Details for: CL0002633

Cell ID: CL0002633

Cell Name: respiratory basal cell

Marker Score Threshold: 1436
(Derived using integrated single-cell and genomic data)

Description: A basal cell in the respiratory tract.

Synonyms: airway basal cell, airway basal stem cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: CFD (ENSG00000197766)
    Fold Change: 10.6
    Ensembl ID: ENSG00000197766
  • Gene Symbol: ASCL2 (ENSG00000183734)
    Fold Change: 10.11
    Ensembl ID: ENSG00000183734
  • Gene Symbol: DEFB1 (ENSG00000164825)
    Fold Change: 8.34
    Ensembl ID: ENSG00000164825
  • Gene Symbol: CRIP1 (ENSG00000213145)
    Fold Change: 8.32
    Ensembl ID: ENSG00000213145
  • Gene Symbol: CYP26A1 (ENSG00000095596)
    Fold Change: 7.62
    Ensembl ID: ENSG00000095596
  • Gene Symbol: CALML3 (ENSG00000178363)
    Fold Change: 6.53
    Ensembl ID: ENSG00000178363
  • Gene Symbol: CRABP2 (ENSG00000143320)
    Fold Change: 3.77
    Ensembl ID: ENSG00000143320
  • Gene Symbol: CDK5 (ENSG00000164885)
    Fold Change: 3.54
    Ensembl ID: ENSG00000164885
  • Gene Symbol: COX7A1 (ENSG00000161281)
    Fold Change: 3.26
    Ensembl ID: ENSG00000161281
  • Gene Symbol: ANG (ENSG00000214274)
    Fold Change: 3.14
    Ensembl ID: ENSG00000214274
  • Gene Symbol: PRDM1 (ENSG00000057657)
    Fold Change: 3.03
    Ensembl ID: ENSG00000057657
  • Gene Symbol: ALDOC (ENSG00000109107)
    Fold Change: 2.74
    Ensembl ID: ENSG00000109107
  • Gene Symbol: CD68 (ENSG00000129226)
    Fold Change: 2.7
    Ensembl ID: ENSG00000129226
  • Gene Symbol: CDC20 (ENSG00000117399)
    Fold Change: 2.55
    Ensembl ID: ENSG00000117399
  • Gene Symbol: ALDH1B1 (ENSG00000137124)
    Fold Change: 2.5
    Ensembl ID: ENSG00000137124
  • Gene Symbol: EFNA3 (ENSG00000143590)
    Fold Change: 2.47
    Ensembl ID: ENSG00000143590
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 2.29
    Ensembl ID: ENSG00000135940
  • Gene Symbol: CDKN3 (ENSG00000100526)
    Fold Change: 2.28
    Ensembl ID: ENSG00000100526
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.25
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ASIC1 (ENSG00000110881)
    Fold Change: 2.15
    Ensembl ID: ENSG00000110881
  • Gene Symbol: CDKN2B (ENSG00000147883)
    Fold Change: 2.12
    Ensembl ID: ENSG00000147883
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 2.12
    Ensembl ID: ENSG00000111775
  • Gene Symbol: ECM1 (ENSG00000143369)
    Fold Change: 2.1
    Ensembl ID: ENSG00000143369
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 2.07
    Ensembl ID: ENSG00000176340
  • Gene Symbol: BCYRN1 (ENSG00000236824)
    Fold Change: 2.06
    Ensembl ID: ENSG00000236824
  • Gene Symbol: CYP2A13 (ENSG00000197838)
    Fold Change: 2.06
    Ensembl ID: ENSG00000197838
  • Gene Symbol: CD14 (ENSG00000170458)
    Fold Change: 2.05
    Ensembl ID: ENSG00000170458
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.05
    Ensembl ID: ENSG00000075624
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 1.9
    Ensembl ID: ENSG00000156508
  • Gene Symbol: E2F2 (ENSG00000007968)
    Fold Change: 1.85
    Ensembl ID: ENSG00000007968
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.81
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CCNA2 (ENSG00000145386)
    Fold Change: 1.79
    Ensembl ID: ENSG00000145386
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 1.77
    Ensembl ID: ENSG00000131174
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 1.76
    Ensembl ID: ENSG00000172757
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.7
    Ensembl ID: ENSG00000149925
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 1.66
    Ensembl ID: ENSG00000130208
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 1.66
    Ensembl ID: ENSG00000131143
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.64
    Ensembl ID: ENSG00000184009
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 1.63
    Ensembl ID: ENSG00000127184
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 1.63
    Ensembl ID: ENSG00000167658
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.63
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.61
    Ensembl ID: ENSG00000198668
  • Gene Symbol: E2F1 (ENSG00000101412)
    Fold Change: 1.59
    Ensembl ID: ENSG00000101412
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.58
    Ensembl ID: ENSG00000241837
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.56
    Ensembl ID: ENSG00000161203
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.56
    Ensembl ID: ENSG00000169100
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 1.54
    Ensembl ID: ENSG00000108654
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 1.54
