CL0008036 - extravillous trophoblast details

Details for: CL0008036

Cell ID: CL0008036

Cell Name: extravillous trophoblast

Marker Score Threshold: 892
(Derived using integrated single-cell and genomic data)

Description: A trophoblast cell that is not part of a placental villous.

Synonyms: EVT, extravillous cytotrophloblast

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Gene Symbol: ACTG1 (ENSG00000184009)
Fold Change: 3.69
Ensembl ID: ENSG00000184009
Gene Symbol: ATP5MC2 (ENSG00000135390)
Fold Change: 3.67
Ensembl ID: ENSG00000135390
Gene Symbol: ATP5F1E (ENSG00000124172)
Fold Change: 3.66
Ensembl ID: ENSG00000124172
Gene Symbol: ATP5PF (ENSG00000154723)
Fold Change: 3.65
Ensembl ID: ENSG00000154723
Gene Symbol: ATP5MC3 (ENSG00000154518)
Fold Change: 3.65
Ensembl ID: ENSG00000154518
Gene Symbol: TLE5 (ENSG00000104964)
Fold Change: 3.64
Ensembl ID: ENSG00000104964
Gene Symbol: ATP5F1C (ENSG00000165629)
Fold Change: 3.62
Ensembl ID: ENSG00000165629
Gene Symbol: ATP5PO (ENSG00000241837)
Fold Change: 3.59
Ensembl ID: ENSG00000241837
Gene Symbol: ATP5F1B (ENSG00000110955)
Fold Change: 3.58
Ensembl ID: ENSG00000110955
Gene Symbol: ATP5F1D (ENSG00000099624)
Fold Change: 3.53
Ensembl ID: ENSG00000099624
Gene Symbol: ATP5ME (ENSG00000169020)
Fold Change: 3.53
Ensembl ID: ENSG00000169020
Gene Symbol: ATP5PB (ENSG00000116459)
Fold Change: 3.5
Ensembl ID: ENSG00000116459
Gene Symbol: ATP5F1A (ENSG00000152234)
Fold Change: 3.44
Ensembl ID: ENSG00000152234
Gene Symbol: ATP5MC1 (ENSG00000159199)
Fold Change: 3.34
Ensembl ID: ENSG00000159199
Gene Symbol: ATP6AP1 (ENSG00000071553)
Fold Change: 3.2
Ensembl ID: ENSG00000071553
Gene Symbol: ABCF1 (ENSG00000204574)
Fold Change: 3.16
Ensembl ID: ENSG00000204574
Gene Symbol: ADSS2 (ENSG00000035687)
Fold Change: 2.88
Ensembl ID: ENSG00000035687
Gene Symbol: GET3 (ENSG00000198356)
Fold Change: 2.81
Ensembl ID: ENSG00000198356
Gene Symbol: ACTB (ENSG00000075624)
Fold Change: 2.43
Ensembl ID: ENSG00000075624
Gene Symbol: BIRC5 (ENSG00000089685)
Fold Change: 2.42
Ensembl ID: ENSG00000089685
Gene Symbol: BTF3 (ENSG00000145741)
Fold Change: 2.31
Ensembl ID: ENSG00000145741
Gene Symbol: ATRX (ENSG00000085224)
Fold Change: 2.31
Ensembl ID: ENSG00000085224
Gene Symbol: SLC25A6 (ENSG00000169100)
Fold Change: 2.31
Ensembl ID: ENSG00000169100
Gene Symbol: ACLY (ENSG00000131473)
Fold Change: 2.23
Ensembl ID: ENSG00000131473
Gene Symbol: BTG1 (ENSG00000133639)
Fold Change: 2.19
Ensembl ID: ENSG00000133639
Gene Symbol: ARCN1 (ENSG00000095139)
Fold Change: 2.14
Ensembl ID: ENSG00000095139
Gene Symbol: TMEM50B (ENSG00000142188)
Fold Change: 2.14
Ensembl ID: ENSG00000142188
Gene Symbol: B2M (ENSG00000166710)
Fold Change: 2.09
Ensembl ID: ENSG00000166710
Gene Symbol: RHOA (ENSG00000067560)
Fold Change: 2.04
Ensembl ID: ENSG00000067560
Gene Symbol: TMEM258 (ENSG00000134825)
Fold Change: 1.95
Ensembl ID: ENSG00000134825
