Details for: CL0002538

Cell ID: CL0002538

Cell Name: intrahepatic cholangiocyte

Marker Score Threshold: 380
(Derived using integrated single-cell and genomic data)

Description: An epithelial cell of the intrahepatic portion of the bile duct. These cells are flattened or cuboidal in shape, and have a small nuclear-to-cytoplasmic ratio relative to large/extrahepatic cholangiocytes.

Synonyms: small bile duct cholangiocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.85
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.5
    Ensembl ID: ENSG00000184009
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.45
    Ensembl ID: ENSG00000131143
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.41
    Ensembl ID: ENSG00000172757
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 2.39
    Ensembl ID: ENSG00000127184
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.36
    Ensembl ID: ENSG00000099622
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.24
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.23
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.13
    Ensembl ID: ENSG00000135390
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 2.09
    Ensembl ID: ENSG00000164919
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.07
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.05
    Ensembl ID: ENSG00000133639
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.96
    Ensembl ID: ENSG00000067560
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.94
    Ensembl ID: ENSG00000126267
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.93
    Ensembl ID: ENSG00000070831
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 1.92
    Ensembl ID: ENSG00000112695
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.88
    Ensembl ID: ENSG00000143933
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.87
    Ensembl ID: ENSG00000135940
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.84
    Ensembl ID: ENSG00000135404
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.8
    Ensembl ID: ENSG00000067082
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.8
    Ensembl ID: ENSG00000077549
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.79
    Ensembl ID: ENSG00000111775
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.76
    Ensembl ID: ENSG00000179218
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.73
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.71
    Ensembl ID: ENSG00000143761
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 1.7
    Ensembl ID: ENSG00000176340
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.7
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.65
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.63
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.6
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.6
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.6
    Ensembl ID: ENSG00000213719
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.58
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.58
    Ensembl ID: ENSG00000154518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.57
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.56
    Ensembl ID: ENSG00000099624
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.54
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 1.51
    Ensembl ID: ENSG00000160213
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 1.5
    Ensembl ID: ENSG00000131174
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.48
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.45
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.44
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 1.44
    Ensembl ID: ENSG00000113712
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.43
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.42
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.41
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.4
    Ensembl ID: ENSG00000122705
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.38
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.38
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.37
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.36
    Ensembl ID: ENSG00000013441
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.33
    Ensembl ID: ENSG00000161203
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.33
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.3
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.3
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.28
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.28
    Ensembl ID: ENSG00000141522
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.28
    Ensembl ID: ENSG00000196776
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 1.28
    Ensembl ID: ENSG00000101439
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.26
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.26
    Ensembl ID: ENSG00000168374
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.26
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.25
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.24
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.24
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.23
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.22
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.21
    Ensembl ID: ENSG00000069849
  • Gene Symbol: CTNNB1 (ENSG00000168036)
    Fold Change: 1.21
    Ensembl ID: ENSG00000168036
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.18
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CTSD (ENSG00000117984)
    Fold Change: 1.17
    Ensembl ID: ENSG00000117984
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.17
    Ensembl ID: ENSG00000173575
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.17
    Ensembl ID: ENSG00000122359
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.14
    Ensembl ID: ENSG00000042753
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.14
    Ensembl ID: ENSG00000123505
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.13
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.12
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.12
    Ensembl ID: ENSG00000072778
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.11
    Ensembl ID: ENSG00000108561
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.11
    Ensembl ID: ENSG00000053254
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.1
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.1
    Ensembl ID: ENSG00000159199
  • Gene Symbol: AP3S1 (ENSG00000177879)
    Fold Change: 1.09
    Ensembl ID: ENSG00000177879
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.09
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.07
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.07
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.07
    Ensembl ID: ENSG00000070961
  • Gene Symbol: CTSB (ENSG00000164733)
    Fold Change: 1.07
    Ensembl ID: ENSG00000164733
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.06
    Ensembl ID: ENSG00000153922
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.04
    Ensembl ID: ENSG00000160710
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.03
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.03
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.02
    Ensembl ID: ENSG00000143727
  • Gene Symbol: CLNS1A (ENSG00000074201)
    Fold Change: 1.02
    Ensembl ID: ENSG00000074201
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.01
    Ensembl ID: ENSG00000164615
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.01
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1
    Ensembl ID: ENSG00000134480
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: N/A
    Ensembl ID: ENSG00000115307
Hovered Details

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Hovered Details

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**Key Characteristics** * Epithelial cell type * Located in the intrahepatic portion of the bile duct * Flattened or cuboidal shape * Small nuclear-to-cytoplasmic ratio * Actin cytoskeleton and adherens junctions are major components of the cell * Involved in bile transport from the liver to the small intestine * Participates in various cellular processes, including: + Cell signaling + Protein localization + Immune responses + Antigen presentation and processing + Cytokine signaling * Gene symbol: ACTB * Ensembl ID: ENSG00000075624 **Clinical Significance** Intrahepatic cholangiocytes play a crucial role in the liver's biliary system, and dysfunction of these cells can lead to various liver diseases. Some of the clinical significance of intrahepatic cholangiocytes includes: * Bile duct obstruction: Intrahepatic cholangiocytes are involved in the transport of bile from the liver to the small intestine. Obstruction of the bile duct can lead to bile duct obstruction, which can cause jaundice, itching, and abdominal pain. * Cholangiocarcinoma: Intrahepatic cholangiocytes are susceptible to malignant transformation, leading to cholangiocarcinoma, a type of cancer that affects the bile ducts. * Primary sclerosing cholangitis: Intrahepatic cholangiocytes are involved in the pathogenesis of primary sclerosing cholangitis, a chronic liver disease characterized by inflammation and scarring of the bile ducts. * Hepatitis: Intrahepatic cholangiocytes are involved in the immune response to hepatitis viruses, such as hepatitis B and C. * Liver transplantation: Intrahepatic cholangiocytes are involved in the bile transport process, and dysfunction of these cells can affect the success of liver transplantation. In summary, intrahepatic cholangiocytes play a critical role in the liver's biliary system, and dysfunction of these cells can lead to various liver diseases. Further research is needed to understand the mechanisms of intrahepatic cholangiocyte function and dysfunction, which can lead to the development of new treatments for liver diseases.