Details for: CL0011005

Cell ID: CL0011005

Cell Name: GABAergic interneuron

Marker Score Threshold: 385
(Derived using integrated single-cell and genomic data)

Description: An interneuron that uses GABA as a vesicular neurotransmitter. These interneurons are inhibitory

Synonyms: GABAergic inhibitory interneuron

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ADARB2 (ENSG00000185736)
    Fold Change: 2.99
    Ensembl ID: ENSG00000185736
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 2.93
    Ensembl ID: ENSG00000145362
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.9
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 2.85
    Ensembl ID: ENSG00000151150
  • Gene Symbol: CACNA1C (ENSG00000151067)
    Fold Change: 2.69
    Ensembl ID: ENSG00000151067
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 2.68
    Ensembl ID: ENSG00000140836
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 2.58
    Ensembl ID: ENSG00000168675
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 2.54
    Ensembl ID: ENSG00000151914
  • Gene Symbol: CACNA1E (ENSG00000198216)
    Fold Change: 2.45
    Ensembl ID: ENSG00000198216
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.44
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CACNB2 (ENSG00000165995)
    Fold Change: 2.32
    Ensembl ID: ENSG00000165995
  • Gene Symbol: CDH2 (ENSG00000170558)
    Fold Change: 2.29
    Ensembl ID: ENSG00000170558
  • Gene Symbol: RUNX1T1 (ENSG00000079102)
    Fold Change: 2.25
    Ensembl ID: ENSG00000079102
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 2.24
    Ensembl ID: ENSG00000151746
  • Gene Symbol: CACNA1B (ENSG00000148408)
    Fold Change: 2.18
    Ensembl ID: ENSG00000148408
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.13
    Ensembl ID: ENSG00000075624
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.11
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: 2.11
    Ensembl ID: ENSG00000164742
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: 2.11
    Ensembl ID: ENSG00000078295
  • Gene Symbol: ASTN1 (ENSG00000152092)
    Fold Change: 2.02
    Ensembl ID: ENSG00000152092
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 2
    Ensembl ID: ENSG00000204217
  • Gene Symbol: CDH8 (ENSG00000150394)
    Fold Change: 2
    Ensembl ID: ENSG00000150394
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 1.99
    Ensembl ID: ENSG00000107282
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.96
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CACNA1A (ENSG00000141837)
    Fold Change: 1.94
    Ensembl ID: ENSG00000141837
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 1.88
    Ensembl ID: ENSG00000278540
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.85
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.82
    Ensembl ID: ENSG00000085224
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.78
    Ensembl ID: ENSG00000134982
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.76
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.76
    Ensembl ID: ENSG00000135404
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 1.73
    Ensembl ID: ENSG00000163697
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 1.69
    Ensembl ID: ENSG00000153956
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.69
    Ensembl ID: ENSG00000152518
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.64
    Ensembl ID: ENSG00000067560
  • Gene Symbol: KIF1A (ENSG00000130294)
    Fold Change: 1.61
    Ensembl ID: ENSG00000130294
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.59
    Ensembl ID: ENSG00000145349
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.58
    Ensembl ID: ENSG00000005022
  • Gene Symbol: APBA2 (ENSG00000034053)
    Fold Change: 1.57
    Ensembl ID: ENSG00000034053
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.56
    Ensembl ID: ENSG00000156110
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 1.54
    Ensembl ID: ENSG00000114423
  • Gene Symbol: CAMK4 (ENSG00000152495)
    Fold Change: 1.54
    Ensembl ID: ENSG00000152495
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.53
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.51
    Ensembl ID: ENSG00000019582
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.5
    Ensembl ID: ENSG00000134825
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.48
    Ensembl ID: ENSG00000157764
  • Gene Symbol: CACNB4 (ENSG00000182389)
    Fold Change: 1.47
    Ensembl ID: ENSG00000182389
  • Gene Symbol: ADD2 (ENSG00000075340)
    Fold Change: 1.45
    Ensembl ID: ENSG00000075340
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.45
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ASIC2 (ENSG00000108684)
    Fold Change: 1.45
    Ensembl ID: ENSG00000108684
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.43
    Ensembl ID: ENSG00000058668
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.43
    Ensembl ID: ENSG00000070831
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.42
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CACNA1D (ENSG00000157388)
    Fold Change: 1.41
    Ensembl ID: ENSG00000157388
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.4
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.38
    Ensembl ID: ENSG00000143761
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.38
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP1A3 (ENSG00000105409)
    Fold Change: 1.35
    Ensembl ID: ENSG00000105409
  • Gene Symbol: ATP2B2 (ENSG00000157087)
    Fold Change: 1.33
    Ensembl ID: ENSG00000157087
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 1.3
    Ensembl ID: ENSG00000148090
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.28
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.26
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.26
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.26
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.26
    Ensembl ID: ENSG00000159842
  • Gene Symbol: ANK1 (ENSG00000029534)
    Fold Change: 1.25
    Ensembl ID: ENSG00000029534
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 1.23
    Ensembl ID: ENSG00000198589
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.22
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.21
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.2
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.19
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.18
    Ensembl ID: ENSG00000170017
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 1.18
    Ensembl ID: ENSG00000107779
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.17
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.17
    Ensembl ID: ENSG00000033627
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.17
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CAMK2B (ENSG00000058404)
    Fold Change: 1.17
    Ensembl ID: ENSG00000058404
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.16
    Ensembl ID: ENSG00000087274
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.16
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ACVR2A (ENSG00000121989)
    Fold Change: 1.16
    Ensembl ID: ENSG00000121989
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.16
    Ensembl ID: ENSG00000162104
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 1.15
    Ensembl ID: ENSG00000078053
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.14
    Ensembl ID: ENSG00000141522
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.1
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ADCY5 (ENSG00000173175)
    Fold Change: 1.09
    Ensembl ID: ENSG00000173175
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.09
    Ensembl ID: ENSG00000108561
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 1.08
    Ensembl ID: ENSG00000083123
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.07
    Ensembl ID: ENSG00000165527
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.07
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ARRB1 (ENSG00000137486)
    Fold Change: 1.06
    Ensembl ID: ENSG00000137486
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.04
    Ensembl ID: ENSG00000168374
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.04
    Ensembl ID: ENSG00000156273
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.04
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.03
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CA8 (ENSG00000178538)
    Fold Change: 1.02
    Ensembl ID: ENSG00000178538
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.02
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ADARB1 (ENSG00000197381)
    Fold Change: 1.01
    Ensembl ID: ENSG00000197381
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.01
    Ensembl ID: ENSG00000149925
  • Gene Symbol: MPPED2 (ENSG00000066382)
    Fold Change: 1
    Ensembl ID: ENSG00000066382
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: N/A
    Ensembl ID: ENSG00000097007
Hovered Details

