Details for: CL0005026

Cell ID: CL0005026

Cell Name: hepatoblast

Marker Score Threshold: 3276
(Derived using integrated single-cell and genomic data)

Description: Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ALB (ENSG00000163631)
    Fold Change: 17.75
    Ensembl ID: ENSG00000163631
  • Gene Symbol: AFP (ENSG00000081051)
    Fold Change: 14.98
    Ensembl ID: ENSG00000081051
  • Gene Symbol: APOA2 (ENSG00000158874)
    Fold Change: 14.4
    Ensembl ID: ENSG00000158874
  • Gene Symbol: APOA1 (ENSG00000118137)
    Fold Change: 14.09
    Ensembl ID: ENSG00000118137
  • Gene Symbol: AHSG (ENSG00000145192)
    Fold Change: 13.35
    Ensembl ID: ENSG00000145192
  • Gene Symbol: APOB (ENSG00000084674)
    Fold Change: 13.34
    Ensembl ID: ENSG00000084674
  • Gene Symbol: APOC3 (ENSG00000110245)
    Fold Change: 12.04
    Ensembl ID: ENSG00000110245
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 10.67
    Ensembl ID: ENSG00000130203
  • Gene Symbol: AMBP (ENSG00000106927)
    Fold Change: 10.28
    Ensembl ID: ENSG00000106927
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 8.94
    Ensembl ID: ENSG00000130208
  • Gene Symbol: C3 (ENSG00000125730)
    Fold Change: 8.17
    Ensembl ID: ENSG00000125730
  • Gene Symbol: ALDOB (ENSG00000136872)
    Fold Change: 7.87
    Ensembl ID: ENSG00000136872
  • Gene Symbol: APOH (ENSG00000091583)
    Fold Change: 7.74
    Ensembl ID: ENSG00000091583
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 6.68
    Ensembl ID: ENSG00000175899
  • Gene Symbol: AGT (ENSG00000135744)
    Fold Change: 6.67
    Ensembl ID: ENSG00000135744
  • Gene Symbol: ASS1 (ENSG00000130707)
    Fold Change: 6.5
    Ensembl ID: ENSG00000130707
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 5.06
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ACADSB (ENSG00000196177)
    Fold Change: 5.05
    Ensembl ID: ENSG00000196177
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 4.23
    Ensembl ID: ENSG00000142599
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 3.82
    Ensembl ID: ENSG00000157764
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 3.73
    Ensembl ID: ENSG00000156110
  • Gene Symbol: C5 (ENSG00000106804)
    Fold Change: 3.6
    Ensembl ID: ENSG00000106804
  • Gene Symbol: BDH1 (ENSG00000161267)
    Fold Change: 3.56
    Ensembl ID: ENSG00000161267
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 3.55
    Ensembl ID: ENSG00000168675
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 3.43
    Ensembl ID: ENSG00000072778
  • Gene Symbol: SERPINC1 (ENSG00000117601)
    Fold Change: 3.41
    Ensembl ID: ENSG00000117601
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 3.24
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 3.13
    Ensembl ID: ENSG00000165092
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 3.1
    Ensembl ID: ENSG00000149131
  • Gene Symbol: AGXT (ENSG00000172482)
    Fold Change: 3.04
    Ensembl ID: ENSG00000172482
  • Gene Symbol: ABCC6 (ENSG00000091262)
    Fold Change: 2.97
    Ensembl ID: ENSG00000091262
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 2.8
    Ensembl ID: ENSG00000122786
  • Gene Symbol: ADH6 (ENSG00000172955)
    Fold Change: 2.73
    Ensembl ID: ENSG00000172955
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.7
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: 2.61
    Ensembl ID: ENSG00000165029
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.57
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ASGR2 (ENSG00000161944)
    Fold Change: 2.5
    Ensembl ID: ENSG00000161944
  • Gene Symbol: ARG1 (ENSG00000118520)
    Fold Change: 2.46
    Ensembl ID: ENSG00000118520
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.26
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ASGR1 (ENSG00000141505)
    Fold Change: 2.25
    Ensembl ID: ENSG00000141505
  • Gene Symbol: ADH1A (ENSG00000187758)
    Fold Change: 2.23
    Ensembl ID: ENSG00000187758
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 2.18
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ATP2B2 (ENSG00000157087)
    Fold Change: 2.14
    Ensembl ID: ENSG00000157087
  • Gene Symbol: AK4 (ENSG00000162433)
    Fold Change: 2.09
    Ensembl ID: ENSG00000162433
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 2.07
    Ensembl ID: ENSG00000148700
  • Gene Symbol: BHMT (ENSG00000145692)
    Fold Change: 2.03
    Ensembl ID: ENSG00000145692
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.92
    Ensembl ID: ENSG00000060971
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.91
    Ensembl ID: ENSG00000111275
  • Gene Symbol: C8A (ENSG00000157131)
    Fold Change: 1.88
    Ensembl ID: ENSG00000157131
  • Gene Symbol: ANPEP (ENSG00000166825)
    Fold Change: 1.86
    Ensembl ID: ENSG00000166825
  • Gene Symbol: CCND1 (ENSG00000110092)
    Fold Change: 1.85
    Ensembl ID: ENSG00000110092
  • Gene Symbol: FXYD2 (ENSG00000137731)
    Fold Change: 1.83
    Ensembl ID: ENSG00000137731
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.8
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ACO1 (ENSG00000122729)
    Fold Change: 1.72
    Ensembl ID: ENSG00000122729
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.65
    Ensembl ID: ENSG00000170634
  • Gene Symbol: CACNB2 (ENSG00000165995)
    Fold Change: 1.63
    Ensembl ID: ENSG00000165995
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.62
    Ensembl ID: ENSG00000204217
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 1.59
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ABAT (ENSG00000183044)
    Fold Change: 1.58
    Ensembl ID: ENSG00000183044
  • Gene Symbol: ACOX1 (ENSG00000161533)
    Fold Change: 1.53
    Ensembl ID: ENSG00000161533
  • Gene Symbol: CA5A (ENSG00000174990)
    Fold Change: 1.51
    Ensembl ID: ENSG00000174990
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.46
    Ensembl ID: ENSG00000133639
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.45
    Ensembl ID: ENSG00000166710
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 1.45
    Ensembl ID: ENSG00000083123
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.43
    Ensembl ID: ENSG00000172270
  • Gene Symbol: AGTR1 (ENSG00000144891)
    Fold Change: 1.41
    Ensembl ID: ENSG00000144891
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.4
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ACAT2 (ENSG00000120437)
    Fold Change: 1.28
    Ensembl ID: ENSG00000120437
  • Gene Symbol: ANK1 (ENSG00000029534)
    Fold Change: 1.26
    Ensembl ID: ENSG00000029534
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 1.25
    Ensembl ID: ENSG00000072210
  • Gene Symbol: C8B (ENSG00000021852)
    Fold Change: 1.21
    Ensembl ID: ENSG00000021852
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.21
    Ensembl ID: ENSG00000097007
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.19
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 1.17
    Ensembl ID: ENSG00000047648
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.14
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ASL (ENSG00000126522)
    Fold Change: 1.14
    Ensembl ID: ENSG00000126522
  • Gene Symbol: BAAT (ENSG00000136881)
    Fold Change: 1.14
    Ensembl ID: ENSG00000136881
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.14
    Ensembl ID: ENSG00000162104
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.13
    Ensembl ID: ENSG00000100852
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.13
    Ensembl ID: ENSG00000101966
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.11
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.09
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.09
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ALAS2 (ENSG00000158578)
    Fold Change: 1.08
    Ensembl ID: ENSG00000158578
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.08
    Ensembl ID: ENSG00000143322
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.08
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.07
    Ensembl ID: ENSG00000117054
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.07
    Ensembl ID: ENSG00000156273
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.06
    Ensembl ID: ENSG00000072110
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.05
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BPHL (ENSG00000137274)
    Fold Change: 1.05
    Ensembl ID: ENSG00000137274
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.05
    Ensembl ID: ENSG00000101444
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 1.04
    Ensembl ID: ENSG00000076555
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.04
    Ensembl ID: ENSG00000164904
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.03
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ATP7B (ENSG00000123191)
    Fold Change: 1.02
    Ensembl ID: ENSG00000123191
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.02
    Ensembl ID: ENSG00000143933
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 1.02
    Ensembl ID: ENSG00000107779
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1
    Ensembl ID: ENSG00000171552
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1
    Ensembl ID: ENSG00000067560
Hovered Details

