CL0002396 - CD14-low, CD16-positive monocyte details

Details for: CL0002396

Cell ID: CL0002396

Cell Name: CD14-low, CD16-positive monocyte

Marker Score Threshold: 706
(Derived using integrated single-cell and genomic data)

Description: A patrolling monocyte that is CD14-low and CD16-positive.

Synonyms: non-classical monocyte, human

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Gene Symbol: AIF1 (ENSG00000204472)
Fold Change: 5.71
Ensembl ID: ENSG00000204472
Gene Symbol: ATP6V0C (ENSG00000185883)
Fold Change: 5.63
Ensembl ID: ENSG00000185883
Gene Symbol: CD68 (ENSG00000129226)
Fold Change: 5.42
Ensembl ID: ENSG00000129226
Gene Symbol: ATP5F1E (ENSG00000124172)
Fold Change: 5.23
Ensembl ID: ENSG00000124172
Gene Symbol: ACTG1 (ENSG00000184009)
Fold Change: 5.2
Ensembl ID: ENSG00000184009
Gene Symbol: ATP5MC2 (ENSG00000135390)
Fold Change: 5.16
Ensembl ID: ENSG00000135390
Gene Symbol: ALDOA (ENSG00000149925)
Fold Change: 5.12
Ensembl ID: ENSG00000149925
Gene Symbol: CALM2 (ENSG00000143933)
Fold Change: 4.94
Ensembl ID: ENSG00000143933
Gene Symbol: SLC25A6 (ENSG00000169100)
Fold Change: 4.93
Ensembl ID: ENSG00000169100
Gene Symbol: ADGRE5 (ENSG00000123146)
Fold Change: 4.74
Ensembl ID: ENSG00000123146
Gene Symbol: ATP5MC3 (ENSG00000154518)
Fold Change: 4.59
Ensembl ID: ENSG00000154518
Gene Symbol: ATP5F1D (ENSG00000099624)
Fold Change: 4.54
Ensembl ID: ENSG00000099624
Gene Symbol: ATP5F1B (ENSG00000110955)
Fold Change: 4.44
Ensembl ID: ENSG00000110955
Gene Symbol: ATP5PO (ENSG00000241837)
Fold Change: 4.36
Ensembl ID: ENSG00000241837
Gene Symbol: ATP5PB (ENSG00000116459)
Fold Change: 3.95
Ensembl ID: ENSG00000116459
Gene Symbol: ATP5F1C (ENSG00000165629)
Fold Change: 3.9
Ensembl ID: ENSG00000165629
Gene Symbol: ATP5PF (ENSG00000154723)
Fold Change: 3.78
Ensembl ID: ENSG00000154723
Gene Symbol: ATP5F1A (ENSG00000152234)
Fold Change: 3.4
Ensembl ID: ENSG00000152234
Gene Symbol: ATP6AP1 (ENSG00000071553)
Fold Change: 3.13
Ensembl ID: ENSG00000071553
Gene Symbol: ACTB (ENSG00000075624)
Fold Change: 3.1
Ensembl ID: ENSG00000075624
Gene Symbol: GRK2 (ENSG00000173020)
Fold Change: 3.02
Ensembl ID: ENSG00000173020
Gene Symbol: ALOX5 (ENSG00000012779)
Fold Change: 2.95
Ensembl ID: ENSG00000012779
Gene Symbol: CD4 (ENSG00000010610)
Fold Change: 2.93
Ensembl ID: ENSG00000010610
Gene Symbol: ARHGAP4 (ENSG00000089820)
Fold Change: 2.82
Ensembl ID: ENSG00000089820
Gene Symbol: BTF3 (ENSG00000145741)
Fold Change: 2.76
Ensembl ID: ENSG00000145741
Gene Symbol: B2M (ENSG00000166710)
Fold Change: 2.75
Ensembl ID: ENSG00000166710
Gene Symbol: C1QBP (ENSG00000108561)
Fold Change: 2.72
Ensembl ID: ENSG00000108561
Gene Symbol: ATP5ME (ENSG00000169020)
Fold Change: 2.62
Ensembl ID: ENSG00000169020
Gene Symbol: CALM1 (ENSG00000198668)
Fold Change: 2.6
Ensembl ID: ENSG00000198668
Gene Symbol: ATP5MC1 (ENSG00000159199)
Fold Change: 2.52
Ensembl ID: ENSG00000159199
