Details for: CL0002632

Cell ID: CL0002632

Cell Name: epithelial cell of lower respiratory tract

Marker Score Threshold: 4169
(Derived using integrated single-cell and genomic data)

Description: Any epithelial cell that is part of some lower respiratory tract epithelium.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 6.23
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 5.68
    Ensembl ID: ENSG00000156110
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 5.37
    Ensembl ID: ENSG00000142599
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 4.87
    Ensembl ID: ENSG00000198589
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 4.55
    Ensembl ID: ENSG00000084234
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 4.39
    Ensembl ID: ENSG00000179218
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 4.12
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 4.05
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 4.02
    Ensembl ID: ENSG00000145349
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 3.76
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 3.76
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 3.7
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 3.58
    Ensembl ID: ENSG00000026508
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 3.57
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.51
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 3.45
    Ensembl ID: ENSG00000143153
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 3.15
    Ensembl ID: ENSG00000157764
  • Gene Symbol: CDK6 (ENSG00000105810)
    Fold Change: 3.06
    Ensembl ID: ENSG00000105810
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 3.01
    Ensembl ID: ENSG00000110651
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.9
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.88
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CD36 (ENSG00000135218)
    Fold Change: 2.86
    Ensembl ID: ENSG00000135218
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.69
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 2.59
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 2.52
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CDH1 (ENSG00000039068)
    Fold Change: 2.5
    Ensembl ID: ENSG00000039068
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 2.5
    Ensembl ID: ENSG00000134982
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 2.44
    Ensembl ID: ENSG00000163697
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 2.33
    Ensembl ID: ENSG00000112576
  • Gene Symbol: SCARB2 (ENSG00000138760)
    Fold Change: 2.31
    Ensembl ID: ENSG00000138760
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 2.3
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.29
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 2.29
    Ensembl ID: ENSG00000100852
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 2.29
    Ensembl ID: ENSG00000107779
  • Gene Symbol: AQP4 (ENSG00000171885)
    Fold Change: 2.25
    Ensembl ID: ENSG00000171885
  • Gene Symbol: CEBPD (ENSG00000221869)
    Fold Change: 2.16
    Ensembl ID: ENSG00000221869
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.12
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.99
    Ensembl ID: ENSG00000087274
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.99
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.96
    Ensembl ID: ENSG00000182718
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.92
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.87
    Ensembl ID: ENSG00000198363
  • Gene Symbol: SERPINH1 (ENSG00000149257)
    Fold Change: 1.84
    Ensembl ID: ENSG00000149257
  • Gene Symbol: BMP3 (ENSG00000152785)
    Fold Change: 1.82
    Ensembl ID: ENSG00000152785
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.81
    Ensembl ID: ENSG00000077549
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 1.78
    Ensembl ID: ENSG00000083123
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.78
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ADCY8 (ENSG00000155897)
    Fold Change: 1.77
    Ensembl ID: ENSG00000155897
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.72
    Ensembl ID: ENSG00000128595
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.71
    Ensembl ID: ENSG00000070831
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.64
    Ensembl ID: ENSG00000104763
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.64
    Ensembl ID: ENSG00000166710
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.58
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.58
    Ensembl ID: ENSG00000174437
  • Gene Symbol: CD151 (ENSG00000177697)
    Fold Change: 1.58
    Ensembl ID: ENSG00000177697
  • Gene Symbol: CAT (ENSG00000121691)
    Fold Change: 1.58
    Ensembl ID: ENSG00000121691
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 1.57
    Ensembl ID: ENSG00000114423
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.56
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.53
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ALB (ENSG00000163631)
    Fold Change: 1.51
    Ensembl ID: ENSG00000163631
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.5
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.5
    Ensembl ID: ENSG00000126247
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.48
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CA2 (ENSG00000104267)
    Fold Change: 1.48
    Ensembl ID: ENSG00000104267
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.43
    Ensembl ID: ENSG00000058668
  • Gene Symbol: CCND1 (ENSG00000110092)
    Fold Change: 1.41
    Ensembl ID: ENSG00000110092
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.39
