Details for: CL0005011

Cell ID: CL0005011

Cell Name: renal alpha-intercalated cell

Marker Score Threshold: 527
(Derived using integrated single-cell and genomic data)

Description: A cuboidal epithelial cell of the kidney which secretes acid and reabsorbs base to regulate acid/base balance.

Synonyms: type A intercalated cell, type A-IC

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: MPPED2 (ENSG00000066382)
    Fold Change: 3.33
    Ensembl ID: ENSG00000066382
  • Gene Symbol: CA12 (ENSG00000074410)
    Fold Change: 3.24
    Ensembl ID: ENSG00000074410
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 3.23
    Ensembl ID: ENSG00000198589
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 3.22
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CACNB2 (ENSG00000165995)
    Fold Change: 3.13
    Ensembl ID: ENSG00000165995
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 3.03
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.81
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 2.81
    Ensembl ID: ENSG00000047648
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 2.79
    Ensembl ID: ENSG00000143153
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 2.69
    Ensembl ID: ENSG00000157764
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 2.68
    Ensembl ID: ENSG00000163697
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 2.52
    Ensembl ID: ENSG00000053254
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.52
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CA8 (ENSG00000178538)
    Fold Change: 2.51
    Ensembl ID: ENSG00000178538
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.49
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 2.44
    Ensembl ID: ENSG00000114573
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 2.36
    Ensembl ID: ENSG00000173575
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 2.27
    Ensembl ID: ENSG00000151914
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 2.26
    Ensembl ID: ENSG00000171791
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 2.22
    Ensembl ID: ENSG00000076555
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 2.17
    Ensembl ID: ENSG00000148090
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 2.16
    Ensembl ID: ENSG00000196975
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.11
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CDK8 (ENSG00000132964)
    Fold Change: 2.03
    Ensembl ID: ENSG00000132964
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.96
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CDH1 (ENSG00000039068)
    Fold Change: 1.96
    Ensembl ID: ENSG00000039068
  • Gene Symbol: FXYD2 (ENSG00000137731)
    Fold Change: 1.9
    Ensembl ID: ENSG00000137731
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.87
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.82
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.77
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.71
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 1.7
    Ensembl ID: ENSG00000099622
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.67
    Ensembl ID: ENSG00000204217
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.65
    Ensembl ID: ENSG00000134480
  • Gene Symbol: AMFR (ENSG00000159461)
    Fold Change: 1.65
    Ensembl ID: ENSG00000159461
  • Gene Symbol: CLCNKA (ENSG00000186510)
    Fold Change: 1.59
    Ensembl ID: ENSG00000186510
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.56
    Ensembl ID: ENSG00000097007
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 1.55
    Ensembl ID: ENSG00000278540
  • Gene Symbol: ASTN1 (ENSG00000152092)
    Fold Change: 1.54
    Ensembl ID: ENSG00000152092
  • Gene Symbol: CACNA1D (ENSG00000157388)
    Fold Change: 1.52
    Ensembl ID: ENSG00000157388
  • Gene Symbol: LYST (ENSG00000143669)
    Fold Change: 1.49
    Ensembl ID: ENSG00000143669
  • Gene Symbol: ATR (ENSG00000175054)
    Fold Change: 1.48
    Ensembl ID: ENSG00000175054
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.48
    Ensembl ID: ENSG00000162909
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 1.48
    Ensembl ID: ENSG00000083123
  • Gene Symbol: CLCN5 (ENSG00000171365)
    Fold Change: 1.47
    Ensembl ID: ENSG00000171365
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 1.44
    Ensembl ID: ENSG00000172757
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.43
    Ensembl ID: ENSG00000156273
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.4
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CKB (ENSG00000166165)
    Fold Change: 1.39
    Ensembl ID: ENSG00000166165
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 1.38
    Ensembl ID: ENSG00000107779
  • Gene Symbol: CCNT2 (ENSG00000082258)
    Fold Change: 1.38
    Ensembl ID: ENSG00000082258
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.38
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CHI3L2 (ENSG00000064886)
    Fold Change: 1.38
    Ensembl ID: ENSG00000064886
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.36
    Ensembl ID: ENSG00000100412
  • Gene Symbol: SHROOM2 (ENSG00000146950)
    Fold Change: 1.33
    Ensembl ID: ENSG00000146950
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.33
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ACADL (ENSG00000115361)
    Fold Change: 1.33
    Ensembl ID: ENSG00000115361
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.31
    Ensembl ID: ENSG00000143322
  • Gene Symbol: CD36 (ENSG00000135218)
    Fold Change: 1.31
    Ensembl ID: ENSG00000135218
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.3
    Ensembl ID: ENSG00000122359
  • Gene Symbol: BMPR1B (ENSG00000138696)
    Fold Change: 1.29
    Ensembl ID: ENSG00000138696
  • Gene Symbol: CBFB (ENSG00000067955)
    Fold Change: 1.29
    Ensembl ID: ENSG00000067955
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.29
    Ensembl ID: ENSG00000166747
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.28
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.27
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.27
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CENPC (ENSG00000145241)
    Fold Change: 1.26
    Ensembl ID: ENSG00000145241
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.25
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.25
    Ensembl ID: ENSG00000153922
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.24
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.22
    Ensembl ID: ENSG00000159842
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.22
    Ensembl ID: ENSG00000087274
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.21
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CHKA (ENSG00000110721)
    Fold Change: 1.2
    Ensembl ID: ENSG00000110721
  • Gene Symbol: CHIT1 (ENSG00000133063)
    Fold Change: 1.19
    Ensembl ID: ENSG00000133063
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.18
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 1.17
    Ensembl ID: ENSG00000114423
  • Gene Symbol: PARP4 (ENSG00000102699)
    Fold Change: 1.17
    Ensembl ID: ENSG00000102699
  • Gene Symbol: CDH16 (ENSG00000166589)
    Fold Change: 1.17
    Ensembl ID: ENSG00000166589
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.16
    Ensembl ID: ENSG00000166710
  • Gene Symbol: KRIT1 (ENSG00000001631)
    Fold Change: 1.15
    Ensembl ID: ENSG00000001631
  • Gene Symbol: CASQ2 (ENSG00000118729)
    Fold Change: 1.15
    Ensembl ID: ENSG00000118729
  • Gene Symbol: CDR2 (ENSG00000140743)
    Fold Change: 1.14
    Ensembl ID: ENSG00000140743
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.13
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CDC27 (ENSG00000004897)
    Fold Change: 1.11
    Ensembl ID: ENSG00000004897
  • Gene Symbol: C8A (ENSG00000157131)
    Fold Change: 1.1
    Ensembl ID: ENSG00000157131
  • Gene Symbol: BCL9 (ENSG00000116128)
    Fold Change: 1.09
    Ensembl ID: ENSG00000116128
  • Gene Symbol: ERCC8 (ENSG00000049167)
    Fold Change: 1.07
    Ensembl ID: ENSG00000049167
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.07
    Ensembl ID: ENSG00000075239
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.07
    Ensembl ID: ENSG00000104964
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.06
    Ensembl ID: ENSG00000122545
  • Gene Symbol: CKMT2 (ENSG00000131730)
    Fold Change: 1.03
    Ensembl ID: ENSG00000131730
  • Gene Symbol: ANGPT1 (ENSG00000154188)
    Fold Change: 1.03
    Ensembl ID: ENSG00000154188
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: 1.02
    Ensembl ID: ENSG00000164742
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.02
    Ensembl ID: ENSG00000149311
  • Gene Symbol: BDKRB2 (ENSG00000168398)
    Fold Change: 1.01
    Ensembl ID: ENSG00000168398
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 1.01
    Ensembl ID: ENSG00000010278
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1
    Ensembl ID: ENSG00000072778
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1
    Ensembl ID: ENSG00000198898
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: N/A
    Ensembl ID: ENSG00000183020
Hovered Details

