Details for: CL0005006

Cell ID: CL0005006

Cell Name: ionocyte

Marker Score Threshold: 304
(Derived using integrated single-cell and genomic data)

Description: Specialized epithelial cells involved in the maintenance of osmotic homeostasis. They are characterized by abundant mitochondria and ion transporters. In amniotes, they are present in the renal system. In freshwater fish, ionocytes in the skin and gills help maintain osmotic homeostasis by absorbing salt from the external environment.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.18
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.09
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.93
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.73
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.7
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.64
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.56
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.52
    Ensembl ID: ENSG00000143933
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.52
    Ensembl ID: ENSG00000169100
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.49
    Ensembl ID: ENSG00000133639
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.27
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.24
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.21
    Ensembl ID: ENSG00000169020
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.19
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.14
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.12
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.05
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.04
    Ensembl ID: ENSG00000154518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.04
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.83
    Ensembl ID: ENSG00000241837
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.83
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.82
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.8
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.79
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.79
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.77
    Ensembl ID: ENSG00000153113
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.76
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.75
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.74
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.73
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.69
    Ensembl ID: ENSG00000164111
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.66
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.64
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.64
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.62
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.58
    Ensembl ID: ENSG00000130402
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.58
    Ensembl ID: ENSG00000100300
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.57
    Ensembl ID: ENSG00000084234
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.56
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.55
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.54
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.52
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.52
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.51
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.49
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.49
    Ensembl ID: ENSG00000122359
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.48
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.44
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.43
    Ensembl ID: ENSG00000141522
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.43
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.42
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.39
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.39
    Ensembl ID: ENSG00000135046
  • Gene Symbol: C2 (ENSG00000166278)
    Fold Change: 1.39
    Ensembl ID: ENSG00000166278
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.36
    Ensembl ID: ENSG00000198898
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.31
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.31
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.3
    Ensembl ID: ENSG00000143727
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.26
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.24
    Ensembl ID: ENSG00000162909
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.23
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.21
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.21
    Ensembl ID: ENSG00000126247
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.2
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.19
    Ensembl ID: ENSG00000069849
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.19
    Ensembl ID: ENSG00000183255
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.19
    Ensembl ID: ENSG00000100823
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.19
    Ensembl ID: ENSG00000107262
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.19
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.16
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.16
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.15
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.15
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.14
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.14
    Ensembl ID: ENSG00000138279
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.14
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.11
    Ensembl ID: ENSG00000087274
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.11
    Ensembl ID: ENSG00000090013
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.11
    Ensembl ID: ENSG00000004455
  • Gene Symbol: AQP1 (ENSG00000240583)
    Fold Change: 1.08
    Ensembl ID: ENSG00000240583
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.08
    Ensembl ID: ENSG00000162772
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.07
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.06
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.06
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.05
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.05
    Ensembl ID: ENSG00000143153
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.04
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.04
    Ensembl ID: ENSG00000156110
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.04
    Ensembl ID: ENSG00000145349
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.03
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.03
    Ensembl ID: ENSG00000198363
  • Gene Symbol: TMEM50B (ENSG00000142188)
    Fold Change: 1.02
    Ensembl ID: ENSG00000142188
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.02
    Ensembl ID: ENSG00000174437
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.02
    Ensembl ID: ENSG00000176171
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.01
    Ensembl ID: ENSG00000100852
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.01
    Ensembl ID: ENSG00000149823
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1
    Ensembl ID: ENSG00000134287
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1
    Ensembl ID: ENSG00000149311
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1
    Ensembl ID: ENSG00000164615
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Abundant Mitochondria**: Ionocytes have a high number of mitochondria, which provide the necessary energy for ion transport and maintenance of osmotic homeostasis. 2. **Ion Transporters**: Ionocytes possess specific ion transporters that enable the regulation of ion concentrations in the surrounding environment. 3. **Specialized Cell Membrane**: The ionocyte cell membrane is specialized to regulate the transport of ions across the membrane. 4. **Presence in Amniotes**: In amniotes, ionocytes are present in the renal system, where they play a crucial role in maintaining osmotic homeostasis. 5. **Presence in Freshwater Fish**: In freshwater fish, ionocytes are found in the skin and gills, where they help maintain osmotic homeostasis by absorbing salt from the external environment. **Clinical Significance** 1. **Osmotic Imbalance**: Ionocytes play a crucial role in maintaining osmotic homeostasis, which is essential for proper cellular function and overall health. 2. **Renal Function**: In amniotes, ionocytes are present in the renal system, where they help regulate the concentration of ions in the urine. 3. **Fish Health**: In freshwater fish, ionocytes help maintain osmotic homeostasis by absorbing salt from the external environment, which is essential for their survival. 4. **Diseases**: Abnormalities in ionocyte function can lead to diseases such as osmotic imbalance, renal dysfunction, and impaired fish health. 5. **Therapeutic Applications**: Understanding the function of ionocytes can lead to the development of therapeutic strategies for treating diseases related to osmotic imbalance and renal dysfunction. **Pathways and Ontology** The ionocyte cell membrane is involved in various signaling pathways, including: 1. **Actin Cytoskeleton**: Ionocytes are involved in the regulation of actin cytoskeleton dynamics, which is essential for maintaining cell shape and function. 2. **Adherens Junction**: Ionocytes are connected to neighboring cells through adherens junctions, which enable the transmission of signals between cells. 3. **Apical Junction Complex**: Ionocytes are part of the apical junction complex, which is involved in the regulation of ion transport and maintenance of osmotic homeostasis. 4. **B-Raf/MAPK Signaling**: Ionocytes are involved in the regulation of B-Raf/MAPK signaling pathways, which are essential for cell proliferation and differentiation. Overall, the ionocyte is a specialized epithelial cell that plays a crucial role in maintaining osmotic homeostasis and regulating ion transport across the cell membrane.