Cell ID: CL0005009

Cell Name: renal principal cell

CSI Thresholds:

Select	Context	Threshold
	Overall	10.5834
	Type 2 diabetes mellitus	47.2176
	Cortex of kidney + Type 2 diabetes mellitus	18.6395
	Cortex of kidney + Healthy	18.5163
	Kidney	10.1360
	Healthy	8.5018
	Renal pelvis	6.0490
	Renal pelvis + Healthy	6.0372
	Cortex of kidney	5.1027
	Renal medulla	2.4498
	Renal medulla + Healthy	1.8063
	Kidney + Healthy	1.5874

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(Cell Significance Index is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers.)

Description: A cuboidal epithelial cell of the kidney which regulates sodium and potassium balance. The activity of sodium and potassium channels on the apical membrane of the cell is regulated by aldosterone and vasopressin. In mammals this cell type is located in the renal collecting duct system.