Details for: CL0002607

Cell ID: CL0002607

Cell Name: migratory enteric neural crest cell

Marker Score Threshold: 941
(Derived using integrated single-cell and genomic data)

Description: A neural crest cell that gives rise to cells of the enteric nervous system.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.86
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.82
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.76
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.76
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.74
    Ensembl ID: ENSG00000135390
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.73
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.63
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.62
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.57
    Ensembl ID: ENSG00000185650
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.57
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.57
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.54
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.5
    Ensembl ID: ENSG00000154518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.48
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ASCL1 (ENSG00000139352)
    Fold Change: 2.47
    Ensembl ID: ENSG00000139352
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.4
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.39
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 2.37
    Ensembl ID: ENSG00000160014
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 2.33
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 2.32
    Ensembl ID: ENSG00000122786
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 2.31
    Ensembl ID: ENSG00000151914
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.3
    Ensembl ID: ENSG00000142192
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.3
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.3
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.29
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.28
    Ensembl ID: ENSG00000169020
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.27
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.25
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.22
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2.2
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.19
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BIRC5 (ENSG00000089685)
    Fold Change: 2.12
    Ensembl ID: ENSG00000089685
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.1
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 2.1
    Ensembl ID: ENSG00000069849
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 2.1
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 2.02
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.97
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.95
    Ensembl ID: ENSG00000152518
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.94
    Ensembl ID: ENSG00000108561
  • Gene Symbol: BCHE (ENSG00000114200)
    Fold Change: 1.93
    Ensembl ID: ENSG00000114200
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.87
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.84
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.82
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.81
    Ensembl ID: ENSG00000164111
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.8
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.8
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.77
    Ensembl ID: ENSG00000077549
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.76
    Ensembl ID: ENSG00000101444
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.75
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.73
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.67
    Ensembl ID: ENSG00000128595
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.67
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.66
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.64
    Ensembl ID: ENSG00000138175
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.64
    Ensembl ID: ENSG00000155366
  • Gene Symbol: CCNG1 (ENSG00000113328)
    Fold Change: 1.63
    Ensembl ID: ENSG00000113328
  • Gene Symbol: CCNA2 (ENSG00000145386)
    Fold Change: 1.59
    Ensembl ID: ENSG00000145386
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.58
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.58
    Ensembl ID: ENSG00000177556
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.57
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.55
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.51
    Ensembl ID: ENSG00000164904
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.5
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ACTL6A (ENSG00000136518)
    Fold Change: 1.49
    Ensembl ID: ENSG00000136518
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.48
    Ensembl ID: ENSG00000176171
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.48
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.46
    Ensembl ID: ENSG00000165092
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.45
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.44
    Ensembl ID: ENSG00000141522
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.43
    Ensembl ID: ENSG00000115307
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.41
    Ensembl ID: ENSG00000198931
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.41
    Ensembl ID: ENSG00000004455
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.41
    Ensembl ID: ENSG00000104765
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.39
    Ensembl ID: ENSG00000087088
  • Gene Symbol: SERPINH1 (ENSG00000149257)
    Fold Change: 1.39
    Ensembl ID: ENSG00000149257
  • Gene Symbol: CCNB1 (ENSG00000134057)
    Fold Change: 1.38
    Ensembl ID: ENSG00000134057
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.36
    Ensembl ID: ENSG00000107262
  • Gene Symbol: CCND1 (ENSG00000110092)
    Fold Change: 1.35
    Ensembl ID: ENSG00000110092
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.35
    Ensembl ID: ENSG00000070961
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.27
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ACYP1 (ENSG00000119640)
    Fold Change: 1.26
    Ensembl ID: ENSG00000119640
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.25
    Ensembl ID: ENSG00000117054
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.22
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CALCB (ENSG00000175868)
    Fold Change: 1.21
    Ensembl ID: ENSG00000175868
  • Gene Symbol: ACAT2 (ENSG00000120437)
    Fold Change: 1.21
    Ensembl ID: ENSG00000120437
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.19
    Ensembl ID: ENSG00000213465
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.19
    Ensembl ID: ENSG00000127837
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.19
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.16
    Ensembl ID: ENSG00000163399
  • Gene Symbol: RUNX1T1 (ENSG00000079102)
    Fold Change: 1.16
    Ensembl ID: ENSG00000079102
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.16
    Ensembl ID: ENSG00000104964
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.15
    Ensembl ID: ENSG00000198356
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.08
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.08
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.06
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.06
    Ensembl ID: ENSG00000130402
  • Gene Symbol: BCAT1 (ENSG00000060982)
    Fold Change: 1.05
    Ensembl ID: ENSG00000060982
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.02
    Ensembl ID: ENSG00000142599
  • Gene Symbol: BCL7A (ENSG00000110987)
    Fold Change: 1.01
    Ensembl ID: ENSG00000110987
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.01
    Ensembl ID: ENSG00000100852
Hovered Details

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Hovered Details

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**Key Characteristics** The MENC is characterized by the following key features: 1. **Migration**: The MENC migrates from the neural crest to the gastrointestinal tract during embryonic development. 2. **Differentiation**: The MENC differentiates into various types of neurons and glial cells, including enteric neurons, glial cells, and pericytes. 3. **Expression of specific genes**: The MENC expresses specific genes, including ACTB and ACTG1, which are involved in regulating cell migration, differentiation, and function. 4. **Regulation of signaling pathways**: The MENC is regulated by a complex interplay of signaling pathways, including those involving growth factors, receptors, and cytoskeletal proteins. 5. **Cell-cell interactions**: The MENC interacts with other cells, including pericytes, endothelial cells, and immune cells, to regulate gut function. **Clinical Significance** The MENC plays a critical role in regulating gut function, and abnormalities in MENC development or function can lead to various gastrointestinal disorders, including: 1. **Hirschsprung's disease**: A congenital disorder characterized by the absence of enteric neurons in the distal gut, leading to intestinal obstruction. 2. **Neurogenic enteritis**: A disorder characterized by the presence of enteric neurons in the gastrointestinal tract, leading to chronic inflammation and diarrhea. 3. **Gastrointestinal motility disorders**: Abnormalities in MENC function can lead to gastrointestinal motility disorders, including constipation, diarrhea, and abdominal pain. Understanding the biology of the MENC is essential for the development of new therapies for gastrointestinal disorders, including Hirschsprung's disease and neurogenic enteritis. Additionally, the study of MENC development and function can provide insights into the regulation of gut function and the development of new treatments for gastrointestinal disorders.