    Ensembl ID: ENSG00000101966
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.38
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.38
    Ensembl ID: ENSG00000097007
  • Gene Symbol: CDKN1C (ENSG00000129757)
    Fold Change: 1.37
    Ensembl ID: ENSG00000129757
  • Gene Symbol: ACVR2A (ENSG00000121989)
    Fold Change: 1.36
    Ensembl ID: ENSG00000121989
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.35
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.34
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.33
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.33
    Ensembl ID: ENSG00000164111
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.3
    Ensembl ID: ENSG00000156273
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 1.29
    Ensembl ID: ENSG00000010278
  • Gene Symbol: C5 (ENSG00000106804)
    Fold Change: 1.29
    Ensembl ID: ENSG00000106804
  • Gene Symbol: CCNT2 (ENSG00000082258)
    Fold Change: 1.28
    Ensembl ID: ENSG00000082258
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.24
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.22
    Ensembl ID: ENSG00000152518
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 1.21
    Ensembl ID: ENSG00000148090
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.21
    Ensembl ID: ENSG00000106546
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.19
    Ensembl ID: ENSG00000196975
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.18
    Ensembl ID: ENSG00000006125
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 1.17
    Ensembl ID: ENSG00000151746
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.11
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.11
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CACNB4 (ENSG00000182389)
    Fold Change: 1.08
    Ensembl ID: ENSG00000182389
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.08
    Ensembl ID: ENSG00000143322
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.06
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ARSD (ENSG00000006756)
    Fold Change: 1.05
    Ensembl ID: ENSG00000006756
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.04
    Ensembl ID: ENSG00000166747
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 1.03
    Ensembl ID: ENSG00000114573
  • Gene Symbol: CDK8 (ENSG00000132964)
    Fold Change: 1.03
    Ensembl ID: ENSG00000132964
  • Gene Symbol: PARP4 (ENSG00000102699)
    Fold Change: 1.02
    Ensembl ID: ENSG00000102699
  • Gene Symbol: ANXA3 (ENSG00000138772)
    Fold Change: 1.02
    Ensembl ID: ENSG00000138772
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.01
    Ensembl ID: ENSG00000164904
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.01
    Ensembl ID: ENSG00000162104
  • Gene Symbol: CDC27 (ENSG00000004897)
    Fold Change: 1.01
    Ensembl ID: ENSG00000004897
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Epithelial Cell of Lower Respiratory Tract**: The cell is an epithelial cell that lines the lower respiratory tract, which includes the trachea, bronchi, and bronchioles. 2. **Cell Adhesion**: The cell expresses ALCAM, a cell adhesion molecule involved in cell-cell adhesion and signaling. 3. **Signaling**: The cell is involved in various signaling pathways, including adaptive immune response, axon guidance, and nervous system development. 4. **Immune Response**: The cell is involved in immune responses, including antigen presentation and processing. 5. **Metabolic Functions**: The cell expresses ADK, which is involved in adenosine kinase activity and metabolism. **Clinical Significance** 1. **Respiratory Diseases**: The cell's role in the lower respiratory tract makes it relevant to the pathogenesis of respiratory diseases, such as asthma, chronic obstructive pulmonary disease (COPD), and pneumonia. 2. **Immune Response**: The cell's involvement in immune responses makes it relevant to the pathogenesis of autoimmune diseases, such as autoimmune lung diseases. 3. **Neurological Disorders**: The cell's involvement in axon guidance and nervous system development makes it relevant to the pathogenesis of neurological disorders, such as Alzheimer's disease and amyotrophic lateral sclerosis (ALS). 4. **Cancer**: The cell's expression of ALCAM and ADK makes it relevant to the pathogenesis of cancer, particularly in the context of metastasis and tumor growth. **Pathways and Ontologies** 1. **Adaptive Immune Response**: The cell is involved in adaptive immune responses, including antigen presentation and processing. 2. **Axon Guidance**: The cell is involved in axon guidance, which is important for nervous system development and function. 3. **Nervous System Development**: The cell is involved in nervous system development, which is important for brain function and behavior. 4. **Cell Adhesion**: The cell is involved in cell adhesion, which is important for tissue development and function. 5. **Metabolism**: The cell is involved in metabolism, including adenosine kinase activity and metabolism. **Gene Expression** 1. **ALCAM**: The cell expresses ALCAM, a cell adhesion molecule involved in cell-cell adhesion and signaling. 2. **ADK**: The cell expresses ADK, which is involved in adenosine kinase activity and metabolism. 3. **RERE**: The cell expresses RERE, which is involved in branching morphogenesis of a nerve and cerebellar purkinje cell layer maturation. 4. **LRBA**: The cell expresses LRBA, which is involved in lysosomal membrane and molecular_function. 5. **APLP2**: The cell expresses APLP2, which is involved in axonogenesis and central nervous system development. 6. **CALR**: The cell expresses CALR, which is involved in adaptive immune system, antigen presentation, and folding of class I MHC molecules.