Gene Symbol: ARF3 (ENSG00000134287)
Fold Change: 2.38
Ensembl ID: ENSG00000134287
Gene Symbol: TLE5 (ENSG00000104964)
Fold Change: 2.35
Ensembl ID: ENSG00000104964
Gene Symbol: BTG1 (ENSG00000133639)
Fold Change: 2.31
Ensembl ID: ENSG00000133639
Gene Symbol: RHOA (ENSG00000067560)
Fold Change: 2.28
Ensembl ID: ENSG00000067560
Gene Symbol: CD63 (ENSG00000135404)
Fold Change: 2.21
Ensembl ID: ENSG00000135404
Gene Symbol: BTK (ENSG00000010671)
Fold Change: 2.2
Ensembl ID: ENSG00000010671
Gene Symbol: GET3 (ENSG00000198356)
Fold Change: 2.19
Ensembl ID: ENSG00000198356
Gene Symbol: ATRX (ENSG00000085224)
Fold Change: 2.17
Ensembl ID: ENSG00000085224
Gene Symbol: CALR (ENSG00000179218)
Fold Change: 2.12
Ensembl ID: ENSG00000179218
Gene Symbol: BCKDHA (ENSG00000248098)
Fold Change: 2.07
Ensembl ID: ENSG00000248098
Gene Symbol: SLC25A5 (ENSG00000005022)
Fold Change: 2.07
Ensembl ID: ENSG00000005022
Gene Symbol: TMEM258 (ENSG00000134825)
Fold Change: 2.04
Ensembl ID: ENSG00000134825
Gene Symbol: ARF1 (ENSG00000143761)
Fold Change: 2.03
Ensembl ID: ENSG00000143761
Gene Symbol: CD74 (ENSG00000019582)
Fold Change: 1.9
Ensembl ID: ENSG00000019582
Gene Symbol: CAPZB (ENSG00000077549)
Fold Change: 1.85
Ensembl ID: ENSG00000077549
Gene Symbol: ZFP36L1 (ENSG00000185650)
Fold Change: 1.84
Ensembl ID: ENSG00000185650
Gene Symbol: ATP6V0B (ENSG00000117410)
Fold Change: 1.83
Ensembl ID: ENSG00000117410
Gene Symbol: BSG (ENSG00000172270)
Fold Change: 1.81
Ensembl ID: ENSG00000172270
Gene Symbol: APRT (ENSG00000198931)
Fold Change: 1.79
Ensembl ID: ENSG00000198931
Gene Symbol: ZFP36L2 (ENSG00000152518)
Fold Change: 1.75
Ensembl ID: ENSG00000152518
Gene Symbol: CALM3 (ENSG00000160014)
Fold Change: 1.74
Ensembl ID: ENSG00000160014
Gene Symbol: TSPO (ENSG00000100300)
Fold Change: 1.68
Ensembl ID: ENSG00000100300
Gene Symbol: ARHGDIA (ENSG00000141522)
Fold Change: 1.66
Ensembl ID: ENSG00000141522
Gene Symbol: APEX1 (ENSG00000100823)
Fold Change: 1.66
Ensembl ID: ENSG00000100823
Gene Symbol: ANXA5 (ENSG00000164111)
Fold Change: 1.64
Ensembl ID: ENSG00000164111
Gene Symbol: ADSL (ENSG00000239900)
Fold Change: 1.61
Ensembl ID: ENSG00000239900
Gene Symbol: CANX (ENSG00000127022)
Fold Change: 1.61
Ensembl ID: ENSG00000127022
Gene Symbol: ANXA2 (ENSG00000182718)
Fold Change: 1.6
Ensembl ID: ENSG00000182718
Gene Symbol: C2 (ENSG00000166278)
Fold Change: 1.56
Ensembl ID: ENSG00000166278
Gene Symbol: ARHGDIB (ENSG00000111348)
Fold Change: 1.55
Ensembl ID: ENSG00000111348
Gene Symbol: CAST (ENSG00000153113)
Fold Change: 1.54
Ensembl ID: ENSG00000153113
Gene Symbol: ABCF1 (ENSG00000204574)
Fold Change: 1.44
Ensembl ID: ENSG00000204574
Gene Symbol: CAPZA2 (ENSG00000198898)
Fold Change: 1.42
Ensembl ID: ENSG00000198898
Gene Symbol: ARF5 (ENSG00000004059)
Fold Change: 1.42
Ensembl ID: ENSG00000004059
Gene Symbol: ARF4 (ENSG00000168374)
Fold Change: 1.42
Ensembl ID: ENSG00000168374
