Details for: CL0002598

Cell ID: CL0002598

Cell Name: bronchial smooth muscle cell

Marker Score Threshold: 283
(Derived using integrated single-cell and genomic data)

Description: Any smooth muscle cell that is part of some bronchus.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.38
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.74
    Ensembl ID: ENSG00000184009
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.66
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.65
    Ensembl ID: ENSG00000172757
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.61
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.6
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.5
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.46
    Ensembl ID: ENSG00000145741
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.39
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.31
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.3
    Ensembl ID: ENSG00000124172
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.23
    Ensembl ID: ENSG00000067560
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.16
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.13
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.02
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.99
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.96
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.89
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.87
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.84
    Ensembl ID: ENSG00000152518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.82
    Ensembl ID: ENSG00000005022
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.82
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.78
    Ensembl ID: ENSG00000130402
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.77
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.75
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.73
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.73
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.71
    Ensembl ID: ENSG00000154723
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.71
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.69
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.68
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.65
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.64
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.63
    Ensembl ID: ENSG00000110955
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.63
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.6
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.6
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.59
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.59
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.54
    Ensembl ID: ENSG00000149925
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.54
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.51
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.51
    Ensembl ID: ENSG00000173575
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.5
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.49
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.49
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.48
    Ensembl ID: ENSG00000141522
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.48
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.42
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.42
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.42
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.39
    Ensembl ID: ENSG00000070961
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.39
    Ensembl ID: ENSG00000053254
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.38
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.36
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.35
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.34
    Ensembl ID: ENSG00000153922
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.34
    Ensembl ID: ENSG00000185883
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.32
    Ensembl ID: ENSG00000165527
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.31
    Ensembl ID: ENSG00000146731
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.3
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.28
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.28
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.27
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.26
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.25
    Ensembl ID: ENSG00000159199
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.25
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.25
    Ensembl ID: ENSG00000182718
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.24
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.23
    Ensembl ID: ENSG00000164111
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.23
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.23
    Ensembl ID: ENSG00000134480
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.22
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CTSC (ENSG00000109861)
    Fold Change: 1.2
    Ensembl ID: ENSG00000109861
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.2
    Ensembl ID: ENSG00000100300
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.19
    Ensembl ID: ENSG00000143799
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.19
    Ensembl ID: ENSG00000115307
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.18
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.18
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.16
    Ensembl ID: ENSG00000138279
  • Gene Symbol: CHD4 (ENSG00000111642)
    Fold Change: 1.13
    Ensembl ID: ENSG00000111642
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.13
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.12
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.12
    Ensembl ID: ENSG00000177556
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.09
    Ensembl ID: ENSG00000122786
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.09
    Ensembl ID: ENSG00000142192
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.09
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.08
    Ensembl ID: ENSG00000135046
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.06
    Ensembl ID: ENSG00000130303
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.06
    Ensembl ID: ENSG00000164615
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.05
    Ensembl ID: ENSG00000149823
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.05
    Ensembl ID: ENSG00000137845
  • Gene Symbol: TBCB (ENSG00000105254)
    Fold Change: 1.05
    Ensembl ID: ENSG00000105254
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.05
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.04
    Ensembl ID: ENSG00000004059
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.03
    Ensembl ID: ENSG00000107262
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.03
    Ensembl ID: ENSG00000149131
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.02
    Ensembl ID: ENSG00000196954
  • Gene Symbol: CAV1 (ENSG00000105974)
    Fold Change: N/A
    Ensembl ID: ENSG00000105974
Hovered Details

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Hovered Details

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**Key Characteristics** * **Cell Type**: BSMCs are a type of smooth muscle cell that is specifically found in the bronchial tree. * **Gene Expression**: BSMCs express specific genes, including ACTB and ACTG1, which are involved in cytoskeleton organization and cell motility. * **Cytoskeleton Organization**: BSMCs have a characteristic cytoskeleton organization, including actin filaments, microtubules, and intermediate filaments. * **Cell-Cell Communication**: BSMCs are involved in cell-cell communication through gap junctions and adherens junctions. * **Cell Motility**: BSMCs are capable of cell motility, which is essential for airway tone regulation. **Clinical Significance** * **Asthma**: BSMCs are implicated in the pathogenesis of asthma, where they play a role in airway inflammation and hyperresponsiveness. * **Chronic Obstructive Pulmonary Disease (COPD)**: BSMCs are also involved in the pathogenesis of COPD, where they contribute to airway remodeling and hyperresponsiveness. * **Airway Tone Regulation**: BSMCs play a crucial role in regulating airway tone and responsiveness, which is essential for maintaining normal respiratory function. * **Pharmacological Targeting**: BSMCs are a potential target for pharmacological intervention in the treatment of respiratory diseases, including asthma and COPD. **Pathways and Ontologies** * **Actin Cytoskeleton**: BSMCs are involved in the organization and regulation of the actin cytoskeleton, which is essential for cell motility and cell-cell communication. * **Adherens Junctions**: BSMCs are involved in cell-cell communication through adherens junctions, which are essential for maintaining tissue structure and function. * **Apical Junction Complex**: BSMCs are involved in the formation and regulation of the apical junction complex, which is essential for maintaining tissue structure and function. * **Blood Microparticle**: BSMCs are involved in the formation and regulation of blood microparticles, which are involved in inflammation and coagulation. * **Chromatin Organization**: BSMCs are involved in the organization and regulation of chromatin, which is essential for gene expression and cell differentiation. **Regulation of Gene Expression** * **Positive Regulation**: BSMCs are involved in the positive regulation of gene expression, including the expression of genes involved in cell motility and cell-cell communication. * **Negative Regulation**: BSMCs are also involved in the negative regulation of gene expression, including the expression of genes involved in cell differentiation and apoptosis. **Cellular Processes** * **Cell Motility**: BSMCs are capable of cell motility, which is essential for airway tone regulation. * **Cell-Cell Communication**: BSMCs are involved in cell-cell communication through gap junctions and adherens junctions. * **Cytoskeleton Organization**: BSMCs have a characteristic cytoskeleton organization, including actin filaments, microtubules, and intermediate filaments. * **Gene Expression**: BSMCs are involved in the regulation of gene expression, including the expression of genes involved in cell motility and cell-cell communication. **Diseases Associated with BSMCs** * **Asthma**: BSMCs are implicated in the pathogenesis of asthma, where they play a role in airway inflammation and hyperresponsiveness. * **Chronic Obstructive Pulmonary Disease (COPD)**: BSMCs are also involved in the pathogenesis of COPD, where they contribute to airway remodeling and hyperresponsiveness. * **Cancer**: BSMCs are also implicated in the pathogenesis of cancer, where they play a role in tumor growth and metastasis. **Future Directions** * **Pharmacological Targeting**: BSMCs are a potential target for pharmacological intervention in the treatment of respiratory diseases, including asthma and COPD. * **Gene Therapy**: BSMCs are also a potential target for gene therapy in the treatment of respiratory diseases, including asthma and COPD. * **Cell-Based Therapies**: BSMCs are also a potential target for cell-based therapies in the treatment of respiratory diseases, including asthma and COPD.