Details for: CL0009012

Cell ID: CL0009012

Cell Name: transit amplifying cell of small intestine

Marker Score Threshold: 415
(Derived using integrated single-cell and genomic data)

Description: A rapidly proliferating population of cells that differentiate from stem cells of the intestinal crypt of the small intestine. Stem cells located in the crypts of Lieberkühn give rise to proliferating progenitor or transit amplifying cells that differentiate into the four major epithelial cell types. These include columnar absorptive cells or enterocytes, mucous secreting goblet cells, enteroendocrine cells and paneth cells.

Synonyms: small intestine transit amplifying cell, transient amplifying cell of crypt of Lieberkuhn of small intestine, transient amplifying cell of small intestine, transit amplifying cell of crypt of Lieberkuhn of small intestine, transit-amplifying cell of small intestine

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.13
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.99
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.91
    Ensembl ID: ENSG00000184009
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.84
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.74
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.74
    Ensembl ID: ENSG00000124172
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.54
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.52
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.47
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.41
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.41
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.38
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.37
    Ensembl ID: ENSG00000110955
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.37
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.29
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.26
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.24
    Ensembl ID: ENSG00000085224
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.24
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.21
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.2
    Ensembl ID: ENSG00000117410
  • Gene Symbol: AFP (ENSG00000081051)
    Fold Change: 1.2
    Ensembl ID: ENSG00000081051
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.2
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.2
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ALPG (ENSG00000163286)
    Fold Change: 1.19
    Ensembl ID: ENSG00000163286
  • Gene Symbol: AVPR1B (ENSG00000198049)
    Fold Change: 1.19
    Ensembl ID: ENSG00000198049
  • Gene Symbol: ACTN3 (ENSG00000248746)
    Fold Change: 1.19
    Ensembl ID: ENSG00000248746
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.19
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CRISP1 (ENSG00000124812)
    Fold Change: 1.18
    Ensembl ID: ENSG00000124812
  • Gene Symbol: ALX3 (ENSG00000156150)
    Fold Change: 1.18
    Ensembl ID: ENSG00000156150
  • Gene Symbol: ACTA1 (ENSG00000143632)
    Fold Change: 1.18
    Ensembl ID: ENSG00000143632
  • Gene Symbol: ADORA3 (ENSG00000282608)
    Fold Change: 1.18
    Ensembl ID: ENSG00000282608
  • Gene Symbol: ADRB3 (ENSG00000188778)
    Fold Change: 1.18
    Ensembl ID: ENSG00000188778
  • Gene Symbol: SERPINC1 (ENSG00000117601)
    Fold Change: 1.18
    Ensembl ID: ENSG00000117601
  • Gene Symbol: ADH1A (ENSG00000187758)
    Fold Change: 1.18
    Ensembl ID: ENSG00000187758
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.18
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ALOX12B (ENSG00000179477)
    Fold Change: 1.18
    Ensembl ID: ENSG00000179477
  • Gene Symbol: ALAS2 (ENSG00000158578)
    Fold Change: 1.18
    Ensembl ID: ENSG00000158578
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 1.18
    Ensembl ID: ENSG00000130203
  • Gene Symbol: ASMT (ENSG00000196433)
    Fold Change: 1.18
    Ensembl ID: ENSG00000196433
  • Gene Symbol: ADRA1D (ENSG00000171873)
    Fold Change: 1.17
    Ensembl ID: ENSG00000171873
  • Gene Symbol: ATP12A (ENSG00000075673)
    Fold Change: 1.17
    Ensembl ID: ENSG00000075673
  • Gene Symbol: SERPINA3 (ENSG00000196136)
    Fold Change: 1.17
    Ensembl ID: ENSG00000196136
  • Gene Symbol: ACADL (ENSG00000115361)
    Fold Change: 1.17
    Ensembl ID: ENSG00000115361
  • Gene Symbol: ADRA1B (ENSG00000170214)
    Fold Change: 1.17
    Ensembl ID: ENSG00000170214
  • Gene Symbol: ALDH3B2 (ENSG00000132746)
    Fold Change: 1.17
    Ensembl ID: ENSG00000132746
  • Gene Symbol: ALOX15 (ENSG00000161905)
    Fold Change: 1.17
    Ensembl ID: ENSG00000161905
  • Gene Symbol: ATP1A3 (ENSG00000105409)
    Fold Change: 1.17
    Ensembl ID: ENSG00000105409
  • Gene Symbol: ADORA2A (ENSG00000128271)
    Fold Change: 1.17
    Ensembl ID: ENSG00000128271
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.17
    Ensembl ID: ENSG00000123505
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 1.17
    Ensembl ID: ENSG00000078053
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.17
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ARR3 (ENSG00000120500)
    Fold Change: 1.17
    Ensembl ID: ENSG00000120500
  • Gene Symbol: ART3 (ENSG00000156219)
    Fold Change: 1.17
    Ensembl ID: ENSG00000156219
  • Gene Symbol: BDNF (ENSG00000176697)
    Fold Change: 1.17
    Ensembl ID: ENSG00000176697
  • Gene Symbol: BMP6 (ENSG00000153162)
    Fold Change: 1.17
    Ensembl ID: ENSG00000153162
  • Gene Symbol: CXCR5 (ENSG00000160683)
    Fold Change: 1.17
    Ensembl ID: ENSG00000160683
  • Gene Symbol: ADD2 (ENSG00000075340)
    Fold Change: 1.16
    Ensembl ID: ENSG00000075340
