Details for: CL0009002

Cell ID: CL0009002

Cell Name: inflammatory cell

Marker Score Threshold: 430
(Derived using integrated single-cell and genomic data)

Description: Any cell participating in the inflammatory response to a foreign substance, e.g. neutrophil, macrophage.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.58
    Ensembl ID: ENSG00000166710
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 3.53
    Ensembl ID: ENSG00000130203
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.45
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CEBPD (ENSG00000221869)
    Fold Change: 3.42
    Ensembl ID: ENSG00000221869
  • Gene Symbol: COL6A2 (ENSG00000142173)
    Fold Change: 3.33
    Ensembl ID: ENSG00000142173
  • Gene Symbol: C1S (ENSG00000182326)
    Fold Change: 3.17
    Ensembl ID: ENSG00000182326
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 3.14
    Ensembl ID: ENSG00000143933
  • Gene Symbol: COL1A2 (ENSG00000164692)
    Fold Change: 3.12
    Ensembl ID: ENSG00000164692
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 3.09
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 3.08
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 3.07
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 3.06
    Ensembl ID: ENSG00000182718
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 3.06
    Ensembl ID: ENSG00000133639
  • Gene Symbol: APOD (ENSG00000189058)
    Fold Change: 2.97
    Ensembl ID: ENSG00000189058
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.95
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.95
    Ensembl ID: ENSG00000099622
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.94
    Ensembl ID: ENSG00000145741
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 2.87
    Ensembl ID: ENSG00000149131
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.86
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.81
    Ensembl ID: ENSG00000172757
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.79
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CEBPB (ENSG00000172216)
    Fold Change: 2.77
    Ensembl ID: ENSG00000172216
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 2.74
    Ensembl ID: ENSG00000122786
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 2.66
    Ensembl ID: ENSG00000010278
  • Gene Symbol: COL1A1 (ENSG00000108821)
    Fold Change: 2.59
    Ensembl ID: ENSG00000108821
  • Gene Symbol: C1R (ENSG00000159403)
    Fold Change: 2.53
    Ensembl ID: ENSG00000159403
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.45
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 2.41
    Ensembl ID: ENSG00000213719
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.39
    Ensembl ID: ENSG00000135046
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 2.35
    Ensembl ID: ENSG00000115963
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.32
    Ensembl ID: ENSG00000198668
  • Gene Symbol: COL6A1 (ENSG00000142156)
    Fold Change: 2.32
    Ensembl ID: ENSG00000142156
  • Gene Symbol: AXL (ENSG00000167601)
    Fold Change: 2.18
    Ensembl ID: ENSG00000167601
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.18
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.18
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.11
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.09
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.06
    Ensembl ID: ENSG00000070831
  • Gene Symbol: COL6A3 (ENSG00000163359)
    Fold Change: 2.03
    Ensembl ID: ENSG00000163359
  • Gene Symbol: CDKN1A (ENSG00000124762)
    Fold Change: 1.95
    Ensembl ID: ENSG00000124762
  • Gene Symbol: C3 (ENSG00000125730)
    Fold Change: 1.94
    Ensembl ID: ENSG00000125730
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.92
    Ensembl ID: ENSG00000110651
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.91
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.9
    Ensembl ID: ENSG00000085063
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.88
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.82
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CAV1 (ENSG00000105974)
    Fold Change: 1.82
    Ensembl ID: ENSG00000105974
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.81
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CNN3 (ENSG00000117519)
    Fold Change: 1.79
    Ensembl ID: ENSG00000117519
  • Gene Symbol: COL3A1 (ENSG00000168542)
    Fold Change: 1.79
    Ensembl ID: ENSG00000168542
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.67
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.66
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.64
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.64
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.63
    Ensembl ID: ENSG00000169020
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.61
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CLU (ENSG00000120885)
    Fold Change: 1.59
    Ensembl ID: ENSG00000120885
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.55
    Ensembl ID: ENSG00000099624
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.51
    Ensembl ID: ENSG00000023445
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.49
    Ensembl ID: ENSG00000165527
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.49
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.48
    Ensembl ID: ENSG00000241837
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.47
    Ensembl ID: ENSG00000172270
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.46
    Ensembl ID: ENSG00000142192
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.43
    Ensembl ID: ENSG00000155366
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.42
    Ensembl ID: ENSG00000179218
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.4
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.37
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.36
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.36
