Details for: CL0011026

Cell ID: CL0011026

Cell Name: progenitor cell

Marker Score Threshold: 6,444
(Derived using integrated single-cell and genomic data)

Description: A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: SERPINB7 (ENSG00000166396)
    Fold Change: 8.24
    Ensembl ID: ENSG00000166396
  • Gene Symbol: TRBV22 1 (ENSG00000240578)
    Fold Change: 8.24
    Ensembl ID: ENSG00000240578
  • Gene Symbol: KCNQ1DN (ENSG00000237941)
    Fold Change: 8.24
    Ensembl ID: ENSG00000237941
  • Gene Symbol: CDRT15 (ENSG00000223510)
    Fold Change: 8.24
    Ensembl ID: ENSG00000223510
  • Gene Symbol: TRBV26OR9 2 (ENSG00000231165)
    Fold Change: 8.24
    Ensembl ID: ENSG00000231165
  • Gene Symbol: PCGEM1 (ENSG00000227418)
    Fold Change: 8.24
    Ensembl ID: ENSG00000227418
  • Gene Symbol: TRBV12 1 (ENSG00000244661)
    Fold Change: 8.24
    Ensembl ID: ENSG00000244661
  • Gene Symbol: OR13C3 (ENSG00000204246)
    Fold Change: 8.24
    Ensembl ID: ENSG00000204246
  • Gene Symbol: PRPS1L1 (ENSG00000229937)
    Fold Change: 8.24
    Ensembl ID: ENSG00000229937
  • Gene Symbol: PYDC2 (ENSG00000253548)
    Fold Change: 8.24
    Ensembl ID: ENSG00000253548
  • Gene Symbol: OR7E24 (ENSG00000237521)
    Fold Change: 8.24
    Ensembl ID: ENSG00000237521
  • Gene Symbol: FAM170B (ENSG00000172538)
    Fold Change: 8.24
    Ensembl ID: ENSG00000172538
  • Gene Symbol: ACTL7A (ENSG00000187003)
    Fold Change: 8.24
    Ensembl ID: ENSG00000187003
  • Gene Symbol: OR2L5 (ENSG00000197454)
    Fold Change: 8.24
    Ensembl ID: ENSG00000197454
  • Gene Symbol: OR2D3 (ENSG00000178358)
    Fold Change: 8.24
    Ensembl ID: ENSG00000178358
  • Gene Symbol: IGLC5 (ENSG00000254030)
    Fold Change: 8.24
    Ensembl ID: ENSG00000254030
  • Gene Symbol: TAS2R7 (ENSG00000121377)
    Fold Change: 8.24
    Ensembl ID: ENSG00000121377
  • Gene Symbol: H2BC1 (ENSG00000146047)
    Fold Change: 8.24
    Ensembl ID: ENSG00000146047
  • Gene Symbol: TSHB (ENSG00000134200)
    Fold Change: 8.24
    Ensembl ID: ENSG00000134200
  • Gene Symbol: IGLV1 41 (ENSG00000253818)
    Fold Change: 8.24
    Ensembl ID: ENSG00000253818
  • Gene Symbol: MAGEB2 (ENSG00000099399)
    Fold Change: 8.24
    Ensembl ID: ENSG00000099399
  • Gene Symbol: CST8 (ENSG00000125815)
    Fold Change: 8.24
    Ensembl ID: ENSG00000125815
  • Gene Symbol: TPD52L3 (ENSG00000170777)
    Fold Change: 8.24
    Ensembl ID: ENSG00000170777
  • Gene Symbol: LINC00161 (ENSG00000226935)
    Fold Change: 8.24
    Ensembl ID: ENSG00000226935
  • Gene Symbol: OR5B21 (ENSG00000198283)
    Fold Change: 8.24
    Ensembl ID: ENSG00000198283
  • Gene Symbol: TUBA3C (ENSG00000198033)
    Fold Change: 8.24
    Ensembl ID: ENSG00000198033
  • Gene Symbol: GJA8 (ENSG00000121634)
    Fold Change: 8.24
    Ensembl ID: ENSG00000121634
  • Gene Symbol: MC4R (ENSG00000166603)
    Fold Change: 8.24
    Ensembl ID: ENSG00000166603
  • Gene Symbol: LINC02914 (ENSG00000176605)
    Fold Change: 8.24
    Ensembl ID: ENSG00000176605
  • Gene Symbol: KRT25 (ENSG00000204897)
    Fold Change: 8.24
    Ensembl ID: ENSG00000204897
  • Gene Symbol: AMELX (ENSG00000125363)
    Fold Change: 8.24
    Ensembl ID: ENSG00000125363
  • Gene Symbol: AMELY (ENSG00000099721)
    Fold Change: 8.24
    Ensembl ID: ENSG00000099721
  • Gene Symbol: SPATS1 (ENSG00000249481)
