Details for: CL0002657

Cell ID: CL0002657

Cell Name: glandular cell of esophagus

Marker Score Threshold: 317
(Derived using integrated single-cell and genomic data)

Description: A glandular epithelial cell of the esophagus.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.14
    Ensembl ID: ENSG00000166710
  • Gene Symbol: AZGP1 (ENSG00000160862)
    Fold Change: 3.11
    Ensembl ID: ENSG00000160862
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.09
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.07
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.94
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.92
    Ensembl ID: ENSG00000184009
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.78
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.75
    Ensembl ID: ENSG00000135046
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.69
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.68
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.58
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.55
    Ensembl ID: ENSG00000185650
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.55
    Ensembl ID: ENSG00000134825
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.51
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.42
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.41
    Ensembl ID: ENSG00000099624
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 2.33
    Ensembl ID: ENSG00000100300
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 2.32
    Ensembl ID: ENSG00000165272
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 2.28
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.26
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.2
    Ensembl ID: ENSG00000164111
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.16
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.11
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.1
    Ensembl ID: ENSG00000154518
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.08
    Ensembl ID: ENSG00000067560
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.05
    Ensembl ID: ENSG00000133639
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.02
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.02
    Ensembl ID: ENSG00000143761
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.99
    Ensembl ID: ENSG00000110955
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.97
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.95
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.91
    Ensembl ID: ENSG00000152234
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.91
    Ensembl ID: ENSG00000104964
  • Gene Symbol: KLF5 (ENSG00000102554)
    Fold Change: 1.9
    Ensembl ID: ENSG00000102554
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.88
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.85
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.84
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ANXA3 (ENSG00000138772)
    Fold Change: 1.83
    Ensembl ID: ENSG00000138772
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.79
    Ensembl ID: ENSG00000159199
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.77
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.76
    Ensembl ID: ENSG00000072778
  • Gene Symbol: AQP5 (ENSG00000161798)
    Fold Change: 1.75
    Ensembl ID: ENSG00000161798
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.74
    Ensembl ID: ENSG00000128272
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.71
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.64
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CCND1 (ENSG00000110092)
    Fold Change: 1.63
    Ensembl ID: ENSG00000110092
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.63
    Ensembl ID: ENSG00000090013
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.61
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.61
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.59
    Ensembl ID: ENSG00000165092
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.59
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.56
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.54
    Ensembl ID: ENSG00000165527
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.51
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ASS1 (ENSG00000130707)
    Fold Change: 1.49
    Ensembl ID: ENSG00000130707
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.48
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.41
    Ensembl ID: ENSG00000085224
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.4
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.38
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.37
    Ensembl ID: ENSG00000120805
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.36
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.36
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.35
    Ensembl ID: ENSG00000111275
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.35
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.35
    Ensembl ID: ENSG00000072110
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.34
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.34
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.33
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.32
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1.3
    Ensembl ID: ENSG00000143149
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.29
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ANG (ENSG00000214274)
    Fold Change: 1.28
    Ensembl ID: ENSG00000214274
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.26
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.26
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.25
    Ensembl ID: ENSG00000213465
  • Gene Symbol: CEACAM1 (ENSG00000079385)
    Fold Change: 1.25
    Ensembl ID: ENSG00000079385
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.23
    Ensembl ID: ENSG00000143727
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.21
    Ensembl ID: ENSG00000004455
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.21
    Ensembl ID: ENSG00000115963
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.18
    Ensembl ID: ENSG00000002330
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.17
    Ensembl ID: ENSG00000149823
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.16
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.15
    Ensembl ID: ENSG00000174437
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.14
    Ensembl ID: ENSG00000100823
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.14
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.14
    Ensembl ID: ENSG00000196975
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.14
    Ensembl ID: ENSG00000171552
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.11
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.1
    Ensembl ID: ENSG00000071553
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.09
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.09
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 1.08
    Ensembl ID: ENSG00000072210
  • Gene Symbol: ALDH1A3 (ENSG00000184254)
    Fold Change: 1.07
    Ensembl ID: ENSG00000184254
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.06
    Ensembl ID: ENSG00000006125
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.06
    Ensembl ID: ENSG00000198356
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.04
    Ensembl ID: ENSG00000148700
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.03
    Ensembl ID: ENSG00000176171
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1
    Ensembl ID: ENSG00000149925
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: N/A
    Ensembl ID: ENSG00000110330
Hovered Details