    Ensembl ID: ENSG00000104529
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.5
    Ensembl ID: ENSG00000135390
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.5
    Ensembl ID: ENSG00000133639
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 1.5
    Ensembl ID: ENSG00000114942
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 1.48
    Ensembl ID: ENSG00000164919
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.47
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 1.47
    Ensembl ID: ENSG00000099622
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 1.45
    Ensembl ID: ENSG00000112695
  • Gene Symbol: CTSD (ENSG00000117984)
    Fold Change: 1.44
    Ensembl ID: ENSG00000117984
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.41
    Ensembl ID: ENSG00000067560
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.4
    Ensembl ID: ENSG00000126267
  • Gene Symbol: RUNX1T1 (ENSG00000079102)
    Fold Change: 1.38
    Ensembl ID: ENSG00000079102
  • Gene Symbol: EIF4A2 (ENSG00000156976)
    Fold Change: 1.35
    Ensembl ID: ENSG00000156976
  • Gene Symbol: CRYBB2 (ENSG00000244752)
    Fold Change: 1.34
    Ensembl ID: ENSG00000244752
  • Gene Symbol: EMP3 (ENSG00000142227)
    Fold Change: 1.32
    Ensembl ID: ENSG00000142227
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.31
    Ensembl ID: ENSG00000067082
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.3
    Ensembl ID: ENSG00000070831
  • Gene Symbol: MYRF (ENSG00000124920)
    Fold Change: 1.28
    Ensembl ID: ENSG00000124920
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.27
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.27
    Ensembl ID: ENSG00000135404
  • Gene Symbol: EIF4G2 (ENSG00000110321)
    Fold Change: 1.25
    Ensembl ID: ENSG00000110321
  • Gene Symbol: ENO1 (ENSG00000074800)
    Fold Change: 1.23
    Ensembl ID: ENSG00000074800
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.22
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CCNE1 (ENSG00000105173)
    Fold Change: 1.21
    Ensembl ID: ENSG00000105173
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.21
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.2
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.18
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.17
    Ensembl ID: ENSG00000154518
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.17
    Ensembl ID: ENSG00000122545
  • Gene Symbol: DUSP1 (ENSG00000120129)
    Fold Change: 1.17
    Ensembl ID: ENSG00000120129
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.16
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CD7 (ENSG00000173762)
    Fold Change: 1.14
    Ensembl ID: ENSG00000173762
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.14
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CYBA (ENSG00000051523)
    Fold Change: 1.14
    Ensembl ID: ENSG00000051523
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.13
    Ensembl ID: ENSG00000152518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.12
    Ensembl ID: ENSG00000005022
  • Gene Symbol: DDT (ENSG00000099977)
    Fold Change: 1.12
    Ensembl ID: ENSG00000099977
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.11
    Ensembl ID: ENSG00000099624
  • Gene Symbol: EIF5 (ENSG00000100664)
    Fold Change: 1.1
    Ensembl ID: ENSG00000100664
  • Gene Symbol: DBI (ENSG00000155368)
    Fold Change: 1.09
    Ensembl ID: ENSG00000155368
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 1.08
    Ensembl ID: ENSG00000160213
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.08
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CSNK2B (ENSG00000204435)
    Fold Change: 1.08
    Ensembl ID: ENSG00000204435
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.07
    Ensembl ID: ENSG00000172270
  • Gene Symbol: DAD1 (ENSG00000129562)
    Fold Change: 1.06
    Ensembl ID: ENSG00000129562
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.06
    Ensembl ID: ENSG00000213719
  • Gene Symbol: TSC22D3 (ENSG00000157514)
    Fold Change: 1.06
    Ensembl ID: ENSG00000157514
  • Gene Symbol: CA9 (ENSG00000107159)
    Fold Change: 1.06
    Ensembl ID: ENSG00000107159
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.06
    Ensembl ID: ENSG00000185650
  • Gene Symbol: EIF4B (ENSG00000063046)
    Fold Change: 1.04
    Ensembl ID: ENSG00000063046
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.03
    Ensembl ID: ENSG00000152234
  • Gene Symbol: EIF4G1 (ENSG00000114867)
    Fold Change: 1.03
    Ensembl ID: ENSG00000114867
  • Gene Symbol: CDC25A (ENSG00000164045)
    Fold Change: 1.02
    Ensembl ID: ENSG00000164045
Hovered Details

