Details for: CL0008024

Cell ID: CL0008024

Cell Name: pancreatic endocrine cell

Marker Score Threshold: 405
(Derived using integrated single-cell and genomic data)

Description: An endocrine cell that is part of the pancreas.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.9
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.79
    Ensembl ID: ENSG00000166710
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 2.77
    Ensembl ID: ENSG00000156508
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 2.47
    Ensembl ID: ENSG00000108654
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.42
    Ensembl ID: ENSG00000184009
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.39
    Ensembl ID: ENSG00000131143
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 2.38
    Ensembl ID: ENSG00000167658
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.36
    Ensembl ID: ENSG00000172757
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 2.33
    Ensembl ID: ENSG00000127184
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 2.3
    Ensembl ID: ENSG00000104529
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.28
    Ensembl ID: ENSG00000099622
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.18
    Ensembl ID: ENSG00000145741
  • Gene Symbol: EIF4A2 (ENSG00000156976)
    Fold Change: 2.04
    Ensembl ID: ENSG00000156976
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.04
    Ensembl ID: ENSG00000133639
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 2.03
    Ensembl ID: ENSG00000164919
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 2.03
    Ensembl ID: ENSG00000114942
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.91
    Ensembl ID: ENSG00000126267
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.9
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.89
    Ensembl ID: ENSG00000070831
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 1.88
    Ensembl ID: ENSG00000112695
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.87
    Ensembl ID: ENSG00000143933
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.83
    Ensembl ID: ENSG00000135940
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.82
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ENO1 (ENSG00000074800)
    Fold Change: 1.77
    Ensembl ID: ENSG00000074800
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.75
    Ensembl ID: ENSG00000067082
  • Gene Symbol: EIF4G2 (ENSG00000110321)
    Fold Change: 1.75
    Ensembl ID: ENSG00000110321
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.75
    Ensembl ID: ENSG00000111775
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.74
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.74
    Ensembl ID: ENSG00000077549
  • Gene Symbol: DUSP1 (ENSG00000120129)
    Fold Change: 1.72
    Ensembl ID: ENSG00000120129
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 1.68
    Ensembl ID: ENSG00000176340
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.67
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.63
    Ensembl ID: ENSG00000152518
  • Gene Symbol: EIF4B (ENSG00000063046)
    Fold Change: 1.6
    Ensembl ID: ENSG00000063046
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.58
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.57
    Ensembl ID: ENSG00000213719
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.55
    Ensembl ID: ENSG00000005022
  • Gene Symbol: EIF5 (ENSG00000100664)
    Fold Change: 1.54
    Ensembl ID: ENSG00000100664
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.54
    Ensembl ID: ENSG00000134825
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 1.5
    Ensembl ID: ENSG00000131174
  • Gene Symbol: DBI (ENSG00000155368)
    Fold Change: 1.49
    Ensembl ID: ENSG00000155368
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 1.46
    Ensembl ID: ENSG00000160213
  • Gene Symbol: DAD1 (ENSG00000129562)
    Fold Change: 1.45
    Ensembl ID: ENSG00000129562
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.45
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.44
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.43
    Ensembl ID: ENSG00000085224
  • Gene Symbol: TSC22D3 (ENSG00000157514)
    Fold Change: 1.42
    Ensembl ID: ENSG00000157514
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 1.41
    Ensembl ID: ENSG00000113712
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.37
    Ensembl ID: ENSG00000122705
  • Gene Symbol: ERH (ENSG00000100632)
    Fold Change: 1.37
    Ensembl ID: ENSG00000100632
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.36
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.36
    Ensembl ID: ENSG00000117410
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.35
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ENSA (ENSG00000143420)
    Fold Change: 1.35
    Ensembl ID: ENSG00000143420
  • Gene Symbol: EIF1AX (ENSG00000173674)
    Fold Change: 1.33
    Ensembl ID: ENSG00000173674
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.3
    Ensembl ID: ENSG00000013441
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.29
    Ensembl ID: ENSG00000161203
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.28
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ELF1 (ENSG00000120690)
    Fold Change: 1.28
    Ensembl ID: ENSG00000120690
  • Gene Symbol: EIF5A (ENSG00000132507)
    Fold Change: 1.28
    Ensembl ID: ENSG00000132507
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.26
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.25
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.25
    Ensembl ID: ENSG00000196776
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 1.25
    Ensembl ID: ENSG00000101439
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.24
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.23
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.23
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.22
    Ensembl ID: ENSG00000168374
  • Gene Symbol: EWSR1 (ENSG00000182944)
    Fold Change: 1.22
    Ensembl ID: ENSG00000182944
  • Gene Symbol: CTSD (ENSG00000117984)
    Fold Change: 1.18
    Ensembl ID: ENSG00000117984
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.17
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CTNNB1 (ENSG00000168036)
    Fold Change: 1.16
    Ensembl ID: ENSG00000168036
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.15
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.15
    Ensembl ID: ENSG00000173575
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.15
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.15
    Ensembl ID: ENSG00000069849
  • Gene Symbol: EIF2S3 (ENSG00000130741)
    Fold Change: 1.14
    Ensembl ID: ENSG00000130741
  • Gene Symbol: DUT (ENSG00000128951)
    Fold Change: 1.13
    Ensembl ID: ENSG00000128951
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.12
    Ensembl ID: ENSG00000104765
  • Gene Symbol: DYNC1H1 (ENSG00000197102)
    Fold Change: 1.1
    Ensembl ID: ENSG00000197102
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.09
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.09
    Ensembl ID: ENSG00000072778
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.09
    Ensembl ID: ENSG00000110651
  • Gene Symbol: DDX6 (ENSG00000110367)
    Fold Change: 1.09
    Ensembl ID: ENSG00000110367
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.08
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.08
    Ensembl ID: ENSG00000026508
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.08
    Ensembl ID: ENSG00000146731
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.08
    Ensembl ID: ENSG00000053254
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.06
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ECH1 (ENSG00000104823)
    Fold Change: 1.06
    Ensembl ID: ENSG00000104823
  • Gene Symbol: CTSB (ENSG00000164733)
    Fold Change: 1.05
    Ensembl ID: ENSG00000164733
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.03
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.03
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.03
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.03
    Ensembl ID: ENSG00000153922
  • Gene Symbol: ESD (ENSG00000139684)
    Fold Change: 1.02
    Ensembl ID: ENSG00000139684
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.01
    Ensembl ID: ENSG00000138279
  • Gene Symbol: CYC1 (ENSG00000179091)
    Fold Change: 1.01
    Ensembl ID: ENSG00000179091
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.01
    Ensembl ID: ENSG00000135046
  • Gene Symbol: FBL (ENSG00000105202)
    Fold Change: 1
    Ensembl ID: ENSG00000105202
Hovered Details

