Details for: CL0009017

Cell ID: CL0009017

Cell Name: intestinal crypt stem cell of small intestine

Marker Score Threshold: 677
(Derived using integrated single-cell and genomic data)

Description: An intestinal stem cell that is located in the small intestine crypt of Liberkuhn. These stem cells reside at the bottom of crypts in the small intestine and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells.

Synonyms: crypt stem cell of small intestine, stem cell of small intestine crypt of Lieberkuhn

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.41
    Ensembl ID: ENSG00000075624
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 1.35
    Ensembl ID: ENSG00000087086
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 1.35
    Ensembl ID: ENSG00000167996
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.32
    Ensembl ID: ENSG00000166710
  • Gene Symbol: H3 3B (ENSG00000132475)
    Fold Change: 1.29
    Ensembl ID: ENSG00000132475
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 1.29
    Ensembl ID: ENSG00000156508
  • Gene Symbol: FAU (ENSG00000149806)
    Fold Change: 1.28
    Ensembl ID: ENSG00000149806
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 1.28
    Ensembl ID: ENSG00000111640
  • Gene Symbol: HNRNPA2B1 (ENSG00000122566)
    Fold Change: 1.28
    Ensembl ID: ENSG00000122566
  • Gene Symbol: APOF (ENSG00000175336)
    Fold Change: 1.27
    Ensembl ID: ENSG00000175336
  • Gene Symbol: CNTF (ENSG00000242689)
    Fold Change: 1.27
    Ensembl ID: ENSG00000242689
  • Gene Symbol: CST4 (ENSG00000101441)
    Fold Change: 1.27
    Ensembl ID: ENSG00000101441
  • Gene Symbol: FOXD4 (ENSG00000170122)
    Fold Change: 1.27
    Ensembl ID: ENSG00000170122
  • Gene Symbol: PRLHR (ENSG00000119973)
    Fold Change: 1.27
    Ensembl ID: ENSG00000119973
  • Gene Symbol: HSP90AA1 (ENSG00000080824)
    Fold Change: 1.27
    Ensembl ID: ENSG00000080824
  • Gene Symbol: IGHEP2 (ENSG00000254017)
    Fold Change: 1.27
    Ensembl ID: ENSG00000254017
  • Gene Symbol: ALX3 (ENSG00000156150)
    Fold Change: 1.27
    Ensembl ID: ENSG00000156150
  • Gene Symbol: AVPR1B (ENSG00000198049)
    Fold Change: 1.27
    Ensembl ID: ENSG00000198049
  • Gene Symbol: C4A (ENSG00000244731)
    Fold Change: 1.27
    Ensembl ID: ENSG00000244731
  • Gene Symbol: C4B (ENSG00000224389)
    Fold Change: 1.27
    Ensembl ID: ENSG00000224389
  • Gene Symbol: CHRM4 (ENSG00000180720)
    Fold Change: 1.27
    Ensembl ID: ENSG00000180720
  • Gene Symbol: CHRNA2 (ENSG00000120903)
    Fold Change: 1.27
    Ensembl ID: ENSG00000120903
  • Gene Symbol: CHRNB2 (ENSG00000160716)
    Fold Change: 1.27
    Ensembl ID: ENSG00000160716
  • Gene Symbol: CRYGC (ENSG00000163254)
    Fold Change: 1.27
    Ensembl ID: ENSG00000163254
  • Gene Symbol: EVX1 (ENSG00000106038)
    Fold Change: 1.27
    Ensembl ID: ENSG00000106038
  • Gene Symbol: GK3 (ENSG00000229894)
    Fold Change: 1.27
    Ensembl ID: ENSG00000229894
  • Gene Symbol: GRM2 (ENSG00000164082)
    Fold Change: 1.27
    Ensembl ID: ENSG00000164082
  • Gene Symbol: GRM6 (ENSG00000113262)
    Fold Change: 1.27
    Ensembl ID: ENSG00000113262
  • Gene Symbol: HGFAC (ENSG00000109758)
    Fold Change: 1.27
    Ensembl ID: ENSG00000109758
  • Gene Symbol: HMX2 (ENSG00000188816)
    Fold Change: 1.27
    Ensembl ID: ENSG00000188816
