Details for: CL0009017

Cell ID: CL0009017

Cell Name: intestinal crypt stem cell of small intestine

Marker Score Threshold: 677
(Derived using integrated single-cell and genomic data)

Description: An intestinal stem cell that is located in the small intestine crypt of Liberkuhn. These stem cells reside at the bottom of crypts in the small intestine and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells.

Synonyms: crypt stem cell of small intestine, stem cell of small intestine crypt of Lieberkuhn

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.41
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.32
    Ensembl ID: ENSG00000166710
  • Gene Symbol: APOF (ENSG00000175336)
    Fold Change: 1.27
    Ensembl ID: ENSG00000175336
  • Gene Symbol: ALX3 (ENSG00000156150)
    Fold Change: 1.27
    Ensembl ID: ENSG00000156150
  • Gene Symbol: AVPR1B (ENSG00000198049)
    Fold Change: 1.27
    Ensembl ID: ENSG00000198049
  • Gene Symbol: C4A (ENSG00000244731)
    Fold Change: 1.27
    Ensembl ID: ENSG00000244731
  • Gene Symbol: C4B (ENSG00000224389)
    Fold Change: 1.27
    Ensembl ID: ENSG00000224389
  • Gene Symbol: ACTA1 (ENSG00000143632)
    Fold Change: 1.27
    Ensembl ID: ENSG00000143632
  • Gene Symbol: ACTN3 (ENSG00000248746)
    Fold Change: 1.27
    Ensembl ID: ENSG00000248746
  • Gene Symbol: ALPG (ENSG00000163286)
    Fold Change: 1.27
    Ensembl ID: ENSG00000163286
  • Gene Symbol: SERPINC1 (ENSG00000117601)
    Fold Change: 1.27
    Ensembl ID: ENSG00000117601
  • Gene Symbol: BAAT (ENSG00000136881)
    Fold Change: 1.27
    Ensembl ID: ENSG00000136881
  • Gene Symbol: ADORA3 (ENSG00000282608)
    Fold Change: 1.27
    Ensembl ID: ENSG00000282608
  • Gene Symbol: ALOX12B (ENSG00000179477)
    Fold Change: 1.27
    Ensembl ID: ENSG00000179477
  • Gene Symbol: AANAT (ENSG00000129673)
    Fold Change: 1.27
    Ensembl ID: ENSG00000129673
  • Gene Symbol: ADH1A (ENSG00000187758)
    Fold Change: 1.27
    Ensembl ID: ENSG00000187758
  • Gene Symbol: ADRB3 (ENSG00000188778)
    Fold Change: 1.27
    Ensembl ID: ENSG00000188778
  • Gene Symbol: CRISP1 (ENSG00000124812)
    Fold Change: 1.27
    Ensembl ID: ENSG00000124812
  • Gene Symbol: KLK3 (ENSG00000142515)
    Fold Change: 1.27
    Ensembl ID: ENSG00000142515
  • Gene Symbol: ASMT (ENSG00000196433)
    Fold Change: 1.27
    Ensembl ID: ENSG00000196433
  • Gene Symbol: C8A (ENSG00000157131)
    Fold Change: 1.27
    Ensembl ID: ENSG00000157131
  • Gene Symbol: C8B (ENSG00000021852)
    Fold Change: 1.27
    Ensembl ID: ENSG00000021852
  • Gene Symbol: AOC2 (ENSG00000131480)
    Fold Change: 1.27
    Ensembl ID: ENSG00000131480
  • Gene Symbol: ACR (ENSG00000100312)
    Fold Change: 1.27
    Ensembl ID: ENSG00000100312
  • Gene Symbol: ADRA1D (ENSG00000171873)
    Fold Change: 1.26
    Ensembl ID: ENSG00000171873
  • Gene Symbol: ADRA2B (ENSG00000274286)
    Fold Change: 1.26
    Ensembl ID: ENSG00000274286
  • Gene Symbol: TNFRSF17 (ENSG00000048462)
    Fold Change: 1.26
    Ensembl ID: ENSG00000048462
  • Gene Symbol: SERPINA3 (ENSG00000196136)
    Fold Change: 1.26
    Ensembl ID: ENSG00000196136
  • Gene Symbol: ASGR2 (ENSG00000161944)
    Fold Change: 1.26
    Ensembl ID: ENSG00000161944
  • Gene Symbol: ATP1A2 (ENSG00000018625)
    Fold Change: 1.26
    Ensembl ID: ENSG00000018625
  • Gene Symbol: ATP2A1 (ENSG00000196296)
    Fold Change: 1.26
    Ensembl ID: ENSG00000196296
  • Gene Symbol: BGLAP (ENSG00000242252)
    Fold Change: 1.26
    Ensembl ID: ENSG00000242252
  • Gene Symbol: BRDT (ENSG00000137948)
    Fold Change: 1.26
    Ensembl ID: ENSG00000137948
  • Gene Symbol: ALOX15 (ENSG00000161905)
    Fold Change: 1.26
    Ensembl ID: ENSG00000161905
  • Gene Symbol: ART3 (ENSG00000156219)
    Fold Change: 1.26
    Ensembl ID: ENSG00000156219
  • Gene Symbol: ATP6V1G2 (ENSG00000213760)
    Fold Change: 1.26
    Ensembl ID: ENSG00000213760
  • Gene Symbol: BHMT (ENSG00000145692)
    Fold Change: 1.26
    Ensembl ID: ENSG00000145692
  • Gene Symbol: ACADL (ENSG00000115361)
