Details for: CL0009012

Cell ID: CL0009012

Cell Name: transit amplifying cell of small intestine

Marker Score Threshold: 415
(Derived using integrated single-cell and genomic data)

Description: A rapidly proliferating population of cells that differentiate from stem cells of the intestinal crypt of the small intestine. Stem cells located in the crypts of Lieberkühn give rise to proliferating progenitor or transit amplifying cells that differentiate into the four major epithelial cell types. These include columnar absorptive cells or enterocytes, mucous secreting goblet cells, enteroendocrine cells and paneth cells.

Synonyms: small intestine transit amplifying cell, transient amplifying cell of crypt of Lieberkuhn of small intestine, transient amplifying cell of small intestine, transit amplifying cell of crypt of Lieberkuhn of small intestine, transit-amplifying cell of small intestine

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.13
    Ensembl ID: ENSG00000075624
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 2.04
    Ensembl ID: ENSG00000087086
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 2.03
    Ensembl ID: ENSG00000156508
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 2.03
    Ensembl ID: ENSG00000167996
  • Gene Symbol: H3 3B (ENSG00000132475)
    Fold Change: 2.02
    Ensembl ID: ENSG00000132475
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 2
    Ensembl ID: ENSG00000111640
  • Gene Symbol: FAU (ENSG00000149806)
    Fold Change: 1.99
    Ensembl ID: ENSG00000149806
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.99
    Ensembl ID: ENSG00000166710
  • Gene Symbol: HNRNPA2B1 (ENSG00000122566)
    Fold Change: 1.97
    Ensembl ID: ENSG00000122566
  • Gene Symbol: HMGB1 (ENSG00000189403)
    Fold Change: 1.94
    Ensembl ID: ENSG00000189403
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.91
    Ensembl ID: ENSG00000184009
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 1.88
    Ensembl ID: ENSG00000131143
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 1.88
    Ensembl ID: ENSG00000127184
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 1.87
    Ensembl ID: ENSG00000172757
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 1.85
    Ensembl ID: ENSG00000104529
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 1.85
    Ensembl ID: ENSG00000167658
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.84
    Ensembl ID: ENSG00000169100
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.82
    Ensembl ID: ENSG00000145741
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 1.81
    Ensembl ID: ENSG00000108654
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.8
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 1.79
    Ensembl ID: ENSG00000099622
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 1.79
    Ensembl ID: ENSG00000114942
  • Gene Symbol: HINT1 (ENSG00000169567)
    Fold Change: 1.76
    Ensembl ID: ENSG00000169567
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.74
    Ensembl ID: ENSG00000135390
  • Gene Symbol: HNRNPC (ENSG00000092199)
    Fold Change: 1.74
    Ensembl ID: ENSG00000092199
  • Gene Symbol: H3 3A (ENSG00000163041)
    Fold Change: 1.74
    Ensembl ID: ENSG00000163041
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.74
    Ensembl ID: ENSG00000124172
  • Gene Symbol: GNAS (ENSG00000087460)
    Fold Change: 1.73
    Ensembl ID: ENSG00000087460
  • Gene Symbol: HNRNPA1 (ENSG00000135486)
    Fold Change: 1.73
    Ensembl ID: ENSG00000135486
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.69
    Ensembl ID: ENSG00000133639
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 1.67
    Ensembl ID: ENSG00000164919
  • Gene Symbol: FUS (ENSG00000089280)
    Fold Change: 1.67
    Ensembl ID: ENSG00000089280
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.67
    Ensembl ID: ENSG00000143933
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.67
    Ensembl ID: ENSG00000126267
  • Gene Symbol: EIF4A2 (ENSG00000156976)
    Fold Change: 1.66
    Ensembl ID: ENSG00000156976
  • Gene Symbol: FGB (ENSG00000171564)
    Fold Change: 1.65
    Ensembl ID: ENSG00000171564
  • Gene Symbol: HMGN1 (ENSG00000205581)
    Fold Change: 1.63
    Ensembl ID: ENSG00000205581
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 1.62
    Ensembl ID: ENSG00000112695
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.62
    Ensembl ID: ENSG00000135940
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.59
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.58
    Ensembl ID: ENSG00000070831
  • Gene Symbol: GPX4 (ENSG00000167468)
    Fold Change: 1.57
    Ensembl ID: ENSG00000167468
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.56
    Ensembl ID: ENSG00000111775
  • Gene Symbol: ENO1 (ENSG00000074800)
    Fold Change: 1.56
    Ensembl ID: ENSG00000074800