Gene Symbol: BST2 (ENSG00000130303)
Fold Change: 1.41
Ensembl ID: ENSG00000130303
Gene Symbol: ATF4 (ENSG00000128272)
Fold Change: 1.41
Ensembl ID: ENSG00000128272
Gene Symbol: APLP2 (ENSG00000084234)
Fold Change: 1.39
Ensembl ID: ENSG00000084234
Gene Symbol: ATOX1 (ENSG00000177556)
Fold Change: 1.39
Ensembl ID: ENSG00000177556
Gene Symbol: ANXA1 (ENSG00000135046)
Fold Change: 1.37
Ensembl ID: ENSG00000135046
Gene Symbol: BAX (ENSG00000087088)
Fold Change: 1.34
Ensembl ID: ENSG00000087088
Gene Symbol: ANXA11 (ENSG00000122359)
Fold Change: 1.34
Ensembl ID: ENSG00000122359
Gene Symbol: CAPZA1 (ENSG00000116489)
Fold Change: 1.33
Ensembl ID: ENSG00000116489
Gene Symbol: ARF6 (ENSG00000165527)
Fold Change: 1.32
Ensembl ID: ENSG00000165527
Gene Symbol: CCT6A (ENSG00000146731)
Fold Change: 1.27
Ensembl ID: ENSG00000146731
Gene Symbol: CAPNS1 (ENSG00000126247)
Fold Change: 1.26
Ensembl ID: ENSG00000126247
Gene Symbol: ARL2 (ENSG00000213465)
Fold Change: 1.26
Ensembl ID: ENSG00000213465
Gene Symbol: AUP1 (ENSG00000115307)
Fold Change: 1.26
Ensembl ID: ENSG00000115307
Gene Symbol: RHOG (ENSG00000177105)
Fold Change: 1.25
Ensembl ID: ENSG00000177105
Gene Symbol: ATP1A1 (ENSG00000163399)
Fold Change: 1.25
Ensembl ID: ENSG00000163399
Gene Symbol: CRYBG1 (ENSG00000112297)
Fold Change: 1.25
Ensembl ID: ENSG00000112297
Gene Symbol: BNIP3L (ENSG00000104765)
Fold Change: 1.24
Ensembl ID: ENSG00000104765
Gene Symbol: RHOB (ENSG00000143878)
Fold Change: 1.23
Ensembl ID: ENSG00000143878
Gene Symbol: ASAH1 (ENSG00000104763)
Fold Change: 1.22
Ensembl ID: ENSG00000104763
Gene Symbol: RHOC (ENSG00000155366)
Fold Change: 1.19
Ensembl ID: ENSG00000155366
Gene Symbol: BAG1 (ENSG00000107262)
Fold Change: 1.18
Ensembl ID: ENSG00000107262
Gene Symbol: CD47 (ENSG00000196776)
Fold Change: 1.15
Ensembl ID: ENSG00000196776
Gene Symbol: ACADVL (ENSG00000072778)
Fold Change: 1.14
Ensembl ID: ENSG00000072778
Gene Symbol: ACTN4 (ENSG00000130402)
Fold Change: 1.13
Ensembl ID: ENSG00000130402
Gene Symbol: ATP1B3 (ENSG00000069849)
Fold Change: 1.12
Ensembl ID: ENSG00000069849
Gene Symbol: ANXA7 (ENSG00000138279)
Fold Change: 1.11
Ensembl ID: ENSG00000138279
Gene Symbol: PTTG1IP (ENSG00000183255)
Fold Change: 1.1
Ensembl ID: ENSG00000183255
Gene Symbol: GRK3 (ENSG00000100077)
Fold Change: 1.1
Ensembl ID: ENSG00000100077
Gene Symbol: ADAR (ENSG00000160710)
Fold Change: 1.08
Ensembl ID: ENSG00000160710
Gene Symbol: ACP1 (ENSG00000143727)
Fold Change: 1.05
Ensembl ID: ENSG00000143727
Gene Symbol: TMEM50B (ENSG00000142188)
Fold Change: 1.05
Ensembl ID: ENSG00000142188
Gene Symbol: CD44 (ENSG00000026508)
Fold Change: 1.04
Ensembl ID: ENSG00000026508
Gene Symbol: CD151 (ENSG00000177697)
Fold Change: 1.01
Ensembl ID: ENSG00000177697
Gene Symbol: BNIP2 (ENSG00000140299)
Fold Change: 1.01
Ensembl ID: ENSG00000140299
Gene Symbol: PARP1 (ENSG00000143799)
Fold Change: 1
Ensembl ID: ENSG00000143799

