Details for: CL0002521

Cell ID: CL0002521

Cell Name: subcutaneous fat cell

Marker Score Threshold: 366
(Derived using integrated single-cell and genomic data)

Description: An adipocyte that is part of subcutaneous adipose tissue.

Synonyms: subcutaneous fat cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 5.65
    Ensembl ID: ENSG00000076555
  • Gene Symbol: PTPRG (ENSG00000144724)
    Fold Change: 5.34
    Ensembl ID: ENSG00000144724
  • Gene Symbol: EBF1 (ENSG00000164330)
    Fold Change: 5.19
    Ensembl ID: ENSG00000164330
  • Gene Symbol: FOXO1 (ENSG00000150907)
    Fold Change: 4.96
    Ensembl ID: ENSG00000150907
  • Gene Symbol: ACSL1 (ENSG00000151726)
    Fold Change: 4.73
    Ensembl ID: ENSG00000151726
  • Gene Symbol: COL4A2 (ENSG00000134871)
    Fold Change: 4.72
    Ensembl ID: ENSG00000134871
  • Gene Symbol: FASN (ENSG00000169710)
    Fold Change: 4.71
    Ensembl ID: ENSG00000169710
  • Gene Symbol: COL4A1 (ENSG00000187498)
    Fold Change: 4.7
    Ensembl ID: ENSG00000187498
  • Gene Symbol: DMD (ENSG00000198947)
    Fold Change: 4.68
    Ensembl ID: ENSG00000198947
  • Gene Symbol: PPARG (ENSG00000132170)
    Fold Change: 4.67
    Ensembl ID: ENSG00000132170
  • Gene Symbol: GHR (ENSG00000112964)
    Fold Change: 4.52
    Ensembl ID: ENSG00000112964
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 4.51
    Ensembl ID: ENSG00000171791
  • Gene Symbol: PLIN1 (ENSG00000166819)
    Fold Change: 4.47
    Ensembl ID: ENSG00000166819
  • Gene Symbol: MGST1 (ENSG00000008394)
    Fold Change: 4.37
    Ensembl ID: ENSG00000008394
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 4.32
    Ensembl ID: ENSG00000163697
  • Gene Symbol: PTPRM (ENSG00000173482)
    Fold Change: 4.25
    Ensembl ID: ENSG00000173482
  • Gene Symbol: GBE1 (ENSG00000114480)
    Fold Change: 4.22
    Ensembl ID: ENSG00000114480
  • Gene Symbol: PDE3B (ENSG00000152270)
    Fold Change: 4.17
    Ensembl ID: ENSG00000152270
  • Gene Symbol: PTEN (ENSG00000171862)
    Fold Change: 4.14
    Ensembl ID: ENSG00000171862
  • Gene Symbol: IGF1 (ENSG00000017427)
    Fold Change: 4.11
    Ensembl ID: ENSG00000017427
  • Gene Symbol: CPM (ENSG00000135678)
    Fold Change: 4.11
    Ensembl ID: ENSG00000135678
  • Gene Symbol: PFKFB3 (ENSG00000170525)
    Fold Change: 3.96
    Ensembl ID: ENSG00000170525
  • Gene Symbol: ADH1B (ENSG00000196616)
    Fold Change: 3.91
    Ensembl ID: ENSG00000196616
  • Gene Symbol: ITGA7 (ENSG00000135424)
    Fold Change: 3.91
    Ensembl ID: ENSG00000135424
  • Gene Symbol: FABP4 (ENSG00000170323)
    Fold Change: 3.73
    Ensembl ID: ENSG00000170323
  • Gene Symbol: BCL6 (ENSG00000113916)
    Fold Change: 3.65
    Ensembl ID: ENSG00000113916
  • Gene Symbol: LPP (ENSG00000145012)
    Fold Change: 3.61
    Ensembl ID: ENSG00000145012
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 3.58
    Ensembl ID: ENSG00000100077
  • Gene Symbol: NFIA (ENSG00000162599)
    Fold Change: 3.54
    Ensembl ID: ENSG00000162599
  • Gene Symbol: AQP7 (ENSG00000165269)
    Fold Change: 3.53
    Ensembl ID: ENSG00000165269
  • Gene Symbol: SLC26A3 (ENSG00000091138)
    Fold Change: 3.51
    Ensembl ID: ENSG00000091138
  • Gene Symbol: MBNL1 (ENSG00000152601)
    Fold Change: 3.46
    Ensembl ID: ENSG00000152601
  • Gene Symbol: GLUL (ENSG00000135821)
    Fold Change: 3.37
    Ensembl ID: ENSG00000135821
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 3.35
    Ensembl ID: ENSG00000278540
  • Gene Symbol: LIPE (ENSG00000079435)
    Fold Change: 3.35
    Ensembl ID: ENSG00000079435
  • Gene Symbol: FKBP5 (ENSG00000096060)
    Fold Change: 3.33
    Ensembl ID: ENSG00000096060
  • Gene Symbol: DUSP1 (ENSG00000120129)
    Fold Change: 3.09
    Ensembl ID: ENSG00000120129
  • Gene Symbol: CD36 (ENSG00000135218)
    Fold Change: 3.05
    Ensembl ID: ENSG00000135218
  • Gene Symbol: GABRE (ENSG00000102287)
    Fold Change: 3.03
    Ensembl ID: ENSG00000102287
  • Gene Symbol: ITPR2 (ENSG00000123104)
    Fold Change: 3.01
    Ensembl ID: ENSG00000123104
  • Gene Symbol: PPP1R12B (ENSG00000077157)
    Fold Change: 3
    Ensembl ID: ENSG00000077157
  • Gene Symbol: LRP4 (ENSG00000134569)
    Fold Change: 2.99
    Ensembl ID: ENSG00000134569
  • Gene Symbol: MEST (ENSG00000106484)
    Fold Change: 2.98
    Ensembl ID: ENSG00000106484
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.96
    Ensembl ID: ENSG00000142599
  • Gene Symbol: LPL (ENSG00000175445)
    Fold Change: 2.95
    Ensembl ID: ENSG00000175445
  • Gene Symbol: DIAPH2 (ENSG00000147202)
    Fold Change: 2.94
    Ensembl ID: ENSG00000147202
  • Gene Symbol: PIK3R1 (ENSG00000145675)
    Fold Change: 2.93
    Ensembl ID: ENSG00000145675
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.92
    Ensembl ID: ENSG00000166710
  • Gene Symbol: PTMA (ENSG00000187514)
