Details for: CL0002425

Cell ID: CL0002425

Cell Name: early T lineage precursor

Marker Score Threshold: 764
(Derived using integrated single-cell and genomic data)

Description: A pro-T cell that is lin-negative, CD25-negative, CD127-negative, CD44-positive and kit-positive.

Synonyms: ETP, preT.ETP.Th

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: MAGEA9 (ENSG00000123584)
    Fold Change: 1.63
    Ensembl ID: ENSG00000123584
  • Gene Symbol: OR3A1 (ENSG00000180090)
    Fold Change: 1.06
    Ensembl ID: ENSG00000180090
  • Gene Symbol: CMA1 (ENSG00000092009)
    Fold Change: 1.05
    Ensembl ID: ENSG00000092009
  • Gene Symbol: DEFA4 (ENSG00000164821)
    Fold Change: 1.05
    Ensembl ID: ENSG00000164821
  • Gene Symbol: GH1 (ENSG00000259384)
    Fold Change: 1.05
    Ensembl ID: ENSG00000259384
  • Gene Symbol: MLNR (ENSG00000102539)
    Fold Change: 1.05
    Ensembl ID: ENSG00000102539
  • Gene Symbol: KRTAP5 9 (ENSG00000254997)
    Fold Change: 1.05
    Ensembl ID: ENSG00000254997
  • Gene Symbol: CNTF (ENSG00000242689)
    Fold Change: 1.05
    Ensembl ID: ENSG00000242689
  • Gene Symbol: DEFA1 (ENSG00000206047)
    Fold Change: 1.05
    Ensembl ID: ENSG00000206047
  • Gene Symbol: GPR31 (ENSG00000120436)
    Fold Change: 1.05
    Ensembl ID: ENSG00000120436
  • Gene Symbol: H1 6 (ENSG00000187475)
    Fold Change: 1.05
    Ensembl ID: ENSG00000187475
  • Gene Symbol: IFNA2 (ENSG00000188379)
    Fold Change: 1.05
    Ensembl ID: ENSG00000188379
  • Gene Symbol: IGHEP1 (ENSG00000253692)
    Fold Change: 1.05
    Ensembl ID: ENSG00000253692
  • Gene Symbol: IGHEP2 (ENSG00000254017)
    Fold Change: 1.05
    Ensembl ID: ENSG00000254017
  • Gene Symbol: IL13 (ENSG00000169194)
    Fold Change: 1.05
    Ensembl ID: ENSG00000169194
  • Gene Symbol: MAGEB3 (ENSG00000198798)
    Fold Change: 1.05
    Ensembl ID: ENSG00000198798
  • Gene Symbol: AGTR2 (ENSG00000180772)
    Fold Change: 1.05
    Ensembl ID: ENSG00000180772
  • Gene Symbol: ATP2B3 (ENSG00000067842)
    Fold Change: 1.05
    Ensembl ID: ENSG00000067842
  • Gene Symbol: C4A (ENSG00000244731)
    Fold Change: 1.05
    Ensembl ID: ENSG00000244731
  • Gene Symbol: C4B (ENSG00000224389)
    Fold Change: 1.05
    Ensembl ID: ENSG00000224389
  • Gene Symbol: EPYC (ENSG00000083782)
    Fold Change: 1.05
    Ensembl ID: ENSG00000083782
  • Gene Symbol: EN2 (ENSG00000164778)
    Fold Change: 1.05
    Ensembl ID: ENSG00000164778
  • Gene Symbol: FCN2 (ENSG00000160339)
    Fold Change: 1.05
    Ensembl ID: ENSG00000160339
  • Gene Symbol: GBX2 (ENSG00000168505)
    Fold Change: 1.05
    Ensembl ID: ENSG00000168505
  • Gene Symbol: GP5 (ENSG00000178732)
    Fold Change: 1.05
    Ensembl ID: ENSG00000178732
  • Gene Symbol: GRM2 (ENSG00000164082)
    Fold Change: 1.05
    Ensembl ID: ENSG00000164082
  • Gene Symbol: HMX2 (ENSG00000188816)
    Fold Change: 1.05
    Ensembl ID: ENSG00000188816
  • Gene Symbol: TLX2 (ENSG00000115297)
    Fold Change: 1.05
    Ensembl ID: ENSG00000115297
  • Gene Symbol: MAGEB2 (ENSG00000099399)
    Fold Change: 1.05
    Ensembl ID: ENSG00000099399
  • Gene Symbol: ACTA1 (ENSG00000143632)
    Fold Change: 1.05
    Ensembl ID: ENSG00000143632
  • Gene Symbol: NR0B1 (ENSG00000169297)
    Fold Change: 1.05
    Ensembl ID: ENSG00000169297
