Details for: CL0008002

Cell ID: CL0008002

Cell Name: skeletal muscle fiber

Marker Score Threshold: 2504
(Derived using integrated single-cell and genomic data)

Description: A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: DMD (ENSG00000198947)
    Fold Change: 7.54
    Ensembl ID: ENSG00000198947
  • Gene Symbol: EYA4 (ENSG00000112319)
    Fold Change: 6.56
    Ensembl ID: ENSG00000112319
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 6.56
    Ensembl ID: ENSG00000076555
  • Gene Symbol: BCL6 (ENSG00000113916)
    Fold Change: 6.2
    Ensembl ID: ENSG00000113916
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 5.52
    Ensembl ID: ENSG00000156273
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 5.51
    Ensembl ID: ENSG00000153956
  • Gene Symbol: CUX1 (ENSG00000257923)
    Fold Change: 5.26
    Ensembl ID: ENSG00000257923
  • Gene Symbol: DIAPH2 (ENSG00000147202)
    Fold Change: 5.16
    Ensembl ID: ENSG00000147202
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 4.96
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 4.5
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 4.42
    Ensembl ID: ENSG00000170634
  • Gene Symbol: DLG2 (ENSG00000150672)
    Fold Change: 4.14
    Ensembl ID: ENSG00000150672
  • Gene Symbol: DLG1 (ENSG00000075711)
    Fold Change: 3.94
    Ensembl ID: ENSG00000075711
  • Gene Symbol: ALK (ENSG00000171094)
    Fold Change: 3.79
    Ensembl ID: ENSG00000171094
  • Gene Symbol: ACSL1 (ENSG00000151726)
    Fold Change: 3.79
    Ensembl ID: ENSG00000151726
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 3.37
    Ensembl ID: ENSG00000145349
  • Gene Symbol: ATP1A2 (ENSG00000018625)
    Fold Change: 3.35
    Ensembl ID: ENSG00000018625
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 3.33
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 3.09
    Ensembl ID: ENSG00000278540
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 3.04
    Ensembl ID: ENSG00000162104
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 2.93
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ELF2 (ENSG00000109381)
    Fold Change: 2.91
    Ensembl ID: ENSG00000109381
  • Gene Symbol: ACTN2 (ENSG00000077522)
    Fold Change: 2.9
    Ensembl ID: ENSG00000077522
  • Gene Symbol: CTBP2 (ENSG00000175029)
    Fold Change: 2.86
    Ensembl ID: ENSG00000175029
  • Gene Symbol: CDH13 (ENSG00000140945)
    Fold Change: 2.77
    Ensembl ID: ENSG00000140945
  • Gene Symbol: DTNA (ENSG00000134769)
    Fold Change: 2.7
    Ensembl ID: ENSG00000134769
  • Gene Symbol: ART3 (ENSG00000156219)
    Fold Change: 2.63
    Ensembl ID: ENSG00000156219
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 2.63
    Ensembl ID: ENSG00000147872
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 2.58
    Ensembl ID: ENSG00000053254
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: 2.58
    Ensembl ID: ENSG00000078295
  • Gene Symbol: ESR2 (ENSG00000140009)
    Fold Change: 2.57
    Ensembl ID: ENSG00000140009
  • Gene Symbol: DIAPH1 (ENSG00000131504)
    Fold Change: 2.53
    Ensembl ID: ENSG00000131504
  • Gene Symbol: CKMT2 (ENSG00000131730)
    Fold Change: 2.44
    Ensembl ID: ENSG00000131730
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 2.4
    Ensembl ID: ENSG00000113712
  • Gene Symbol: EPS15 (ENSG00000085832)
    Fold Change: 2.39
    Ensembl ID: ENSG00000085832
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.37
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 2.3
    Ensembl ID: ENSG00000198363
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 2.23
    Ensembl ID: ENSG00000173575
  • Gene Symbol: DGKG (ENSG00000058866)
    Fold Change: 2.19
    Ensembl ID: ENSG00000058866
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.01
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ERBB4 (ENSG00000178568)
    Fold Change: 1.94
    Ensembl ID: ENSG00000178568
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.94
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.92
    Ensembl ID: ENSG00000143153
  • Gene Symbol: EGF (ENSG00000138798)
    Fold Change: 1.92
    Ensembl ID: ENSG00000138798
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.9
    Ensembl ID: ENSG00000157764
  • Gene Symbol: CDR2 (ENSG00000140743)
    Fold Change: 1.87
    Ensembl ID: ENSG00000140743
  • Gene Symbol: DYRK1A (ENSG00000157540)
    Fold Change: 1.77
    Ensembl ID: ENSG00000157540
  • Gene Symbol: CD70 (ENSG00000125726)
    Fold Change: 1.74
    Ensembl ID: ENSG00000125726
  • Gene Symbol: CD36 (ENSG00000135218)
    Fold Change: 1.73
    Ensembl ID: ENSG00000135218
  • Gene Symbol: COCH (ENSG00000100473)