    Fold Change: 8.24
    Ensembl ID: ENSG00000249481
  • Gene Symbol: CYP2A13 (ENSG00000197838)
    Fold Change: 8.24
    Ensembl ID: ENSG00000197838
  • Gene Symbol: IGLV4 60 (ENSG00000211639)
    Fold Change: 8.24
    Ensembl ID: ENSG00000211639
  • Gene Symbol: ASCL3 (ENSG00000176009)
    Fold Change: 8.24
    Ensembl ID: ENSG00000176009
  • Gene Symbol: SPO11 (ENSG00000054796)
    Fold Change: 8.24
    Ensembl ID: ENSG00000054796
  • Gene Symbol: OR2T12 (ENSG00000177201)
    Fold Change: 8.24
    Ensembl ID: ENSG00000177201
  • Gene Symbol: IGHV1 69 (ENSG00000211973)
    Fold Change: 8.24
    Ensembl ID: ENSG00000211973
  • Gene Symbol: ADAM7 (ENSG00000069206)
    Fold Change: 8.23
    Ensembl ID: ENSG00000069206
  • Gene Symbol: POTEH (ENSG00000198062)
    Fold Change: 8.23
    Ensembl ID: ENSG00000198062
  • Gene Symbol: BPIFB4 (ENSG00000186191)
    Fold Change: 8.23
    Ensembl ID: ENSG00000186191
  • Gene Symbol: SPINK13 (ENSG00000214510)
    Fold Change: 8.23
    Ensembl ID: ENSG00000214510
  • Gene Symbol: DNAJB8 (ENSG00000179407)
    Fold Change: 8.23
    Ensembl ID: ENSG00000179407
  • Gene Symbol: ADH7 (ENSG00000196344)
    Fold Change: 8.23
    Ensembl ID: ENSG00000196344
  • Gene Symbol: TEKTL1 (ENSG00000160994)
    Fold Change: 8.23
    Ensembl ID: ENSG00000160994
  • Gene Symbol: KRT16 (ENSG00000186832)
    Fold Change: 8.23
    Ensembl ID: ENSG00000186832
  • Gene Symbol: NUTM2F (ENSG00000130950)
    Fold Change: 8.23
    Ensembl ID: ENSG00000130950
  • Gene Symbol: SPATA19 (ENSG00000166118)
    Fold Change: 8.23
    Ensembl ID: ENSG00000166118
  • Gene Symbol: IFNA2 (ENSG00000188379)
    Fold Change: 8.23
    Ensembl ID: ENSG00000188379
  • Gene Symbol: MAGEB3 (ENSG00000198798)
    Fold Change: 8.23
    Ensembl ID: ENSG00000198798
  • Gene Symbol: ELOA2 (ENSG00000206181)
    Fold Change: 8.23
    Ensembl ID: ENSG00000206181
  • Gene Symbol: BTG4 (ENSG00000137707)
    Fold Change: 8.23
    Ensembl ID: ENSG00000137707
  • Gene Symbol: CYLC2 (ENSG00000155833)
    Fold Change: 8.23
    Ensembl ID: ENSG00000155833
  • Gene Symbol: DAZL (ENSG00000092345)
    Fold Change: 8.23
    Ensembl ID: ENSG00000092345
  • Gene Symbol: RDH8 (ENSG00000080511)
    Fold Change: 8.23
    Ensembl ID: ENSG00000080511
  • Gene Symbol: SPACA7 (ENSG00000153498)
    Fold Change: 8.23
    Ensembl ID: ENSG00000153498
  • Gene Symbol: OR8G5 (ENSG00000255298)
    Fold Change: 8.23
    Ensembl ID: ENSG00000255298
  • Gene Symbol: BRS3 (ENSG00000102239)
    Fold Change: 8.23
    Ensembl ID: ENSG00000102239
  • Gene Symbol: HTR3D (ENSG00000186090)
    Fold Change: 8.23
    Ensembl ID: ENSG00000186090
  • Gene Symbol: SSTR5 (ENSG00000162009)
    Fold Change: 8.23
    Ensembl ID: ENSG00000162009
  • Gene Symbol: KLK5 (ENSG00000167754)
    Fold Change: 8.23
    Ensembl ID: ENSG00000167754
  • Gene Symbol: GABRR3 (ENSG00000183185)
    Fold Change: 8.23
    Ensembl ID: ENSG00000183185
  • Gene Symbol: CACNA1S (ENSG00000081248)
    Fold Change: 8.23
    Ensembl ID: ENSG00000081248
  • Gene Symbol: SAGE1 (ENSG00000181433)
    Fold Change: 8.23
    Ensembl ID: ENSG00000181433
  • Gene Symbol: LINC00305 (ENSG00000179676)
    Fold Change: 8.23
    Ensembl ID: ENSG00000179676
  • Gene Symbol: IFNA13 (ENSG00000233816)
    Fold Change: 8.23
    Ensembl ID: ENSG00000233816