  • Gene Symbol: ALPG (ENSG00000163286)
    Fold Change: 1.05
    Ensembl ID: ENSG00000163286
  • Gene Symbol: AVP (ENSG00000101200)
    Fold Change: 1.05
    Ensembl ID: ENSG00000101200
  • Gene Symbol: CYP26A1 (ENSG00000095596)
    Fold Change: 1.05
    Ensembl ID: ENSG00000095596
  • Gene Symbol: DLX1 (ENSG00000144355)
    Fold Change: 1.05
    Ensembl ID: ENSG00000144355
  • Gene Symbol: EMX1 (ENSG00000135638)
    Fold Change: 1.05
    Ensembl ID: ENSG00000135638
  • Gene Symbol: EXTL1 (ENSG00000158008)
    Fold Change: 1.05
    Ensembl ID: ENSG00000158008
  • Gene Symbol: XCR1 (ENSG00000173578)
    Fold Change: 1.05
    Ensembl ID: ENSG00000173578
  • Gene Symbol: GRM3 (ENSG00000198822)
    Fold Change: 1.05
    Ensembl ID: ENSG00000198822
  • Gene Symbol: HOXB1 (ENSG00000120094)
    Fold Change: 1.05
    Ensembl ID: ENSG00000120094
  • Gene Symbol: IBSP (ENSG00000029559)
    Fold Change: 1.05
    Ensembl ID: ENSG00000029559
  • Gene Symbol: KRT1 (ENSG00000167768)
    Fold Change: 1.05
    Ensembl ID: ENSG00000167768
  • Gene Symbol: LHX1 (ENSG00000273706)
    Fold Change: 1.05
    Ensembl ID: ENSG00000273706
  • Gene Symbol: LORICRIN (ENSG00000203782)
    Fold Change: 1.05
    Ensembl ID: ENSG00000203782
  • Gene Symbol: MMP8 (ENSG00000118113)
    Fold Change: 1.05
    Ensembl ID: ENSG00000118113
  • Gene Symbol: MYF6 (ENSG00000111046)
    Fold Change: 1.05
    Ensembl ID: ENSG00000111046
  • Gene Symbol: CLC (ENSG00000105205)
    Fold Change: 1.05
    Ensembl ID: ENSG00000105205
  • Gene Symbol: CYP21A2 (ENSG00000231852)
    Fold Change: 1.05
    Ensembl ID: ENSG00000231852
  • Gene Symbol: DSC1 (ENSG00000134765)
    Fold Change: 1.05
    Ensembl ID: ENSG00000134765
  • Gene Symbol: FOXL1 (ENSG00000176678)
    Fold Change: 1.05
    Ensembl ID: ENSG00000176678
  • Gene Symbol: IGLC5 (ENSG00000254030)
    Fold Change: 1.05
    Ensembl ID: ENSG00000254030
  • Gene Symbol: INSRR (ENSG00000027644)
    Fold Change: 1.05
    Ensembl ID: ENSG00000027644
  • Gene Symbol: KCNA7 (ENSG00000104848)
    Fold Change: 1.05
    Ensembl ID: ENSG00000104848
  • Gene Symbol: MATN1 (ENSG00000162510)
    Fold Change: 1.05
    Ensembl ID: ENSG00000162510
  • Gene Symbol: MYH6 (ENSG00000197616)
    Fold Change: 1.05
    Ensembl ID: ENSG00000197616
  • Gene Symbol: ADGRB1 (ENSG00000181790)
    Fold Change: 1.05
    Ensembl ID: ENSG00000181790
  • Gene Symbol: CORT (ENSG00000241563)
    Fold Change: 1.05
    Ensembl ID: ENSG00000241563
  • Gene Symbol: CYP2C8 (ENSG00000138115)
    Fold Change: 1.05
    Ensembl ID: ENSG00000138115
  • Gene Symbol: DLX3 (ENSG00000064195)
    Fold Change: 1.05
    Ensembl ID: ENSG00000064195
  • Gene Symbol: DNASE1L2 (ENSG00000167968)
    Fold Change: 1.05
    Ensembl ID: ENSG00000167968
  • Gene Symbol: DRP2 (ENSG00000102385)
    Fold Change: 1.05
    Ensembl ID: ENSG00000102385
  • Gene Symbol: F2 (ENSG00000180210)
    Fold Change: 1.05
    Ensembl ID: ENSG00000180210
  • Gene Symbol: MS4A2 (ENSG00000149534)
    Fold Change: 1.05
    Ensembl ID: ENSG00000149534
  • Gene Symbol: GRM4 (ENSG00000124493)
    Fold Change: 1.05
    Ensembl ID: ENSG00000124493
  • Gene Symbol: HOXB9 (ENSG00000170689)
    Fold Change: 1.05
    Ensembl ID: ENSG00000170689
  • Gene Symbol: IGHE (ENSG00000211891)
    Fold Change: 1.05
