Details for: CL0002489

Cell ID: CL0002489

Cell Name: double negative thymocyte

Marker Score Threshold: 1380
(Derived using integrated single-cell and genomic data)

Description: A thymocyte that lacks expression of CD4 and CD8.

Synonyms: CD4-CD8- T cell, double negative T cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: CD1E (ENSG00000158488)
    Fold Change: 18.83
    Ensembl ID: ENSG00000158488
  • Gene Symbol: CD1B (ENSG00000158485)
    Fold Change: 18.82
    Ensembl ID: ENSG00000158485
  • Gene Symbol: ADORA1 (ENSG00000163485)
    Fold Change: 6.43
    Ensembl ID: ENSG00000163485
  • Gene Symbol: CRISP1 (ENSG00000124812)
    Fold Change: 6.28
    Ensembl ID: ENSG00000124812
  • Gene Symbol: AR (ENSG00000169083)
    Fold Change: 3.84
    Ensembl ID: ENSG00000169083
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.57
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.56
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CA8 (ENSG00000178538)
    Fold Change: 3.49
    Ensembl ID: ENSG00000178538
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 3.47
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 3.44
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.3
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 3.26
    Ensembl ID: ENSG00000111348
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.09
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.07
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.01
    Ensembl ID: ENSG00000124172
  • Gene Symbol: AGXT (ENSG00000172482)
    Fold Change: 2.94
    Ensembl ID: ENSG00000172482
  • Gene Symbol: CCKBR (ENSG00000110148)
    Fold Change: 2.94
    Ensembl ID: ENSG00000110148
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.9
    Ensembl ID: ENSG00000135390
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.85
    Ensembl ID: ENSG00000169100
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.84
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.69
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ADCY8 (ENSG00000155897)
    Fold Change: 2.66
    Ensembl ID: ENSG00000155897
  • Gene Symbol: CD1C (ENSG00000158481)
    Fold Change: 2.63
    Ensembl ID: ENSG00000158481
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.62
    Ensembl ID: ENSG00000143761
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.58
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.56
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.56
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CD1A (ENSG00000158477)
    Fold Change: 2.47
    Ensembl ID: ENSG00000158477
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 2.42
    Ensembl ID: ENSG00000134480
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 2.35
    Ensembl ID: ENSG00000112576
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.3
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.3
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CA6 (ENSG00000131686)
    Fold Change: 2.25
    Ensembl ID: ENSG00000131686
  • Gene Symbol: AQP4 (ENSG00000171885)
    Fold Change: 2.18
    Ensembl ID: ENSG00000171885
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 2.16
    Ensembl ID: ENSG00000185883
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.15
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 2.06
    Ensembl ID: ENSG00000141522
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.02
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CAV3 (ENSG00000182533)
    Fold Change: 2
    Ensembl ID: ENSG00000182533
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.99
    Ensembl ID: ENSG00000154518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.98
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.93
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.91
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.89
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.82
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.78
    Ensembl ID: ENSG00000122359
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.74
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.74
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.7
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.7
    Ensembl ID: ENSG00000148700
  • Gene Symbol: RUNX3 (ENSG00000020633)
    Fold Change: 1.69
    Ensembl ID: ENSG00000020633
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.67
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 1.66
    Ensembl ID: ENSG00000114423
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.66
    Ensembl ID: ENSG00000100300
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.63
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.61
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.59
    Ensembl ID: ENSG00000152234
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.59
    Ensembl ID: ENSG00000177105
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.58
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.57
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.55
    Ensembl ID: ENSG00000141480
  • Gene Symbol: ART1 (ENSG00000129744)
    Fold Change: 1.5
    Ensembl ID: ENSG00000129744
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.46
    Ensembl ID: ENSG00000149311
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.46
    Ensembl ID: ENSG00000136717
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.46
    Ensembl ID: ENSG00000087088
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.46
    Ensembl ID: ENSG00000162909
  • Gene Symbol: CASP8 (ENSG00000064012)
    Fold Change: 1.44
    Ensembl ID: ENSG00000064012
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.44
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.42
    Ensembl ID: ENSG00000154723
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 1.42
    Ensembl ID: ENSG00000168421
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.4
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.33
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.33
    Ensembl ID: ENSG00000165629
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.32
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.31
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CRYBG1 (ENSG00000112297)
    Fold Change: 1.3
    Ensembl ID: ENSG00000112297
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.29
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.28
    Ensembl ID: ENSG00000169020
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.26
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.24
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.24
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.22
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.21
    Ensembl ID: ENSG00000143727
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.18
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.18
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ARHGAP4 (ENSG00000089820)
    Fold Change: 1.17
    Ensembl ID: ENSG00000089820
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.15
    Ensembl ID: ENSG00000070961
  • Gene Symbol: C4BPA (ENSG00000123838)
    Fold Change: 1.11
    Ensembl ID: ENSG00000123838
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.09
    Ensembl ID: ENSG00000132965
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.08
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.06
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.06
    Ensembl ID: ENSG00000058668
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.05
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ANGPT1 (ENSG00000154188)
    Fold Change: 1.05
    Ensembl ID: ENSG00000154188
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.05
    Ensembl ID: ENSG00000196954
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.03
    Ensembl ID: ENSG00000149823
  • Gene Symbol: FMNL1 (ENSG00000184922)
    Fold Change: 1.02
    Ensembl ID: ENSG00000184922
  • Gene Symbol: BMPR1B (ENSG00000138696)
    Fold Change: 1.02
    Ensembl ID: ENSG00000138696
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.01
    Ensembl ID: ENSG00000072778
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.01
    Ensembl ID: ENSG00000164615
Hovered Details

