Details for: CL0005009

Cell ID: CL0005009

Cell Name: renal principal cell

Marker Score Threshold: 770
(Derived using integrated single-cell and genomic data)

Description: A cuboidal epithelial cell of the kidney which regulates sodium and potassium balance. The activity of sodium and potassium channels on the apical membrane of the cell is regulated by aldosterone and vasopressin. In mammals this cell type is located in the renal collecting duct system.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 3.9
    Ensembl ID: ENSG00000151150
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 3.64
    Ensembl ID: ENSG00000198589
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 3.52
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 3.36
    Ensembl ID: ENSG00000156110
  • Gene Symbol: BMPR1B (ENSG00000138696)
    Fold Change: 3.34
    Ensembl ID: ENSG00000138696
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 3.28
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 3.28
    Ensembl ID: ENSG00000047648
  • Gene Symbol: MPPED2 (ENSG00000066382)
    Fold Change: 3.21
    Ensembl ID: ENSG00000066382
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 3.15
    Ensembl ID: ENSG00000157764
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 2.89
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.82
    Ensembl ID: ENSG00000085224
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.78
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CRYBG1 (ENSG00000112297)
    Fold Change: 2.67
    Ensembl ID: ENSG00000112297
  • Gene Symbol: COL4A5 (ENSG00000188153)
    Fold Change: 2.66
    Ensembl ID: ENSG00000188153
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 2.57
    Ensembl ID: ENSG00000173575
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 2.5
    Ensembl ID: ENSG00000076555
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 2.48
    Ensembl ID: ENSG00000113712
  • Gene Symbol: AQP2 (ENSG00000167580)
    Fold Change: 2.4
    Ensembl ID: ENSG00000167580
  • Gene Symbol: CA12 (ENSG00000074410)
    Fold Change: 2.35
    Ensembl ID: ENSG00000074410
  • Gene Symbol: CDK6 (ENSG00000105810)
    Fold Change: 2.28
    Ensembl ID: ENSG00000105810
  • Gene Symbol: CLCN5 (ENSG00000171365)
    Fold Change: 2.25
    Ensembl ID: ENSG00000171365
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 2.23
    Ensembl ID: ENSG00000171791
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 2.23
    Ensembl ID: ENSG00000151746
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 2.19
    Ensembl ID: ENSG00000148090
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 2.16
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.12
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CDH1 (ENSG00000039068)
    Fold Change: 2.08
    Ensembl ID: ENSG00000039068
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 2.05
    Ensembl ID: ENSG00000083123
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 2.03
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.95
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.93
    Ensembl ID: ENSG00000140836
  • Gene Symbol: CDH16 (ENSG00000166589)
    Fold Change: 1.91
    Ensembl ID: ENSG00000166589
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.84
    Ensembl ID: ENSG00000204217
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 1.82
    Ensembl ID: ENSG00000153956
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.79
    Ensembl ID: ENSG00000183020
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.78
    Ensembl ID: ENSG00000134480
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.77
    Ensembl ID: ENSG00000170634
  • Gene Symbol: CDK8 (ENSG00000132964)
    Fold Change: 1.77
    Ensembl ID: ENSG00000132964
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.76
    Ensembl ID: ENSG00000156273
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 1.76
    Ensembl ID: ENSG00000099622
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.72
    Ensembl ID: ENSG00000053254
  • Gene Symbol: CHRM3 (ENSG00000133019)
    Fold Change: 1.72
    Ensembl ID: ENSG00000133019
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.7
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CREM (ENSG00000095794)
    Fold Change: 1.69
    Ensembl ID: ENSG00000095794
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 1.69
    Ensembl ID: ENSG00000114423
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 1.69
    Ensembl ID: ENSG00000278540
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.67
    Ensembl ID: ENSG00000097007
  • Gene Symbol: CREBBP (ENSG00000005339)
    Fold Change: 1.66
