Details for: CL0002410

Cell ID: CL0002410

Cell Name: pancreatic stellate cell

Marker Score Threshold: 631
(Derived using integrated single-cell and genomic data)

Description: A cell that is found in the periacinar space of the exocrine pancreas and in perivascular and periductal regions of the pancreas, and has long cytoplasmic processes that encircle the base of the acinus. Expresses several intermediate filament proteins including vimentin and nestin. Shares many of the characteristics of hepatatic stellate cells, but not stellate cells of the central nervous system. Upon activation, this cell type undergoes morphological and gene expression changes that make the cell suggestive of being a type of myofibroblast.

Synonyms: PaSC, pancreas stellate cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.89
    Ensembl ID: ENSG00000169100
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.76
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.7
    Ensembl ID: ENSG00000075624
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.66
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.49
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.46
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.31
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.3
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.3
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.24
    Ensembl ID: ENSG00000164111
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.23
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.21
    Ensembl ID: ENSG00000169020
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.2
    Ensembl ID: ENSG00000005022
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.19
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.18
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.18
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.16
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 2.15
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.14
    Ensembl ID: ENSG00000110955
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.08
    Ensembl ID: ENSG00000172270
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 2.06
    Ensembl ID: ENSG00000149131
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.05
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 2.04
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.02
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.96
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.95
    Ensembl ID: ENSG00000141522
  • Gene Symbol: BGN (ENSG00000182492)
    Fold Change: 1.95
    Ensembl ID: ENSG00000182492
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.93
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.93
    Ensembl ID: ENSG00000241837
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.91
    Ensembl ID: ENSG00000155366
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.9
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.87
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.84
    Ensembl ID: ENSG00000165629
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.83
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.82
    Ensembl ID: ENSG00000135046
  • Gene Symbol: C1R (ENSG00000159403)
    Fold Change: 1.82
    Ensembl ID: ENSG00000159403
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.81
    Ensembl ID: ENSG00000152234
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.81
    Ensembl ID: ENSG00000084234
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.79
    Ensembl ID: ENSG00000115963
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.79
    Ensembl ID: ENSG00000142192
  • Gene Symbol: APOD (ENSG00000189058)
    Fold Change: 1.78
    Ensembl ID: ENSG00000189058
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.77
    Ensembl ID: ENSG00000130303
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.77
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.76
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.75
    Ensembl ID: ENSG00000116459
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 1.73
    Ensembl ID: ENSG00000175899
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.72
    Ensembl ID: ENSG00000159199
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.71
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.65
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.59
    Ensembl ID: ENSG00000152518
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.57
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.57
    Ensembl ID: ENSG00000165527
  • Gene Symbol: AEBP1 (ENSG00000106624)
    Fold Change: 1.57
    Ensembl ID: ENSG00000106624
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.57
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.57
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.55
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.55
    Ensembl ID: ENSG00000198363
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.54
    Ensembl ID: ENSG00000100823
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.51
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.49
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.49
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.46
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.42
    Ensembl ID: ENSG00000163399
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.42
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.39
    Ensembl ID: ENSG00000104763
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.37
    Ensembl ID: ENSG00000198356
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.36
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.35
    Ensembl ID: ENSG00000122359
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.33
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.31
    Ensembl ID: ENSG00000160710
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.31
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.3
    Ensembl ID: ENSG00000204574
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.3
    Ensembl ID: ENSG00000120805
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.29
    Ensembl ID: ENSG00000110330
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.29
    Ensembl ID: ENSG00000119138
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.29
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.27
    Ensembl ID: ENSG00000149925
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.26
    Ensembl ID: ENSG00000085662
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.26
    Ensembl ID: ENSG00000127837
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.26
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.19
    Ensembl ID: ENSG00000138175
  • Gene Symbol: A1BG (ENSG00000121410)
    Fold Change: 1.18
    Ensembl ID: ENSG00000121410
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.18
    Ensembl ID: ENSG00000143322
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.15
    Ensembl ID: ENSG00000134287
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.15
    Ensembl ID: ENSG00000002330
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.14
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.12
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP6V1B2 (ENSG00000147416)
    Fold Change: 1.12
    Ensembl ID: ENSG00000147416
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.09
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.08
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.08
    Ensembl ID: ENSG00000174437
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.07
    Ensembl ID: ENSG00000176171
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.06
    Ensembl ID: ENSG00000151914
  • Gene Symbol: AXL (ENSG00000167601)
    Fold Change: 1.06
    Ensembl ID: ENSG00000167601
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.04
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.04
    Ensembl ID: ENSG00000143153
  • Gene Symbol: BLVRA (ENSG00000106605)
    Fold Change: 1.03
    Ensembl ID: ENSG00000106605
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.02
    Ensembl ID: ENSG00000090013
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1
    Ensembl ID: ENSG00000101444
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: N/A
    Ensembl ID: ENSG00000071553
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** 1. **Location**: PaSCs are found in the periacinar space of the exocrine pancreas and in perivascular and periductal regions of the pancreas. 2. **Morphology**: PaSCs have long cytoplasmic processes that encircle the base of the acinus. 3. **Intermediate Filament Proteins**: PaSCs express intermediate filament proteins such as vimentin and nestin. 4. **Gene Expression**: PaSCs undergo morphological and gene expression changes upon activation, making them suggestive of being a type of myofibroblast. 5. **Function**: PaSCs play a crucial role in the pathogenesis of pancreatic fibrosis. **Clinical Significance** 1. **Pancreatic Fibrosis**: PaSCs are involved in the pathogenesis of pancreatic fibrosis, a condition characterized by the excessive deposition of extracellular matrix proteins in the pancreas, leading to its progressive destruction. 2. **Pancreatitis**: PaSCs are activated in response to pancreatic inflammation, leading to the production of extracellular matrix proteins and the activation of fibrosis. 3. **Diabetes**: PaSCs have been implicated in the development of diabetes, as they can produce pro-inflammatory cytokines that contribute to insulin resistance. 4. **Cancer**: PaSCs have been shown to support the growth and metastasis of pancreatic cancer cells, highlighting the importance of their role in the tumor microenvironment. 5. **Therapeutic Targets**: PaSCs have been identified as a potential target for the treatment of pancreatic fibrosis and cancer, highlighting the need for further research into their role in human disease. In conclusion, the pancreatic stellate cell is a specialized cell type that plays a crucial role in the pathogenesis of pancreatic fibrosis and other diseases. Further research into the biology and function of PaSCs is necessary to understand their role in human disease and to identify potential therapeutic targets for the treatment of these conditions.