Gene Symbol: ARF1 (ENSG00000143761)
Fold Change: 1.94
Ensembl ID: ENSG00000143761
Gene Symbol: SLC25A5 (ENSG00000005022)
Fold Change: 1.88
Ensembl ID: ENSG00000005022
Gene Symbol: GRK3 (ENSG00000100077)
Fold Change: 1.86
Ensembl ID: ENSG00000100077
Gene Symbol: BGN (ENSG00000182492)
Fold Change: 1.76
Ensembl ID: ENSG00000182492
Gene Symbol: ATP6V0B (ENSG00000117410)
Fold Change: 1.75
Ensembl ID: ENSG00000117410
Gene Symbol: APRT (ENSG00000198931)
Fold Change: 1.73
Ensembl ID: ENSG00000198931
Gene Symbol: ALDOA (ENSG00000149925)
Fold Change: 1.73
Ensembl ID: ENSG00000149925
Gene Symbol: BSG (ENSG00000172270)
Fold Change: 1.73
Ensembl ID: ENSG00000172270
Gene Symbol: ANXA2 (ENSG00000182718)
Fold Change: 1.7
Ensembl ID: ENSG00000182718
Gene Symbol: ANXA5 (ENSG00000164111)
Fold Change: 1.64
Ensembl ID: ENSG00000164111
Gene Symbol: ATF4 (ENSG00000128272)
Fold Change: 1.62
Ensembl ID: ENSG00000128272
Gene Symbol: ARF4 (ENSG00000168374)
Fold Change: 1.61
Ensembl ID: ENSG00000168374
Gene Symbol: ANXA11 (ENSG00000122359)
Fold Change: 1.6
Ensembl ID: ENSG00000122359
Gene Symbol: DDR1 (ENSG00000204580)
Fold Change: 1.58
Ensembl ID: ENSG00000204580
Gene Symbol: ZFP36L1 (ENSG00000185650)
Fold Change: 1.58
Ensembl ID: ENSG00000185650
Gene Symbol: APLP2 (ENSG00000084234)
Fold Change: 1.56
Ensembl ID: ENSG00000084234
Gene Symbol: ATP1A1 (ENSG00000163399)
Fold Change: 1.56
Ensembl ID: ENSG00000163399
Gene Symbol: ATOX1 (ENSG00000177556)
Fold Change: 1.54
Ensembl ID: ENSG00000177556
Gene Symbol: ATP1B3 (ENSG00000069849)
Fold Change: 1.52
Ensembl ID: ENSG00000069849
Gene Symbol: ARHGDIA (ENSG00000141522)
Fold Change: 1.51
Ensembl ID: ENSG00000141522
Gene Symbol: ACADVL (ENSG00000072778)
Fold Change: 1.51
Ensembl ID: ENSG00000072778
Gene Symbol: C1QBP (ENSG00000108561)
Fold Change: 1.5
Ensembl ID: ENSG00000108561
Gene Symbol: AARS1 (ENSG00000090861)
Fold Change: 1.5
Ensembl ID: ENSG00000090861
Gene Symbol: TSPO (ENSG00000100300)
Fold Change: 1.49
Ensembl ID: ENSG00000100300
Gene Symbol: BNIP3L (ENSG00000104765)
Fold Change: 1.48
Ensembl ID: ENSG00000104765
Gene Symbol: ARF6 (ENSG00000165527)
Fold Change: 1.48
Ensembl ID: ENSG00000165527
Gene Symbol: BST1 (ENSG00000109743)
Fold Change: 1.46
Ensembl ID: ENSG00000109743
Gene Symbol: ARHGDIB (ENSG00000111348)
Fold Change: 1.44
Ensembl ID: ENSG00000111348
Gene Symbol: ACP1 (ENSG00000143727)
Fold Change: 1.42
Ensembl ID: ENSG00000143727
Gene Symbol: APEX1 (ENSG00000100823)
Fold Change: 1.4
Ensembl ID: ENSG00000100823
Gene Symbol: RHOB (ENSG00000143878)
Fold Change: 1.4
Ensembl ID: ENSG00000143878
Gene Symbol: ABCD1 (ENSG00000101986)
Fold Change: 1.39
Ensembl ID: ENSG00000101986
Gene Symbol: APP (ENSG00000142192)
Fold Change: 1.39
Ensembl ID: ENSG00000142192
Gene Symbol: AUP1 (ENSG00000115307)
Fold Change: 1.39
Ensembl ID: ENSG00000115307
Gene Symbol: ANXA7 (ENSG00000138279)
Fold Change: 1.39
Ensembl ID: ENSG00000138279