    Ensembl ID: ENSG00000005339
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.63
    Ensembl ID: ENSG00000148700
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.6
    Ensembl ID: ENSG00000166747
  • Gene Symbol: ARG2 (ENSG00000081181)
    Fold Change: 1.56
    Ensembl ID: ENSG00000081181
  • Gene Symbol: CLCN3 (ENSG00000109572)
    Fold Change: 1.56
    Ensembl ID: ENSG00000109572
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 1.55
    Ensembl ID: ENSG00000107779
  • Gene Symbol: CDR2 (ENSG00000140743)
    Fold Change: 1.53
    Ensembl ID: ENSG00000140743
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.49
    Ensembl ID: ENSG00000075624
  • Gene Symbol: COL4A6 (ENSG00000197565)
    Fold Change: 1.48
    Ensembl ID: ENSG00000197565
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.47
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.46
    Ensembl ID: ENSG00000162104
  • Gene Symbol: ATR (ENSG00000175054)
    Fold Change: 1.44
    Ensembl ID: ENSG00000175054
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.41
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.38
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CALB1 (ENSG00000104327)
    Fold Change: 1.37
    Ensembl ID: ENSG00000104327
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.37
    Ensembl ID: ENSG00000153922
  • Gene Symbol: ACVR1B (ENSG00000135503)
    Fold Change: 1.36
    Ensembl ID: ENSG00000135503
  • Gene Symbol: COL4A2 (ENSG00000134871)
    Fold Change: 1.35
    Ensembl ID: ENSG00000134871
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.34
    Ensembl ID: ENSG00000087274
  • Gene Symbol: MAPK14 (ENSG00000112062)
    Fold Change: 1.34
    Ensembl ID: ENSG00000112062
  • Gene Symbol: CBFB (ENSG00000067955)
    Fold Change: 1.34
    Ensembl ID: ENSG00000067955
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 1.33
    Ensembl ID: ENSG00000114573
  • Gene Symbol: CLTC (ENSG00000141367)
    Fold Change: 1.3
    Ensembl ID: ENSG00000141367
  • Gene Symbol: CACNB4 (ENSG00000182389)
    Fold Change: 1.3
    Ensembl ID: ENSG00000182389
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.29
    Ensembl ID: ENSG00000072778
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.28
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.27
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.24
    Ensembl ID: ENSG00000100412
  • Gene Symbol: COL4A1 (ENSG00000187498)
    Fold Change: 1.23
    Ensembl ID: ENSG00000187498
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.22
    Ensembl ID: ENSG00000184009
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.2
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.2
    Ensembl ID: ENSG00000143322
  • Gene Symbol: CENPC (ENSG00000145241)
    Fold Change: 1.19
    Ensembl ID: ENSG00000145241
  • Gene Symbol: LYST (ENSG00000143669)
    Fold Change: 1.19
    Ensembl ID: ENSG00000143669
  • Gene Symbol: COPA (ENSG00000122218)
    Fold Change: 1.18
    Ensembl ID: ENSG00000122218
  • Gene Symbol: ASPA (ENSG00000108381)
    Fold Change: 1.16
    Ensembl ID: ENSG00000108381
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.16
    Ensembl ID: ENSG00000145349
  • Gene Symbol: ABO (ENSG00000175164)
    Fold Change: 1.15
    Ensembl ID: ENSG00000175164
  • Gene Symbol: ACVR2A (ENSG00000121989)
    Fold Change: 1.15
    Ensembl ID: ENSG00000121989
  • Gene Symbol: BCR (ENSG00000186716)
    Fold Change: 1.13
    Ensembl ID: ENSG00000186716
  • Gene Symbol: CCNT2 (ENSG00000082258)
    Fold Change: 1.13
    Ensembl ID: ENSG00000082258
  • Gene Symbol: CHKA (ENSG00000110721)
    Fold Change: 1.11
    Ensembl ID: ENSG00000110721
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 1.1
    Ensembl ID: ENSG00000165272
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.09
    Ensembl ID: ENSG00000149311
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.09
    Ensembl ID: ENSG00000067082
  • Gene Symbol: TMEM50B (ENSG00000142188)
    Fold Change: 1.09
    Ensembl ID: ENSG00000142188
  • Gene Symbol: CLCNKB (ENSG00000184908)
    Fold Change: 1.09
    Ensembl ID: ENSG00000184908
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.06
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.06
    Ensembl ID: ENSG00000165629
  • Gene Symbol: COL4A3 (ENSG00000169031)
    Fold Change: 1.06
    Ensembl ID: ENSG00000169031
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 1.04
    Ensembl ID: ENSG00000172757
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.03
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CDC27 (ENSG00000004897)
    Fold Change: 1.02
    Ensembl ID: ENSG00000004897
Hovered Details

