Details for: CL0008015

Cell ID: CL0008015

Cell Name: inhibitory motor neuron

Marker Score Threshold: 472
(Derived using integrated single-cell and genomic data)

Description: A motor neuron that is capable of directly inhibiting muscle contraction.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.18
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.03
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.9
    Ensembl ID: ENSG00000143933
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.86
    Ensembl ID: ENSG00000145741
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.84
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.81
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.71
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.69
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.51
    Ensembl ID: ENSG00000110955
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.5
    Ensembl ID: ENSG00000133639
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.42
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.37
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.36
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.29
    Ensembl ID: ENSG00000154518
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.27
    Ensembl ID: ENSG00000172270
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.24
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.21
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 2.2
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.2
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.17
    Ensembl ID: ENSG00000179218
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.17
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 2.16
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.16
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.16
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.14
    Ensembl ID: ENSG00000070831
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.04
    Ensembl ID: ENSG00000005022
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.02
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.02
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.96
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.95
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 1.94
    Ensembl ID: ENSG00000010278
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.93
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.91
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ASCL1 (ENSG00000139352)
    Fold Change: 1.87
    Ensembl ID: ENSG00000139352
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.87
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.86
    Ensembl ID: ENSG00000168374
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.82
    Ensembl ID: ENSG00000151914
  • Gene Symbol: PHOX2A (ENSG00000165462)
    Fold Change: 1.78
    Ensembl ID: ENSG00000165462
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.77
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CDH2 (ENSG00000170558)
    Fold Change: 1.76
    Ensembl ID: ENSG00000170558
  • Gene Symbol: APLP1 (ENSG00000105290)
    Fold Change: 1.73
    Ensembl ID: ENSG00000105290
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.68
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.66
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.65
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.64
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.63
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 1.63
    Ensembl ID: ENSG00000145362
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.62
    Ensembl ID: ENSG00000128272
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.59
    Ensembl ID: ENSG00000108561
  • Gene Symbol: SCARB2 (ENSG00000138760)
    Fold Change: 1.56
    Ensembl ID: ENSG00000138760
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.55
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.55
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ASS1 (ENSG00000130707)
    Fold Change: 1.53
    Ensembl ID: ENSG00000130707
  • Gene Symbol: KIF1A (ENSG00000130294)
    Fold Change: 1.53
    Ensembl ID: ENSG00000130294
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.53
    Ensembl ID: ENSG00000143727
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.52
    Ensembl ID: ENSG00000198898
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.52
    Ensembl ID: ENSG00000183255
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.51
    Ensembl ID: ENSG00000104765
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.5
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.49
    Ensembl ID: ENSG00000197894
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.49
    Ensembl ID: ENSG00000176171
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.48
    Ensembl ID: ENSG00000143799
  • Gene Symbol: CD151 (ENSG00000177697)
    Fold Change: 1.47
    Ensembl ID: ENSG00000177697
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.46
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.4
    Ensembl ID: ENSG00000148700
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.4
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.39
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.38
    Ensembl ID: ENSG00000164111
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.38
    Ensembl ID: ENSG00000136717
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.36
    Ensembl ID: ENSG00000122786
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.3
    Ensembl ID: ENSG00000107262
  • Gene Symbol: CDK4 (ENSG00000135446)
    Fold Change: 1.29
    Ensembl ID: ENSG00000135446
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.29
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.27
    Ensembl ID: ENSG00000149925
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.25
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.22
    Ensembl ID: ENSG00000069849
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.18
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.18
    Ensembl ID: ENSG00000071553
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.18
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.18
    Ensembl ID: ENSG00000019582
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.16
    Ensembl ID: ENSG00000002330
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.15
    Ensembl ID: ENSG00000087088
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.15
    Ensembl ID: ENSG00000196776
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.14
    Ensembl ID: ENSG00000142599
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.13
    Ensembl ID: ENSG00000151729
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.12
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.11
    Ensembl ID: ENSG00000126247
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.08
    Ensembl ID: ENSG00000085063
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.08
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ASL (ENSG00000126522)
    Fold Change: 1.07
    Ensembl ID: ENSG00000126522
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.05
    Ensembl ID: ENSG00000131100
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.05
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.05
    Ensembl ID: ENSG00000197043
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.04
    Ensembl ID: ENSG00000134982
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.03
    Ensembl ID: ENSG00000185883
  • Gene Symbol: CDC5L (ENSG00000096401)
    Fold Change: 1.03
    Ensembl ID: ENSG00000096401
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.02
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.02
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1
    Ensembl ID: ENSG00000134287
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Inhibitory motor neuron**: This cell is a type of motor neuron that directly inhibits muscle contraction. 2. **Actin cytoskeleton organization**: The cell's gene expression profile includes genes involved in actin cytoskeleton organization, including ACTB and ACTG1. 3. **Adherens junction assembly**: The cell's gene expression profile also includes genes involved in adherens junction assembly, including ENSG00000075624. 4. **Apical junction complex formation**: The cell's gene expression profile includes genes involved in apical junction complex formation, including ENSG00000075624. 5. **Cell-cell communication**: The cell is involved in cell-cell communication, including signaling by growth factor receptors and second messengers. 6. **Cell motility**: The cell is involved in cell motility, including regulation of actin dynamics for phagocytic cup formation. 7. **Regulation of actin dynamics**: The cell's gene expression profile includes genes involved in regulation of actin dynamics, including Rho GTPase cycle and MAPK signaling cascades. 8. **Gene expression regulation**: The cell's gene expression profile is influenced by various signaling pathways, including the RSC-type complex and MAPK signaling cascades. **Clinical Significance** 1. **Neurological disorders**: Inhibitory motor neurons are involved in various neurological disorders, including Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis (ALS). 2. **Muscle contraction regulation**: The cell's ability to directly inhibit muscle contraction makes it an important regulator of muscle contraction in various physiological and pathological conditions. 3. **Cell-cell communication**: The cell's involvement in cell-cell communication is important for the regulation of various cellular processes, including immune response and tissue repair. 4. **Regulation of actin dynamics**: The cell's regulation of actin dynamics is important for the regulation of various cellular processes, including cell motility and phagocytosis. 5. **Cancer research**: The cell's gene expression profile and signaling pathways may be involved in cancer development and progression, and may be useful for the development of novel cancer therapies. In conclusion, the inhibitory motor neuron is a complex cell that plays a crucial role in various cellular processes, including muscle contraction regulation, cell-cell communication, and regulation of actin dynamics. Its unique gene expression profile and signaling pathways make it an important target for the development of novel therapies for various diseases, including neurological disorders and cancer.