Details for: CL0008011

Cell ID: CL0008011

Cell Name: skeletal muscle satellite stem cell

Marker Score Threshold: 1068
(Derived using integrated single-cell and genomic data)

Description: A skeletal muscle satellite cell that divides by stem cell division. A proportion of this population undergoes symmetric stem cell division, producing two skeletal muscle satellite stem cells. The rest undergo asymmetric stem cell division - retaining their identity while budding off a daughter cell that differentiates into an adult skeletal muscle myoblast.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 4.04
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 4.03
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 4.03
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.96
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 3.91
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.76
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 3.75
    Ensembl ID: ENSG00000182718
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 3.73
    Ensembl ID: ENSG00000067560
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 3.64
    Ensembl ID: ENSG00000130203
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 3.44
    Ensembl ID: ENSG00000135046
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 3.31
    Ensembl ID: ENSG00000130208
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.28
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 3.17
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 3.17
    Ensembl ID: ENSG00000152518
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 3.16
    Ensembl ID: ENSG00000143878
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 3.16
    Ensembl ID: ENSG00000151914
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 3.16
    Ensembl ID: ENSG00000123505
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 3.07
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 3.05
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.99
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 2.96
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.89
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 2.89
    Ensembl ID: ENSG00000128272
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.86
    Ensembl ID: ENSG00000198931
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.84
    Ensembl ID: ENSG00000005022
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.82
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.81
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.8
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.77
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 2.7
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.62
    Ensembl ID: ENSG00000241837
  • Gene Symbol: JAG1 (ENSG00000101384)
    Fold Change: 2.58
    Ensembl ID: ENSG00000101384
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 2.55
    Ensembl ID: ENSG00000115963
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 2.51
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.41
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.4
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 2.4
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 2.34
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.23
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 2.11
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 2.11
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 2.05
    Ensembl ID: ENSG00000168374
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 2.04
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.97
    Ensembl ID: ENSG00000069849
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.95
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.94
    Ensembl ID: ENSG00000141522
  • Gene Symbol: BCL6 (ENSG00000113916)
    Fold Change: 1.93
    Ensembl ID: ENSG00000113916
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.92
    Ensembl ID: ENSG00000090013
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.9
    Ensembl ID: ENSG00000156273
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.9
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.86
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.84
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.82
    Ensembl ID: ENSG00000117410
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.76
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.76
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.75
    Ensembl ID: ENSG00000174437
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.73
    Ensembl ID: ENSG00000176171
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.69
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.55
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.53
    Ensembl ID: ENSG00000165527
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.51
    Ensembl ID: ENSG00000157764
  • Gene Symbol: ARCN1 (ENSG00000095139)
    Fold Change: 1.48
    Ensembl ID: ENSG00000095139
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.47
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 1.47
    Ensembl ID: ENSG00000047648
  • Gene Symbol: BCL3 (ENSG00000069399)
    Fold Change: 1.45
    Ensembl ID: ENSG00000069399
  • Gene Symbol: ATP1A2 (ENSG00000018625)
    Fold Change: 1.42
    Ensembl ID: ENSG00000018625
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.41
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.39
    Ensembl ID: ENSG00000033627
  • Gene Symbol: BMP2 (ENSG00000125845)
    Fold Change: 1.38
    Ensembl ID: ENSG00000125845
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.38
    Ensembl ID: ENSG00000110330
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.35
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.35
    Ensembl ID: ENSG00000204574
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.34
    Ensembl ID: ENSG00000140299
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 1.33
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ATP6V1B2 (ENSG00000147416)
    Fold Change: 1.32
    Ensembl ID: ENSG00000147416
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.3
    Ensembl ID: ENSG00000104765
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.28
    Ensembl ID: ENSG00000143799
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.28
    Ensembl ID: ENSG00000147872
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.27
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.24
    Ensembl ID: ENSG00000197894
  • Gene Symbol: AXL (ENSG00000167601)
    Fold Change: 1.22
    Ensembl ID: ENSG00000167601
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.22
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.21
    Ensembl ID: ENSG00000087274
  • Gene Symbol: AR (ENSG00000169083)
    Fold Change: 1.21
    Ensembl ID: ENSG00000169083
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.2
    Ensembl ID: ENSG00000101966
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.17
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.16
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.13
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.13
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.12
    Ensembl ID: ENSG00000138175
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 1.11
    Ensembl ID: ENSG00000171791
  • Gene Symbol: ASS1 (ENSG00000130707)
    Fold Change: 1.1
    Ensembl ID: ENSG00000130707
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.08
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.08
    Ensembl ID: ENSG00000104763
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.07
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.03
    Ensembl ID: ENSG00000097007
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.01
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.01
    Ensembl ID: ENSG00000058668
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ANK1 (ENSG00000029534)
    Fold Change: 1
    Ensembl ID: ENSG00000029534
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Symmetric and Asymmetric Stem Cell Division**: SMSSCs can undergo symmetric stem cell division, producing two SMSSCs, and asymmetric stem cell division, producing a daughter cell that differentiates into an adult skeletal muscle myoblast. 2. **ACTB Gene Expression**: The ACTB gene is associated with SMSSCs and is involved in various cellular processes such as actin cytoskeleton organization, cell-cell junction formation, and protein localization. 3. **Adaptive Immune System**: SMSSCs are involved in the adaptive immune system and have been implicated in various diseases, including amyloidosis and infectious diseases. 4. **Cell-Cell Junction Formation**: SMSSCs are involved in the formation of cell-cell junctions, which are essential for maintaining tissue structure and function. 5. **Actin Cytoskeleton Organization**: SMSSCs are involved in the organization of the actin cytoskeleton, which is essential for cell movement, division, and differentiation. **Clinical Significance** 1. **Muscle Regeneration**: SMSSCs play a crucial role in the regeneration of skeletal muscle tissue, and their dysfunction can lead to muscle wasting and weakness. 2. **Muscular Dystrophy**: SMSSCs have been implicated in the pathogenesis of muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. 3. **Amyloidosis**: SMSSCs have been implicated in the pathogenesis of amyloidosis, a group of diseases characterized by the deposition of abnormal proteins in tissues. 4. **Infectious Diseases**: SMSSCs have been implicated in the pathogenesis of infectious diseases, including HIV and Mycobacterium tuberculosis infections. 5. **Cancer**: SMSSCs have been implicated in the pathogenesis of certain types of cancer, including muscle cancer and lymphoma. In conclusion, skeletal muscle satellite stem cells are a type of stem cell that plays a crucial role in the maintenance and regeneration of skeletal muscle tissue. Their dysfunction can lead to various diseases, including muscular dystrophy, amyloidosis, and infectious diseases. Further research is needed to understand the role of SMSSCs in human health and disease.