Details for: CL0009011

Cell ID: CL0009011

Cell Name: transit amplifying cell of colon

Marker Score Threshold: 460
(Derived using integrated single-cell and genomic data)

Description: A rapidly proliferating population of cells that differentiate from stem cells of the intestinal crypt of the colon. Stem cells located in the crypts of Lieberkühn give rise to proliferating progenitor or transit amplifying cells that differentiate into the four major epithelial cell types. These include columnar absorptive cells or enterocytes, mucous secreting goblet cells, enteroendocrine cells and paneth cells.

Synonyms: transit amplifying cell of large intestine, colon transit amplifying cell, transient amplifying cell of colon, transient amplifying cell of crypt of Lieberkuhn of colon, transit amplifying cell of crypt of Lieberkuhn of colon, transit-amplifying cell of colon

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.9
    Ensembl ID: ENSG00000075624
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.74
    Ensembl ID: ENSG00000169100
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.73
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ADH1B (ENSG00000196616)
    Fold Change: 2.7
    Ensembl ID: ENSG00000196616
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.52
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.4
    Ensembl ID: ENSG00000145741
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.35
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.21
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.21
    Ensembl ID: ENSG00000135390
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.14
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.91
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.88
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.84
    Ensembl ID: ENSG00000154723
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.82
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.8
    Ensembl ID: ENSG00000152518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.79
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.76
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.76
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.76
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.73
    Ensembl ID: ENSG00000099624
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.66
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.6
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.58
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.55
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ADH1A (ENSG00000187758)
    Fold Change: 1.46
    Ensembl ID: ENSG00000187758
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.46
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.46
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.42
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.4
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.4
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.39
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.39
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.35
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.31
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.28
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.26
    Ensembl ID: ENSG00000069849
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.25
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.25
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.25
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.22
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.21
    Ensembl ID: ENSG00000159199
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.17
    Ensembl ID: ENSG00000123505
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.15
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.14
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.13
    Ensembl ID: ENSG00000072778
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.13
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.12
    Ensembl ID: ENSG00000070961
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.12
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ALPG (ENSG00000163286)
    Fold Change: 1.11
    Ensembl ID: ENSG00000163286
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.11
    Ensembl ID: ENSG00000100823
  • Gene Symbol: AVPR1B (ENSG00000198049)
    Fold Change: 1.11
    Ensembl ID: ENSG00000198049
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.11
    Ensembl ID: ENSG00000177556
  • Gene Symbol: C4A (ENSG00000244731)
    Fold Change: 1.11
    Ensembl ID: ENSG00000244731
  • Gene Symbol: ACTN3 (ENSG00000248746)
    Fold Change: 1.11
    Ensembl ID: ENSG00000248746
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.11
    Ensembl ID: ENSG00000142192
  • Gene Symbol: C4B (ENSG00000224389)
    Fold Change: 1.11
    Ensembl ID: ENSG00000224389
  • Gene Symbol: CRISP1 (ENSG00000124812)
    Fold Change: 1.1
    Ensembl ID: ENSG00000124812
  • Gene Symbol: ALX3 (ENSG00000156150)
    Fold Change: 1.1
    Ensembl ID: ENSG00000156150
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.1
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ADORA3 (ENSG00000282608)
    Fold Change: 1.1
    Ensembl ID: ENSG00000282608
  • Gene Symbol: ADRB3 (ENSG00000188778)
    Fold Change: 1.1
    Ensembl ID: ENSG00000188778
  • Gene Symbol: SERPINC1 (ENSG00000117601)
    Fold Change: 1.1
    Ensembl ID: ENSG00000117601
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.1
    Ensembl ID: ENSG00000115307
  • Gene Symbol: C8B (ENSG00000021852)
    Fold Change: 1.1
    Ensembl ID: ENSG00000021852
  • Gene Symbol: ALOX12B (ENSG00000179477)
    Fold Change: 1.1
    Ensembl ID: ENSG00000179477
  • Gene Symbol: ALAS2 (ENSG00000158578)
    Fold Change: 1.1
    Ensembl ID: ENSG00000158578
  • Gene Symbol: ASMT (ENSG00000196433)
    Fold Change: 1.1
    Ensembl ID: ENSG00000196433
  • Gene Symbol: ADRA1D (ENSG00000171873)
    Fold Change: 1.09
    Ensembl ID: ENSG00000171873
  • Gene Symbol: ASCL1 (ENSG00000139352)
    Fold Change: 1.09
    Ensembl ID: ENSG00000139352
  • Gene Symbol: SERPINA3 (ENSG00000196136)
    Fold Change: 1.09
    Ensembl ID: ENSG00000196136
  • Gene Symbol: ACADL (ENSG00000115361)
    Fold Change: 1.09
    Ensembl ID: ENSG00000115361
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.09
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ADRA1B (ENSG00000170214)
    Fold Change: 1.09
    Ensembl ID: ENSG00000170214
  • Gene Symbol: ALDH3B2 (ENSG00000132746)
    Fold Change: 1.09
    Ensembl ID: ENSG00000132746
  • Gene Symbol: ALOX15 (ENSG00000161905)
    Fold Change: 1.09
    Ensembl ID: ENSG00000161905
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.09
    Ensembl ID: ENSG00000004059
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 1.09
    Ensembl ID: ENSG00000078053
  • Gene Symbol: ARR3 (ENSG00000120500)
    Fold Change: 1.09
    Ensembl ID: ENSG00000120500
  • Gene Symbol: ATP6V1G2 (ENSG00000213760)
    Fold Change: 1.09
    Ensembl ID: ENSG00000213760
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.09
    Ensembl ID: ENSG00000087088
  • Gene Symbol: BDNF (ENSG00000176697)
    Fold Change: 1.09
    Ensembl ID: ENSG00000176697
  • Gene Symbol: BMP6 (ENSG00000153162)
    Fold Change: 1.09
    Ensembl ID: ENSG00000153162
  • Gene Symbol: ADORA2A (ENSG00000128271)
    Fold Change: 1.09
    Ensembl ID: ENSG00000128271
  • Gene Symbol: CXCR5 (ENSG00000160683)
    Fold Change: 1.09
    Ensembl ID: ENSG00000160683
  • Gene Symbol: ADARB2 (ENSG00000185736)
    Fold Change: 1.09
    Ensembl ID: ENSG00000185736
  • Gene Symbol: ADD2 (ENSG00000075340)
    Fold Change: 1.09
    Ensembl ID: ENSG00000075340
  • Gene Symbol: ANGPT1 (ENSG00000154188)
    Fold Change: 1.08
    Ensembl ID: ENSG00000154188
  • Gene Symbol: ANK1 (ENSG00000029534)
    Fold Change: 1.08
    Ensembl ID: ENSG00000029534
  • Gene Symbol: ALPL (ENSG00000162551)
    Fold Change: 1.08
    Ensembl ID: ENSG00000162551
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.08
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ALDH1A3 (ENSG00000184254)
    Fold Change: 1.07
    Ensembl ID: ENSG00000184254
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.07
    Ensembl ID: ENSG00000149925
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.06
    Ensembl ID: ENSG00000142599
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.06
    Ensembl ID: ENSG00000183255
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.06
    Ensembl ID: ENSG00000104964
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.05
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.04
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.04
    Ensembl ID: ENSG00000197894
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.03
    Ensembl ID: ENSG00000100300
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.02
    Ensembl ID: ENSG00000107262
Hovered Details