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Hovered Details

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**Key Characteristics** The renal alpha-intercalated cell is a cuboidal epithelial cell that is specifically localized to the kidney's intercalated cells, which are found in the renal medulla. This cell type is characterized by its unique expression of genes involved in acid-base regulation, including: * MPPED2 (calcium-activated chloride channel 1) * CA12 (carbonic anhydrase 12) * LRBA (lymphoid-specific protein 2, also known as RERE) * CACNB2 (calcium channel, voltage-gated, L-type, beta 2 subunit) * ANK3 (ankyrin repeat and membrane-associated protein 3) These genes are involved in the regulation of acid-base balance by controlling the secretion and reabsorption of ions and protons in the kidney. The renal alpha-intercalated cell also expresses genes involved in other cellular processes, including: * Cell signaling: LRBA, CACNB2, and ANK3 * Protein localization: LRBA, CACNB2, and ANK3 * Ion transport: MPPED2, CA12, and LRBA **Clinical Significance** The renal alpha-intercalated cell plays a crucial role in maintaining acid-base balance, and its dysregulation has been implicated in various diseases, including: * Kidney disease: The renal alpha-intercalated cell is involved in the regulation of acid-base balance, and its dysfunction can lead to kidney disease. * Metabolic disorders: The renal alpha-intercalated cell is also involved in the regulation of electrolyte balance, and its dysfunction can lead to metabolic disorders such as hyperkalemia and metabolic acidosis. * Neurological disorders: The renal alpha-intercalated cell is involved in the regulation of acid-base balance, and its dysfunction can lead to neurological disorders such as seizures and coma. In addition, the renal alpha-intercalated cell has been implicated in various other diseases, including: * Hypertension: The renal alpha-intercalated cell is involved in the regulation of blood pressure, and its dysfunction can lead to hypertension. * Cardiovascular disease: The renal alpha-intercalated cell is involved in the regulation of electrolyte balance, and its dysfunction can lead to cardiovascular disease. * Cancer: The renal alpha-intercalated cell is involved in the regulation of cell signaling and protein localization, and its dysfunction can lead to cancer. Overall, the renal alpha-intercalated cell is a critical component of the kidney's function to maintain acid-base homeostasis, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of the renal alpha-intercalated cell in human disease.