  • Gene Symbol: TLX2 (ENSG00000115297)
    Fold Change: 1.27
    Ensembl ID: ENSG00000115297
  • Gene Symbol: ERAS (ENSG00000187682)
    Fold Change: 1.27
    Ensembl ID: ENSG00000187682
  • Gene Symbol: IAPP (ENSG00000121351)
    Fold Change: 1.27
    Ensembl ID: ENSG00000121351
  • Gene Symbol: FOXE3 (ENSG00000186790)
    Fold Change: 1.27
    Ensembl ID: ENSG00000186790
  • Gene Symbol: ACTA1 (ENSG00000143632)
    Fold Change: 1.27
    Ensembl ID: ENSG00000143632
  • Gene Symbol: ACTN3 (ENSG00000248746)
    Fold Change: 1.27
    Ensembl ID: ENSG00000248746
  • Gene Symbol: ALPG (ENSG00000163286)
    Fold Change: 1.27
    Ensembl ID: ENSG00000163286
  • Gene Symbol: CASQ1 (ENSG00000143318)
    Fold Change: 1.27
    Ensembl ID: ENSG00000143318
  • Gene Symbol: AKR1C4 (ENSG00000198610)
    Fold Change: 1.27
    Ensembl ID: ENSG00000198610
  • Gene Symbol: CRYGB (ENSG00000182187)
    Fold Change: 1.27
    Ensembl ID: ENSG00000182187
  • Gene Symbol: EMX1 (ENSG00000135638)
    Fold Change: 1.27
    Ensembl ID: ENSG00000135638
  • Gene Symbol: F13B (ENSG00000143278)
    Fold Change: 1.27
    Ensembl ID: ENSG00000143278
  • Gene Symbol: FOXI1 (ENSG00000168269)
    Fold Change: 1.27
    Ensembl ID: ENSG00000168269
  • Gene Symbol: GCGR (ENSG00000215644)
    Fold Change: 1.27
    Ensembl ID: ENSG00000215644
  • Gene Symbol: GRM3 (ENSG00000198822)
    Fold Change: 1.27
    Ensembl ID: ENSG00000198822
  • Gene Symbol: GRPR (ENSG00000126010)
    Fold Change: 1.27
    Ensembl ID: ENSG00000126010
  • Gene Symbol: HSD3B1 (ENSG00000203857)
    Fold Change: 1.27
    Ensembl ID: ENSG00000203857
  • Gene Symbol: HSD3B2 (ENSG00000203859)
    Fold Change: 1.27
    Ensembl ID: ENSG00000203859
  • Gene Symbol: HTR1F (ENSG00000179097)
    Fold Change: 1.27
    Ensembl ID: ENSG00000179097
  • Gene Symbol: SERPINC1 (ENSG00000117601)
    Fold Change: 1.27
    Ensembl ID: ENSG00000117601
  • Gene Symbol: BAAT (ENSG00000136881)
    Fold Change: 1.27
    Ensembl ID: ENSG00000136881
  • Gene Symbol: SIGLEC6 (ENSG00000105492)
    Fold Change: 1.27
    Ensembl ID: ENSG00000105492
  • Gene Symbol: CRYBA4 (ENSG00000196431)
    Fold Change: 1.27
    Ensembl ID: ENSG00000196431
  • Gene Symbol: CYP3A7 (ENSG00000160870)
    Fold Change: 1.27
    Ensembl ID: ENSG00000160870
  • Gene Symbol: CYP7A1 (ENSG00000167910)
    Fold Change: 1.27
    Ensembl ID: ENSG00000167910
  • Gene Symbol: DRD5 (ENSG00000169676)
    Fold Change: 1.27
    Ensembl ID: ENSG00000169676
  • Gene Symbol: DSC1 (ENSG00000134765)
    Fold Change: 1.27
    Ensembl ID: ENSG00000134765
  • Gene Symbol: G6PC1 (ENSG00000131482)
    Fold Change: 1.27
    Ensembl ID: ENSG00000131482
  • Gene Symbol: GABRG2 (ENSG00000113327)
    Fold Change: 1.27
    Ensembl ID: ENSG00000113327
  • Gene Symbol: GFAP (ENSG00000131095)
    Fold Change: 1.27
    Ensembl ID: ENSG00000131095
  • Gene Symbol: GHRH (ENSG00000118702)
    Fold Change: 1.27
    Ensembl ID: ENSG00000118702
  • Gene Symbol: GJB5 (ENSG00000189280)
    Fold Change: 1.27
    Ensembl ID: ENSG00000189280
  • Gene Symbol: GPR12 (ENSG00000132975)
    Fold Change: 1.27
    Ensembl ID: ENSG00000132975
  • Gene Symbol: H2AC7 (ENSG00000196866)
    Fold Change: 1.27
    Ensembl ID: ENSG00000196866
  • Gene Symbol: TLX1 (ENSG00000107807)
    Fold Change: 1.27
    Ensembl ID: ENSG00000107807
