Details for: CL0009006

Cell ID: CL0009006

Cell Name: enteroendocrine cell of small intestine

Marker Score Threshold: 285
(Derived using integrated single-cell and genomic data)

Description: An enteroendocrine cell that is located in the small intestine.

Synonyms: small intestine enteroendocrine cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.96
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.82
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.3
    Ensembl ID: ENSG00000184009
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.2
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 3.2
    Ensembl ID: ENSG00000172757
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.01
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.95
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.79
    Ensembl ID: ENSG00000135390
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.78
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.77
    Ensembl ID: ENSG00000124172
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.58
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.56
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.51
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.41
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.35
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.29
    Ensembl ID: ENSG00000077549
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.26
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.25
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.23
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.13
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.12
    Ensembl ID: ENSG00000152518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.09
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.08
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.08
    Ensembl ID: ENSG00000154518
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.07
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.04
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2
    Ensembl ID: ENSG00000185650
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.98
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.96
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.92
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.91
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.9
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.9
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.84
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.8
    Ensembl ID: ENSG00000165629
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.79
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.78
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.71
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.7
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.69
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.68
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.66
    Ensembl ID: ENSG00000164111
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.65
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.65
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.64
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.64
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.63
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.63
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.62
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.6
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.53
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.52
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.51
    Ensembl ID: ENSG00000122359
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.51
    Ensembl ID: ENSG00000084234
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.48
    Ensembl ID: ENSG00000100300
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.46
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.46
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.45
    Ensembl ID: ENSG00000072778
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.45
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.43
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.43
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.41
    Ensembl ID: ENSG00000026508
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.41
    Ensembl ID: ENSG00000173575
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.4
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.36
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.34
    Ensembl ID: ENSG00000138279
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.32
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.31
    Ensembl ID: ENSG00000110651
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.31
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.3
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.28
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.27
    Ensembl ID: ENSG00000177556
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.26
    Ensembl ID: ENSG00000164615
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.24
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.24
    Ensembl ID: ENSG00000165527
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.24
    Ensembl ID: ENSG00000087088
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.23
    Ensembl ID: ENSG00000134480
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.23
    Ensembl ID: ENSG00000153922
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.22
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.22
    Ensembl ID: ENSG00000004059
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.21
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.2
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.18
    Ensembl ID: ENSG00000126247
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.17
    Ensembl ID: ENSG00000107262
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.17
    Ensembl ID: ENSG00000085063
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.17
    Ensembl ID: ENSG00000143878
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.17
    Ensembl ID: ENSG00000112576
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.16
    Ensembl ID: ENSG00000143799
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.16
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.14
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.1
    Ensembl ID: ENSG00000131100
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.1
    Ensembl ID: ENSG00000162909
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.09
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.09
    Ensembl ID: ENSG00000197894
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.08
    Ensembl ID: ENSG00000149823
  • Gene Symbol: CTSC (ENSG00000109861)
    Fold Change: 1.02
    Ensembl ID: ENSG00000109861
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.02
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.01
    Ensembl ID: ENSG00000137845
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1
    Ensembl ID: ENSG00000004455
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1
    Ensembl ID: ENSG00000155366
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** 1. **Location**: Enteroendocrine cells are located in the small intestine, specifically in the mucosal epithelium. 2. **Morphology**: These cells have a unique morphology, with a distinct apical and basolateral domain, and are characterized by the presence of secretory granules, which are specialized organelles that store and release hormones. 3. **Hormone Secretion**: Enteroendocrine cells are responsible for the secretion of various hormones, including gastrin, secretin, and cholecystokinin, which regulate digestion, nutrient absorption, and other physiological processes. 4. **Apical and Basolateral Domains**: Enteroendocrine cells have distinct apical and basolateral domains, which are specialized regions that interact with the lumen and the underlying connective tissue, respectively. 5. **Signaling Pathways**: These cells are equipped with specialized signaling pathways that enable them to interact with their environment and regulate their functions, including the PI3K/Akt and MAPK/ERK pathways. 6. **Immune Responses**: Enteroendocrine cells are also involved in immune responses, particularly in the context of gastrointestinal infections and inflammation. **Clinical Significance** 1. **Digestive Disorders**: Enteroendocrine cells play a crucial role in the regulation of digestion and nutrient absorption, and dysfunction of these cells can lead to various digestive disorders, including gastrointestinal cancer, diabetes, and metabolic syndrome. 2. **Immune System**: Enteroendocrine cells are involved in immune responses, particularly in the context of gastrointestinal infections and inflammation, and dysfunction of these cells can lead to various immune-related disorders, including autoimmune diseases and immunodeficiency syndromes. 3. **Hormonal Imbalances**: Enteroendocrine cells are responsible for the secretion of various hormones, and dysfunction of these cells can lead to hormonal imbalances, which can cause a range of symptoms, including weight gain, insulin resistance, and reproductive disorders. 4. **Cancer**: Enteroendocrine cells are involved in the development of various cancers, including gastrointestinal cancer, and dysfunction of these cells can lead to the development of cancer. In conclusion, enteroendocrine cells are specialized cells found in the small intestine that play a crucial role in the regulation of various physiological processes, including digestion, nutrient absorption, and hormone secretion. Dysfunction of these cells can lead to various clinical disorders, including digestive disorders, immune-related disorders, hormonal imbalances, and cancer. Further research is needed to understand the mechanisms underlying the functions of enteroendocrine cells and to develop novel therapeutic strategies for the treatment of these disorders.