    Fold Change: 2.89
    Ensembl ID: ENSG00000187514
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 2.86
    Ensembl ID: ENSG00000156508
  • Gene Symbol: LRP1 (ENSG00000123384)
    Fold Change: 2.85
    Ensembl ID: ENSG00000123384
  • Gene Symbol: PPP3CA (ENSG00000138814)
    Fold Change: 2.84
    Ensembl ID: ENSG00000138814
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 2.83
    Ensembl ID: ENSG00000198363
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 2.79
    Ensembl ID: ENSG00000108654
  • Gene Symbol: PCCA (ENSG00000175198)
    Fold Change: 2.79
    Ensembl ID: ENSG00000175198
  • Gene Symbol: PTPRF (ENSG00000142949)
    Fold Change: 2.76
    Ensembl ID: ENSG00000142949
  • Gene Symbol: MAP4 (ENSG00000047849)
    Fold Change: 2.74
    Ensembl ID: ENSG00000047849
  • Gene Symbol: GPD1 (ENSG00000167588)
    Fold Change: 2.74
    Ensembl ID: ENSG00000167588
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 2.73
    Ensembl ID: ENSG00000111640
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 2.73
    Ensembl ID: ENSG00000053254
  • Gene Symbol: LAMC1 (ENSG00000135862)
    Fold Change: 2.68
    Ensembl ID: ENSG00000135862
  • Gene Symbol: PBX1 (ENSG00000185630)
    Fold Change: 2.68
    Ensembl ID: ENSG00000185630
  • Gene Symbol: FOXO3 (ENSG00000118689)
    Fold Change: 2.67
    Ensembl ID: ENSG00000118689
  • Gene Symbol: PRKAR2B (ENSG00000005249)
    Fold Change: 2.66
    Ensembl ID: ENSG00000005249
  • Gene Symbol: PTGER3 (ENSG00000050628)
    Fold Change: 2.63
    Ensembl ID: ENSG00000050628
  • Gene Symbol: NACA (ENSG00000196531)
    Fold Change: 2.63
    Ensembl ID: ENSG00000196531
  • Gene Symbol: H3 3B (ENSG00000132475)
    Fold Change: 2.62
    Ensembl ID: ENSG00000132475
  • Gene Symbol: PRKN (ENSG00000185345)
    Fold Change: 2.62
    Ensembl ID: ENSG00000185345
  • Gene Symbol: GOLGA4 (ENSG00000144674)
    Fold Change: 2.61
    Ensembl ID: ENSG00000144674
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: 2.54
    Ensembl ID: ENSG00000165029
  • Gene Symbol: NHS (ENSG00000188158)
    Fold Change: 2.54
    Ensembl ID: ENSG00000188158
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.53
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.52
    Ensembl ID: ENSG00000172757
  • Gene Symbol: EFNA5 (ENSG00000184349)
    Fold Change: 2.5
    Ensembl ID: ENSG00000184349
  • Gene Symbol: NFIB (ENSG00000147862)
    Fold Change: 2.5
    Ensembl ID: ENSG00000147862
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 2.49
    Ensembl ID: ENSG00000167996
  • Gene Symbol: MKLN1 (ENSG00000128585)
    Fold Change: 2.48
    Ensembl ID: ENSG00000128585
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.47
    Ensembl ID: ENSG00000156110
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 2.42
    Ensembl ID: ENSG00000127184
  • Gene Symbol: ME1 (ENSG00000065833)
    Fold Change: 2.42
    Ensembl ID: ENSG00000065833
  • Gene Symbol: PTPRS (ENSG00000105426)
    Fold Change: 2.4
    Ensembl ID: ENSG00000105426
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.38
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ADRA1A (ENSG00000120907)
    Fold Change: 2.38
    Ensembl ID: ENSG00000120907
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.37
    Ensembl ID: ENSG00000075624
  • Gene Symbol: MAPK10 (ENSG00000109339)
    Fold Change: 2.35
    Ensembl ID: ENSG00000109339
  • Gene Symbol: INSR (ENSG00000171105)
    Fold Change: 2.34
    Ensembl ID: ENSG00000171105
  • Gene Symbol: LAMA4 (ENSG00000112769)
    Fold Change: 2.34
    Ensembl ID: ENSG00000112769
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 2.33
    Ensembl ID: ENSG00000104529
  • Gene Symbol: AGFG1 (ENSG00000173744)
    Fold Change: 2.32
    Ensembl ID: ENSG00000173744
  • Gene Symbol: RAB2A (ENSG00000104388)
    Fold Change: 2.32
    Ensembl ID: ENSG00000104388
  • Gene Symbol: PCSK5 (ENSG00000099139)
    Fold Change: 2.31
    Ensembl ID: ENSG00000099139
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 2.3
    Ensembl ID: ENSG00000167658
  • Gene Symbol: EXT1 (ENSG00000182197)
    Fold Change: 2.3
    Ensembl ID: ENSG00000182197
  • Gene Symbol: MYL6 (ENSG00000092841)
    Fold Change: 2.3
    Ensembl ID: ENSG00000092841
  • Gene Symbol: CYP3A5 (ENSG00000106258)
    Fold Change: 2.29
    Ensembl ID: ENSG00000106258
  • Gene Symbol: COL5A2 (ENSG00000204262)
    Fold Change: 2.26
    Ensembl ID: ENSG00000204262
  • Gene Symbol: EMP1 (ENSG00000134531)
    Fold Change: 2.26
    Ensembl ID: ENSG00000134531
  • Gene Symbol: GTF2I (ENSG00000263001)
    Fold Change: 2.24
    Ensembl ID: ENSG00000263001
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.24
    Ensembl ID: ENSG00000169100
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.24
    Ensembl ID: ENSG00000131143

