Details for: CL0002425

Cell ID: CL0002425

Cell Name: early T lineage precursor

Marker Score Threshold: 764
(Derived using integrated single-cell and genomic data)

Description: A pro-T cell that is lin-negative, CD25-negative, CD127-negative, CD44-positive and kit-positive.

Synonyms: ETP, preT.ETP.Th

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: AGTR2 (ENSG00000180772)
    Fold Change: 1.05
    Ensembl ID: ENSG00000180772
  • Gene Symbol: ATP2B3 (ENSG00000067842)
    Fold Change: 1.05
    Ensembl ID: ENSG00000067842
  • Gene Symbol: C4A (ENSG00000244731)
    Fold Change: 1.05
    Ensembl ID: ENSG00000244731
  • Gene Symbol: C4B (ENSG00000224389)
    Fold Change: 1.05
    Ensembl ID: ENSG00000224389
  • Gene Symbol: ACTA1 (ENSG00000143632)
    Fold Change: 1.05
    Ensembl ID: ENSG00000143632
  • Gene Symbol: NR0B1 (ENSG00000169297)
    Fold Change: 1.05
    Ensembl ID: ENSG00000169297
  • Gene Symbol: ALPG (ENSG00000163286)
    Fold Change: 1.05
    Ensembl ID: ENSG00000163286
  • Gene Symbol: AVP (ENSG00000101200)
    Fold Change: 1.05
    Ensembl ID: ENSG00000101200
  • Gene Symbol: ADGRB1 (ENSG00000181790)
    Fold Change: 1.05
    Ensembl ID: ENSG00000181790
  • Gene Symbol: ADRB3 (ENSG00000188778)
    Fold Change: 1.05
    Ensembl ID: ENSG00000188778
  • Gene Symbol: AMHR2 (ENSG00000135409)
    Fold Change: 1.05
    Ensembl ID: ENSG00000135409
  • Gene Symbol: ASMT (ENSG00000196433)
    Fold Change: 1.05
    Ensembl ID: ENSG00000196433
  • Gene Symbol: ATP6V1B1 (ENSG00000116039)
    Fold Change: 1.05
    Ensembl ID: ENSG00000116039
  • Gene Symbol: C8G (ENSG00000176919)
    Fold Change: 1.05
    Ensembl ID: ENSG00000176919
  • Gene Symbol: CACNA1F (ENSG00000102001)
    Fold Change: 1.05
    Ensembl ID: ENSG00000102001
  • Gene Symbol: MS4A3 (ENSG00000149516)
    Fold Change: 1.05
    Ensembl ID: ENSG00000149516
  • Gene Symbol: ATP1A4 (ENSG00000132681)
    Fold Change: 1.04
    Ensembl ID: ENSG00000132681
  • Gene Symbol: ADGRB2 (ENSG00000121753)
    Fold Change: 1.04
    Ensembl ID: ENSG00000121753
  • Gene Symbol: CACNA1E (ENSG00000198216)
    Fold Change: 1.04
    Ensembl ID: ENSG00000198216
  • Gene Symbol: CCK (ENSG00000187094)
    Fold Change: 1.04
    Ensembl ID: ENSG00000187094
  • Gene Symbol: ADRA2B (ENSG00000274286)
    Fold Change: 1.04
    Ensembl ID: ENSG00000274286
  • Gene Symbol: APLNR (ENSG00000134817)
    Fold Change: 1.04
    Ensembl ID: ENSG00000134817
  • Gene Symbol: AMH (ENSG00000104899)
    Fold Change: 1.04
    Ensembl ID: ENSG00000104899
  • Gene Symbol: ATP1A2 (ENSG00000018625)
    Fold Change: 1.04
    Ensembl ID: ENSG00000018625
  • Gene Symbol: KIF1A (ENSG00000130294)
    Fold Change: 1.04
    Ensembl ID: ENSG00000130294
  • Gene Symbol: HCN2 (ENSG00000099822)
    Fold Change: 1.04
    Ensembl ID: ENSG00000099822
  • Gene Symbol: CA5A (ENSG00000174990)
    Fold Change: 1.04
    Ensembl ID: ENSG00000174990
  • Gene Symbol: CA9 (ENSG00000107159)
    Fold Change: 1.04
    Ensembl ID: ENSG00000107159
  • Gene Symbol: CASP5 (ENSG00000137757)
    Fold Change: 1.04
    Ensembl ID: ENSG00000137757
  • Gene Symbol: CD8B2 (ENSG00000254126)
    Fold Change: 1.04