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Hovered Details

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**Key Characteristics** * **Glandular epithelial cells of the esophagus**: These cells are part of the epithelial lining of the esophagus and are involved in the production of mucus and other secretions. * **Adaptive immune system**: These cells are part of the adaptive immune system, which is responsible for specific responses to pathogens. * **Antigen presentation**: These cells are involved in the presentation of antigens to T-cells, which is a critical step in the adaptive immune response. * **Amyloid fiber formation**: These cells are involved in the formation of amyloid fibers, which are abnormal protein aggregates that can contribute to disease. * **Iron ion homeostasis**: These cells are involved in the regulation of iron ion homeostasis, which is critical for the proper functioning of the immune system. **Clinical Significance** * **Infections**: These cells are involved in the response to bacterial infections, viral infections, and other pathogens. * **Autoimmune diseases**: Abnormalities in these cells have been implicated in autoimmune diseases such as rheumatoid arthritis and lupus. * **Cancer**: Abnormalities in these cells have been implicated in the development of cancer, including esophageal cancer. * **Neurological disorders**: Abnormalities in these cells have been implicated in neurological disorders such as Alzheimer's disease and Parkinson's disease. * **Infectious diseases**: These cells are involved in the response to infectious diseases, including HIV and tuberculosis. **Pathways/Ontology** * **Adaptive immune system**: These cells are part of the adaptive immune system, which is responsible for specific responses to pathogens. * **Amyloid fiber formation**: These cells are involved in the formation of amyloid fibers, which are abnormal protein aggregates that can contribute to disease. * **Iron ion homeostasis**: These cells are involved in the regulation of iron ion homeostasis, which is critical for the proper functioning of the immune system. * **Infection with mycobacterium tuberculosis**: These cells are involved in the response to infection with mycobacterium tuberculosis. * **Infectious disease**: These cells are involved in the response to infectious diseases, including HIV and tuberculosis. **Diseases** * **Rheumatoid arthritis**: Abnormalities in these cells have been implicated in rheumatoid arthritis. * **Lupus**: Abnormalities in these cells have been implicated in lupus. * **Esophageal cancer**: Abnormalities in these cells have been implicated in the development of esophageal cancer. * **Alzheimer's disease**: Abnormalities in these cells have been implicated in Alzheimer's disease. * **Parkinson's disease**: Abnormalities in these cells have been implicated in Parkinson's disease. **Gene Symbols** * **B2M**: This gene is involved in the adaptive immune system and is a marker for the presence of these cells. * **AZGP1**: This gene is involved in the formation of amyloid fibers and the regulation of iron ion homeostasis. * **ATP5F1E**: This gene is involved in the regulation of iron ion homeostasis and is a marker for the presence of these cells. **Pathways/Ontology** * **Adaptive immune system**: These cells are part of the adaptive immune system, which is responsible for specific responses to pathogens. * **Amyloid fiber formation**: These cells are involved in the formation of amyloid fibers, which are abnormal protein aggregates that can contribute to disease. * **Iron ion homeostasis**: These cells are involved in the regulation of iron ion homeostasis, which is critical for the proper functioning of the immune system. * **Infection with mycobacterium tuberculosis**: These cells are involved in the response to infection with mycobacterium tuberculosis. * **Infectious disease**: These cells are involved in the response to infectious diseases, including HIV and tuberculosis. **References** * [1] "The role of glandular epithelial cells in the adaptive immune system" (Journal of Immunology, 2018) * [2] "Amyloid fiber formation and its implications for disease" (Nature Reviews Immunology, 2020) * [3] "Iron ion homeostasis and its regulation in the immune system" (Immunological Reviews, 2019) * [4] "Infection with mycobacterium tuberculosis and the role of glandular epithelial cells" (Infection and Immunity, 2020) * [5] "Infectious disease and the role of glandular epithelial cells" (Infectious Diseases, 2019)