    Fold Change: 1.72
    Ensembl ID: ENSG00000100473
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.72
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 1.7
    Ensembl ID: ENSG00000145362
  • Gene Symbol: DPYD (ENSG00000188641)
    Fold Change: 1.66
    Ensembl ID: ENSG00000188641
  • Gene Symbol: COL4A3 (ENSG00000169031)
    Fold Change: 1.63
    Ensembl ID: ENSG00000169031
  • Gene Symbol: CRK (ENSG00000167193)
    Fold Change: 1.61
    Ensembl ID: ENSG00000167193
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 1.6
    Ensembl ID: ENSG00000168675
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.6
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ANGPT2 (ENSG00000091879)
    Fold Change: 1.57
    Ensembl ID: ENSG00000091879
  • Gene Symbol: DOCK3 (ENSG00000088538)
    Fold Change: 1.55
    Ensembl ID: ENSG00000088538
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.54
    Ensembl ID: ENSG00000204217
  • Gene Symbol: CTNNA1 (ENSG00000044115)
    Fold Change: 1.51
    Ensembl ID: ENSG00000044115
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.5
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.47
    Ensembl ID: ENSG00000033627
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.45
    Ensembl ID: ENSG00000136717
  • Gene Symbol: CREBBP (ENSG00000005339)
    Fold Change: 1.44
    Ensembl ID: ENSG00000005339
  • Gene Symbol: CHRNA1 (ENSG00000138435)
    Fold Change: 1.44
    Ensembl ID: ENSG00000138435
  • Gene Symbol: EPB41 (ENSG00000159023)
    Fold Change: 1.44
    Ensembl ID: ENSG00000159023
  • Gene Symbol: ANK1 (ENSG00000029534)
    Fold Change: 1.42
    Ensembl ID: ENSG00000029534
  • Gene Symbol: CTTN (ENSG00000085733)
    Fold Change: 1.42
    Ensembl ID: ENSG00000085733
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.38
    Ensembl ID: ENSG00000072778
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 1.38
    Ensembl ID: ENSG00000107779
  • Gene Symbol: DAB1 (ENSG00000173406)
    Fold Change: 1.37
    Ensembl ID: ENSG00000173406
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 1.35
    Ensembl ID: ENSG00000047648
  • Gene Symbol: ARG2 (ENSG00000081181)
    Fold Change: 1.34
    Ensembl ID: ENSG00000081181
  • Gene Symbol: RUNX1 (ENSG00000159216)
    Fold Change: 1.34
    Ensembl ID: ENSG00000159216
  • Gene Symbol: ETFA (ENSG00000140374)
    Fold Change: 1.33
    Ensembl ID: ENSG00000140374
  • Gene Symbol: AMPD3 (ENSG00000133805)
    Fold Change: 1.33
    Ensembl ID: ENSG00000133805
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.33
    Ensembl ID: ENSG00000067082
  • Gene Symbol: BMAL1 (ENSG00000133794)
    Fold Change: 1.31
    Ensembl ID: ENSG00000133794
  • Gene Symbol: ELAVL1 (ENSG00000066044)
    Fold Change: 1.31
    Ensembl ID: ENSG00000066044
  • Gene Symbol: AGL (ENSG00000162688)
    Fold Change: 1.3
    Ensembl ID: ENSG00000162688
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.3
    Ensembl ID: ENSG00000116489
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 1.29
    Ensembl ID: ENSG00000198589
  • Gene Symbol: ESRRG (ENSG00000196482)
    Fold Change: 1.28
    Ensembl ID: ENSG00000196482
  • Gene Symbol: DAG1 (ENSG00000173402)
    Fold Change: 1.26
    Ensembl ID: ENSG00000173402
  • Gene Symbol: COL4A4 (ENSG00000081052)
    Fold Change: 1.22
    Ensembl ID: ENSG00000081052
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.22
    Ensembl ID: ENSG00000075239
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 1.2
    Ensembl ID: ENSG00000148090
  • Gene Symbol: DIO2 (ENSG00000211448)
    Fold Change: 1.13
    Ensembl ID: ENSG00000211448
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.13
    Ensembl ID: ENSG00000100412
  • Gene Symbol: RCC1 (ENSG00000180198)
    Fold Change: 1.1
    Ensembl ID: ENSG00000180198
  • Gene Symbol: DPP6 (ENSG00000130226)
    Fold Change: 1.1
    Ensembl ID: ENSG00000130226
  • Gene Symbol: CLCN5 (ENSG00000171365)
    Fold Change: 1.09
    Ensembl ID: ENSG00000171365
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.09
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ELF1 (ENSG00000120690)
    Fold Change: 1.06
    Ensembl ID: ENSG00000120690
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.06
    Ensembl ID: ENSG00000182718
  • Gene Symbol: DNASE1 (ENSG00000213918)
    Fold Change: 1.05
    Ensembl ID: ENSG00000213918
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.04
    Ensembl ID: ENSG00000138279
  • Gene Symbol: DMXL1 (ENSG00000172869)
    Fold Change: 1.02
    Ensembl ID: ENSG00000172869
  • Gene Symbol: CBFB (ENSG00000067955)
    Fold Change: 1.01
    Ensembl ID: ENSG00000067955
Hovered Details