Gene representation (1633)
Gene/Pathway representation (1633)

Hovered Details

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Hovered Details

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**Key Characteristics** * CD14-low: This cell type has a low expression of the CD14 co-receptor, which is typically associated with classical monocytes. * CD16-positive: The cell expresses CD16, also known as FcγRIIIA, which is a receptor for the Fc portion of IgG antibodies. * Non-classical monocyte: This cell type is distinct from classical monocytes, which are typically CD14-high and CD16-negative. * AIF1 gene: The AIF1 gene is specifically expressed in monocytes and macrophages, and is involved in the regulation of cell migration and chemotaxis. * Actin crosslink formation: The cell's actin cytoskeleton plays a crucial role in its migration and phagocytic activities. * Cellular responses to oxidative stress: The cell is able to respond to oxidative stress through various pathways, including the activation of antioxidant enzymes and the regulation of gene expression. **Clinical Significance** * Monocytes and macrophages play a crucial role in the innate immune system, and their dysregulation has been implicated in various diseases, including atherosclerosis, cancer, and inflammatory disorders. * The non-classical monocyte is thought to be involved in the regulation of immune responses, particularly in the context of chronic inflammation. * The AIF1 gene has been implicated in the regulation of cell migration and chemotaxis, and its dysregulation may contribute to the development of various diseases. * The cell's ability to respond to oxidative stress makes it an important target for the development of therapeutic strategies aimed at reducing oxidative damage in diseases such as atherosclerosis and cancer. **Pathways and Ontology** * Actin crosslink formation: The cell's actin cytoskeleton plays a crucial role in its migration and phagocytic activities. * Actin filament assembly: The cell's actin filaments are involved in the regulation of cell migration and chemotaxis. * Cellular responses to oxidative stress: The cell is able to respond to oxidative stress through various pathways, including the activation of antioxidant enzymes and the regulation of gene expression. * Cellular response to type II interferon: The cell is able to respond to type II interferon through various pathways, including the activation of interferon-stimulated genes. * Cytoplasm: The cell's cytoplasm is involved in the regulation of various cellular processes, including protein synthesis and degradation. * Cytosol: The cell's cytosol is involved in the regulation of various cellular processes, including protein synthesis and degradation. * Glial cell projection: The cell's glial cell projections are involved in the regulation of immune responses. * Inflammatory response: The cell is involved in the regulation of inflammatory responses, particularly in the context of chronic inflammation. * Lamellipodium: The cell's lamellipodium is involved in the regulation of cell migration and chemotaxis. * Microglial cell activation: The cell is able to activate microglial cells, which are involved in the regulation of immune responses. * Molecular function: The cell's molecular function is involved in the regulation of various cellular processes, including protein synthesis and degradation. * Negative regulation of smooth muscle cell chemotaxis: The cell is able to regulate smooth muscle cell chemotaxis, which is involved in the regulation of blood pressure. * Negative regulation of smooth muscle cell proliferation: The cell is able to regulate smooth muscle cell proliferation, which is involved in the regulation of blood vessel formation. * Positive regulation of cell migration: The cell is able to regulate cell migration, which is involved in the regulation of immune responses. * Positive regulation of cell population proliferation: The cell is able to regulate cell population proliferation, which is involved in the regulation of immune responses. * Positive regulation of chemokine production: The cell is able to produce chemokines, which are involved in the regulation of immune responses. * Positive regulation of chemotaxis: The cell is able to regulate chemotaxis, which is involved in the regulation of immune responses. * Positive regulation of fibroblast growth factor production: The cell is able to produce fibroblast growth factors, which are involved in the regulation of immune responses. * Positive regulation of g1/s transition of mitotic cell cycle: The cell is able to regulate the g1/s transition of the mitotic cell cycle, which is involved in the regulation of cell proliferation. * Positive regulation of interleukin-6 production: The cell is able to produce interleukin-6, which is involved in the regulation of immune responses. * Positive regulation of monocyte chemotaxis: The cell is able to regulate monocyte chemotaxis, which is involved in the regulation of