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Hovered Details

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**Key Characteristics** * Location: Renal collecting duct system of the kidney * Function: Regulates sodium and potassium balance * Regulation: Aldosterone and vasopressin regulate the activity of sodium and potassium channels * Gene symbols: + ANK3 (ANK3) + LRBA (LRBA) + RERE (RERE) + ADK (ADK) + BMPR1B (BMPR1B) + ATP1B1 (ATP1B1) + ARHGAP6 (ARHGAP6) + MPPED2 (MPPED2) * Pathways and ontologies: + Asparagine n-linked glycosylation + Axon guidance + Axon initial segment + Axonogenesis + Basal plasma membrane + Basolateral plasma membrane + Bicellular tight junction + Cadherin binding + Cell surface + Cellular response to magnesium ion + Copi-mediated anterograde transport + Costamere + Cytoskeletal anchor activity + Cytoskeletal protein binding + Cytoskeleton organization + Cytosol + Dendrite + Developmental biology + Endoplasmic reticulum + Er to golgi anterograde transport + Establishment of protein localization + Golgi apparatus + Golgi to plasma membrane protein transport + Interaction between l1 and ankyrins + Intercalated disc + L1cam interactions + Lateral plasma membrane + Lysosome + Magnesium ion homeostasis + Maintenance of protein location in plasma membrane + Membrane assembly + Membrane trafficking + Metabolism of proteins + Mitotic cytokinesis + Negative regulation of delayed rectifier potassium channel activity + Nervous system development + Neuromuscular junction + Neuromuscular junction development + Neuronal action potential + Neuron projection + Node of ranvier + Plasma membrane + Plasma membrane organization + Positive regulation of cation channel activity + Positive regulation of cell communication by electrical coupling + Positive regulation of gene expression + Positive regulation of homotypic cell-cell adhesion + Positive regulation of membrane depolarization during cardiac muscle cell action potential + Positive regulation of membrane potential + Positive regulation of protein targeting to membrane + Positive regulation of sodium ion transmembrane transporter activity + Positive regulation of sodium ion transport + Post-translational protein modification + Postsynaptic membrane + Protein-macromolecule adaptor activity + Protein binding + Protein localization to axon + Protein localization to plasma membrane + Regulation of potassium ion transport + Sarcolemma + Sarcoplasmic reticulum + Signal transduction + Spectrin-associated cytoskeleton + Spectrin binding + Structural constituent of cytoskeleton + T-tubule + Transmembrane transporter binding + Transport to the golgi and subsequent modification + Vesicle-mediated transport + Z disc **Clinical Significance** The renal principal cell plays a crucial role in maintaining electrolyte balance and blood pressure regulation. Dysregulation of the renal principal cell has been implicated in various diseases, including hypertension, kidney disease, and metabolic disorders. Understanding the function and regulation of the renal principal cell can provide insights into the development of novel therapeutic strategies for these diseases. In addition, the renal principal cell is also involved in the regulation of gene expression and protein localization to the plasma membrane, which can have implications for the development and progression of various diseases. Further research into the role of the renal principal cell in disease pathophysiology and the development of novel therapeutic strategies is needed. **References** * [Insert references here] Note: This is a summary of the provided cell information and should not be considered a comprehensive review of the literature on the topic.