Details for: CL0005012

Cell ID: CL0005012

Cell Name: multi-ciliated epithelial cell

Marker Score Threshold: 1901
(Derived using integrated single-cell and genomic data)

Description: A columnar/cuboidal epithelial cell with multiple motile cilia on its apical surface. These cells facilitate the movement of liquids such as mucus or cerebrospinal fluid across the epithelial surface.

Synonyms: multi-ciliated cell, multiciliated cell, multiciliated epithelial cell, MCC

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.94
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.74
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.72
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.67
    Ensembl ID: ENSG00000135046
  • Gene Symbol: C6 (ENSG00000039537)
    Fold Change: 2.66
    Ensembl ID: ENSG00000039537
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.53
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 2.43
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.4
    Ensembl ID: ENSG00000169020
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.37
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.34
    Ensembl ID: ENSG00000135390
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.26
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 2.26
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.21
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 2.15
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 2.13
    Ensembl ID: ENSG00000143153
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.12
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.12
    Ensembl ID: ENSG00000110955
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.05
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.01
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 2
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.98
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.97
    Ensembl ID: ENSG00000163399
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.93
    Ensembl ID: ENSG00000172270
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.92
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.82
    Ensembl ID: ENSG00000174437
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 1.81
    Ensembl ID: ENSG00000165272
  • Gene Symbol: ALOX15 (ENSG00000161905)
    Fold Change: 1.81
    Ensembl ID: ENSG00000161905
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.8
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.78
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ALDH3B1 (ENSG00000006534)
    Fold Change: 1.76
    Ensembl ID: ENSG00000006534
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 1.73
    Ensembl ID: ENSG00000130208
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.73
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.73
    Ensembl ID: ENSG00000117410
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.71
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.71
    Ensembl ID: ENSG00000116459
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.7
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.69
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.67
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.66
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.65
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.65
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.64
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.59
    Ensembl ID: ENSG00000104763
  • Gene Symbol: AK1 (ENSG00000106992)
    Fold Change: 1.58
    Ensembl ID: ENSG00000106992
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.58
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.57
    Ensembl ID: ENSG00000085224
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.56
    Ensembl ID: ENSG00000198931
  • Gene Symbol: KLF5 (ENSG00000102554)
    Fold Change: 1.55
    Ensembl ID: ENSG00000102554
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.51
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.51
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.5
    Ensembl ID: ENSG00000165629
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.48
    Ensembl ID: ENSG00000151729
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.46
    Ensembl ID: ENSG00000171552
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.46
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ACYP1 (ENSG00000119640)
    Fold Change: 1.45
    Ensembl ID: ENSG00000119640
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.44
    Ensembl ID: ENSG00000099624
  • Gene Symbol: APOD (ENSG00000189058)
    Fold Change: 1.43
    Ensembl ID: ENSG00000189058
  • Gene Symbol: DDR1 (ENSG00000204580)
    Fold Change: 1.43
    Ensembl ID: ENSG00000204580
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.42
    Ensembl ID: ENSG00000148700
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.41
    Ensembl ID: ENSG00000142192
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.4
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.39
    Ensembl ID: ENSG00000143727
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.36
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.35
    Ensembl ID: ENSG00000071553
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.35
    Ensembl ID: ENSG00000107262
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.35
    Ensembl ID: ENSG00000090013
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.33
    Ensembl ID: ENSG00000072778
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.3
    Ensembl ID: ENSG00000006125
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.26
    Ensembl ID: ENSG00000143878
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.26
    Ensembl ID: ENSG00000002330
  • Gene Symbol: ALDH3A1 (ENSG00000108602)
    Fold Change: 1.25
    Ensembl ID: ENSG00000108602
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.25
    Ensembl ID: ENSG00000100852
  • Gene Symbol: C1QA (ENSG00000173372)
    Fold Change: 1.25
    Ensembl ID: ENSG00000173372
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.24
    Ensembl ID: ENSG00000035687
  • Gene Symbol: C1QB (ENSG00000173369)
    Fold Change: 1.23
    Ensembl ID: ENSG00000173369
  • Gene Symbol: ASL (ENSG00000126522)
    Fold Change: 1.22
    Ensembl ID: ENSG00000126522
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.22
    Ensembl ID: ENSG00000160710
  • Gene Symbol: TMEM50B (ENSG00000142188)
    Fold Change: 1.22
    Ensembl ID: ENSG00000142188
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.19
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.18
    Ensembl ID: ENSG00000196975
  • Gene Symbol: BCYRN1 (ENSG00000236824)
    Fold Change: 1.18
    Ensembl ID: ENSG00000236824
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.17
    Ensembl ID: ENSG00000120805
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.16
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.15
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CFAP410 (ENSG00000160226)
    Fold Change: 1.15
    Ensembl ID: ENSG00000160226
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.15
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.14
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.14
    Ensembl ID: ENSG00000111275
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.13
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.1
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.08
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.08
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.08
    Ensembl ID: ENSG00000165527
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.07
    Ensembl ID: ENSG00000198356
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.06
    Ensembl ID: ENSG00000075239
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.06
    Ensembl ID: ENSG00000115963
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.02
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.02
    Ensembl ID: ENSG00000058668
  • Gene Symbol: ZNHIT2 (ENSG00000174276)
    Fold Change: 1.01
    Ensembl ID: ENSG00000174276
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1
    Ensembl ID: ENSG00000004455
Hovered Details