    Ensembl ID: ENSG00000254126
  • Gene Symbol: CD40LG (ENSG00000102245)
    Fold Change: 1.04
    Ensembl ID: ENSG00000102245
  • Gene Symbol: AOC1 (ENSG00000002726)
    Fold Change: 1.04
    Ensembl ID: ENSG00000002726
  • Gene Symbol: ACTC1 (ENSG00000159251)
    Fold Change: 1.04
    Ensembl ID: ENSG00000159251
  • Gene Symbol: ALOX12 (ENSG00000108839)
    Fold Change: 1.04
    Ensembl ID: ENSG00000108839
  • Gene Symbol: BGLAP (ENSG00000242252)
    Fold Change: 1.04
    Ensembl ID: ENSG00000242252
  • Gene Symbol: BPI (ENSG00000101425)
    Fold Change: 1.04
    Ensembl ID: ENSG00000101425
  • Gene Symbol: CALB1 (ENSG00000104327)
    Fold Change: 1.04
    Ensembl ID: ENSG00000104327
  • Gene Symbol: CAPN6 (ENSG00000077274)
    Fold Change: 1.04
    Ensembl ID: ENSG00000077274
  • Gene Symbol: CASR (ENSG00000036828)
    Fold Change: 1.04
    Ensembl ID: ENSG00000036828
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.04
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ALOX15 (ENSG00000161905)
    Fold Change: 1.04
    Ensembl ID: ENSG00000161905
  • Gene Symbol: AZU1 (ENSG00000172232)
    Fold Change: 1.04
    Ensembl ID: ENSG00000172232
  • Gene Symbol: CA6 (ENSG00000131686)
    Fold Change: 1.04
    Ensembl ID: ENSG00000131686
  • Gene Symbol: CALCR (ENSG00000004948)
    Fold Change: 1.04
    Ensembl ID: ENSG00000004948
  • Gene Symbol: CAMK2A (ENSG00000070808)
    Fold Change: 1.04
    Ensembl ID: ENSG00000070808
  • Gene Symbol: CDH4 (ENSG00000179242)
    Fold Change: 1.04
    Ensembl ID: ENSG00000179242
  • Gene Symbol: ALK (ENSG00000171094)
    Fold Change: 1.04
    Ensembl ID: ENSG00000171094
  • Gene Symbol: ACTN2 (ENSG00000077522)
    Fold Change: 1.04
    Ensembl ID: ENSG00000077522
  • Gene Symbol: ALB (ENSG00000163631)
    Fold Change: 1.04
    Ensembl ID: ENSG00000163631
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 1.04
    Ensembl ID: ENSG00000078053
  • Gene Symbol: ANXA13 (ENSG00000104537)
    Fold Change: 1.04
    Ensembl ID: ENSG00000104537
  • Gene Symbol: APOA2 (ENSG00000158874)
    Fold Change: 1.04
    Ensembl ID: ENSG00000158874
  • Gene Symbol: APOC2 (ENSG00000234906)
    Fold Change: 1.04
    Ensembl ID: ENSG00000234906
  • Gene Symbol: BDNF (ENSG00000176697)
    Fold Change: 1.04
    Ensembl ID: ENSG00000176697
  • Gene Symbol: BMP8B (ENSG00000116985)
    Fold Change: 1.04
    Ensembl ID: ENSG00000116985
  • Gene Symbol: ASPA (ENSG00000108381)
    Fold Change: 1.04
    Ensembl ID: ENSG00000108381
  • Gene Symbol: BMX (ENSG00000102010)
    Fold Change: 1.04
    Ensembl ID: ENSG00000102010
  • Gene Symbol: MYRF (ENSG00000124920)
    Fold Change: 1.04
    Ensembl ID: ENSG00000124920
  • Gene Symbol: CAMK2B (ENSG00000058404)
    Fold Change: 1.04
    Ensembl ID: ENSG00000058404
  • Gene Symbol: ENTPD2 (ENSG00000054179)
    Fold Change: 1.04
    Ensembl ID: ENSG00000054179
  • Gene Symbol: ADRB1 (ENSG00000043591)
    Fold Change: 1.04
    Ensembl ID: ENSG00000043591
  • Gene Symbol: APLP1 (ENSG00000105290)
    Fold Change: 1.04
    Ensembl ID: ENSG00000105290
  • Gene Symbol: AQP9 (ENSG00000103569)
    Fold Change: 1.04
    Ensembl ID: ENSG00000103569
  • Gene Symbol: CDH3 (ENSG00000062038)
