Details for: CL0009022

Cell ID: CL0009022

Cell Name: stromal cell of lamina propria of small intestine

Marker Score Threshold: 225
(Derived using integrated single-cell and genomic data)

Description: A stromal cell found in the lamina propria of the small intestine.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 2.8
    Ensembl ID: ENSG00000156508
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 2.8
    Ensembl ID: ENSG00000167996
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.79
    Ensembl ID: ENSG00000166710
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 2.79
    Ensembl ID: ENSG00000087086
  • Gene Symbol: H3 3B (ENSG00000132475)
    Fold Change: 2.76
    Ensembl ID: ENSG00000132475
  • Gene Symbol: COX1 (ENSG00000198804)
    Fold Change: 2.76
    Ensembl ID: ENSG00000198804
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.75
    Ensembl ID: ENSG00000075624
  • Gene Symbol: COX2 (ENSG00000198712)
    Fold Change: 2.74
    Ensembl ID: ENSG00000198712
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 2.73
    Ensembl ID: ENSG00000111640
  • Gene Symbol: ATP6 (ENSG00000198899)
    Fold Change: 2.73
    Ensembl ID: ENSG00000198899
  • Gene Symbol: COX3 (ENSG00000198938)
    Fold Change: 2.72
    Ensembl ID: ENSG00000198938
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 2.72
    Ensembl ID: ENSG00000104529
  • Gene Symbol: FAU (ENSG00000149806)
    Fold Change: 2.72
    Ensembl ID: ENSG00000149806
  • Gene Symbol: ND2 (ENSG00000198763)
    Fold Change: 2.72
    Ensembl ID: ENSG00000198763
  • Gene Symbol: ND1 (ENSG00000198888)
    Fold Change: 2.7
    Ensembl ID: ENSG00000198888
  • Gene Symbol: ND4 (ENSG00000198886)
    Fold Change: 2.7
    Ensembl ID: ENSG00000198886
  • Gene Symbol: CYTB (ENSG00000198727)
    Fold Change: 2.69
    Ensembl ID: ENSG00000198727
  • Gene Symbol: MYL6 (ENSG00000092841)
    Fold Change: 2.69
    Ensembl ID: ENSG00000092841
  • Gene Symbol: ND3 (ENSG00000198840)
    Fold Change: 2.69
    Ensembl ID: ENSG00000198840
  • Gene Symbol: NACA (ENSG00000196531)
    Fold Change: 2.69
    Ensembl ID: ENSG00000196531
  • Gene Symbol: RPSA (ENSG00000168028)
    Fold Change: 2.68
    Ensembl ID: ENSG00000168028
  • Gene Symbol: LGALS1 (ENSG00000100097)
    Fold Change: 2.67
    Ensembl ID: ENSG00000100097
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.66
    Ensembl ID: ENSG00000124172
  • Gene Symbol: COL1A2 (ENSG00000164692)
    Fold Change: 2.65
    Ensembl ID: ENSG00000164692
  • Gene Symbol: HLA B (ENSG00000234745)
    Fold Change: 2.65
    Ensembl ID: ENSG00000234745
  • Gene Symbol: COL3A1 (ENSG00000168542)
    Fold Change: 2.64
    Ensembl ID: ENSG00000168542
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.62
    Ensembl ID: ENSG00000184009
  • Gene Symbol: LUM (ENSG00000139329)
    Fold Change: 2.62
    Ensembl ID: ENSG00000139329
  • Gene Symbol: H3 3A (ENSG00000163041)
    Fold Change: 2.61
    Ensembl ID: ENSG00000163041
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.61
    Ensembl ID: ENSG00000169100
  • Gene Symbol: DCN (ENSG00000011465)
    Fold Change: 2.6
    Ensembl ID: ENSG00000011465
  • Gene Symbol: HLA C (ENSG00000204525)
    Fold Change: 2.6
    Ensembl ID: ENSG00000204525
  • Gene Symbol: HLA A (ENSG00000206503)
    Fold Change: 2.6
    Ensembl ID: ENSG00000206503
  • Gene Symbol: C1S (ENSG00000182326)
    Fold Change: 2.59
    Ensembl ID: ENSG00000182326
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 2.59
    Ensembl ID: ENSG00000167658
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.58
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 2.57
    Ensembl ID: ENSG00000122786
  • Gene Symbol: HMGB1 (ENSG00000189403)
    Fold Change: 2.54
    Ensembl ID: ENSG00000189403
  • Gene Symbol: COL1A1 (ENSG00000108821)
    Fold Change: 2.53
    Ensembl ID: ENSG00000108821
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 2.53
    Ensembl ID: ENSG00000127184
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.52
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ND5 (ENSG00000198786)
    Fold Change: 2.51
    Ensembl ID: ENSG00000198786
  • Gene Symbol: HNRNPA2B1 (ENSG00000122566)
    Fold Change: 2.5
    Ensembl ID: ENSG00000122566
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.49
    Ensembl ID: ENSG00000131143
  • Gene Symbol: FOS (ENSG00000170345)
    Fold Change: 2.49
    Ensembl ID: ENSG00000170345
  • Gene Symbol: MMP2 (ENSG00000087245)
    Fold Change: 2.49
    Ensembl ID: ENSG00000087245
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 2.49
    Ensembl ID: ENSG00000114942
  • Gene Symbol: HNRNPA1 (ENSG00000135486)
    Fold Change: 2.49
    Ensembl ID: ENSG00000135486
  • Gene Symbol: JUNB (ENSG00000171223)
    Fold Change: 2.48
