Details for: CL0011027

Cell ID: CL0011027

Cell Name: skeletal muscle fibroblast

Marker Score Threshold: 658
(Derived using integrated single-cell and genomic data)

Description: Any fibroblast that is part of skeletal muscle tissue.

Synonyms: skeleton muscle fibroblast

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: LAMA2 (ENSG00000196569)
    Fold Change: 8.79
    Ensembl ID: ENSG00000196569
  • Gene Symbol: DCN (ENSG00000011465)
    Fold Change: 8.38
    Ensembl ID: ENSG00000011465
  • Gene Symbol: PTPRG (ENSG00000144724)
    Fold Change: 8.2
    Ensembl ID: ENSG00000144724
  • Gene Symbol: RORA (ENSG00000069667)
    Fold Change: 7.65
    Ensembl ID: ENSG00000069667
  • Gene Symbol: ZBTB16 (ENSG00000109906)
    Fold Change: 7.56
    Ensembl ID: ENSG00000109906
  • Gene Symbol: FKBP5 (ENSG00000096060)
    Fold Change: 7.49
    Ensembl ID: ENSG00000096060
  • Gene Symbol: GSN (ENSG00000148180)
    Fold Change: 7.17
    Ensembl ID: ENSG00000148180
  • Gene Symbol: LAMC1 (ENSG00000135862)
    Fold Change: 7.17
    Ensembl ID: ENSG00000135862
  • Gene Symbol: APOD (ENSG00000189058)
    Fold Change: 7.04
    Ensembl ID: ENSG00000189058
  • Gene Symbol: LPP (ENSG00000145012)
    Fold Change: 6.99
    Ensembl ID: ENSG00000145012
  • Gene Symbol: GPX3 (ENSG00000211445)
    Fold Change: 6.72
    Ensembl ID: ENSG00000211445
  • Gene Symbol: NOVA1 (ENSG00000139910)
    Fold Change: 6.59
    Ensembl ID: ENSG00000139910
  • Gene Symbol: TGFBR3 (ENSG00000069702)
    Fold Change: 6.14
    Ensembl ID: ENSG00000069702
  • Gene Symbol: EBF1 (ENSG00000164330)
    Fold Change: 6.13
    Ensembl ID: ENSG00000164330
  • Gene Symbol: COL4A1 (ENSG00000187498)
    Fold Change: 6.1
    Ensembl ID: ENSG00000187498
  • Gene Symbol: COL6A3 (ENSG00000163359)
    Fold Change: 6.03
    Ensembl ID: ENSG00000163359
  • Gene Symbol: TSC22D3 (ENSG00000157514)
    Fold Change: 5.96
    Ensembl ID: ENSG00000157514
  • Gene Symbol: FOXO3 (ENSG00000118689)
    Fold Change: 5.95
    Ensembl ID: ENSG00000118689
  • Gene Symbol: COL4A2 (ENSG00000134871)
    Fold Change: 5.93
    Ensembl ID: ENSG00000134871
  • Gene Symbol: CFD (ENSG00000197766)
    Fold Change: 5.89
    Ensembl ID: ENSG00000197766
  • Gene Symbol: MBNL1 (ENSG00000152601)
    Fold Change: 5.5
    Ensembl ID: ENSG00000152601
  • Gene Symbol: IGFBP7 (ENSG00000163453)
    Fold Change: 5.39
    Ensembl ID: ENSG00000163453
  • Gene Symbol: LAMB1 (ENSG00000091136)
    Fold Change: 5.33
    Ensembl ID: ENSG00000091136
  • Gene Symbol: NID1 (ENSG00000116962)
    Fold Change: 5.25
    Ensembl ID: ENSG00000116962
  • Gene Symbol: EGFR (ENSG00000146648)
    Fold Change: 5.22
    Ensembl ID: ENSG00000146648
  • Gene Symbol: NFIA (ENSG00000162599)
    Fold Change: 5.13
    Ensembl ID: ENSG00000162599
  • Gene Symbol: TACC1 (ENSG00000147526)
    Fold Change: 5.06
    Ensembl ID: ENSG00000147526
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 5.04
    Ensembl ID: ENSG00000114423
  • Gene Symbol: MAN1A1 (ENSG00000111885)
    Fold Change: 5.04
    Ensembl ID: ENSG00000111885
  • Gene Symbol: BCL6 (ENSG00000113916)
    Fold Change: 5.01