    Fold Change: 1.26
    Ensembl ID: ENSG00000115361
  • Gene Symbol: ADRA1B (ENSG00000170214)
    Fold Change: 1.26
    Ensembl ID: ENSG00000170214
  • Gene Symbol: ADRA2C (ENSG00000184160)
    Fold Change: 1.26
    Ensembl ID: ENSG00000184160
  • Gene Symbol: AOX1 (ENSG00000138356)
    Fold Change: 1.26
    Ensembl ID: ENSG00000138356
  • Gene Symbol: ATP12A (ENSG00000075673)
    Fold Change: 1.26
    Ensembl ID: ENSG00000075673
  • Gene Symbol: BDKRB1 (ENSG00000100739)
    Fold Change: 1.26
    Ensembl ID: ENSG00000100739
  • Gene Symbol: BDNF (ENSG00000176697)
    Fold Change: 1.26
    Ensembl ID: ENSG00000176697
  • Gene Symbol: ABCA4 (ENSG00000198691)
    Fold Change: 1.26
    Ensembl ID: ENSG00000198691
  • Gene Symbol: ADORA2A (ENSG00000128271)
    Fold Change: 1.26
    Ensembl ID: ENSG00000128271
  • Gene Symbol: ALDH3B2 (ENSG00000132746)
    Fold Change: 1.26
    Ensembl ID: ENSG00000132746
  • Gene Symbol: CXCR5 (ENSG00000160683)
    Fold Change: 1.26
    Ensembl ID: ENSG00000160683
  • Gene Symbol: BMX (ENSG00000102010)
    Fold Change: 1.26
    Ensembl ID: ENSG00000102010
  • Gene Symbol: ADD2 (ENSG00000075340)
    Fold Change: 1.26
    Ensembl ID: ENSG00000075340
  • Gene Symbol: ARR3 (ENSG00000120500)
    Fold Change: 1.26
    Ensembl ID: ENSG00000120500
  • Gene Symbol: BMP6 (ENSG00000153162)
    Fold Change: 1.26
    Ensembl ID: ENSG00000153162
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: 1.26
    Ensembl ID: ENSG00000164742
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 1.26
    Ensembl ID: ENSG00000107282
  • Gene Symbol: BFSP1 (ENSG00000125864)
    Fold Change: 1.26
    Ensembl ID: ENSG00000125864
  • Gene Symbol: ADARB2 (ENSG00000185736)
    Fold Change: 1.25
    Ensembl ID: ENSG00000185736
  • Gene Symbol: ADH1B (ENSG00000196616)
    Fold Change: 1.25
    Ensembl ID: ENSG00000196616
  • Gene Symbol: ANK1 (ENSG00000029534)
    Fold Change: 1.25
    Ensembl ID: ENSG00000029534
  • Gene Symbol: ACP3 (ENSG00000014257)
    Fold Change: 1.25
    Ensembl ID: ENSG00000014257
  • Gene Symbol: BTK (ENSG00000010671)
    Fold Change: 1.25
    Ensembl ID: ENSG00000010671
  • Gene Symbol: C4BPA (ENSG00000123838)
    Fold Change: 1.25
    Ensembl ID: ENSG00000123838
  • Gene Symbol: STS (ENSG00000101846)
    Fold Change: 1.25
    Ensembl ID: ENSG00000101846
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.25
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BMPR1B (ENSG00000138696)
    Fold Change: 1.25
    Ensembl ID: ENSG00000138696
  • Gene Symbol: AR (ENSG00000169083)
    Fold Change: 1.25
    Ensembl ID: ENSG00000169083
  • Gene Symbol: ALDH1A3 (ENSG00000184254)
    Fold Change: 1.24
    Ensembl ID: ENSG00000184254
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.24
    Ensembl ID: ENSG00000169100
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.23
    Ensembl ID: ENSG00000145741
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 1.22
    Ensembl ID: ENSG00000168421
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.22
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.2
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.19
    Ensembl ID: ENSG00000124172
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.16
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.11
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.09
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.09
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.09
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.08
    Ensembl ID: ENSG00000152518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.08
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.07
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.05
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.05
    Ensembl ID: ENSG00000110955
  • Gene Symbol: AGXT (ENSG00000172482)
    Fold Change: 1.04
    Ensembl ID: ENSG00000172482
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.04
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ADGRB1 (ENSG00000181790)