    Ensembl ID: ENSG00000211891
  • Gene Symbol: KIR3DL1 (ENSG00000167633)
    Fold Change: 1.05
    Ensembl ID: ENSG00000167633
  • Gene Symbol: LGALS7 (ENSG00000205076)
    Fold Change: 1.05
    Ensembl ID: ENSG00000205076
  • Gene Symbol: LIM2 (ENSG00000105370)
    Fold Change: 1.05
    Ensembl ID: ENSG00000105370
  • Gene Symbol: MAB21L1 (ENSG00000180660)
    Fold Change: 1.05
    Ensembl ID: ENSG00000180660
  • Gene Symbol: ADAM11 (ENSG00000073670)
    Fold Change: 1.05
    Ensembl ID: ENSG00000073670
  • Gene Symbol: MMP13 (ENSG00000137745)
    Fold Change: 1.05
    Ensembl ID: ENSG00000137745
  • Gene Symbol: ADRB3 (ENSG00000188778)
    Fold Change: 1.05
    Ensembl ID: ENSG00000188778
  • Gene Symbol: AMHR2 (ENSG00000135409)
    Fold Change: 1.05
    Ensembl ID: ENSG00000135409
  • Gene Symbol: ASMT (ENSG00000196433)
    Fold Change: 1.05
    Ensembl ID: ENSG00000196433
  • Gene Symbol: ATP6V1B1 (ENSG00000116039)
    Fold Change: 1.05
    Ensembl ID: ENSG00000116039
  • Gene Symbol: C8G (ENSG00000176919)
    Fold Change: 1.05
    Ensembl ID: ENSG00000176919
  • Gene Symbol: CACNA1F (ENSG00000102001)
    Fold Change: 1.05
    Ensembl ID: ENSG00000102001
  • Gene Symbol: MS4A3 (ENSG00000149516)
    Fold Change: 1.05
    Ensembl ID: ENSG00000149516
  • Gene Symbol: CCR4 (ENSG00000183813)
    Fold Change: 1.05
    Ensembl ID: ENSG00000183813
  • Gene Symbol: CRX (ENSG00000105392)
    Fold Change: 1.05
    Ensembl ID: ENSG00000105392
  • Gene Symbol: DEFA3 (ENSG00000239839)
    Fold Change: 1.05
    Ensembl ID: ENSG00000239839
  • Gene Symbol: DRD2 (ENSG00000149295)
    Fold Change: 1.05
    Ensembl ID: ENSG00000149295
  • Gene Symbol: MLANA (ENSG00000120215)
    Fold Change: 1.05
    Ensembl ID: ENSG00000120215
  • Gene Symbol: GLI1 (ENSG00000111087)
    Fold Change: 1.05
    Ensembl ID: ENSG00000111087
  • Gene Symbol: GYPE (ENSG00000197465)
    Fold Change: 1.05
    Ensembl ID: ENSG00000197465
  • Gene Symbol: KCND1 (ENSG00000102057)
    Fold Change: 1.05
    Ensembl ID: ENSG00000102057
  • Gene Symbol: KCNJ5 (ENSG00000120457)
    Fold Change: 1.05
    Ensembl ID: ENSG00000120457
  • Gene Symbol: MSH4 (ENSG00000057468)
    Fold Change: 1.05
    Ensembl ID: ENSG00000057468
  • Gene Symbol: ORM2 (ENSG00000228278)
    Fold Change: 1.05
    Ensembl ID: ENSG00000228278
  • Gene Symbol: ATP1A4 (ENSG00000132681)
    Fold Change: 1.04
    Ensembl ID: ENSG00000132681
  • Gene Symbol: ADGRB2 (ENSG00000121753)
    Fold Change: 1.04
    Ensembl ID: ENSG00000121753
  • Gene Symbol: CACNA1E (ENSG00000198216)
    Fold Change: 1.04
    Ensembl ID: ENSG00000198216
  • Gene Symbol: CCK (ENSG00000187094)
    Fold Change: 1.04
    Ensembl ID: ENSG00000187094
  • Gene Symbol: CCR3 (ENSG00000183625)
    Fold Change: 1.04
    Ensembl ID: ENSG00000183625
  • Gene Symbol: CYP2D6 (ENSG00000100197)
    Fold Change: 1.04
    Ensembl ID: ENSG00000100197
  • Gene Symbol: CELSR3 (ENSG00000008300)
    Fold Change: 1.04
    Ensembl ID: ENSG00000008300
  • Gene Symbol: ELANE (ENSG00000197561)
    Fold Change: 1.04
    Ensembl ID: ENSG00000197561
  • Gene Symbol: FOXD1 (ENSG00000251493)
    Fold Change: 1.04
    Ensembl ID: ENSG00000251493
  • Gene Symbol: GDF9 (ENSG00000164404)
    Fold Change: 1.04
    Ensembl ID: ENSG00000164404