    Ensembl ID: ENSG00000113916
  • Gene Symbol: MKLN1 (ENSG00000128585)
    Fold Change: 4.95
    Ensembl ID: ENSG00000128585
  • Gene Symbol: DLG2 (ENSG00000150672)
    Fold Change: 4.7
    Ensembl ID: ENSG00000150672
  • Gene Symbol: SCN7A (ENSG00000136546)
    Fold Change: 4.7
    Ensembl ID: ENSG00000136546
  • Gene Symbol: TGFBR2 (ENSG00000163513)
    Fold Change: 4.69
    Ensembl ID: ENSG00000163513
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 4.6
    Ensembl ID: ENSG00000140836
  • Gene Symbol: SPARCL1 (ENSG00000152583)
    Fold Change: 4.53
    Ensembl ID: ENSG00000152583
  • Gene Symbol: GLUL (ENSG00000135821)
    Fold Change: 4.51
    Ensembl ID: ENSG00000135821
  • Gene Symbol: VIT (ENSG00000205221)
    Fold Change: 4.49
    Ensembl ID: ENSG00000205221
  • Gene Symbol: DIAPH2 (ENSG00000147202)
    Fold Change: 4.37
    Ensembl ID: ENSG00000147202
  • Gene Symbol: DUSP1 (ENSG00000120129)
    Fold Change: 4.37
    Ensembl ID: ENSG00000120129
  • Gene Symbol: CEBPD (ENSG00000221869)
    Fold Change: 4.33
    Ensembl ID: ENSG00000221869
  • Gene Symbol: MAP1B (ENSG00000131711)
    Fold Change: 4.27
    Ensembl ID: ENSG00000131711
  • Gene Symbol: FOXO1 (ENSG00000150907)
    Fold Change: 4.24
    Ensembl ID: ENSG00000150907
  • Gene Symbol: COL6A2 (ENSG00000142173)
    Fold Change: 4.12
    Ensembl ID: ENSG00000142173
  • Gene Symbol: OPHN1 (ENSG00000079482)
    Fold Change: 4.06
    Ensembl ID: ENSG00000079482
  • Gene Symbol: C1S (ENSG00000182326)
    Fold Change: 3.95
    Ensembl ID: ENSG00000182326
  • Gene Symbol: ADH1B (ENSG00000196616)
    Fold Change: 3.94
    Ensembl ID: ENSG00000196616
  • Gene Symbol: PTPRS (ENSG00000105426)
    Fold Change: 3.88
    Ensembl ID: ENSG00000105426
  • Gene Symbol: PTEN (ENSG00000171862)
    Fold Change: 3.87
    Ensembl ID: ENSG00000171862
  • Gene Symbol: MGST1 (ENSG00000008394)
    Fold Change: 3.82
    Ensembl ID: ENSG00000008394
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 3.79
    Ensembl ID: ENSG00000087086
  • Gene Symbol: MFAP5 (ENSG00000197614)
    Fold Change: 3.78
    Ensembl ID: ENSG00000197614
  • Gene Symbol: NNMT (ENSG00000166741)
    Fold Change: 3.72
    Ensembl ID: ENSG00000166741
  • Gene Symbol: FBN1 (ENSG00000166147)
    Fold Change: 3.72
    Ensembl ID: ENSG00000166147
  • Gene Symbol: TCF12 (ENSG00000140262)
    Fold Change: 3.72
    Ensembl ID: ENSG00000140262
  • Gene Symbol: ZEB1 (ENSG00000148516)
    Fold Change: 3.66
    Ensembl ID: ENSG00000148516
  • Gene Symbol: TIMP3 (ENSG00000100234)
    Fold Change: 3.63
    Ensembl ID: ENSG00000100234
  • Gene Symbol: CYP4B1 (ENSG00000142973)
    Fold Change: 3.61
    Ensembl ID: ENSG00000142973
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.56
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CFH (ENSG00000000971)
    Fold Change: 3.56
    Ensembl ID: ENSG00000000971
  • Gene Symbol: AOX1 (ENSG00000138356)
    Fold Change: 3.54
    Ensembl ID: ENSG00000138356
  • Gene Symbol: TFPI (ENSG00000003436)
    Fold Change: 3.54
    Ensembl ID: ENSG00000003436
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 3.52
    Ensembl ID: ENSG00000153956
