Details for: CL0002457

Cell ID: CL0002457

Cell Name: epidermal Langerhans cell

Marker Score Threshold: 403
(Derived using integrated single-cell and genomic data)

Description: A Langerhans cell that is in the epidermis and is CD45-positive, MHCII-positive, and CD11b-positive.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.9
    Ensembl ID: ENSG00000075624
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 2.79
    Ensembl ID: ENSG00000156508
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.76
    Ensembl ID: ENSG00000166710
  • Gene Symbol: H3 3B (ENSG00000132475)
    Fold Change: 2.68
    Ensembl ID: ENSG00000132475
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 2.6
    Ensembl ID: ENSG00000111640
  • Gene Symbol: HNRNPA2B1 (ENSG00000122566)
    Fold Change: 2.57
    Ensembl ID: ENSG00000122566
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 2.45
    Ensembl ID: ENSG00000108654
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.4
    Ensembl ID: ENSG00000131143
  • Gene Symbol: HMGB1 (ENSG00000189403)
    Fold Change: 2.38
    Ensembl ID: ENSG00000189403
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 2.31
    Ensembl ID: ENSG00000104529
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.27
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.19
    Ensembl ID: ENSG00000198668
  • Gene Symbol: HLA A (ENSG00000206503)
    Fold Change: 2.11
    Ensembl ID: ENSG00000206503
  • Gene Symbol: HINT1 (ENSG00000169567)
    Fold Change: 2.08
    Ensembl ID: ENSG00000169567
  • Gene Symbol: EIF4A2 (ENSG00000156976)
    Fold Change: 2.03
    Ensembl ID: ENSG00000156976
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.03
    Ensembl ID: ENSG00000133639
  • Gene Symbol: HNRNPK (ENSG00000165119)
    Fold Change: 2.01
    Ensembl ID: ENSG00000165119
  • Gene Symbol: HNRNPC (ENSG00000092199)
    Fold Change: 2.01
    Ensembl ID: ENSG00000092199
  • Gene Symbol: GNAS (ENSG00000087460)
    Fold Change: 2
    Ensembl ID: ENSG00000087460
  • Gene Symbol: HLA C (ENSG00000204525)
    Fold Change: 1.95
    Ensembl ID: ENSG00000204525
  • Gene Symbol: HLA B (ENSG00000234745)
    Fold Change: 1.95
    Ensembl ID: ENSG00000234745
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.91
    Ensembl ID: ENSG00000067560
  • Gene Symbol: HNRNPA1 (ENSG00000135486)
    Fold Change: 1.89
    Ensembl ID: ENSG00000135486
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.89
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.83
    Ensembl ID: ENSG00000135404
  • Gene Symbol: FUS (ENSG00000089280)
    Fold Change: 1.79
    Ensembl ID: ENSG00000089280
  • Gene Symbol: ENO1 (ENSG00000074800)
    Fold Change: 1.77
    Ensembl ID: ENSG00000074800
  • Gene Symbol: EIF4G2 (ENSG00000110321)
    Fold Change: 1.77
    Ensembl ID: ENSG00000110321
  • Gene Symbol: GPX4 (ENSG00000167468)
    Fold Change: 1.76
    Ensembl ID: ENSG00000167468
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.76
    Ensembl ID: ENSG00000067082
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.74
    Ensembl ID: ENSG00000077549
  • Gene Symbol: HNRNPH1 (ENSG00000169045)
    Fold Change: 1.7
    Ensembl ID: ENSG00000169045
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.69
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.68
    Ensembl ID: ENSG00000143761
  • Gene Symbol: PDIA3 (ENSG00000167004)
    Fold Change: 1.65
    Ensembl ID: ENSG00000167004
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.61
    Ensembl ID: ENSG00000152518
  • Gene Symbol: HMGN2 (ENSG00000198830)
    Fold Change: 1.6
    Ensembl ID: ENSG00000198830
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.59
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.57
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.57
    Ensembl ID: ENSG00000213719
  • Gene Symbol: EIF5 (ENSG00000100664)
    Fold Change: 1.55
    Ensembl ID: ENSG00000100664
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.5
    Ensembl ID: ENSG00000172270
  • Gene Symbol: DDX3X (ENSG00000215301)
    Fold Change: 1.44
    Ensembl ID: ENSG00000215301
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.42
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.4
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.38
    Ensembl ID: ENSG00000122705
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 1.38
    Ensembl ID: ENSG00000113712
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.37
    Ensembl ID: ENSG00000019582
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.37
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.37
    Ensembl ID: ENSG00000128272
  • Gene Symbol: GDI2 (ENSG00000057608)
    Fold Change: 1.36
    Ensembl ID: ENSG00000057608
  • Gene Symbol: HNRNPD (ENSG00000138668)
    Fold Change: 1.36
    Ensembl ID: ENSG00000138668
  • Gene Symbol: TSC22D3 (ENSG00000157514)
    Fold Change: 1.35
    Ensembl ID: ENSG00000157514
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.34
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.3
    Ensembl ID: ENSG00000013441
  • Gene Symbol: GOLGA4 (ENSG00000144674)
    Fold Change: 1.29
    Ensembl ID: ENSG00000144674
  • Gene Symbol: ELF1 (ENSG00000120690)
    Fold Change: 1.26
    Ensembl ID: ENSG00000120690
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.26
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.26
    Ensembl ID: ENSG00000116489
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.24
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.24
    Ensembl ID: ENSG00000182718
  • Gene Symbol: BPTF (ENSG00000171634)
    Fold Change: 1.24
    Ensembl ID: ENSG00000171634
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.24
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.23
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.22
    Ensembl ID: ENSG00000196776
  • Gene Symbol: EWSR1 (ENSG00000182944)
    Fold Change: 1.22
    Ensembl ID: ENSG00000182944
  • Gene Symbol: HADHA (ENSG00000084754)
    Fold Change: 1.21
    Ensembl ID: ENSG00000084754
  • Gene Symbol: GNB1 (ENSG00000078369)
    Fold Change: 1.17
    Ensembl ID: ENSG00000078369
  • Gene Symbol: HSPA9 (ENSG00000113013)
    Fold Change: 1.17
    Ensembl ID: ENSG00000113013
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.16
    Ensembl ID: ENSG00000122359
  • Gene Symbol: GRB2 (ENSG00000177885)
    Fold Change: 1.16
    Ensembl ID: ENSG00000177885
  • Gene Symbol: EIF2S3 (ENSG00000130741)
    Fold Change: 1.16
    Ensembl ID: ENSG00000130741
  • Gene Symbol: CTNNB1 (ENSG00000168036)
    Fold Change: 1.15
    Ensembl ID: ENSG00000168036
  • Gene Symbol: ID2 (ENSG00000115738)
    Fold Change: 1.15
    Ensembl ID: ENSG00000115738
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.14
    Ensembl ID: ENSG00000173575
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.14
    Ensembl ID: ENSG00000084234
  • Gene Symbol: GNB2 (ENSG00000172354)
    Fold Change: 1.13
    Ensembl ID: ENSG00000172354
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.13
    Ensembl ID: ENSG00000069849
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.13
    Ensembl ID: ENSG00000104765
  • Gene Symbol: HIF1A (ENSG00000100644)
    Fold Change: 1.12
    Ensembl ID: ENSG00000100644
  • Gene Symbol: PRMT2 (ENSG00000160310)
    Fold Change: 1.12
    Ensembl ID: ENSG00000160310
  • Gene Symbol: DUT (ENSG00000128951)
    Fold Change: 1.11
    Ensembl ID: ENSG00000128951
  • Gene Symbol: GNAI2 (ENSG00000114353)
    Fold Change: 1.09
    Ensembl ID: ENSG00000114353
  • Gene Symbol: DDX6 (ENSG00000110367)
    Fold Change: 1.08
    Ensembl ID: ENSG00000110367
  • Gene Symbol: DYNC1H1 (ENSG00000197102)
    Fold Change: 1.08
    Ensembl ID: ENSG00000197102
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.08
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.08
    Ensembl ID: ENSG00000026508
  • Gene Symbol: IFI16 (ENSG00000163565)
    Fold Change: 1.08
    Ensembl ID: ENSG00000163565
  • Gene Symbol: HMGB2 (ENSG00000164104)
    Fold Change: 1.07
    Ensembl ID: ENSG00000164104
  • Gene Symbol: CTSB (ENSG00000164733)
    Fold Change: 1.06
    Ensembl ID: ENSG00000164733
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.04
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.03
    Ensembl ID: ENSG00000160710
  • Gene Symbol: AP3S1 (ENSG00000177879)
    Fold Change: 1.03
    Ensembl ID: ENSG00000177879
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.03
    Ensembl ID: ENSG00000070961
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.02
    Ensembl ID: ENSG00000053254
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.01
    Ensembl ID: ENSG00000153922
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.01
    Ensembl ID: ENSG00000135046
  • Gene Symbol: RBPJ (ENSG00000168214)
    Fold Change: 1.01
    Ensembl ID: ENSG00000168214
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1
    Ensembl ID: ENSG00000100823
  • Gene Symbol: UBE2K (ENSG00000078140)
    Fold Change: N/A
    Ensembl ID: ENSG00000078140
Hovered Details