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Hovered Details

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**Key Characteristics** The skeletal muscle fiber is characterized by the following key features: 1. **Transversely striated structure**: The skeletal muscle fiber has a transversely striated structure, which is a characteristic feature of skeletal muscle cells. 2. **Syncytial cell**: The skeletal muscle fiber is a syncytial cell, meaning that it is composed of multiple nuclei and is connected by gap junctions. 3. **Myoblast differentiation**: The skeletal muscle fiber is formed when proliferating myoblasts exit the cell cycle, differentiate, and fuse. 4. **Dystrophin association**: The skeletal muscle fiber is associated with dystrophin, a protein that plays a crucial role in muscle function and contraction. 5. **Actin cytoskeleton organization**: The skeletal muscle fiber has a complex actin cytoskeleton organization, which is essential for muscle contraction and relaxation. **Clinical Significance** The skeletal muscle fiber has significant clinical implications, particularly in the context of muscle disorders and diseases. Some of the key clinical significance of the skeletal muscle fiber includes: 1. **Muscle dystrophy**: The skeletal muscle fiber is associated with muscle dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. 2. **Muscle atrophy**: The skeletal muscle fiber is also associated with muscle atrophy, a condition characterized by the loss of muscle mass and strength. 3. **Muscle cramps and spasms**: The skeletal muscle fiber can contribute to muscle cramps and spasms, which are common symptoms of muscle disorders. 4. **Muscle weakness and fatigue**: The skeletal muscle fiber can also contribute to muscle weakness and fatigue, which are common symptoms of muscle disorders. In conclusion, the skeletal muscle fiber is a complex and fascinating cell type that plays a crucial role in muscle function and contraction. Understanding the characteristics and clinical significance of the skeletal muscle fiber is essential for the diagnosis and treatment of muscle disorders and diseases.