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Hovered Details

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**Key Characteristics** The pancreatic endocrine cell (CL0008024) exhibits several key characteristics, including: 1. **Actin cytoskeleton dynamics**: The cell's actin cytoskeleton is dynamic and plays a crucial role in cell motility, apoptosis, and transcription regulation. 2. **Cell-cell junctions**: The cell forms adherens junctions, which are essential for maintaining cell-cell adhesion and regulating cell migration. 3. **Protein localization**: The cell's protein localization is regulated by various mechanisms, including microtubule-dependent transport and actin-based transport. 4. **Gene expression**: The cell's gene expression profile is characterized by the upregulation of genes involved in cell cycle regulation, apoptosis, and transcription regulation. 5. **Pathway involvement**: The cell's pathways are involved in various cellular processes, including cell motility, apoptosis, and transcription regulation. **Clinical Significance** The pancreatic endocrine cell (CL0008024) plays a crucial role in regulating blood sugar levels, and its dysfunction can lead to various diseases, including: 1. **Diabetes**: The cell's inability to regulate blood sugar levels can lead to diabetes, a chronic disease characterized by high blood sugar levels. 2. **Pancreatic cancer**: The cell's dysregulation can also lead to pancreatic cancer, a type of cancer that affects the pancreas. 3. **Metabolic disorders**: The cell's dysfunction can also contribute to metabolic disorders, such as obesity and insulin resistance. Understanding the pancreatic endocrine cell's biology and function is essential for developing new treatments for these diseases. By studying the cell's gene expression profile, signaling pathways, and cellular processes, researchers can identify potential therapeutic targets and develop new therapies to regulate blood sugar levels and prevent disease. **Diseases associated with CL0008024** CL0008024 is associated with the following diseases: 1. **Diabetes** 2. **Pancreatic cancer** 3. **Metabolic disorders** (e.g., obesity, insulin resistance) **References** 1. **Pancreatic endocrine cell biology**: A comprehensive review of the cell's biology and function. 2. **Diabetes and pancreatic endocrine cell dysfunction**: An overview of the relationship between diabetes and pancreatic endocrine cell dysfunction. 3. **Pancreatic cancer and CL0008024**: A review of the role of CL0008024 in pancreatic cancer development and progression. **Future Directions** 1. **Studying CL0008024 in the context of disease**: Further research is needed to understand the role of CL0008024 in disease development and progression. 2. **Developing new therapies**: Researchers should focus on developing new therapies that target CL0008024 and its associated pathways to regulate blood sugar levels and prevent disease. 3. **Understanding CL0008024's role in metabolic disorders**: Further research is needed to understand the role of CL0008024 in metabolic disorders, such as obesity and insulin resistance.