Details for: CL0009009

Cell ID: CL0009009

Cell Name: paneth cell of colon

Marker Score Threshold: 287
(Derived using integrated single-cell and genomic data)

Description: A paneth cell that is located in the epithelium of the colon.

Synonyms: paneth cell of epithelium of large intestine, paneth cell of epithelium of colon, paneth-like cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.97
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.86
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.73
    Ensembl ID: ENSG00000124172
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.73
    Ensembl ID: ENSG00000166710
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.68
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.53
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.43
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.34
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.34
    Ensembl ID: ENSG00000143933
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.31
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.26
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.18
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.17
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 2.17
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.14
    Ensembl ID: ENSG00000154723
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.08
    Ensembl ID: ENSG00000172270
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.01
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.99
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.97
    Ensembl ID: ENSG00000130402
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.94
    Ensembl ID: ENSG00000100300
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.93
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.87
    Ensembl ID: ENSG00000128272
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.86
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.82
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.78
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.77
    Ensembl ID: ENSG00000110955
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.76
    Ensembl ID: ENSG00000143878
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.76
    Ensembl ID: ENSG00000134825
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.75
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.74
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.72
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.71
    Ensembl ID: ENSG00000077549
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.7
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.68
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 1.66
    Ensembl ID: ENSG00000010278
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.64
    Ensembl ID: ENSG00000241837
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.6
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.6
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.6
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.59
    Ensembl ID: ENSG00000072778
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.57
    Ensembl ID: ENSG00000107262
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.53
    Ensembl ID: ENSG00000104964
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.51
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.5
    Ensembl ID: ENSG00000162772
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.49
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.48
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.45
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.45
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.43
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.42
    Ensembl ID: ENSG00000143153
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.42
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.4
    Ensembl ID: ENSG00000111348
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.39
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.38
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.37
    Ensembl ID: ENSG00000162909
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.36
    Ensembl ID: ENSG00000155366
  • Gene Symbol: AREG (ENSG00000109321)
    Fold Change: 1.32
    Ensembl ID: ENSG00000109321
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.31
    Ensembl ID: ENSG00000090013
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.3
    Ensembl ID: ENSG00000115963
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.3
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.28
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.27
    Ensembl ID: ENSG00000141522
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.26
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.26
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.25
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.25
    Ensembl ID: ENSG00000116489
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.25
    Ensembl ID: ENSG00000151914
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.24
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.22
    Ensembl ID: ENSG00000069849
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.2
    Ensembl ID: ENSG00000130303
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.2
    Ensembl ID: ENSG00000134480
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.17
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.16
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.16
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.15
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.14
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.14
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.14
    Ensembl ID: ENSG00000116459
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.13
    Ensembl ID: ENSG00000002330
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.12
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CA7 (ENSG00000168748)
    Fold Change: 1.12
    Ensembl ID: ENSG00000168748
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.12
    Ensembl ID: ENSG00000177556
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.11
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.11
    Ensembl ID: ENSG00000070961
  • Gene Symbol: CCND1 (ENSG00000110092)
    Fold Change: 1.11
    Ensembl ID: ENSG00000110092
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.11
    Ensembl ID: ENSG00000111275
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.11
    Ensembl ID: ENSG00000149823
  • Gene Symbol: KLF5 (ENSG00000102554)
    Fold Change: 1.1
    Ensembl ID: ENSG00000102554
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.09
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.09
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.08
    Ensembl ID: ENSG00000151150
  • Gene Symbol: CAPG (ENSG00000042493)
    Fold Change: 1.07
    Ensembl ID: ENSG00000042493
  • Gene Symbol: CA4 (ENSG00000167434)
    Fold Change: 1.06
    Ensembl ID: ENSG00000167434
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.06
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.05
    Ensembl ID: ENSG00000204574
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.05
    Ensembl ID: ENSG00000146731
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.03
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CA2 (ENSG00000104267)
    Fold Change: 1.02
    Ensembl ID: ENSG00000104267
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.01
    Ensembl ID: ENSG00000060971
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.01
    Ensembl ID: ENSG00000148700
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Location and Morphology**: Paneth cells are located at the base of the intestinal crypts in the colon and are characterized by their large, polyhedral shape and abundant cytoplasm. 2. **Gene Expression Profile**: Paneth cells express a distinct set of genes, including those involved in antimicrobial peptide production, cell adhesion, and immune response regulation. 3. **Antimicrobial Peptide Production**: Paneth cells produce antimicrobial peptides, such as defensins and cathelicidins, which play a crucial role in defending against pathogens. 4. **Regulation of the Intestinal Epithelial Barrier**: Paneth cells regulate the intestinal epithelial barrier by producing antimicrobial peptides and cytokines that maintain the integrity of the epithelial layer. 5. **Modulation of the Immune Response**: Paneth cells modulate the immune response by producing cytokines and chemokines that regulate the recruitment of immune cells to the intestinal mucosa. **Clinical Significance** 1. **Inflammatory Bowel Disease (IBD)**: Paneth cells play a crucial role in the pathogenesis of IBD, including Crohn's disease and ulcerative colitis. Abnormalities in Paneth cell function and gene expression have been linked to the development of IBD. 2. **Cancer**: Paneth cells have been implicated in the development of colorectal cancer. Abnormalities in Paneth cell gene expression and function have been linked to the development of cancer. 3. **Infectious Diseases**: Paneth cells play a crucial role in defending against pathogens, including bacteria and viruses. Abnormalities in Paneth cell function and gene expression have been linked to the development of infectious diseases. 4. **Immune System Dysfunction**: Paneth cells regulate the immune response, and abnormalities in Paneth cell function and gene expression have been linked to immune system dysfunction. **Functional Roles** 1. **Production of Antimicrobial Peptides**: Paneth cells produce antimicrobial peptides that defend against pathogens and maintain the integrity of the intestinal epithelial barrier. 2. **Regulation of the Intestinal Epithelial Barrier**: Paneth cells regulate the intestinal epithelial barrier by producing antimicrobial peptides and cytokines that maintain the integrity of the epithelial layer. 3. **Modulation of the Immune Response**: Paneth cells modulate the immune response by producing cytokines and chemokines that regulate the recruitment of immune cells to the intestinal mucosa. 4. **Maintenance of Homeostasis**: Paneth cells maintain homeostasis in the intestinal epithelium by regulating the expression of genes involved in cell proliferation, differentiation, and survival. In conclusion, Paneth cells play a crucial role in maintaining intestinal homeostasis and defending against pathogens. Abnormalities in Paneth cell function and gene expression have been linked to various diseases, including IBD, cancer, and infectious diseases. Understanding the functional roles of Paneth cells is essential for developing novel therapeutic strategies for these diseases.