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Hovered Details

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**Key Characteristics** * Rapid proliferation and differentiation from stem cells of the intestinal crypt of the colon * Gives rise to four major epithelial cell types: enterocytes, goblet cells, enteroendocrine cells, and Paneth cells * Involved in the development and maintenance of the intestinal epithelium * Plays a crucial role in nutrient absorption, barrier function, and immune system regulation * Associated genes: ACTB, SLC25A6, and B2M * Cellular processes: cytoskeleton organization, energy metabolism, and antigen presentation **Clinical Significance** The transit amplifying cells of the colon play a critical role in maintaining the integrity of the intestinal epithelium, which is essential for preventing diseases such as: * Inflammatory bowel disease (IBD) * Irritable bowel syndrome (IBS) * Cancer of the colon and rectum * Malabsorption syndromes * Immune system disorders Dysregulation of the transit amplifying cells of the colon has been implicated in various diseases, including: * Inflammatory bowel disease (IBD): chronic inflammation and damage to the intestinal epithelium * Irritable bowel syndrome (IBS): altered gut motility and secretion * Cancer of the colon and rectum: uncontrolled cell proliferation and tumor formation * Malabsorption syndromes: impaired nutrient absorption and utilization * Immune system disorders: impaired immune function and increased susceptibility to infections Understanding the biology and function of the transit amplifying cells of the colon is essential for the development of novel therapeutic strategies for the treatment of these diseases.