Details for: CL0007010

Cell ID: CL0007010

Cell Name: preosteoblast

Marker Score Threshold: 283
(Derived using integrated single-cell and genomic data)

Description: Skeletogenic cell that has the potential to transform into an osteoblast, and develops from neural crest or mesodermal cells.

Synonyms: osteoprogenitor cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.69
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.48
    Ensembl ID: ENSG00000124172
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.44
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.35
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.29
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.29
    Ensembl ID: ENSG00000182718
  • Gene Symbol: BGN (ENSG00000182492)
    Fold Change: 2.28
    Ensembl ID: ENSG00000182492
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.22
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 2.15
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.13
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.12
    Ensembl ID: ENSG00000164111
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 2.1
    Ensembl ID: ENSG00000175899
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.09
    Ensembl ID: ENSG00000169100
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 2.01
    Ensembl ID: ENSG00000149131
  • Gene Symbol: ALPL (ENSG00000162551)
    Fold Change: 1.98
    Ensembl ID: ENSG00000162551
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.93
    Ensembl ID: ENSG00000177556
  • Gene Symbol: AEBP1 (ENSG00000106624)
    Fold Change: 1.92
    Ensembl ID: ENSG00000106624
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.87
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.86
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ANGPT1 (ENSG00000154188)
    Fold Change: 1.85
    Ensembl ID: ENSG00000154188
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.85
    Ensembl ID: ENSG00000100300
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.81
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.8
    Ensembl ID: ENSG00000072110
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.8
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.79
    Ensembl ID: ENSG00000198363
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.78
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.78
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.78
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.77
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.75
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.75
    Ensembl ID: ENSG00000154723
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.73
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.73
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.71
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.67
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.65
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.63
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.63
    Ensembl ID: ENSG00000156110
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.63
    Ensembl ID: ENSG00000133639
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.59
    Ensembl ID: ENSG00000004455
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 1.57
    Ensembl ID: ENSG00000130203
  • Gene Symbol: BMP1 (ENSG00000168487)
    Fold Change: 1.56
    Ensembl ID: ENSG00000168487
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.56
    Ensembl ID: ENSG00000176171
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.56
    Ensembl ID: ENSG00000120805
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.52
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.51
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.51
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.51
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.51
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.51
    Ensembl ID: ENSG00000070961
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.51
    Ensembl ID: ENSG00000115307
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.5
    Ensembl ID: ENSG00000100823
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.47
    Ensembl ID: ENSG00000115963
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.45
    Ensembl ID: ENSG00000198931
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.43
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.42
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.42
    Ensembl ID: ENSG00000165629
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.41
    Ensembl ID: ENSG00000108561
  • Gene Symbol: AK1 (ENSG00000106992)
    Fold Change: 1.38
    Ensembl ID: ENSG00000106992
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.37
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.37
    Ensembl ID: ENSG00000130402
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.36
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.35
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.35
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.34
    Ensembl ID: ENSG00000163399
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.33
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.32
    Ensembl ID: ENSG00000128272
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.32
    Ensembl ID: ENSG00000087088
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.3
    Ensembl ID: ENSG00000101444
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.3
    Ensembl ID: ENSG00000110330
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.29
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.29
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.28
    Ensembl ID: ENSG00000071553
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.2
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.2
    Ensembl ID: ENSG00000122359
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.17
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.16
    Ensembl ID: ENSG00000100412
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.16
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.15
    Ensembl ID: ENSG00000164904
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.15
    Ensembl ID: ENSG00000002330
  • Gene Symbol: ARCN1 (ENSG00000095139)
    Fold Change: 1.15
    Ensembl ID: ENSG00000095139
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.13
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.13
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.12
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.12
    Ensembl ID: ENSG00000134287
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.12
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.11
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.1
    Ensembl ID: ENSG00000117410
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.08
    Ensembl ID: ENSG00000006125
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.07
    Ensembl ID: ENSG00000198356
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.07
    Ensembl ID: ENSG00000140836
  • Gene Symbol: BCAT1 (ENSG00000060982)
    Fold Change: 1.06
    Ensembl ID: ENSG00000060982
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.06
    Ensembl ID: ENSG00000060971
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.04
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.04
    Ensembl ID: ENSG00000117054
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.02
    Ensembl ID: ENSG00000104765
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.01
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ADSL (ENSG00000239900)
    Fold Change: 1.01
    Ensembl ID: ENSG00000239900
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1
    Ensembl ID: ENSG00000241837
  • Gene Symbol: BMP5 (ENSG00000112175)
    Fold Change: N/A
    Ensembl ID: ENSG00000112175
Hovered Details

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Hovered Details

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**Key Characteristics** Preosteoblasts are characterized by the following key features: 1. **Skeletogenic potential**: Preosteoblasts have the ability to differentiate into mature osteoblasts, which are responsible for bone formation. 2. **Cellular origin**: Preosteoblasts are derived from neural crest or mesodermal cells. 3. **Actin cytoskeleton**: Preosteoblasts have a dynamic actin cytoskeleton that plays a crucial role in their differentiation and function. 4. **Adherens junctions**: Preosteoblasts form adherens junctions, which are critical for cell-cell interactions and tissue organization. 5. **Gene expression**: Preosteoblasts express a range of genes involved in osteoblast differentiation, including ACTB, which encodes for the beta subunit of the actin cytoskeleton. **Clinical Significance** Preosteoblasts have significant clinical implications in the following areas: 1. **Bone disease**: Preosteoblasts play a crucial role in bone development and remodeling, making them a target for the study of bone-related diseases, such as osteoporosis and bone cancer. 2. **Regenerative medicine**: Preosteoblasts have the potential to be used as a cell source for bone tissue engineering and regenerative medicine. 3. **Disease modeling**: Preosteoblasts can be used to model osteoblast-related diseases, such as osteopenia and bone cancer, in vitro. 4. **Therapeutic applications**: Preosteoblasts may be used as a therapeutic tool for the treatment of bone-related disorders, such as osteoporosis and bone fractures. In conclusion, preosteoblasts are an important cell type that plays a critical role in bone development and remodeling. Their study has significant clinical implications in the fields of bone disease, regenerative medicine, and therapeutic applications.