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Hovered Details

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**Key Characteristics** * Multi-fate stem cells with the ability to differentiate into hepatocytes and cholangiocytes * Fetal precursors of hepatocytes * Endogenous, derived from the liver itself * Can also be acquired from the bone marrow via the bloodstream * Express a wide range of genes involved in various cellular processes, including metabolism, signaling, and transport * Involved in liver development and regeneration * Play a crucial role in liver disease and injury **Clinical Significance** Hepatoblasts have significant clinical implications in the context of liver disease and injury. They are involved in liver development and regeneration, and play a crucial role in maintaining liver function. In the context of liver injury, hepatoblasts can differentiate into hepatocytes to replace damaged liver cells. This process is essential for liver regeneration and repair. Hepatoblasts have also been studied in the context of liver cancer, where they have been shown to have the ability to differentiate into hepatocytes and cholangiocytes. This has led to the development of new therapeutic strategies for liver cancer treatment, including the use of hepatoblasts to replace damaged liver cells. In addition, hepatoblasts have been studied in the context of liver transplantation, where they have been shown to play a crucial role in liver regeneration and repair. Hepatoblasts have also been used in the development of new liver cell therapies, including the use of hepatoblasts to replace damaged liver cells in patients with liver disease. Overall, hepatoblasts are a critical component of liver development and regeneration, and play a significant role in liver disease and injury. Further research on hepatoblasts is needed to fully understand their role in liver function and to develop new therapeutic strategies for liver disease and injury. **Gene Expression** Hepatoblasts express a wide range of genes involved in various cellular processes, including metabolism, signaling, and transport. Some of the key genes expressed by hepatoblasts include: * ALB (albumin): involved in protein synthesis and transport * AFP (alpha-fetoprotein): involved in liver development and regeneration * APOA2 (apolipoprotein A-II): involved in lipid metabolism and transport * APOA1 (apolipoprotein A-I): involved in lipid metabolism and transport These genes are involved in various cellular processes, including metabolism, signaling, and transport, and play a crucial role in liver function. **Pathways and Ontologies** Hepatoblasts are involved in various cellular processes, including metabolism, signaling, and transport. Some of the key pathways and ontologies involved in hepatoblast function include: * Antioxidant activity: involved in protecting cells from oxidative stress * Aspirin adme: involved in the metabolism and clearance of aspirin * Bile acid and bile salt metabolism: involved in the metabolism and transport of bile acids and bile salts * Binding and uptake of ligands by scavenger receptors: involved in the uptake of lipids and other molecules by cells * Cellular responses to stimuli: involved in responding to changes in the cellular environment * Cellular responses to stress: involved in responding to cellular stress * Cellular response to calcium ion starvation: involved in responding to changes in calcium ion levels * Cellular response to chemical stress: involved in responding to changes in the cellular environment These pathways and ontologies are involved in various cellular processes, including metabolism, signaling, and transport, and play a crucial role in liver function.