Details for: CL0010012

Cell ID: CL0010012

Cell Name: cerebral cortex neuron

Marker Score Threshold: 2853
(Derived using integrated single-cell and genomic data)

Description: A CNS neuron of the cerebral cortex.

Synonyms: cortical neuron, neuron of cerebral cortex

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 3.18
    Ensembl ID: ENSG00000135298
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 3.12
    Ensembl ID: ENSG00000151150
  • Gene Symbol: CACNA1C (ENSG00000151067)
    Fold Change: 3.07
    Ensembl ID: ENSG00000151067
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 3.07
    Ensembl ID: ENSG00000145362
  • Gene Symbol: CACNB2 (ENSG00000165995)
    Fold Change: 2.98
    Ensembl ID: ENSG00000165995
  • Gene Symbol: CACNA1E (ENSG00000198216)
    Fold Change: 2.96
    Ensembl ID: ENSG00000198216
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 2.89
    Ensembl ID: ENSG00000153956
  • Gene Symbol: CACNA1B (ENSG00000148408)
    Fold Change: 2.86
    Ensembl ID: ENSG00000148408
  • Gene Symbol: ADRA1A (ENSG00000120907)
    Fold Change: 2.85
    Ensembl ID: ENSG00000120907
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 2.82
    Ensembl ID: ENSG00000151914
  • Gene Symbol: CDH8 (ENSG00000150394)
    Fold Change: 2.71
    Ensembl ID: ENSG00000150394
  • Gene Symbol: CDH18 (ENSG00000145526)
    Fold Change: 2.61
    Ensembl ID: ENSG00000145526
  • Gene Symbol: CAMK2B (ENSG00000058404)
    Fold Change: 2.61
    Ensembl ID: ENSG00000058404
  • Gene Symbol: CAMK2A (ENSG00000070808)
    Fold Change: 2.56
    Ensembl ID: ENSG00000070808
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.5
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CDH9 (ENSG00000113100)
    Fold Change: 2.48
    Ensembl ID: ENSG00000113100
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.47
    Ensembl ID: ENSG00000142192
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 2.47
    Ensembl ID: ENSG00000168675
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 2.45
    Ensembl ID: ENSG00000070961
  • Gene Symbol: CACNA1D (ENSG00000157388)
    Fold Change: 2.38
    Ensembl ID: ENSG00000157388
  • Gene Symbol: ASIC2 (ENSG00000108684)
    Fold Change: 2.36
    Ensembl ID: ENSG00000108684
  • Gene Symbol: MPPED2 (ENSG00000066382)
    Fold Change: 2.3
    Ensembl ID: ENSG00000066382
  • Gene Symbol: ASTN1 (ENSG00000152092)
    Fold Change: 2.3
    Ensembl ID: ENSG00000152092
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 2.24
    Ensembl ID: ENSG00000162104
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 2.23
    Ensembl ID: ENSG00000107282
  • Gene Symbol: CACNA1A (ENSG00000141837)
    Fold Change: 2.22
    Ensembl ID: ENSG00000141837
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 2.16
    Ensembl ID: ENSG00000157764
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 2.16
    Ensembl ID: ENSG00000278540
  • Gene Symbol: CDH13 (ENSG00000140945)
    Fold Change: 2.15
    Ensembl ID: ENSG00000140945
  • Gene Symbol: CDH2 (ENSG00000170558)
    Fold Change: 2.13
    Ensembl ID: ENSG00000170558
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 2.12
    Ensembl ID: ENSG00000198589
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 2.12
    Ensembl ID: ENSG00000151746
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.08
    Ensembl ID: ENSG00000198668
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 2.07
    Ensembl ID: ENSG00000100077
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 2.06
    Ensembl ID: ENSG00000143153
  • Gene Symbol: BDNF (ENSG00000176697)
    Fold Change: 2.02
    Ensembl ID: ENSG00000176697
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 2.02
    Ensembl ID: ENSG00000148700
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 1.99
    Ensembl ID: ENSG00000078053
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 1.94
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.89
    Ensembl ID: ENSG00000170634
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.89
    Ensembl ID: ENSG00000134480
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.86
    Ensembl ID: ENSG00000156110
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.82
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ADARB1 (ENSG00000197381)
    Fold Change: 1.8
    Ensembl ID: ENSG00000197381
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.76
    Ensembl ID: ENSG00000170017
  • Gene Symbol: APBA2 (ENSG00000034053)
    Fold Change: 1.7
    Ensembl ID: ENSG00000034053
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.7
    Ensembl ID: ENSG00000143322
  • Gene Symbol: ATP2B2 (ENSG00000157087)
    Fold Change: 1.68
    Ensembl ID: ENSG00000157087
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.68
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ACVR1 (ENSG00000115170)
    Fold Change: 1.65
    Ensembl ID: ENSG00000115170
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.62
    Ensembl ID: ENSG00000033627
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.59
    Ensembl ID: ENSG00000159842
  • Gene Symbol: CDH12 (ENSG00000154162)
    Fold Change: 1.58
    Ensembl ID: ENSG00000154162
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 1.58
    Ensembl ID: ENSG00000148090
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.58
    Ensembl ID: ENSG00000053254
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.55
    Ensembl ID: ENSG00000134982
  • Gene Symbol: CDH11 (ENSG00000140937)
    Fold Change: 1.53
    Ensembl ID: ENSG00000140937
  • Gene Symbol: CDC27 (ENSG00000004897)
    Fold Change: 1.53
    Ensembl ID: ENSG00000004897
  • Gene Symbol: CDH10 (ENSG00000040731)
    Fold Change: 1.51
    Ensembl ID: ENSG00000040731
  • Gene Symbol: CDK8 (ENSG00000132964)
    Fold Change: 1.48
    Ensembl ID: ENSG00000132964
  • Gene Symbol: ADD2 (ENSG00000075340)
    Fold Change: 1.46
    Ensembl ID: ENSG00000075340
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 1.46
    Ensembl ID: ENSG00000107779
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: 1.45
    Ensembl ID: ENSG00000164742
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.44
    Ensembl ID: ENSG00000122545
  • Gene Symbol: CAMK4 (ENSG00000152495)
    Fold Change: 1.44
    Ensembl ID: ENSG00000152495
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.43
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.37
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ADRA1B (ENSG00000170214)
    Fold Change: 1.37
    Ensembl ID: ENSG00000170214
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.37
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.34
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 1.32
    Ensembl ID: ENSG00000114573
  • Gene Symbol: ACVR2A (ENSG00000121989)
    Fold Change: 1.32
    Ensembl ID: ENSG00000121989
  • Gene Symbol: BCR (ENSG00000186716)
    Fold Change: 1.29
    Ensembl ID: ENSG00000186716
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.29
    Ensembl ID: ENSG00000198363
  • Gene Symbol: CDH4 (ENSG00000179242)
    Fold Change: 1.29
    Ensembl ID: ENSG00000179242
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.28
    Ensembl ID: ENSG00000136717
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.27
    Ensembl ID: ENSG00000006125
  • Gene Symbol: CDR2 (ENSG00000140743)
    Fold Change: 1.27
    Ensembl ID: ENSG00000140743
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.27
    Ensembl ID: ENSG00000058668
  • Gene Symbol: ATR (ENSG00000175054)
    Fold Change: 1.23
    Ensembl ID: ENSG00000175054
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.22
    Ensembl ID: ENSG00000087274
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.21
    Ensembl ID: ENSG00000196776
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 1.19
    Ensembl ID: ENSG00000083123
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.18
    Ensembl ID: ENSG00000097007
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.16
    Ensembl ID: ENSG00000174437
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.16
    Ensembl ID: ENSG00000145349
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: 1.13
    Ensembl ID: ENSG00000078295
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 1.13
    Ensembl ID: ENSG00000072210
  • Gene Symbol: RUNX1T1 (ENSG00000079102)
    Fold Change: 1.12
    Ensembl ID: ENSG00000079102
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.11
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.11
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ABCA3 (ENSG00000167972)
    Fold Change: 1.11
    Ensembl ID: ENSG00000167972
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.11
    Ensembl ID: ENSG00000173575
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.07
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ADGRB2 (ENSG00000121753)
    Fold Change: 1.05
    Ensembl ID: ENSG00000121753
  • Gene Symbol: BBS2 (ENSG00000125124)
    Fold Change: 1.03
    Ensembl ID: ENSG00000125124
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.03
    Ensembl ID: ENSG00000183020
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.02
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.01
    Ensembl ID: ENSG00000122786
  • Gene Symbol: CDK6 (ENSG00000105810)
    Fold Change: 1
    Ensembl ID: ENSG00000105810
Hovered Details