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.55
    Ensembl ID: ENSG00000179218
  • Gene Symbol: GSTP1 (ENSG00000084207)
    Fold Change: 1.55
    Ensembl ID: ENSG00000084207
  • Gene Symbol: H2AZ1 (ENSG00000164032)
    Fold Change: 1.55
    Ensembl ID: ENSG00000164032
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.54
    Ensembl ID: ENSG00000067560
  • Gene Symbol: FOS (ENSG00000170345)
    Fold Change: 1.52
    Ensembl ID: ENSG00000170345
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.52
    Ensembl ID: ENSG00000169020
  • Gene Symbol: EIF4G2 (ENSG00000110321)
    Fold Change: 1.49
    Ensembl ID: ENSG00000110321
  • Gene Symbol: HMGN2 (ENSG00000198830)
    Fold Change: 1.48
    Ensembl ID: ENSG00000198830
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 1.48
    Ensembl ID: ENSG00000176340
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.47
    Ensembl ID: ENSG00000154723
  • Gene Symbol: FGG (ENSG00000171557)
    Fold Change: 1.47
    Ensembl ID: ENSG00000171557
  • Gene Symbol: PDIA3 (ENSG00000167004)
    Fold Change: 1.47
    Ensembl ID: ENSG00000167004
  • Gene Symbol: HLA A (ENSG00000206503)
    Fold Change: 1.46
    Ensembl ID: ENSG00000206503
  • Gene Symbol: HLA B (ENSG00000234745)
    Fold Change: 1.45
    Ensembl ID: ENSG00000234745
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.45
    Ensembl ID: ENSG00000134825
  • Gene Symbol: DUSP1 (ENSG00000120129)
    Fold Change: 1.44
    Ensembl ID: ENSG00000120129
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.44
    Ensembl ID: ENSG00000122545
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.44
    Ensembl ID: ENSG00000067082
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.43
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 1.43
    Ensembl ID: ENSG00000160213
  • Gene Symbol: CYBA (ENSG00000051523)
    Fold Change: 1.42
    Ensembl ID: ENSG00000051523
  • Gene Symbol: HLA C (ENSG00000204525)
    Fold Change: 1.42
    Ensembl ID: ENSG00000204525
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.41
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.41
    Ensembl ID: ENSG00000213719
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.41
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ERH (ENSG00000100632)
    Fold Change: 1.39
    Ensembl ID: ENSG00000100632
  • Gene Symbol: EIF5 (ENSG00000100664)
    Fold Change: 1.39
    Ensembl ID: ENSG00000100664
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.38
    Ensembl ID: ENSG00000099624
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 1.38
    Ensembl ID: ENSG00000131174
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.38
    Ensembl ID: ENSG00000172270
  • Gene Symbol: DBI (ENSG00000155368)
    Fold Change: 1.38
    Ensembl ID: ENSG00000155368
  • Gene Symbol: GUK1 (ENSG00000143774)
    Fold Change: 1.38
    Ensembl ID: ENSG00000143774
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.37
    Ensembl ID: ENSG00000110955
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.37
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.36
    Ensembl ID: ENSG00000185650
  • Gene Symbol: EIF4B (ENSG00000063046)
    Fold Change: 1.35
    Ensembl ID: ENSG00000063046
  • Gene Symbol: HNRNPD (ENSG00000138668)
    Fold Change: 1.33
    Ensembl ID: ENSG00000138668
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.32
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.31
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.31
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.3
    Ensembl ID: ENSG00000122705
  • Gene Symbol: GNG5 (ENSG00000174021)
    Fold Change: 1.3
    Ensembl ID: ENSG00000174021
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.29
    Ensembl ID: ENSG00000152234
  • Gene Symbol: EIF1AX (ENSG00000173674)
    Fold Change: 1.28
    Ensembl ID: ENSG00000173674
  • Gene Symbol: HNRNPF (ENSG00000169813)
    Fold Change: 1.27
    Ensembl ID: ENSG00000169813
  • Gene Symbol: DAD1 (ENSG00000129562)
    Fold Change: 1.27
    Ensembl ID: ENSG00000129562
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.26
    Ensembl ID: ENSG00000165629
  • Gene Symbol: DDX3X (ENSG00000215301)
    Fold Change: 1.26
    Ensembl ID: ENSG00000215301
  • Gene Symbol: EIF5A (ENSG00000132507)
    Fold Change: 1.25
    Ensembl ID: ENSG00000132507
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 1.25
    Ensembl ID: ENSG00000101439
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.24
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 1.24
    Ensembl ID: ENSG00000113712
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.24
    Ensembl ID: ENSG00000198931
  • Gene Symbol: XRCC6 (ENSG00000196419)
    Fold Change: 1.24
    Ensembl ID: ENSG00000196419
  • Gene Symbol: GDI2 (ENSG00000057608)
    Fold Change: 1.24
    Ensembl ID: ENSG00000057608
  • Gene Symbol: ENSA (ENSG00000143420)
    Fold Change: 1.23
    Ensembl ID: ENSG00000143420