Gene Symbol: ARF5 (ENSG00000004059)
Fold Change: 1.37
Ensembl ID: ENSG00000004059
Gene Symbol: ACTN4 (ENSG00000130402)
Fold Change: 1.37
Ensembl ID: ENSG00000130402
Gene Symbol: AMD1 (ENSG00000123505)
Fold Change: 1.36
Ensembl ID: ENSG00000123505
Gene Symbol: ANXA1 (ENSG00000135046)
Fold Change: 1.36
Ensembl ID: ENSG00000135046
Gene Symbol: BAX (ENSG00000087088)
Fold Change: 1.35
Ensembl ID: ENSG00000087088
Gene Symbol: ADH5 (ENSG00000197894)
Fold Change: 1.33
Ensembl ID: ENSG00000197894
Gene Symbol: ASAH1 (ENSG00000104763)
Fold Change: 1.33
Ensembl ID: ENSG00000104763
Gene Symbol: ATP6V1E1 (ENSG00000131100)
Fold Change: 1.27
Ensembl ID: ENSG00000131100
Gene Symbol: PTTG1IP (ENSG00000183255)
Fold Change: 1.25
Ensembl ID: ENSG00000183255
Gene Symbol: RHOG (ENSG00000177105)
Fold Change: 1.22
Ensembl ID: ENSG00000177105
Gene Symbol: ADAR (ENSG00000160710)
Fold Change: 1.22
Ensembl ID: ENSG00000160710
Gene Symbol: ARL4D (ENSG00000175906)
Fold Change: 1.22
Ensembl ID: ENSG00000175906
Gene Symbol: AK2 (ENSG00000004455)
Fold Change: 1.22
Ensembl ID: ENSG00000004455
Gene Symbol: RHOC (ENSG00000155366)
Fold Change: 1.22
Ensembl ID: ENSG00000155366
Gene Symbol: PARP1 (ENSG00000143799)
Fold Change: 1.19
Ensembl ID: ENSG00000143799
Gene Symbol: BNIP2 (ENSG00000140299)
Fold Change: 1.17
Ensembl ID: ENSG00000140299
Gene Symbol: BCAT2 (ENSG00000105552)
Fold Change: 1.17
Ensembl ID: ENSG00000105552
Gene Symbol: VPS51 (ENSG00000149823)
Fold Change: 1.14
Ensembl ID: ENSG00000149823
Gene Symbol: CFAP410 (ENSG00000160226)
Fold Change: 1.14
Ensembl ID: ENSG00000160226
Gene Symbol: BLVRB (ENSG00000090013)
Fold Change: 1.14
Ensembl ID: ENSG00000090013
Gene Symbol: BAG1 (ENSG00000107262)
Fold Change: 1.11
Ensembl ID: ENSG00000107262
Gene Symbol: ALDH2 (ENSG00000111275)
Fold Change: 1.11
Ensembl ID: ENSG00000111275
Gene Symbol: ARL2 (ENSG00000213465)
Fold Change: 1.1
Ensembl ID: ENSG00000213465
Gene Symbol: AAMP (ENSG00000127837)
Fold Change: 1.1
Ensembl ID: ENSG00000127837
Gene Symbol: ADAM10 (ENSG00000137845)
Fold Change: 1.1
Ensembl ID: ENSG00000137845
Gene Symbol: PLIN2 (ENSG00000147872)
Fold Change: 1.08
Ensembl ID: ENSG00000147872
Gene Symbol: ATP2B1 (ENSG00000070961)
Fold Change: 1.08
Ensembl ID: ENSG00000070961
Gene Symbol: AKR1B1 (ENSG00000085662)
Fold Change: 1.08
Ensembl ID: ENSG00000085662
Gene Symbol: ZFP36L2 (ENSG00000152518)
Fold Change: 1.07
Ensembl ID: ENSG00000152518
Gene Symbol: ARL1 (ENSG00000120805)
Fold Change: 1.06
Ensembl ID: ENSG00000120805
Gene Symbol: ADD1 (ENSG00000087274)
Fold Change: 1.05
Ensembl ID: ENSG00000087274
Gene Symbol: ASPH (ENSG00000198363)
Fold Change: 1.04
Ensembl ID: ENSG00000198363
Gene Symbol: ATF3 (ENSG00000162772)
Fold Change: 1.03
Ensembl ID: ENSG00000162772
Gene Symbol: BAD (ENSG00000002330)
Fold Change: 1.01
Ensembl ID: ENSG00000002330
Gene Symbol: BST2 (ENSG00000130303)
Fold Change: 1.01
Ensembl ID: ENSG00000130303