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Hovered Details

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**Key Characteristics** * **Location**: Langerhans cells are found in the epidermis. * **Markers**: CD45, MHCII, and CD11b. * **Function**: Present antigens to T-cells and initiate an immune response. * **Cellular processes**: Cell motility, adhesion, and signaling. * **Genes**: ACTB, EEF1A1, and B2M. * **Pathways**: Actin cytoskeleton, autophagy, cellular responses to stimuli, and antigen presentation. **Clinical Significance** Langerhans cells play a crucial role in the immune system, and their dysfunction can lead to various diseases. Some of the clinical significance of Langerhans cells includes: * **Autoimmune diseases**: Langerhans cells can contribute to autoimmune diseases, such as psoriasis and vitiligo, by presenting antigens to T-cells in an inappropriate manner. * **Cancer**: Langerhans cells can also contribute to cancer development by presenting antigens to T-cells, leading to an immune response against the tumor. * **Infectious diseases**: Langerhans cells can play a role in the development of infectious diseases, such as HIV and tuberculosis, by presenting antigens to T-cells. * **Skin disorders**: Langerhans cells can contribute to skin disorders, such as eczema and acne, by presenting antigens to T-cells and initiating an immune response. In summary, Langerhans cells are a type of dendritic cell that plays a crucial role in the immune system. Their function and dysfunction can lead to various diseases, making them an important area of research in immunology and medicine.