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in transit amplifying cell of small intestine cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in transit amplifying cell of small intestine cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** 1. **Rapid Proliferation**: TACs are characterized by their rapid proliferation and ability to differentiate into various epithelial cell types. 2. **Differentiation from Stem Cells**: TACs differentiate from stem cells located in the crypts of Lieberkühn, which are the stem cell niches of the small intestine. 3. **Epithelial Cell Types**: TACs can differentiate into four major epithelial cell types: enterocytes, goblet cells, enteroendocrine cells, and Paneth cells. 4. **Actin Cytoskeleton and Adherens Junctions**: TACs rely on actin cytoskeleton and adherens junctions for cell-cell adhesion and migration. 5. **Epigenetic Regulation**: TACs are regulated by epigenetic mechanisms, including DNA methylation and histone modifications, which control gene expression. **Clinical Significance** 1. **Intestinal Regeneration**: TACs play a crucial role in the regeneration of the intestinal epithelium, which is essential for maintaining immune function and nutrient absorption. 2. **Gastrointestinal Diseases**: Dysregulation of TACs has been implicated in various gastrointestinal diseases, including inflammatory bowel disease (IBD), Crohn's disease, and ulcerative colitis. 3. **Cancer**: TACs have been implicated in the development of colorectal cancer, as aberrant differentiation of TACs can lead to the formation of aberrant crypts, which are precursors to cancer. 4. **Infectious Diseases**: TACs are essential for the immune response to infectious diseases, such as bacterial and viral infections, which can affect the intestinal epithelium. **Gene Expression and Signaling Pathways** 1. **Gene Expression**: TACs are regulated by multiple signaling pathways, including those mediated by actin cytoskeleton, adherens junctions, and epigenetic mechanisms. 2. **Gene Symbol**: The gene symbol for TACs is ACTB, which encodes a protein involved in the regulation of actin cytoskeleton. 3. **Ensembl ID**: The Ensembl ID for TACs is ENSG00000075624, which corresponds to the human genome assembly. 4. **Pathways/Ontology**: TACs are involved in multiple pathways, including those mediated by actin cytoskeleton, adherens junctions, and epigenetic mechanisms. In conclusion, Transit Amplifying Cells (TACs) of the Small Intestine (CL0009012) are a rapidly proliferating population of cells that differentiate from stem cells of the intestinal crypt of the small intestine. These cells are crucial for the maintenance and regeneration of the intestinal epithelium, which is essential for nutrient absorption and immune function. Understanding the key characteristics, clinical significance, and gene expression and signaling pathways of TACs is essential for the development of novel therapeutic strategies for gastrointestinal diseases.