Cell ID: CL0005006

Cell Name: ionocyte

CSI Thresholds:

Select	Context	Threshold
	Overall	10.4555
	Lung parenchyma	191.0444
	Lung parenchyma + Healthy	181.2660
	Nasopharynx + Healthy	96.6040
	Lung adenocarcinoma	48.5987
	Submandibular gland + Healthy	27.6388
	Submandibular gland	27.5851
	Labial gland	23.8435
	Respiratory airway + Healthy	22.9497
	Nasopharynx	20.9796
	Respiratory airway	16.0830
	Lung + COVID-19	10.9078
	Healthy	8.8752
	COVID-19	8.5101
	Lung + Healthy	8.3100
	Lung	6.1445
	Cystic fibrosis	5.7488
	Lung + Cystic fibrosis	5.7280
	Nose + Healthy	5.0556
	Trachea	4.2125
	Lung + Interstitial lung disease	4.0941
	Interstitial lung disease	4.0870
	Long COVID-19	3.5524
	Nasopharynx + Long COVID-19	3.5524
	Trachea + Healthy	3.5032
	Sublingual gland	3.0816
	Sublingual gland + Healthy	3.0816
	Nose	2.7334
	Respiratory failure	2.5204
	Nasopharynx + Respiratory failure	2.5204
	Non-specific interstitial pneumonia	2.4647
	Lung + Non-specific interstitial pneumonia	2.4537
	Lung + Pulmonary fibrosis	1.7390
	Pulmonary fibrosis	1.7292
	Nasopharynx + COVID-19	1.6457
	Hypersensitivity pneumonitis	1.0970
	Lung + Hypersensitivity pneumonitis	1.0923
	Lung + Lung adenocarcinoma	0.4014
	Respiratory airway + COVID-19	0.3225
	Chronic rhinitis	0.2774
	Nose + Chronic rhinitis	0.2749
	Pneumonia	0.0545
	Lung + Pneumonia	0.0543

Select

(Cell Significance Index is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers.)

Description: Specialized epithelial cells involved in the maintenance of osmotic homeostasis. They are characterized by abundant mitochondria and ion transporters. In amniotes, they are present in the renal system. In freshwater fish, ionocytes in the skin and gills help maintain osmotic homeostasis by absorbing salt from the external environment.