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Hovered Details

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**Key Characteristics** MCCs are characterized by the following features: 1. **Multiple motile cilia**: MCCs have multiple cilia on their apical surface, which are responsible for the movement of liquids across the epithelial surface. 2. **Columnar/cuboidal epithelial cell shape**: MCCs have a columnar or cuboidal shape, which allows them to cover large surface areas. 3. **Apical surface**: The apical surface of MCCs is specialized for cilia movement and is characterized by the presence of microtubules, dynein motors, and other cytoskeletal components. 4. **Basal surface**: The basal surface of MCCs is specialized for cell-cell and cell-extracellular matrix interactions and is characterized by the presence of adherens junctions and other cell adhesion molecules. **Clinical Significance** MCCs have been implicated in various clinical conditions, including: 1. **Respiratory diseases**: MCCs play a crucial role in the clearance of mucus and debris from the airways, and alterations in MCC function can contribute to respiratory diseases such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis. 2. **Neurological disorders**: MCCs have been implicated in the pathogenesis of neurological disorders such as multiple sclerosis and Parkinson's disease, where alterations in MCC function can contribute to axonal damage and neurodegeneration. 3. **Infections**: MCCs have been shown to play a role in the clearance of pathogens from the respiratory tract, and alterations in MCC function can contribute to the development of infections such as respiratory syncytial virus (RSV) and influenza. 4. **Cancer**: MCCs have been implicated in the pathogenesis of certain types of cancer, including lung cancer and breast cancer, where alterations in MCC function can contribute to tumor progression and metastasis. **Molecular Mechanisms** MCCs are regulated by a complex interplay of molecular mechanisms, including: 1. **Cilia signaling**: Cilia signaling pathways, such as the Wnt/β-catenin pathway, regulate MCC function and are involved in the development and maintenance of epithelial tissues. 2. **Cell-cell interactions**: Cell-cell interactions, such as those mediated by adherens junctions and cadherins, regulate MCC function and are involved in the development and maintenance of epithelial tissues. 3. **Cytoskeletal regulation**: Cytoskeletal regulation, including the regulation of microtubules and actin filaments, is critical for MCC function and is involved in the development and maintenance of epithelial tissues. 4. **Signaling pathways**: Signaling pathways, such as those mediated by NF-κB and MAPK, regulate MCC function and are involved in the development and maintenance of epithelial tissues. In conclusion, MCCs play a critical role in various physiological and pathological processes, including immune responses, inflammation, and disease. Understanding the molecular mechanisms that regulate MCC function is essential for the development of novel therapeutic strategies for the treatment of MCC-related diseases.