  • Gene Symbol: LINC01104 (ENSG00000232084)
    Fold Change: 8.23
    Ensembl ID: ENSG00000232084
  • Gene Symbol: TRHR (ENSG00000174417)
    Fold Change: 8.23
    Ensembl ID: ENSG00000174417
  • Gene Symbol: BHLHE23 (ENSG00000125533)
    Fold Change: 8.23
    Ensembl ID: ENSG00000125533
  • Gene Symbol: EIF4E1B (ENSG00000175766)
    Fold Change: 8.23
    Ensembl ID: ENSG00000175766
  • Gene Symbol: TAS2R41 (ENSG00000221855)
    Fold Change: 8.23
    Ensembl ID: ENSG00000221855
  • Gene Symbol: HTR1B (ENSG00000135312)
    Fold Change: 8.23
    Ensembl ID: ENSG00000135312
  • Gene Symbol: KCNU1 (ENSG00000215262)
    Fold Change: 8.23
    Ensembl ID: ENSG00000215262
  • Gene Symbol: TEX55 (ENSG00000163424)
    Fold Change: 8.23
    Ensembl ID: ENSG00000163424
  • Gene Symbol: CSRP3 (ENSG00000129170)
    Fold Change: 8.23
    Ensembl ID: ENSG00000129170
  • Gene Symbol: TFAP2D (ENSG00000008197)
    Fold Change: 8.23
    Ensembl ID: ENSG00000008197
  • Gene Symbol: ZNRF4 (ENSG00000105428)
    Fold Change: 8.23
    Ensembl ID: ENSG00000105428
  • Gene Symbol: ADAM2 (ENSG00000104755)
    Fold Change: 8.23
    Ensembl ID: ENSG00000104755
  • Gene Symbol: DMRTB1 (ENSG00000143006)
    Fold Change: 8.23
    Ensembl ID: ENSG00000143006
  • Gene Symbol: MT4 (ENSG00000102891)
    Fold Change: 8.23
    Ensembl ID: ENSG00000102891
  • Gene Symbol: TMEM132D AS1 (ENSG00000249196)
    Fold Change: 8.23
    Ensembl ID: ENSG00000249196
  • Gene Symbol: PCAT4 (ENSG00000251321)
    Fold Change: 8.23
    Ensembl ID: ENSG00000251321
  • Gene Symbol: MROH2B (ENSG00000171495)
    Fold Change: 8.23
    Ensembl ID: ENSG00000171495
  • Gene Symbol: TRIM67 AS1 (ENSG00000235710)
    Fold Change: 8.23
    Ensembl ID: ENSG00000235710
  • Gene Symbol: TYR (ENSG00000077498)
    Fold Change: 8.23
    Ensembl ID: ENSG00000077498
  • Gene Symbol: OPALIN (ENSG00000197430)
    Fold Change: 8.23
    Ensembl ID: ENSG00000197430
  • Gene Symbol: TRPC7 (ENSG00000069018)
    Fold Change: 8.23
    Ensembl ID: ENSG00000069018
  • Gene Symbol: HPYR1 (ENSG00000253521)
    Fold Change: 8.23
    Ensembl ID: ENSG00000253521
  • Gene Symbol: CIMIP1 (ENSG00000124237)
    Fold Change: 8.23
    Ensembl ID: ENSG00000124237
  • Gene Symbol: LINC00410 (ENSG00000231674)
    Fold Change: 8.23
    Ensembl ID: ENSG00000231674
  • Gene Symbol: TECRL (ENSG00000205678)
    Fold Change: 8.23
    Ensembl ID: ENSG00000205678
  • Gene Symbol: PDCL2 (ENSG00000163440)
    Fold Change: 8.23
    Ensembl ID: ENSG00000163440
  • Gene Symbol: CSAG1 (ENSG00000198930)
    Fold Change: 8.23
    Ensembl ID: ENSG00000198930
  • Gene Symbol: LINC00567 (ENSG00000259831)
    Fold Change: 8.23
    Ensembl ID: ENSG00000259831
  • Gene Symbol: CACNG5 (ENSG00000075429)
    Fold Change: 8.23
    Ensembl ID: ENSG00000075429
  • Gene Symbol: PAX7 (ENSG00000009709)
    Fold Change: 8.23
    Ensembl ID: ENSG00000009709
  • Gene Symbol: IL9 (ENSG00000145839)
    Fold Change: 8.23
    Ensembl ID: ENSG00000145839
  • Gene Symbol: NEUROG1 (ENSG00000181965)
    Fold Change: 8.23
    Ensembl ID: ENSG00000181965
  • Gene Symbol: SLC17A6 (ENSG00000091664)
    Fold Change: 8.23
    Ensembl ID: ENSG00000091664