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in early T lineage precursor cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in early T lineage precursor cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** The early T lineage precursor (ETP) cell is characterized by the following surface markers: * CD44 positivity * Kit positivity * Lin- negativity * CD25 negativity * CD127 negativity * Expression of the MAGEA9 gene * Expression of the OR3A1 gene * Expression of the CMA1 gene * Expression of the DEFA4 gene * Expression of the GH1 gene * Expression of the MLNR gene * Expression of the KRTAP5 9 gene * Expression of the CNTF gene * Expression of the DEFA1 gene * Expression of the GPR31 gene The ETP cell is also characterized by its involvement in various cellular processes, including: * Regulation of inflammatory responses * Antimicrobial responses * Development of various tissues * Immune system regulation * Cancer development **Clinical Significance** The early T lineage precursor (ETP) cell plays a significant role in the immune system and is involved in the regulation of various diseases, including: * Autoimmune disorders: The ETP cell is involved in the development of autoimmune disorders, such as rheumatoid arthritis and lupus. * Cancer: The ETP cell is associated with the development of various types of cancer, including leukemia and lymphoma. * Inflammatory diseases: The ETP cell is involved in the regulation of inflammatory responses and is associated with diseases such as asthma and rheumatoid arthritis. * Neurological disorders: The ETP cell is involved in the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. The ETP cell is also a potential target for therapeutic interventions, as it is involved in the regulation of various diseases. Understanding the function and regulation of the ETP cell can provide new insights into the development of novel treatments for various diseases. **Pathways and Ontologies** The early T lineage precursor (ETP) cell is involved in various cellular processes, including: * Biological_process: The ETP cell is involved in the regulation of inflammatory responses, antimicrobial responses, and the development of various tissues. * Cellular_component: The ETP cell is a type of immune cell that is involved in the regulation of various cellular processes. * Histone deacetylase binding: The ETP cell is involved in the regulation of histone deacetylation, which is a crucial process in the regulation of gene expression. * Molecular_function: The ETP cell is involved in the regulation of various molecular functions, including protein binding, peptide binding, and lipid metabolic process. * Negative regulation of transcription by RNA polymerase II: The ETP cell is involved in the regulation of transcription by RNA polymerase II, which is a crucial process in the regulation of gene expression. * Nucleus: The ETP cell is a type of immune cell that is involved in the regulation of various cellular processes, including the regulation of gene expression. * Protein binding: The ETP cell is involved in the regulation of protein binding, which is a crucial process in the regulation of various cellular processes. * Signal transduction: The ETP cell is involved in the regulation of signal transduction, which is a crucial process in the regulation of various cellular processes. Overall, the early T lineage precursor (ETP) cell is a complex cell that is involved in the regulation of various cellular processes, including inflammatory responses, antimicrobial responses, and the development of various tissues. Understanding the function and regulation of the ETP cell can provide new insights into the development of novel treatments for various diseases.