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Hovered Details

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**Key Characteristics** Respiratory basal cells are characterized by their: 1. **Expression of specific genes**: RBCs express a unique set of genes, including ASCL2, DEFB1, CRIP1, CYP26A1, CALML3, and CRABP2, which are involved in various cellular processes such as differentiation, immune response, and metabolism. 2. **Stem cell properties**: RBCs possess stem cell-like properties, including self-renewal and differentiation capabilities. 3. **Location**: RBCs are found in the basal layer of the respiratory epithelium, where they can differentiate into various cell types. 4. **Functional roles**: RBCs play a crucial role in maintaining the homeostasis of the respiratory epithelium and are involved in the defense against pathogens and environmental stressors. **Clinical Significance** Respiratory basal cells have significant clinical implications, including: 1. **Respiratory diseases**: Abnormalities in RBC function and differentiation have been implicated in various respiratory diseases, such as chronic obstructive pulmonary disease (COPD), asthma, and cystic fibrosis. 2. **Cancer**: RBCs have been found to be involved in the development and progression of lung cancer. 3. **Regenerative medicine**: RBCs have the potential to be used as a source of stem cells for regenerative medicine, particularly in the treatment of respiratory diseases. 4. **Immunotherapy**: RBCs can be used as a target for immunotherapy, particularly in the treatment of cancer. **Functional Roles** Respiratory basal cells have several functional roles, including: 1. **Differentiation**: RBCs can differentiate into various cell types, including ciliated cells, goblet cells, and secretory cells. 2. **Immune response**: RBCs are involved in the defense against pathogens and environmental stressors, and can produce antimicrobial peptides and other immune molecules. 3. **Metabolism**: RBCs are involved in the metabolism of various nutrients and can produce energy-rich molecules. 4. **Regulation of epithelial homeostasis**: RBCs play a crucial role in maintaining the homeostasis of the respiratory epithelium and can regulate the expression of various genes involved in epithelial function. In conclusion, respiratory basal cells are a unique and important cell type that play a crucial role in maintaining the homeostasis of the respiratory epithelium and are involved in the defense against pathogens and environmental stressors. Further research is needed to fully understand the functional roles of RBCs and to explore their potential applications in regenerative medicine and immunotherapy.