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in progenitor cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in progenitor cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** * Descendants of stem cells, but with limited differentiation potential and capacity for self-renewal * Tendency to differentiate into specific cell types * Can maintain some degree of plasticity, allowing for flexibility in differentiation * Play a crucial role in development, tissue repair, and regeneration * Can be found in various tissues and organs, including the nervous system, hematopoietic system, and epithelial tissues **Genes and Pathways** The progenitor cell (CL0011026) is characterized by the expression of several genes that are involved in various cellular processes. The genes included in this cell are: * **SERPINB7**: involved in negative regulation of endopeptidase activity, positive regulation of collagen biosynthetic process, and positive regulation of glomerular mesangial cell proliferation * **TRBV22 1**: involved in positive regulation of platelet-derived growth factor production and transforming growth factor beta1 production * **KCNQ1DN**: involved in regulation of apoptotic process * **CDRT15**: involved in regulation of apoptotic process * **TRBV26OR9 2**: involved in positive regulation of platelet-derived growth factor production and transforming growth factor beta1 production * **PCGEM1**: involved in regulation of apoptotic process * **TRBV12 1**: involved in positive regulation of platelet-derived growth factor production and transforming growth factor beta1 production * **OR13C3**: involved in detection of chemical stimulus involved in sensory perception of smell * **PRPS1L1**: involved in 5-phosphoribose 1-diphosphate biosynthesis and pentose phosphate pathway * **PYDC2**: involved in negative regulation of inflammatory response and innate immune response These genes are involved in various cellular processes, including regulation of apoptosis, cell proliferation, and differentiation. They play a crucial role in the development and maintenance of progenitor cells. **Clinical Significance** Progenitor cells have significant clinical implications, particularly in the treatment of various diseases and disorders. Some of the clinical applications of progenitor cells include: * **Regenerative medicine**: progenitor cells can be used to repair or replace damaged tissues and organs, such as heart tissue, brain tissue, and skin. * **Cancer therapy**: progenitor cells can be used to deliver cancer therapies, such as chemotherapy and radiation therapy, to specific cell types. * **Tissue engineering**: progenitor cells can be used to generate functional tissue, such as skin, bone, and cartilage. * **Gene therapy**: progenitor cells can be used to deliver genes to specific cell types, allowing for the treatment of genetic disorders. In conclusion, progenitor cells are a type of precursor cell that plays a crucial role in development, tissue repair, and regeneration. They are characterized by their ability to differentiate into specific cell types, while maintaining some degree of plasticity. The genes and pathways involved in progenitor cells are involved in various cellular processes, including regulation of apoptosis, cell proliferation, and differentiation. The clinical significance of progenitor cells is significant, particularly in the treatment of various diseases and disorders.