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Hovered Details

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**Key Characteristics** * Lacks expression of CD4 and CD8, two co-receptors essential for T cell function * Characterized by the absence of CD1E, CD1B, and ADORA1 * Involved in antigen processing and presentation, immune response, and signaling pathways * May play a specific role in the development and function of the immune system * Rare and poorly understood cell type **Clinical Significance** The double negative thymocyte is a rare cell type that may be involved in various immune-related disorders. Further research is needed to understand the role of this cell type in the immune system and its potential implications for human health. Some possible clinical implications of the double negative thymocyte include: * Immunodeficiency disorders: The double negative thymocyte may be involved in the development of immunodeficiency disorders, such as severe combined immunodeficiency (SCID). * Autoimmune diseases: The double negative thymocyte may play a role in the development of autoimmune diseases, such as multiple sclerosis or type 1 diabetes. * Cancer: The double negative thymocyte may be involved in the development of cancer, particularly in the context of immune evasion. * Infectious diseases: The double negative thymocyte may be involved in the development of infectious diseases, such as HIV or tuberculosis. **Gene Expression and Pathways** The double negative thymocyte is characterized by the absence of CD1E, CD1B, and ADORA1, which are involved in various cellular processes, including: * Antigen processing and presentation: CD1E and CD1B are involved in the presentation of antigens to T cells. * Immune response: ADORA1 is involved in signaling pathways that regulate immune responses. * Signaling pathways: The double negative thymocyte is involved in various signaling pathways, including G-protein coupled receptor signaling pathways and MAPK cascades. **Regulation and Expression** The expression of CD1E, CD1B, and ADORA1 is regulated by various transcription factors and signaling pathways. The double negative thymocyte is characterized by the absence of these genes, which may be due to mutations or epigenetic modifications. **Conclusion** The double negative thymocyte is a rare and poorly understood cell type that is characterized by the absence of CD1E, CD1B, and ADORA1. Further research is needed to understand the role of this cell type in the immune system and its potential implications for human health. The double negative thymocyte may be involved in various immune-related disorders, including immunodeficiency disorders, autoimmune diseases, cancer, and infectious diseases.