Details for: CL0009010

Cell ID: CL0009010

Cell Name: transit amplifying cell

Marker Score Threshold: 5707
(Derived using integrated single-cell and genomic data)

Description: Transit-amplifying cells (TACs) are an undifferentiated population in transition between stem cells and differentiated cells.

Synonyms: transient amplifying cell, transit amplifying progenitor cell, transit-amplifying cell, TAC, TACs

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: POLR2J3 (ENSG00000285437)
    Fold Change: 2.05
    Ensembl ID: ENSG00000285437
  • Gene Symbol: MALAT1 (ENSG00000251562)
    Fold Change: 1.94
    Ensembl ID: ENSG00000251562
  • Gene Symbol: LOC101929309 (ENSG00000228559)
    Fold Change: 1
    Ensembl ID: ENSG00000228559
  • Gene Symbol: RN7SL34P (ENSG00000239868)
    Fold Change: 1
    Ensembl ID: ENSG00000239868
  • Gene Symbol: RUVBL1 AS1 (ENSG00000239608)
    Fold Change: N/A
    Ensembl ID: ENSG00000239608
  • Gene Symbol: RN7SL835P (ENSG00000264250)
    Fold Change: N/A
    Ensembl ID: ENSG00000264250
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** 1. **Undifferentiated state**: TACs are an intermediate stage between stem cells and differentiated cells, characterized by a lack of specific lineage commitment. 2. **Proliferation and differentiation**: TACs have the ability to proliferate and differentiate into multiple cell types, depending on the specific tissue or organ. 3. **Gene expression profile**: TACs express a unique set of genes, including those involved in transcriptional regulation, DNA binding, and protein-protein interactions. 4. **Regulation of cellular processes**: TACs are involved in various cellular processes, including cell motility, cardiac muscle myoblast proliferation, and response to hypoxia. **Clinical Significance** 1. **Cancer research**: TACs have been implicated in the development and progression of various cancers, including leukemia, lymphoma, and solid tumors. 2. **Regenerative medicine**: TACs have the potential to be used as a source of stem cells for tissue engineering and regenerative medicine applications. 3. **Neurological disorders**: TACs have been associated with neurological disorders, such as Alzheimer's disease and Parkinson's disease, where they may contribute to disease progression. 4. **Tissue development**: TACs play a crucial role in the development and maintenance of various tissues and organs, including the heart, brain, and skeletal muscle. **Genes and Pathways** The following genes and pathways have been associated with the function and regulation of TACs: 1. **POLR2J3**: involved in transcriptional regulation and DNA binding. 2. **MALAT1**: involved in post-transcriptional gene silencing and regulation of cardiac muscle myoblast proliferation. 3. **LOC101929309**: involved in regulation of cell motility and microRNA-mediated post-transcriptional gene silencing. 4. **RN7SL34P**: involved in regulation of cell motility and microRNA-mediated post-transcriptional gene silencing. 5. **RUVBL1 AS1**: involved in regulation of cellular processes, including cell motility and response to hypoxia. 6. **RN7SL835P**: involved in regulation of cellular processes, including cell motility and response to hypoxia. **Pathways and Ontologies** The following pathways and ontologies have been associated with TACs: 1. **DNA binding**: involved in the regulation of gene expression. 2. **Protein binding**: involved in the regulation of protein-protein interactions. 3. **Protein dimerization activity**: involved in the regulation of protein-protein interactions. 4. **RNA polymerase II**: involved in transcriptional regulation. 5. **Core complex**: involved in transcriptional regulation. 6. **Transcription by RNA polymerase II**: involved in the regulation of gene expression. 7. **Cellular response to hypoxia**: involved in the regulation of cellular processes in response to low oxygen levels. 8. **LncRNA-mediated post-transcriptional gene silencing**: involved in the regulation of gene expression through long non-coding RNA-mediated mechanisms. 9. **miRNA inhibitor activity via base-pairing**: involved in the regulation of gene expression through microRNA-mediated mechanisms. 10. **Nucleus**: involved in the regulation of gene expression and cellular processes. In conclusion, Transit Amplifying Cells (TACs) are an undifferentiated cell type that plays a crucial role in the development and maintenance of various tissues and organs. The expression of specific genes and involvement in various pathways and ontologies make TACs an important area of research in the fields of immunology, regenerative medicine, and cancer research.