    Ensembl ID: ENSG00000171223
  • Gene Symbol: IGFBP4 (ENSG00000141753)
    Fold Change: 2.46
    Ensembl ID: ENSG00000141753
  • Gene Symbol: JUN (ENSG00000177606)
    Fold Change: 2.46
    Ensembl ID: ENSG00000177606
  • Gene Symbol: NDUFA4 (ENSG00000189043)
    Fold Change: 2.46
    Ensembl ID: ENSG00000189043
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.45
    Ensembl ID: ENSG00000135390
  • Gene Symbol: COL6A2 (ENSG00000142173)
    Fold Change: 2.45
    Ensembl ID: ENSG00000142173
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 2.45
    Ensembl ID: ENSG00000108654
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.45
    Ensembl ID: ENSG00000172757
  • Gene Symbol: IGFBP7 (ENSG00000163453)
    Fold Change: 2.43
    Ensembl ID: ENSG00000163453
  • Gene Symbol: HINT1 (ENSG00000169567)
    Fold Change: 2.41
    Ensembl ID: ENSG00000169567
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 2.38
    Ensembl ID: ENSG00000101439
  • Gene Symbol: MIF (ENSG00000240972)
    Fold Change: 2.38
    Ensembl ID: ENSG00000240972
  • Gene Symbol: GUK1 (ENSG00000143774)
    Fold Change: 2.36
    Ensembl ID: ENSG00000143774
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.35
    Ensembl ID: ENSG00000143933
  • Gene Symbol: GPX4 (ENSG00000167468)
    Fold Change: 2.33
    Ensembl ID: ENSG00000167468
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 2.33
    Ensembl ID: ENSG00000126267
  • Gene Symbol: LY6E (ENSG00000160932)
    Fold Change: 2.33
    Ensembl ID: ENSG00000160932
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.32
    Ensembl ID: ENSG00000185650
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 2.32
    Ensembl ID: ENSG00000130303
  • Gene Symbol: HSP90AA1 (ENSG00000080824)
    Fold Change: 2.32
    Ensembl ID: ENSG00000080824
  • Gene Symbol: IGFBP5 (ENSG00000115461)
    Fold Change: 2.31
    Ensembl ID: ENSG00000115461
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.31
    Ensembl ID: ENSG00000099622
  • Gene Symbol: DUSP1 (ENSG00000120129)
    Fold Change: 2.31
    Ensembl ID: ENSG00000120129
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 2.3
    Ensembl ID: ENSG00000112695
  • Gene Symbol: LDHA (ENSG00000134333)
    Fold Change: 2.3
    Ensembl ID: ENSG00000134333
  • Gene Symbol: COL6A1 (ENSG00000142156)
    Fold Change: 2.29
    Ensembl ID: ENSG00000142156
  • Gene Symbol: COL6A3 (ENSG00000163359)
    Fold Change: 2.28
    Ensembl ID: ENSG00000163359
  • Gene Symbol: HSP90AB1 (ENSG00000096384)
    Fold Change: 2.28
    Ensembl ID: ENSG00000096384
  • Gene Symbol: NAP1L1 (ENSG00000187109)
    Fold Change: 2.25
    Ensembl ID: ENSG00000187109
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.25
    Ensembl ID: ENSG00000169020
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.25
    Ensembl ID: ENSG00000134825
  • Gene Symbol: BGN (ENSG00000182492)
    Fold Change: 2.23
    Ensembl ID: ENSG00000182492
  • Gene Symbol: CTSK (ENSG00000143387)
    Fold Change: 2.23
    Ensembl ID: ENSG00000143387
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 2.22
    Ensembl ID: ENSG00000164919
  • Gene Symbol: EIF3E (ENSG00000104408)
    Fold Change: 2.21
    Ensembl ID: ENSG00000104408
  • Gene Symbol: CYBA (ENSG00000051523)
    Fold Change: 2.21
    Ensembl ID: ENSG00000051523
  • Gene Symbol: C1R (ENSG00000159403)
    Fold Change: 2.2
    Ensembl ID: ENSG00000159403
  • Gene Symbol: GSTP1 (ENSG00000084207)
    Fold Change: 2.2
    Ensembl ID: ENSG00000084207
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 2.2
    Ensembl ID: ENSG00000213719
  • Gene Symbol: HLA E (ENSG00000204592)
    Fold Change: 2.2
    Ensembl ID: ENSG00000204592
  • Gene Symbol: NDUFS5 (ENSG00000168653)
    Fold Change: 2.2
    Ensembl ID: ENSG00000168653
  • Gene Symbol: HMGN1 (ENSG00000205581)
    Fold Change: 2.19
    Ensembl ID: ENSG00000205581
  • Gene Symbol: HSPB1 (ENSG00000106211)
    Fold Change: 2.18
    Ensembl ID: ENSG00000106211
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.17
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.16
    Ensembl ID: ENSG00000019582
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.15
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CTSB (ENSG00000164733)
    Fold Change: 2.14
    Ensembl ID: ENSG00000164733
  • Gene Symbol: MT2A (ENSG00000125148)
    Fold Change: 2.13
    Ensembl ID: ENSG00000125148
  • Gene Symbol: FKBP1A (ENSG00000088832)
    Fold Change: 2.12
    Ensembl ID: ENSG00000088832
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.11
    Ensembl ID: ENSG00000067560
  • Gene Symbol: COL12A1 (ENSG00000111799)
    Fold Change: 2.11
    Ensembl ID: ENSG00000111799
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 2.1
    Ensembl ID: ENSG00000177556