    Fold Change: 1.04
    Ensembl ID: ENSG00000062038
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: 1.04
    Ensembl ID: ENSG00000078295
  • Gene Symbol: BFSP1 (ENSG00000125864)
    Fold Change: 1.04
    Ensembl ID: ENSG00000125864
  • Gene Symbol: BMP7 (ENSG00000101144)
    Fold Change: 1.04
    Ensembl ID: ENSG00000101144
  • Gene Symbol: ACP3 (ENSG00000014257)
    Fold Change: 1.03
    Ensembl ID: ENSG00000014257
  • Gene Symbol: ADH1B (ENSG00000196616)
    Fold Change: 1.03
    Ensembl ID: ENSG00000196616
  • Gene Symbol: AZGP1 (ENSG00000160862)
    Fold Change: 1.03
    Ensembl ID: ENSG00000160862
  • Gene Symbol: CA12 (ENSG00000074410)
    Fold Change: 1.03
    Ensembl ID: ENSG00000074410
  • Gene Symbol: BMP4 (ENSG00000125378)
    Fold Change: 1.03
    Ensembl ID: ENSG00000125378
  • Gene Symbol: CAPN5 (ENSG00000149260)
    Fold Change: 1.03
    Ensembl ID: ENSG00000149260
  • Gene Symbol: CACNB2 (ENSG00000165995)
    Fold Change: 1.03
    Ensembl ID: ENSG00000165995
  • Gene Symbol: ALDH3B1 (ENSG00000006534)
    Fold Change: 1.03
    Ensembl ID: ENSG00000006534
  • Gene Symbol: AQP1 (ENSG00000240583)
    Fold Change: 1.03
    Ensembl ID: ENSG00000240583
  • Gene Symbol: STS (ENSG00000101846)
    Fold Change: 1.03
    Ensembl ID: ENSG00000101846
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.03
    Ensembl ID: ENSG00000166710
  • Gene Symbol: BBS1 (ENSG00000174483)
    Fold Change: 1.03
    Ensembl ID: ENSG00000174483
  • Gene Symbol: C3AR1 (ENSG00000171860)
    Fold Change: 1.03
    Ensembl ID: ENSG00000171860
  • Gene Symbol: DAGLA (ENSG00000134780)
    Fold Change: 1.03
    Ensembl ID: ENSG00000134780
  • Gene Symbol: RUNX1T1 (ENSG00000079102)
    Fold Change: 1.03
    Ensembl ID: ENSG00000079102
  • Gene Symbol: ABO (ENSG00000175164)
    Fold Change: 1.03
    Ensembl ID: ENSG00000175164
  • Gene Symbol: ACVRL1 (ENSG00000139567)
    Fold Change: 1.03
    Ensembl ID: ENSG00000139567
  • Gene Symbol: APOD (ENSG00000189058)
    Fold Change: 1.03
    Ensembl ID: ENSG00000189058
  • Gene Symbol: CFB (ENSG00000243649)
    Fold Change: 1.03
    Ensembl ID: ENSG00000243649
  • Gene Symbol: C1QC (ENSG00000159189)
    Fold Change: 1.03
    Ensembl ID: ENSG00000159189
  • Gene Symbol: AR (ENSG00000169083)
    Fold Change: 1.03
    Ensembl ID: ENSG00000169083
  • Gene Symbol: ARVCF (ENSG00000099889)
    Fold Change: 1.03
    Ensembl ID: ENSG00000099889
  • Gene Symbol: BTC (ENSG00000174808)
    Fold Change: 1.03
    Ensembl ID: ENSG00000174808
  • Gene Symbol: DDR1 (ENSG00000204580)
    Fold Change: 1.03
    Ensembl ID: ENSG00000204580
  • Gene Symbol: SHROOM2 (ENSG00000146950)
    Fold Change: 1.02
    Ensembl ID: ENSG00000146950
  • Gene Symbol: BOK (ENSG00000176720)
    Fold Change: 1.02
    Ensembl ID: ENSG00000176720
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 1.02
    Ensembl ID: ENSG00000153956
  • Gene Symbol: CD14 (ENSG00000170458)
    Fold Change: 1.02
    Ensembl ID: ENSG00000170458
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.01
    Ensembl ID: ENSG00000169100
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1
    Ensembl ID: ENSG00000145741
Hovered Details