immune responses. * Positive regulation of mononuclear cell migration: The cell is able to regulate mononuclear cell migration, which is involved in the regulation of immune responses. * Positive regulation of smooth muscle cell chemotaxis: The cell is able to regulate smooth muscle cell chemotaxis, which is involved in the regulation of blood pressure. * Positive regulation of smooth muscle cell proliferation: The cell is able to regulate smooth muscle cell proliferation, which is involved in the regulation of blood vessel formation. * Positive regulation of t cell migration: The cell is able to regulate t cell migration, which is involved in the regulation of immune responses. * Positive regulation of t cell proliferation: The cell is able to regulate t cell proliferation, which is involved in the regulation of immune responses. **Gene Symbol and Ensembl ID** * Gene Symbol: AIF1 * Ensembl ID: ENSG00000204472 **Protein Binding** * The cell's proteins are involved in the regulation of various cellular processes, including protein synthesis and degradation. **Rac Protein Signal Transduction** * The cell's Rac protein is involved in the regulation of cell migration and chemotaxis. **Regulation of Gene Expression** * The cell is able to regulate gene expression, particularly in the context of immune responses. **Ruffle** * The cell's ruffle is involved in the regulation of cell migration and chemotaxis. **Ruffle Assembly** * The cell's ruffle assembly is involved in the regulation of cell migration and chemotaxis. **Ruffle Membrane** * The cell's ruffle membrane is involved in the regulation of cell migration and chemotaxis. **ATP6V0C** * The cell's ATP6V0C protein is involved in the regulation of cellular processes, including protein synthesis and degradation. **ATP5F1E** * The cell's ATP5F1E protein is involved in the regulation of cellular processes, including protein synthesis and degradation. **ACTG1** * The cell's ACTG1 protein is involved in the regulation of cellular processes, including protein synthesis and degradation. **ATP5MC2** * The cell's ATP5MC2 protein is involved in the regulation of cellular processes, including protein synthesis and degradation. **Lipid Binding** * The cell's lipid binding protein is involved in the regulation of cellular processes, including protein synthesis and degradation. **Metabolism** * The cell's metabolism is involved in the regulation of various cellular processes, including protein synthesis and degradation. **Mitochondrial Biogenesis** * The cell's mitochondrial biogenesis is involved in the regulation of cellular processes, including protein synthesis and degradation. **Mitochondrial Inner Membrane** * The cell's mitochondrial inner membrane is involved in the regulation of cellular processes, including protein synthesis and degradation. **Mitochondrial Outer Membrane** * The cell's mitochondrial outer membrane is involved in the regulation of cellular processes, including protein synthesis and degradation. **Mitochondrial Proton-Transporting ATP Synthase Complex** * The cell's mitochondrial proton-transporting ATP synthase complex is involved in the regulation of cellular processes, including protein synthesis and degradation. **Mitochondrial Proton-Transporting ATP Synthase Complex, Coupling Factor F(O)** * The cell's mitochondrial proton-transporting ATP synthase complex, coupling factor F(O) is involved in the regulation of cellular processes, including protein synthesis and degradation. **Cristae Formation** * The cell's cristae formation is involved in the regulation of cellular processes, including protein synthesis and degradation. **Formation of ATP by Chemiosmotic Coupling** * The cell's formation of ATP by chemiosmotic coupling is involved in the regulation of cellular processes, including protein synthesis and degradation. **Hydrolase Activity** * The cell's hydrolase activity is involved in the regulation of cellular processes, including protein synthesis and degradation. **Metabolism** * The cell's metabolism is involved in the regulation of various cellular processes, including protein synthesis and degradation. **Mitochondrial Biogenesis** * The cell's mitochondrial biogenesis is involved in the regulation of cellular processes, including protein synthesis and degradation. **Mitochondrial Inner Membrane** * The cell's mitochondrial inner membrane is involved in the regulation of cellular processes, including protein synthesis and degradation. **Mitochondrial Outer Membrane** * The cell's mitochondrial outer membrane is involved in the regulation of cellular processes, including protein synthesis and degradation. **Mitochondrial Proton-Transporting ATP Synthase Complex** * The cell's mitochondrial proton-transporting ATP synthase complex is involved in the regulation of cellular processes, including protein synthesis and degradation. **Mitochondrial Proton-Transporting ATP Synthase Complex, Coupling Factor F(O)** * The

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.