Gene representation (2485)
Gene/Pathway representation (2485)

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**Key Characteristics** * EVTs are a subset of trophoblast cells that are not part of the placental villous structure. * They are characterized by their ability to invade the uterine decidua and form a network of cytotrophoblast cells that surround the spiral arteries. * EVTs are involved in the regulation of angiogenesis, inflammation, and immune responses. * They express a range of cell surface molecules, including integrins, adhesion molecules, and chemokine receptors. * EVTs are capable of differentiating into syncytiotrophoblast cells, which form the placental villous structure. * They play a crucial role in the establishment of the maternal-fetal interface and are involved in the regulation of fetal development. **Clinical Significance** * EVTs are involved in the pathogenesis of various pregnancy-related disorders, including preeclampsia, placental insufficiency, and recurrent pregnancy loss. * Abnormalities in EVT function and differentiation have been implicated in the development of these disorders. * EVTs are also involved in the regulation of immune responses and inflammation during pregnancy, and dysfunction of these cells has been linked to pregnancy-related complications. * Understanding the role of EVTs in normal and pathological pregnancy is important for the development of new therapeutic strategies for pregnancy-related disorders. **Cell ID: CL0008036** * Gene Symbol: ACTG1 * Ensembl ID: ENSG00000184009 * Pathways/Ontology: Actin filament, Adherens junction interactions, Angiogenesis, Apical junction complex, Atp binding, Axon, Axon guidance, Axonogenesis, Basal body patch, Blood microparticle, Calyx of held, Cell-cell communication, Cell-cell junction, Cell-cell junction organization, Cell-extracellular matrix interactions, Cell junction organization, Cell motility, Cellular response to type ii interferon, Clathrin-mediated endocytosis, Cytoplasm, Cytoskeleton, Cytosol, Dense body, Developmental biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Eph-ephrin mediated repulsion of cells, Eph-ephrin signaling, Ephb-mediated forward signaling, Extracellular exosome, Extracellular space, Fcgamma receptor (fcgr) dependent phagocytosis, Fcgr3a-mediated phagocytosis, Filamentous actin, Focal adhesion, Formation of annular gap junctions, Gap junction degradation, Gap junction trafficking, Gap junction trafficking and regulation, Hydrolase activity, Identical protein binding, Immune system, Infectious disease, Innate immune system, Interaction between l1 and ankyrins, L1cam interactions, Leishmania infection, Leishmania phagocytosis, Maintenance of blood-brain barrier, Map2k and mapk activation, Mapk1/mapk3 signaling, Mapk family signaling cascades, Membrane, Membrane trafficking, Morphogenesis of a polarized epithelium, Myofibril, Nervous system development, Nua4 histone acetyltransferase complex, Nucleus, Oncogenic mapk signaling, Paradoxical activation of raf signaling by kinase inactive braf, Parasite infection, Parasitic infection pathways, Phagocytic vesicle, Plasma membrane, Platelet aggregation, Positive regulation of cell migration, Positive regulation of gene expression, Positive regulation of wound healing, Postsynaptic actin cytoskeleton organization, Profilin binding, Protein binding, Protein kinase binding, Protein localization to bicellular tight junction, Raf/map kinase cascade, Recycling pathway of l1, Regulation of actin dynamics for phagocytic cup formation, Regulation of focal adhesion assembly, Regulation of stress fiber assembly, Regulation of synaptic vesicle endocytosis, Regulation of transepithelial transport, Rhobtb2 gtpase cycle, Rhobtb gtpase cycle, Rho gtpase cycle, Rho gtpase effectors, Rho gtpases activate formins, Rho gtpases activate iqgaps, Rho gtpases activate wasps and waves, Sarcomere organization, Schaffer collateral - ca1 synapse, Sensory perception, Sensory processing of sound, Sensory processing of sound by inner hair cells of the cochlea, Sensory processing of sound by outer hair cells of the cochlea, Signaling by braf and raf1 fusions, Signaling by high-kinase activity braf mutants, Signaling by moderate kinase activity braf mutants, Signaling by raf1 mutants, Signaling by ras mutants, Signaling by receptor tyrosine kinases, Signaling by rho gtpases, Signaling by rho gtpases, miro gtpases and rhobtb3, Signaling by vegf, Signaling downstream of ras mutants, Signal transduction, Structural constituent of cytoskeleton, Structural constituent of postsynaptic actin cytoskeleton, Synapse, Tight junction assembly, Translocation of slc2a4 (glut4) to the plasma membrane, Ubiquitin protein ligase binding, Vegfa-vegfr2 pathway, Vesicle-mediated transport

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.