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in stromal cell of lamina propria of small intestine cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in stromal cell of lamina propria of small intestine cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** 1. **Stromal Cell**: The cell is a stromal cell found in the lamina propria of the small intestine. 2. **EEF1A1 Gene**: The EEF1A1 gene is involved in protein synthesis and is part of the autophagy pathway. 3. **FTH1 Gene**: The FTH1 gene is involved in iron ion homeostasis and is part of the ferritin complex. 4. **B2M Gene**: The B2M gene is involved in antigen presentation and is part of the major histocompatibility complex (MHC) class I. 5. **FTL Gene**: The FTL gene is involved in iron ion homeostasis and is part of the ferritin complex. 6. **Autophagy Pathway**: The cell is involved in autophagy, a process in which cells recycle damaged or dysfunctional components. 7. **Immune System Regulation**: The cell plays a role in regulating the immune system, including antigen presentation and immune response modulation. 8. **Iron Ion Homeostasis**: The cell is involved in maintaining iron ion homeostasis, which is essential for various cellular processes. **Clinical Significance** 1. **Intestinal Health**: The stromal cell plays a crucial role in maintaining the integrity of the intestinal epithelium, which is essential for proper nutrient absorption and immune system function. 2. **Immune System Disorders**: Dysregulation of the stromal cell's function can lead to immune system disorders, such as inflammatory bowel disease (IBD) and autoimmune diseases. 3. **Iron Deficiency**: Iron ion homeostasis is essential for various cellular processes, including DNA synthesis and cell signaling. Dysregulation of iron ion homeostasis can lead to iron deficiency, which can cause anemia and other health problems. 4. **Cancer**: The stromal cell's function can be altered in cancer, leading to changes in immune system regulation and iron ion homeostasis. 5. **Infectious Diseases**: The stromal cell's function can be altered in response to infectious diseases, leading to changes in immune system regulation and iron ion homeostasis. In conclusion, the stromal cell of the lamina propria of the small intestine is a complex cell type that plays a crucial role in maintaining intestinal health and regulating the immune system. Dysregulation of its function can lead to various health problems, including immune system disorders, iron deficiency, and cancer.