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CLTB (ENSG00000175416)
    Fold Change: 1.35
    Ensembl ID: ENSG00000175416
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.34
    Ensembl ID: ENSG00000154518
  • Gene Symbol: AP3S1 (ENSG00000177879)
    Fold Change: 1.33
    Ensembl ID: ENSG00000177879
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.31
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.29
    Ensembl ID: ENSG00000013441
  • Gene Symbol: AEBP1 (ENSG00000106624)
    Fold Change: 1.26
    Ensembl ID: ENSG00000106624
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.24
    Ensembl ID: ENSG00000122705
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.23
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.22
    Ensembl ID: ENSG00000148700
  • Gene Symbol: BGN (ENSG00000182492)
    Fold Change: 1.2
    Ensembl ID: ENSG00000182492
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.19
    Ensembl ID: ENSG00000162772
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.18
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.17
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.17
    Ensembl ID: ENSG00000164615
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.16
    Ensembl ID: ENSG00000084234
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.15
    Ensembl ID: ENSG00000161203
  • Gene Symbol: ADH1B (ENSG00000196616)
    Fold Change: 1.14
    Ensembl ID: ENSG00000196616
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.14
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.14
    Ensembl ID: ENSG00000153922
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.11
    Ensembl ID: ENSG00000106546
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.09
    Ensembl ID: ENSG00000127022
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.08
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.07
    Ensembl ID: ENSG00000152234
  • Gene Symbol: RUNX1 (ENSG00000159216)
    Fold Change: 1.07
    Ensembl ID: ENSG00000159216
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.06
    Ensembl ID: ENSG00000119138
  • Gene Symbol: COL15A1 (ENSG00000204291)
    Fold Change: 1.05
    Ensembl ID: ENSG00000204291
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.03
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.01
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.01
    Ensembl ID: ENSG00000069849
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1
    Ensembl ID: ENSG00000128595
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** Inflammatory cells are characterized by several key features, including: 1. **Activation**: Inflammatory cells can be activated by a variety of stimuli, including bacterial infections, toxins, and other foreign particles. 2. **Phagocytosis**: Inflammatory cells are capable of phagocytosing foreign particles and microorganisms, using their membrane-bound receptors to recognize and engulf pathogens. 3. **Antigen presentation**: Inflammatory cells can present antigens to T-cells, activating an immune response against the pathogen. 4. **Cytokine production**: Inflammatory cells produce cytokines, signaling molecules that coordinate the immune response and recruit other immune cells to the site of inflammation. 5. **Cellular responses**: Inflammatory cells can respond to a range of stimuli, including bacterial infections, toxins, and other foreign particles, by producing cytokines and activating immune responses. **Clinical Significance** Inflammatory cells play a critical role in the defense against infection and disease. Abnormalities in inflammatory cell function can lead to a range of clinical conditions, including: 1. **Autoimmune diseases**: Inflammatory cells can contribute to autoimmune diseases, such as rheumatoid arthritis and lupus, by producing cytokines that promote inflammation and tissue damage. 2. **Infectious diseases**: Inflammatory cells are essential for the defense against infection, and abnormalities in their function can lead to increased susceptibility to infection. 3. **Cancer**: Inflammatory cells can contribute to cancer development and progression by promoting inflammation and tissue damage. 4. **Chronic diseases**: Inflammatory cells can contribute to chronic diseases, such as atherosclerosis and Alzheimer's disease, by promoting inflammation and tissue damage. **Genes and Pathways** Inflammatory cells are regulated by a range of genes and pathways, including: 1. **B2M**: The B2M gene encodes a component of the major histocompatibility complex (MHC) class I, which is essential for antigen presentation and immune response. 2. **APOE**: The APOE gene encodes a protein involved in lipid metabolism and transport, and has been implicated in the regulation of inflammatory responses. 3. **Adaptive immune system**: The adaptive immune system is a complex network of cells and pathways that work together to recognize and respond to pathogens. 4. **Amyloid fiber formation**: Amyloid fibers are formed through the aggregation of proteins, and have been implicated in a range of diseases, including Alzheimer's disease and amyloidosis. **Interactions with Other Cells and Pathways** Inflammatory cells interact with a range of other cells and pathways, including: 1. **Lymphoid cells**: Inflammatory cells interact with lymphoid cells, such as T-cells and B-cells, to coordinate the immune response. 2. **Macrophages**: Inflammatory cells interact with macrophages, which are involved in the phagocytosis of foreign particles and pathogens. 3. **Endothelial cells**: Inflammatory cells interact with endothelial cells, which line blood vessels and regulate blood flow and immune responses. 4. **Neurotransmitters**: Inflammatory cells interact with neurotransmitters, such as serotonin and dopamine, to regulate immune responses and behavior. Overall, inflammatory cells play a critical role in the defense against infection and disease, and abnormalities in their function can lead to a range of clinical conditions.