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Hovered Details

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**Key Characteristics** * **Inhibitory neurotransmitter:** GABAergic interneurons use GABA as their primary neurotransmitter, which inhibits neuronal activity and synaptic transmission. * **Synaptic regulation:** These interneurons regulate synaptic transmission and neuronal activity within the brain, playing a crucial role in maintaining neural homeostasis. * **Gene expression:** The cell's gene symbol ADARB2 is involved in regulating gene expression, particularly in the context of synaptic transmission and neuronal activity. * **Protein localization:** The cell's gene symbol ANK2 is involved in regulating protein localization, including the targeting of proteins to specific cellular compartments and the regulation of protein stability. * **Cellular processes:** The cell is involved in various cellular processes, including adenosine deaminase activity, adenosine to inosine editing, and metal ion binding. **Clinical Significance** * **Neurological disorders:** GABAergic interneurons play a crucial role in regulating neuronal activity and synaptic transmission, and dysfunction in these cells has been implicated in various neurological disorders, including epilepsy, anxiety, and depression. * **Neurodevelopmental disorders:** The cell's involvement in synaptic transmission and neuronal activity makes it an important target for understanding neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. * **Neurological diseases:** The cell's role in regulating protein localization and gene expression makes it an important target for understanding the pathogenesis of various neurological diseases, including Alzheimer's disease and Parkinson's disease. * **Therapeutic applications:** Understanding the cell's role in regulating neuronal activity and synaptic transmission has led to the development of various therapeutic applications, including the use of GABAergic interneurons as targets for gene therapy and the development of novel pharmacological agents that target these cells. In conclusion, the cell ID CL0011005 corresponds to a GABAergic interneuron, a type of inhibitory interneuron that plays a crucial role in regulating neuronal activity and synaptic transmission within the brain. The cell's gene symbol ADARB2 and gene symbol ANK2 are involved in regulating gene expression and protein localization, respectively, and its pathways and ontologies include various cellular processes, including adenosine deaminase activity, adenosine to inosine editing, and metal ion binding. The cell's clinical significance is evident in its role in regulating neuronal activity and synaptic transmission, and its dysfunction has been implicated in various neurological disorders.