Details for: CL0005022

Cell ID: CL0005022

Cell Name: vascular lymphangioblast

Marker Score Threshold: 1693
(Derived using integrated single-cell and genomic data)

Description: Lymphatic progenitor cells, derived from the veins, that give rise to lymphatic endothelial cells.

Synonyms: parachordal lymphangioblast

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.48
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.47
    Ensembl ID: ENSG00000075624
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.27
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.22
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 3.08
    Ensembl ID: ENSG00000133639
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.04
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.99
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CAV1 (ENSG00000105974)
    Fold Change: 2.86
    Ensembl ID: ENSG00000105974
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.85
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.82
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.74
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.74
    Ensembl ID: ENSG00000135390
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.66
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.6
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.56
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.48
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.44
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.42
    Ensembl ID: ENSG00000152518
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 2.37
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 2.36
    Ensembl ID: ENSG00000128272
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.36
    Ensembl ID: ENSG00000005022
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 2.34
    Ensembl ID: ENSG00000155366
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.29
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.25
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 2.23
    Ensembl ID: ENSG00000162772
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.19
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.18
    Ensembl ID: ENSG00000154723
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 2.17
    Ensembl ID: ENSG00000175899
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.17
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.15
    Ensembl ID: ENSG00000241837
  • Gene Symbol: AQP1 (ENSG00000240583)
    Fold Change: 2.06
    Ensembl ID: ENSG00000240583
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.03
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 2.03
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.03
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2
    Ensembl ID: ENSG00000179218
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.99
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.97
    Ensembl ID: ENSG00000169020
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.96
    Ensembl ID: ENSG00000100300
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.92
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.91
    Ensembl ID: ENSG00000141522
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.9
    Ensembl ID: ENSG00000149131
  • Gene Symbol: CAV2 (ENSG00000105971)
    Fold Change: 1.88
    Ensembl ID: ENSG00000105971
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.85
    Ensembl ID: ENSG00000122786
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.84
    Ensembl ID: ENSG00000152234
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.83
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.78
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ANGPT2 (ENSG00000091879)
    Fold Change: 1.78
    Ensembl ID: ENSG00000091879
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.75
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.72
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.69
    Ensembl ID: ENSG00000168374
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.69
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.64
    Ensembl ID: ENSG00000165629
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.62
    Ensembl ID: ENSG00000023445
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.6
    Ensembl ID: ENSG00000153113
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.6
    Ensembl ID: ENSG00000198931
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.59
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.58
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.57
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.56
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.56
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.53
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.51
    Ensembl ID: ENSG00000116459
  • Gene Symbol: APOD (ENSG00000189058)
    Fold Change: 1.48
    Ensembl ID: ENSG00000189058
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.45
    Ensembl ID: ENSG00000146731
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.45
    Ensembl ID: ENSG00000108561
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.45
    Ensembl ID: ENSG00000183255
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.43
    Ensembl ID: ENSG00000162909
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.43
    Ensembl ID: ENSG00000072778
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.43
    Ensembl ID: ENSG00000196954
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.4
    Ensembl ID: ENSG00000127022
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.39
    Ensembl ID: ENSG00000149823
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.38
    Ensembl ID: ENSG00000164615
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.37
    Ensembl ID: ENSG00000119138
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.37
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.35
    Ensembl ID: ENSG00000111348
  • Gene Symbol: SERPINH1 (ENSG00000149257)
    Fold Change: 1.34
    Ensembl ID: ENSG00000149257
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.33
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ADRB2 (ENSG00000169252)
    Fold Change: 1.33
    Ensembl ID: ENSG00000169252
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.31
    Ensembl ID: ENSG00000138279
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.3
    Ensembl ID: ENSG00000126247
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.29
    Ensembl ID: ENSG00000107262
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.2
    Ensembl ID: ENSG00000160014
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.17
    Ensembl ID: ENSG00000140299
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.15
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.14
    Ensembl ID: ENSG00000112576
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.14
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.14
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.13
    Ensembl ID: ENSG00000160710
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.1
    Ensembl ID: ENSG00000127837
  • Gene Symbol: AZGP1 (ENSG00000160862)
    Fold Change: 1.08
    Ensembl ID: ENSG00000160862
  • Gene Symbol: CAT (ENSG00000121691)
    Fold Change: 1.06
    Ensembl ID: ENSG00000121691
  • Gene Symbol: AREG (ENSG00000109321)
    Fold Change: 1.06
    Ensembl ID: ENSG00000109321
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.05
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.05
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.05
    Ensembl ID: ENSG00000104763
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.05
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.03
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.02
    Ensembl ID: ENSG00000196975
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.02
    Ensembl ID: ENSG00000087088
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.01
    Ensembl ID: ENSG00000004455
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** The vascular lymphangioblast is characterized by its ability to differentiate into lymphatic endothelial cells, which form the lining of lymphatic vessels. It also expresses specific surface markers, such as the B2M protein, which is involved in the presentation of antigens to T-cells. The vascular lymphangioblast is responsive to various signals, including cytokines, chemokines, and growth factors, which regulate its proliferation, differentiation, and migration. **Clinical Significance** The vascular lymphangioblast plays a critical role in various clinical conditions, including: 1. **Amyloidosis**: The vascular lymphangioblast is involved in the formation of amyloid fibers, which are abnormal protein deposits that can accumulate in tissues and organs, leading to organ dysfunction and failure. 2. **Iron deficiency anemia**: The vascular lymphangioblast regulates iron ion homeostasis, and its dysfunction can lead to iron deficiency anemia. 3. **Immunodeficiency disorders**: The vascular lymphangioblast is involved in the presentation of antigens to T-cells, and its dysfunction can lead to impaired immune function and increased susceptibility to infections. 4. **Lymphatic disorders**: The vascular lymphangioblast is essential for the development and maintenance of the lymphatic system, and its dysfunction can lead to lymphatic disorders, such as lymphedema and lymphangiectasia. 5. **Cancer**: The vascular lymphangioblast has been implicated in the development and progression of certain types of cancer, including lymphoma and leukemia. **Pathways and Ontologies** The vascular lymphangioblast is involved in various signaling pathways and ontologies, including: 1. **Adaptive immune system**: The vascular lymphangioblast is involved in the presentation of antigens to T-cells and the regulation of immune responses. 2. **Amyloid fiber formation**: The vascular lymphangioblast is involved in the formation of amyloid fibers, which are abnormal protein deposits that can accumulate in tissues and organs. 3. **Antigen processing and presentation**: The vascular lymphangioblast is involved in the processing and presentation of antigens to T-cells. 4. **Cytokine signaling**: The vascular lymphangioblast is responsive to various cytokines, which regulate its proliferation, differentiation, and migration. 5. **Innate immune system**: The vascular lymphangioblast is involved in the regulation of innate immune responses, including the production of cytokines and the activation of immune cells. In conclusion, the vascular lymphangioblast is a critical component of the lymphatic system, and its dysfunction has been implicated in various diseases. Further research is needed to fully understand the role of the vascular lymphangioblast in health and disease.