  • Gene Symbol: ADORA3 (ENSG00000282608)
    Fold Change: 1.27
    Ensembl ID: ENSG00000282608
  • Gene Symbol: ALOX12B (ENSG00000179477)
    Fold Change: 1.27
    Ensembl ID: ENSG00000179477
  • Gene Symbol: CCKBR (ENSG00000110148)
    Fold Change: 1.27
    Ensembl ID: ENSG00000110148
  • Gene Symbol: CEACAM8 (ENSG00000124469)
    Fold Change: 1.27
    Ensembl ID: ENSG00000124469
  • Gene Symbol: CHRNA1 (ENSG00000138435)
    Fold Change: 1.27
    Ensembl ID: ENSG00000138435
  • Gene Symbol: CHRNG (ENSG00000196811)
    Fold Change: 1.27
    Ensembl ID: ENSG00000196811
  • Gene Symbol: CORT (ENSG00000241563)
    Fold Change: 1.27
    Ensembl ID: ENSG00000241563
  • Gene Symbol: CYP2A7 (ENSG00000198077)
    Fold Change: 1.27
    Ensembl ID: ENSG00000198077
  • Gene Symbol: DNASE1L2 (ENSG00000167968)
    Fold Change: 1.27
    Ensembl ID: ENSG00000167968
  • Gene Symbol: DRP2 (ENSG00000102385)
    Fold Change: 1.27
    Ensembl ID: ENSG00000102385
  • Gene Symbol: F2 (ENSG00000180210)
    Fold Change: 1.27
    Ensembl ID: ENSG00000180210
  • Gene Symbol: FCAR (ENSG00000186431)
    Fold Change: 1.27
    Ensembl ID: ENSG00000186431
  • Gene Symbol: MS4A2 (ENSG00000149534)
    Fold Change: 1.27
    Ensembl ID: ENSG00000149534
  • Gene Symbol: VEGFD (ENSG00000165197)
    Fold Change: 1.27
    Ensembl ID: ENSG00000165197
  • Gene Symbol: GALR1 (ENSG00000166573)
    Fold Change: 1.27
    Ensembl ID: ENSG00000166573
  • Gene Symbol: GHRHR (ENSG00000106128)
    Fold Change: 1.27
    Ensembl ID: ENSG00000106128
  • Gene Symbol: GLP1R (ENSG00000112164)
    Fold Change: 1.27
    Ensembl ID: ENSG00000112164
  • Gene Symbol: FFAR3 (ENSG00000185897)
    Fold Change: 1.27
    Ensembl ID: ENSG00000185897
  • Gene Symbol: GPR42 (ENSG00000126251)
    Fold Change: 1.27
    Ensembl ID: ENSG00000126251
  • Gene Symbol: GRM4 (ENSG00000124493)
    Fold Change: 1.27
    Ensembl ID: ENSG00000124493
  • Gene Symbol: CEACAM3 (ENSG00000170956)
    Fold Change: 1.27
    Ensembl ID: ENSG00000170956
  • Gene Symbol: AANAT (ENSG00000129673)
    Fold Change: 1.27
    Ensembl ID: ENSG00000129673
  • Gene Symbol: ADH1A (ENSG00000187758)
    Fold Change: 1.27
    Ensembl ID: ENSG00000187758
  • Gene Symbol: ADRB3 (ENSG00000188778)
    Fold Change: 1.27
    Ensembl ID: ENSG00000188778
  • Gene Symbol: CRISP1 (ENSG00000124812)
    Fold Change: 1.27
    Ensembl ID: ENSG00000124812
  • Gene Symbol: KLK3 (ENSG00000142515)
    Fold Change: 1.27
    Ensembl ID: ENSG00000142515
  • Gene Symbol: ASMT (ENSG00000196433)
    Fold Change: 1.27
    Ensembl ID: ENSG00000196433
  • Gene Symbol: C8A (ENSG00000157131)
    Fold Change: 1.27
    Ensembl ID: ENSG00000157131
  • Gene Symbol: C8B (ENSG00000021852)
    Fold Change: 1.27
    Ensembl ID: ENSG00000021852
  • Gene Symbol: CACNA1F (ENSG00000102001)
    Fold Change: 1.27
    Ensembl ID: ENSG00000102001
  • Gene Symbol: S100G (ENSG00000169906)
    Fold Change: 1.27
    Ensembl ID: ENSG00000169906
  • Gene Symbol: CLPS (ENSG00000137392)
    Fold Change: 1.27
    Ensembl ID: ENSG00000137392
  • Gene Symbol: CCR4 (ENSG00000183813)
    Fold Change: 1.27
    Ensembl ID: ENSG00000183813
  • Gene Symbol: CR2 (ENSG00000117322)
    Fold Change: 1.27
    Ensembl ID: ENSG00000117322
  • Gene Symbol: CRX (ENSG00000105392)
    Fold Change: 1.27
    Ensembl ID: ENSG00000105392

