl ID: ENSG00000074800
  • Gene Symbol: EIF4G2 (ENSG00000110321)
    Fold Change: 1.51
    Ensembl ID: ENSG00000110321
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.49
    Ensembl ID: ENSG00000077549
  • Gene Symbol: FOS (ENSG00000170345)
    Fold Change: 1.49
    Ensembl ID: ENSG00000170345
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.48
    Ensembl ID: ENSG00000111775
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.47
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.43
    Ensembl ID: ENSG00000169020
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.42
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.42
    Ensembl ID: ENSG00000143761
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 1.42
    Ensembl ID: ENSG00000176340
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.41
    Ensembl ID: ENSG00000152518
  • Gene Symbol: EIF4B (ENSG00000063046)
    Fold Change: 1.37
    Ensembl ID: ENSG00000063046
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.36
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.33
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.33
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.33
    Ensembl ID: ENSG00000213719
  • Gene Symbol: CYBA (ENSG00000051523)
    Fold Change: 1.32
    Ensembl ID: ENSG00000051523
  • Gene Symbol: EIF5 (ENSG00000100664)
    Fold Change: 1.32
    Ensembl ID: ENSG00000100664
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.32
    Ensembl ID: ENSG00000154518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.31
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.3
    Ensembl ID: ENSG00000099624
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.3
    Ensembl ID: ENSG00000134825
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 1.28
    Ensembl ID: ENSG00000131174
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 1.27
    Ensembl ID: ENSG00000160213
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.26
    Ensembl ID: ENSG00000172270
  • Gene Symbol: DBI (ENSG00000155368)
    Fold Change: 1.26
    Ensembl ID: ENSG00000155368
  • Gene Symbol: DDX3X (ENSG00000215301)
    Fold Change: 1.25
    Ensembl ID: ENSG00000215301
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.23
    Ensembl ID: ENSG00000127022
  • Gene Symbol: DAD1 (ENSG00000129562)
    Fold Change: 1.22
    Ensembl ID: ENSG00000129562
  • Gene Symbol: TSC22D3 (ENSG00000157514)
    Fold Change: 1.21
    Ensembl ID: ENSG00000157514
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.21
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.2
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 1.19
    Ensembl ID: ENSG00000113712
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.19
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.17
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ENSA (ENSG00000143420)
    Fold Change: 1.17
    Ensembl ID: ENSG00000143420
  • Gene Symbol: ERH (ENSG00000100632)
    Fold Change: 1.16
    Ensembl ID: ENSG00000100632
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.16
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.16
    Ensembl ID: ENSG00000122705
  • Gene Symbol: GDI2 (ENSG00000057608)
    Fold Change: 1.15
    Ensembl ID: ENSG00000057608
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.15
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.13
    Ensembl ID: ENSG00000013441
  • Gene Symbol: ELF1 (ENSG00000120690)
    Fold Change: 1.12
    Ensembl ID: ENSG00000120690
  • Gene Symbol: EIF1AX (ENSG00000173674)
    Fold Change: 1.12
    Ensembl ID: ENSG00000173674
  • Gene Symbol: XRCC6 (ENSG00000196419)
    Fold Change: 1.12
    Ensembl ID: ENSG00000196419
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.12
    Ensembl ID: ENSG00000116489
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.11
    Ensembl ID: ENSG00000161203
  • Gene Symbol: BPTF (ENSG00000171634)
    Fold Change: 1.09
    Ensembl ID: ENSG00000171634
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.08
    Ensembl ID: ENSG00000198898
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.08
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.08
    Ensembl ID: ENSG00000196776
  • Gene Symbol: EIF5A (ENSG00000132507)
    Fold Change: 1.08
    Ensembl ID: ENSG00000132507
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.07
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.07
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.07
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.07
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 1.06
    Ensembl ID: ENSG00000101439
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.06
    Ensembl ID: ENSG00000182718
  • Gene Symbol: FKBP1A (ENSG00000088832)
    Fold Change: 1.06
    Ensembl ID: ENSG00000088832
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.05
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.04
    Ensembl ID: ENSG00000168374
  • Gene Symbol: EWSR1 (ENSG00000182944)
    Fold Change: 1.03
    Ensembl ID: ENSG00000182944
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.02
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.01
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1
    Ensembl ID: ENSG00000173575
Hovered Details

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Hovered Details

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**Key Characteristics** The immature Schwann cell has several key characteristics that distinguish it from other types of cells: 1. **Basal Lamina**: Immature Schwann cells have a basal lamina, a layer of extracellular matrix that separates them from the surrounding tissue. 2. **Axon Ensheathment**: Immature Schwann cells are capable of ensheathing axons, which is essential for the development and maintenance of the nervous system. 3. **Cell-Cell Communication**: Immature Schwann cells are able to communicate with other cells through various signaling pathways, including those involved in cell-cell adhesion and signaling. 4. **Protein Localization**: Immature Schwann cells have a unique ability to localize proteins to specific regions of the cell, which is essential for their function in the nervous system. 5. **Survival without Axon**: Immature Schwann cells are able to survive without an axon present, which is a unique characteristic that distinguishes them from other types of glial cells. **Clinical Significance** The immature Schwann cell has several clinical significance: 1. **Neurological Disorders**: Immature Schwann cells have been implicated in various neurological disorders, including multiple sclerosis, peripheral neuropathy, and amyotrophic lateral sclerosis (ALS). 2. **Neurodevelopmental Disorders**: Immature Schwann cells have been implicated in neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. 3. **Cancer**: Immature Schwann cells have been implicated in cancer, including glioblastoma and melanoma. 4. **Regenerative Medicine**: Immature Schwann cells have been explored as a potential tool for regenerative medicine, including the treatment of spinal cord injuries and peripheral nerve damage. **Pathways/Ontology** The immature Schwann cell is involved in various signaling pathways and ontologies, including: 1. **Actin Cytoskeleton**: Immature Schwann cells have a dynamic actin cytoskeleton that is essential for their function in the nervous system. 2. **Apical Junction Complex**: Immature Schwann cells have a complex of proteins that interact with the apical surface of the cell, which is essential for cell-cell communication. 3. **Adherens Junctions**: Immature Schwann cells have adherens junctions that are essential for cell-cell adhesion and signaling. 4. **Apical Protein Localization**: Immature Schwann cells have a unique ability to localize proteins to specific regions of the cell, which is essential for their function in the nervous system. 5. **Chromatin Remodeling**: Immature Schwann cells have a dynamic chromatin landscape that is essential for their function in gene expression and regulation. Overall, the immature Schwann cell is a complex and dynamic cell type that plays a crucial role in the development and maintenance of the nervous system. Further research is needed to fully understand the biology and clinical significance of this cell type.