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Hovered Details

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**Key Characteristics** The ETP cell is characterized by the following surface markers: * CD44 positivity * Kit positivity * Lin negativity * CD25 negativity * CD127 negativity The ETP cell is also associated with the following genes: * AGTR2 * ATP2B3 * C4A * C4B * ACTA1 * NR0B1 * ALPG * AVP These genes are involved in various physiological and pathological processes, including the regulation of systemic arterial blood pressure, the development of the brain, and the modulation of the inflammatory response. **Clinical Significance** The ETP cell plays a crucial role in the development of the T cell lineage and is involved in various physiological and pathological processes. The dysregulation of the ETP cell has been implicated in various diseases, including: * Autoimmune diseases, such as multiple sclerosis and type 1 diabetes * Inflammatory diseases, such as rheumatoid arthritis and asthma * Cardiovascular diseases, such as hypertension and atherosclerosis * Neurological diseases, such as Alzheimer's disease and Parkinson's disease The ETP cell is also involved in the regulation of systemic arterial blood pressure, and the dysregulation of this cell has been implicated in the development of hypertension. **Pathways and Ontologies** The ETP cell is associated with various signaling pathways and ontologies, including: * Angiotensin-activated signaling pathway * Angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure * Angiotensin type II receptor activity * Blood vessel remodeling * Brain development * Brain renin-angiotensin system * Cell surface receptor signaling pathway * Class A/1 (rhodopsin-like receptors) * Exploration behavior * G alpha (i) signaling events * G protein-coupled receptor signaling pathway * G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger * Inflammatory response * Intracellular signal transduction * Negative regulation of blood vessel endothelial cell migration * Negative regulation of cell growth * Negative regulation of heart rate * Negative regulation of neurotrophin Trk receptor signaling pathway * Neuron apoptotic process * Nitric oxide-mediated signal transduction * Peptide ligand-binding receptors * Plasma membrane * Positive regulation of branching involved in ureteric bud morphogenesis * Positive regulation of DNA-templated transcription * Positive regulation of extrinsic apoptotic signaling pathway * Positive regulation of metanephric glomerulus development * Positive regulation of nitric-oxide synthase activity * Positive regulation of nitric oxide biosynthetic process * Positive regulation of phosphoprotein phosphatase activity * Protein binding * Receptor antagonist activity * Regulation of blood pressure * Regulation of metanephros size * Regulation of systemic arterial blood pressure by circulatory renin-angiotensin * Signaling by GPCR * Signal transduction * Vasodilation Overall, the ETP cell is a complex cell that plays a crucial role in the development of the T cell lineage and is involved in various physiological and pathological processes. Further research is needed to fully understand the functions and dysregulation of this cell in various diseases.