    Fold Change: 1.04
    Ensembl ID: ENSG00000181790
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.03
    Ensembl ID: ENSG00000085224
  • Gene Symbol: AIRE (ENSG00000160224)
    Fold Change: 1.03
    Ensembl ID: ENSG00000160224
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.03
    Ensembl ID: ENSG00000111348
  • Gene Symbol: C5AR1 (ENSG00000197405)
    Fold Change: 1.03
    Ensembl ID: ENSG00000197405
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.03
    Ensembl ID: ENSG00000152234
  • Gene Symbol: APOA2 (ENSG00000158874)
    Fold Change: 1.03
    Ensembl ID: ENSG00000158874
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.02
    Ensembl ID: ENSG00000117410
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 1.02
    Ensembl ID: ENSG00000078053
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.01
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.01
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.01
    Ensembl ID: ENSG00000132965
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.01
    Ensembl ID: ENSG00000104765
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP1A3 (ENSG00000105409)
    Fold Change: N/A
    Ensembl ID: ENSG00000105409
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Location and Structure**: Intestinal crypt stem cells are located at the bottom of crypts in the small intestine, where they are in close proximity to the intestinal epithelium. 2. **High Proliferation Rate**: Intestinal crypt stem cells exhibit a high proliferation rate, allowing them to rapidly replace damaged or lost epithelial cells. 3. **Differentiation and Self-Renewal**: These stem cells can differentiate into transit amplifying cells or self-renew to form new stem cells, ensuring the continuous maintenance of the intestinal epithelium. 4. **Gene Expression Profile**: Intestinal crypt stem cells exhibit a unique gene expression profile, which involves the regulation of various cellular processes, including cell cycle, differentiation, and immune responses. 5. **Adherens Junctions**: Intestinal crypt stem cells express adherens junctions, which play a crucial role in maintaining the integrity of the epithelial barrier. **Clinical Significance** 1. **Gastrointestinal Disorders**: Dysregulation of intestinal crypt stem cells has been implicated in various gastrointestinal disorders, including inflammatory bowel disease (IBD), cancer, and other epithelial disorders. 2. **Immune System**: Intestinal crypt stem cells play a critical role in regulating immune responses, including the activation of immune cells and the production of cytokines. 3. **Cancer Development**: Abnormalities in intestinal crypt stem cells have been identified as a key factor in the development of colorectal cancer. 4. **Therapeutic Targeting**: Intestinal crypt stem cells are a potential target for therapeutic interventions aimed at treating gastrointestinal disorders, including IBD and cancer. **Potential Implications** 1. **Understanding Gut Homeostasis**: Studying intestinal crypt stem cells can provide valuable insights into the mechanisms underlying gut homeostasis and the regulation of the intestinal epithelium. 2. **Developing Novel Therapies**: Targeting intestinal crypt stem cells may lead to the development of novel therapies for gastrointestinal disorders, including IBD and cancer. 3. **Improving Patient Outcomes**: Understanding the role of intestinal crypt stem cells in gastrointestinal disorders may lead to improved patient outcomes and more effective treatment strategies. In conclusion, the intestinal crypt stem cell is a critical component of the small intestine's epithelial lining, playing a vital role in maintaining the integrity and function of the gut. Further research on this cell type is essential to understanding the mechanisms underlying gut homeostasis and the regulation of the intestinal epithelium, with potential implications for the development of novel therapies for gastrointestinal disorders.