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in subcutaneous fat cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in subcutaneous fat cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** The subcutaneous fat cell is characterized by the following key features: 1. **Adipocyte morphology**: The cell is a large, multinucleated cell with a characteristic "fat cell" shape. 2. **Triglyceride storage**: The cell stores energy in the form of triglycerides, which are composed of glycerol and fatty acids. 3. **Adipose tissue location**: The cell is found in subcutaneous adipose tissue, which is a layer of fat that lies just beneath the skin. 4. **Gene expression**: The cell expresses a range of genes involved in energy metabolism, including those involved in fatty acid synthesis, oxidation, and storage. 5. **Signaling pathways**: The cell is involved in various signaling pathways, including those involved in glucose and lipid metabolism, cell growth and differentiation, and immune responses. **Clinical Significance** The subcutaneous fat cell plays a critical role in various physiological and pathological processes, including: 1. **Energy homeostasis**: The cell regulates energy homeostasis by storing and releasing energy as needed. 2. **Metabolic disorders**: Imbalances in adipocyte function can contribute to metabolic disorders, such as obesity, insulin resistance, and type 2 diabetes. 3. **Lipid metabolism**: The cell plays a crucial role in lipid metabolism, including the synthesis, oxidation, and storage of fatty acids. 4. **Inflammation**: The cell is involved in inflammatory responses, including the production of pro-inflammatory cytokines and the regulation of immune cell function. 5. **Cancer**: Abnormal adipocyte function has been implicated in the development and progression of certain types of cancer, including breast and colon cancer. **Gene Expression Profile** The subcutaneous fat cell expresses a range of genes involved in energy metabolism, including: 1. **ACACB**: A gene involved in fatty acid biosynthesis and oxidation. 2. **PTPRG**: A gene involved in phosphatase activity and cellular signaling. 3. **EBF1**: A gene involved in transcriptional regulation and cell growth. 4. **FOXO1**: A gene involved in transcriptional regulation and cell survival. 5. **ACSL1**: A gene involved in fatty acid metabolism and regulation of lipid biosynthesis. Overall, the subcutaneous fat cell is a complex cell type that plays a critical role in various physiological and pathological processes. Understanding the cell's function and gene expression profile can provide valuable insights into the development and treatment of metabolic disorders and other diseases.