Details for: CL0009016

Cell ID: CL0009016

Cell Name: intestinal crypt stem cell of large intestine

Marker Score Threshold: 300
(Derived using integrated single-cell and genomic data)

Description: An intestinal stem cell that is located in the large intestine crypt of Liberkuhn. These stem cells reside at the bottom of crypts in the large intestine and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells.

Synonyms: crypt stem cell of large intestine, stem cell of large intestine crypt of Lieberkuhn

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.51
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.36
    Ensembl ID: ENSG00000166710
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.1
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.87
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.63
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.61
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.47
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.44
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.39
    Ensembl ID: ENSG00000124172
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.34
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.33
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.17
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.14
    Ensembl ID: ENSG00000135404
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.12
    Ensembl ID: ENSG00000122545
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.11
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.05
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.99
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.87
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.86
    Ensembl ID: ENSG00000185650
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.84
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.84
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.84
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.82
    Ensembl ID: ENSG00000110955
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.81
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.81
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.78
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.73
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.73
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.7
    Ensembl ID: ENSG00000085224
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.7
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.69
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.64
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.62
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.6
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.58
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.57
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.56
    Ensembl ID: ENSG00000128272
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.55
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.55
    Ensembl ID: ENSG00000070961
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.55
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.54
    Ensembl ID: ENSG00000196776
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.51
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.49
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.47
    Ensembl ID: ENSG00000241837
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.46
    Ensembl ID: ENSG00000107262
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.45
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.45
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.43
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.4
    Ensembl ID: ENSG00000069849
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.4
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.4
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.38
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.35
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.35
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.35
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.35
    Ensembl ID: ENSG00000163399
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.31
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.31
    Ensembl ID: ENSG00000138279
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.31
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.3
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.29
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.29
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.29
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.27
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CDC5L (ENSG00000096401)
    Fold Change: 1.27
    Ensembl ID: ENSG00000096401
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.26
    Ensembl ID: ENSG00000146731
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.26
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.25
    Ensembl ID: ENSG00000162772
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.22
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.22
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1.21
    Ensembl ID: ENSG00000143149
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.19
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.18
    Ensembl ID: ENSG00000177556
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.18
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.18
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.18
    Ensembl ID: ENSG00000143727
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.18
    Ensembl ID: ENSG00000006125
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.17
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.17
    Ensembl ID: ENSG00000072778
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.15
    Ensembl ID: ENSG00000110330
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.15
    Ensembl ID: ENSG00000087088
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.14
    Ensembl ID: ENSG00000100823
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.14
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.13
    Ensembl ID: ENSG00000087274
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.13
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.13
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.13
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.11
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.11
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.09
    Ensembl ID: ENSG00000085063
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 1.08
    Ensembl ID: ENSG00000130208
  • Gene Symbol: CAPG (ENSG00000042493)
    Fold Change: 1.07
    Ensembl ID: ENSG00000042493
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.06
    Ensembl ID: ENSG00000131100
  • Gene Symbol: CDK6 (ENSG00000105810)
    Fold Change: 1.06
    Ensembl ID: ENSG00000105810
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.05
    Ensembl ID: ENSG00000142192
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.05
    Ensembl ID: ENSG00000002330
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.04
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.04
    Ensembl ID: ENSG00000134480
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.02
    Ensembl ID: ENSG00000126247
  • Gene Symbol: BMP7 (ENSG00000101144)
    Fold Change: 1.01
    Ensembl ID: ENSG00000101144
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Location**: Intestinal crypt stem cells are located at the base of the intestinal crypts in the large intestine. 2. **Cellular Differentiation**: Intestinal crypt stem cells can differentiate into transit-amplifying cells or self-renew to form new stem cells. 3. **High Proliferation Rate**: Intestinal crypt stem cells are highly proliferative, allowing them to maintain the integrity of the intestinal epithelium. 4. **Regulation of Cell Cycle**: The cell cycle of intestinal crypt stem cells is regulated by various signaling pathways, including the Wnt/β-catenin pathway and the p53/p21 pathway. 5. **Apoptosis**: Intestinal crypt stem cells have a low rate of apoptosis, which is essential for their maintenance and function. 6. **Cell-Cell Communication**: Intestinal crypt stem cells communicate with each other and with other cells in the intestinal epithelium through various signaling pathways, including the Wnt/β-catenin pathway and the Notch signaling pathway. 7. **Cytoskeletal Organization**: The cytoskeleton of intestinal crypt stem cells is organized in a unique way, with actin filaments and microtubules playing critical roles in cell shape, movement, and signaling. **Clinical Significance** 1. **Intestinal Cancer**: Intestinal crypt stem cells are thought to be the origin of most intestinal cancers, including colorectal cancer. 2. **Inflammatory Bowel Disease**: Intestinal crypt stem cells play a critical role in the development and maintenance of inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. 3. **Gastrointestinal Motility**: Intestinal crypt stem cells are involved in the regulation of gastrointestinal motility, including the movement of food through the digestive tract. 4. **Immune System**: Intestinal crypt stem cells are essential for the development and maintenance of the gut-associated lymphoid tissue (GALT), which plays a critical role in the immune system. 5. **Nutrient Absorption**: Intestinal crypt stem cells are involved in the regulation of nutrient absorption, including the absorption of vitamins and minerals. **Gene Expression** The gene expression profile of intestinal crypt stem cells is characterized by the expression of various genes involved in cell proliferation, differentiation, and survival, including: 1. **ACTB**: Actin beta, a gene involved in cell shape and movement. 2. **B2M**: Beta-2 microglobulin, a gene involved in antigen presentation. 3. **MAPK**: Mitogen-activated protein kinase, a gene involved in signaling pathways. 4. **NF-κB**: Nuclear factor kappa B, a gene involved in inflammation and immune response. 5. **WNT**: Wnt, a gene involved in cell proliferation and differentiation. Overall, the intestinal crypt stem cell is a complex cell type that plays a critical role in maintaining the integrity of the intestinal epithelium and the gut-associated lymphoid tissue. Understanding the characteristics and functions of intestinal crypt stem cells is essential for the development of novel therapeutic strategies for intestinal diseases.