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 1.16
    Ensembl ID: ENSG00000107282
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.16
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.16
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.16
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ALPL (ENSG00000162551)
    Fold Change: 1.16
    Ensembl ID: ENSG00000162551
  • Gene Symbol: ANGPT1 (ENSG00000154188)
    Fold Change: 1.16
    Ensembl ID: ENSG00000154188
  • Gene Symbol: ANK1 (ENSG00000029534)
    Fold Change: 1.16
    Ensembl ID: ENSG00000029534
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.15
    Ensembl ID: ENSG00000141522
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.15
    Ensembl ID: ENSG00000176171
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.14
    Ensembl ID: ENSG00000177556
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.14
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.14
    Ensembl ID: ENSG00000163399
  • Gene Symbol: BCL2A1 (ENSG00000140379)
    Fold Change: 1.14
    Ensembl ID: ENSG00000140379
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.13
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.13
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.13
    Ensembl ID: ENSG00000111348
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.12
    Ensembl ID: ENSG00000100823
  • Gene Symbol: APOA2 (ENSG00000158874)
    Fold Change: 1.12
    Ensembl ID: ENSG00000158874
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.12
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.12
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.11
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.1
    Ensembl ID: ENSG00000135046
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.1
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.08
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.08
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.08
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.07
    Ensembl ID: ENSG00000149925
  • Gene Symbol: KIF1A (ENSG00000130294)
    Fold Change: 1.07
    Ensembl ID: ENSG00000130294
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.07
    Ensembl ID: ENSG00000072778
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.07
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.06
    Ensembl ID: ENSG00000197894
  • Gene Symbol: BAAT (ENSG00000136881)
    Fold Change: 1.05
    Ensembl ID: ENSG00000136881
  • Gene Symbol: APOF (ENSG00000175336)
    Fold Change: 1.05
    Ensembl ID: ENSG00000175336
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.04
    Ensembl ID: ENSG00000115307
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.04
    Ensembl ID: ENSG00000143799
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.03
    Ensembl ID: ENSG00000142192
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.03
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.02
    Ensembl ID: ENSG00000004059
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.02
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ATP1A2 (ENSG00000018625)
    Fold Change: 1.01
    Ensembl ID: ENSG00000018625
  • Gene Symbol: BMPR1B (ENSG00000138696)
    Fold Change: 1.01
    Ensembl ID: ENSG00000138696
  • Gene Symbol: AIRE (ENSG00000160224)
    Fold Change: 1.01
    Ensembl ID: ENSG00000160224
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: N/A
    Ensembl ID: ENSG00000197043
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Cell Proliferation**: Transit amplifying cells are rapidly proliferating, indicating their role in maintaining the integrity of the intestinal epithelium. 2. **Differentiation**: These cells differentiate into the four major epithelial cell types, which are essential for nutrient absorption, immune function, and barrier integrity. 3. **Location**: Transit amplifying cells are located in the crypts of Lieberkühn, which are specialized structures at the base of the intestinal villi. 4. **Function**: The transit amplifying cell plays a crucial role in maintaining the homeostasis of the intestinal epithelium, which is essential for nutrient absorption, immune function, and barrier integrity. 5. **Gene Expression**: The gene expression profile of transit amplifying cells is characterized by the expression of genes involved in cell proliferation, differentiation, and survival. **Clinical Significance** 1. **Intestinal Regeneration**: Transit amplifying cells play a crucial role in the regeneration of the intestinal epithelium after injury or disease, which is essential for maintaining nutrient absorption and immune function. 2. **Cancer**: Alterations in the function and regulation of transit amplifying cells have been implicated in the development of intestinal cancer, highlighting the importance of these cells in maintaining tissue homeostasis. 3. **Inflammatory Bowel Disease**: Transit amplifying cells may play a role in the pathogenesis of inflammatory bowel disease (IBD), a chronic inflammatory condition characterized by intestinal inflammation and damage. 4. **Gastrointestinal Disorders**: Alterations in the function and regulation of transit amplifying cells may contribute to gastrointestinal disorders such as celiac disease, Crohn's disease, and ulcerative colitis. In conclusion, the transit amplifying cell of the small intestine is a critical component of the intestinal epithelium, playing a central role in maintaining tissue homeostasis, regulating differentiation, and preventing disease. Further research is needed to fully understand the function and regulation of these cells and their role in maintaining intestinal health.