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in intestinal crypt stem cell of small intestine cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in intestinal crypt stem cell of small intestine cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** 1. **Location**: Intestinal crypt stem cells are located at the base of the intestinal crypts in the small intestine, specifically within the Lieberkuhn crypts. 2. **High Proliferation**: These stem cells exhibit high proliferative capacity, allowing them to self-renew and differentiate into transit-amplifying cells. 3. **Gene Expression**: Intestinal crypt stem cells express specific genes, including ACTB, FTL, and FTH1, which are involved in various cellular processes. 4. **Actin Cytoskeleton Organization**: The expression of ACTB is associated with the organization of the actin cytoskeleton, which is essential for cell migration, division, and differentiation. 5. **Iron Homeostasis**: FTL and FTH1 are involved in iron homeostasis, regulating the uptake, transport, and sequestration of iron ions in the gut. 6. **Antigen Presentation**: The expression of B2M is associated with antigen presentation via MHC class I and II molecules, which is essential for the immune system's recognition and response to pathogens. **Clinical Significance** 1. **Gut Barrier Function**: Intestinal crypt stem cells play a crucial role in maintaining the gut barrier function, which is essential for preventing the entry of pathogens and toxins into the bloodstream. 2. **Immune System Regulation**: The intestinal crypt stem cell is involved in regulating the immune system, responding to pathogens and toxins, and maintaining immune homeostasis. 3. **Cancer Development**: Abnormalities in intestinal crypt stem cells have been linked to the development of various cancers, including colorectal cancer. 4. **Gastrointestinal Diseases**: Dysfunction or mutations in intestinal crypt stem cells can contribute to gastrointestinal diseases, such as inflammatory bowel disease (IBD) and celiac disease. 5. **Nutritional Deficiencies**: Impaired iron homeostasis due to mutations in FTL and FTH1 can lead to nutritional deficiencies, including iron deficiency anemia. In conclusion, the intestinal crypt stem cell is a vital component of the small intestine's epithelial lining, playing a crucial role in maintaining the gut barrier function, regulating the immune system, and responding to pathogens and toxins. Understanding the characteristics and clinical significance of intestinal crypt stem cells can provide valuable insights into the development of various gastrointestinal diseases and the importance of maintaining gut health.