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Hovered Details

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**Key Characteristics** * **Gene Symbol:** ADGRB3 (ADGRL3) * **Ensembl ID:** ENSG00000135298 * **Pathways/Ontology:** Adenylate cyclase-activating g protein-coupled receptor signaling pathway, Cell surface receptor signaling pathway, Cerebellar climbing fiber to purkinje cell synapse, G protein-coupled receptor activity, G protein-coupled receptor signaling pathway, Gtpase activator activity, Maintenance of synapse structure, Membrane, Motor learning, Myoblast fusion, Negative regulation of angiogenesis, Neuron remodeling, Plasma membrane, Positive regulation of synapse assembly, Postsynapse, Postsynaptic density membrane, Protein binding, Regulation of dendrite morphogenesis, Regulation of synapse maturation, Regulation of synapse pruning, Synaptic cleft * **Cellular Location:** Plasma membrane, postsynaptic density * **Function:** Regulates synaptic transmission, neuronal development, and synaptic plasticity * **Synonyms:** Cortical neuron, Neuron of cerebral cortex **Clinical Significance** * **Neurological Disorders:** Dysregulation of the cerebral cortex neuron has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. * **Cognitive Functions:** The cerebral cortex neuron plays a critical role in regulating various cognitive functions, including attention, memory, and decision-making. Dysfunction of this neuron has been linked to cognitive impairments in individuals with neurological disorders. * **Neuroplasticity:** The cerebral cortex neuron is involved in synaptic plasticity, the ability of neurons to reorganize and adapt in response to experience and learning. Dysregulation of this process has been linked to various neurological disorders. * **Therapeutic Targets:** Understanding the function and regulation of the cerebral cortex neuron has led to the development of therapeutic targets for the treatment of neurological disorders, including medications that modulate synaptic transmission and neuronal development. **Genetic Association** * **ANK3:** Variants in the ANK3 gene have been associated with schizophrenia and other neurological disorders. * **CACNA1C:** Variants in the CACNA1C gene have been associated with schizophrenia, bipolar disorder, and other neurological disorders. * **CACNB2:** Variants in the CACNB2 gene have been associated with schizophrenia and other neurological disorders. In conclusion, the cerebral cortex neuron is a critical component of the brain's neural circuitry, playing a key role in regulating various cognitive functions and synaptic transmission. Dysregulation of this neuron has been implicated in various neurological disorders, and understanding its function and regulation has led to the development of therapeutic targets for the treatment of these disorders.