  • Gene Symbol: AFF1 (ENSG00000172493)
    Fold Change: 3.5
    Ensembl ID: ENSG00000172493
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 3.45
    Ensembl ID: ENSG00000053254
  • Gene Symbol: TCF7L2 (ENSG00000148737)
    Fold Change: 3.44
    Ensembl ID: ENSG00000148737
  • Gene Symbol: REV3L (ENSG00000009413)
    Fold Change: 3.42
    Ensembl ID: ENSG00000009413
  • Gene Symbol: TCF4 (ENSG00000196628)
    Fold Change: 3.39
    Ensembl ID: ENSG00000196628
  • Gene Symbol: DPYD (ENSG00000188641)
    Fold Change: 3.38
    Ensembl ID: ENSG00000188641
  • Gene Symbol: NFIB (ENSG00000147862)
    Fold Change: 3.38
    Ensembl ID: ENSG00000147862
  • Gene Symbol: VIM (ENSG00000026025)
    Fold Change: 3.36
    Ensembl ID: ENSG00000026025
  • Gene Symbol: TMSB4X (ENSG00000205542)
    Fold Change: 3.36
    Ensembl ID: ENSG00000205542
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 3.35
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ABLIM1 (ENSG00000099204)
    Fold Change: 3.3
    Ensembl ID: ENSG00000099204
  • Gene Symbol: H3 3B (ENSG00000132475)
    Fold Change: 3.29
    Ensembl ID: ENSG00000132475
  • Gene Symbol: GHR (ENSG00000112964)
    Fold Change: 3.28
    Ensembl ID: ENSG00000112964
  • Gene Symbol: SELENOP (ENSG00000250722)
    Fold Change: 3.23
    Ensembl ID: ENSG00000250722
  • Gene Symbol: LTBP4 (ENSG00000090006)
    Fold Change: 3.22
    Ensembl ID: ENSG00000090006
  • Gene Symbol: S100A6 (ENSG00000197956)
    Fold Change: 3.21
    Ensembl ID: ENSG00000197956
  • Gene Symbol: PIAS1 (ENSG00000033800)
    Fold Change: 3.19
    Ensembl ID: ENSG00000033800
  • Gene Symbol: SRSF5 (ENSG00000100650)
    Fold Change: 3.17
    Ensembl ID: ENSG00000100650
  • Gene Symbol: DMD (ENSG00000198947)
    Fold Change: 3.14
    Ensembl ID: ENSG00000198947
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 3.11
    Ensembl ID: ENSG00000122786
  • Gene Symbol: LRP1 (ENSG00000123384)
    Fold Change: 3.1
    Ensembl ID: ENSG00000123384
  • Gene Symbol: ZFAND5 (ENSG00000107372)
    Fold Change: 3.1
    Ensembl ID: ENSG00000107372
  • Gene Symbol: STK3 (ENSG00000104375)
    Fold Change: 3.08
    Ensembl ID: ENSG00000104375
  • Gene Symbol: FBLN2 (ENSG00000163520)
    Fold Change: 3.06
    Ensembl ID: ENSG00000163520
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 3.01
    Ensembl ID: ENSG00000149131
  • Gene Symbol: COL5A2 (ENSG00000204262)
    Fold Change: 3
    Ensembl ID: ENSG00000204262
  • Gene Symbol: PCDH9 (ENSG00000184226)
    Fold Change: 2.99
    Ensembl ID: ENSG00000184226
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.99
    Ensembl ID: ENSG00000152518
  • Gene Symbol: AXL (ENSG00000167601)
    Fold Change: 2.98
    Ensembl ID: ENSG00000167601
  • Gene Symbol: LIFR (ENSG00000113594)
    Fold Change: 2.95
    Ensembl ID: ENSG00000113594
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 2.94
    Ensembl ID: ENSG00000108654
  • Gene Symbol: MGP (ENSG00000111341)
    Fold Change: 2.93
    Ensembl ID: ENSG00000111341
  • Gene Symbol: C1R (ENSG00000159403)
    Fold Change: 2.93
    Ensembl ID: ENSG00000159403
  • Gene Symbol: COL6A1 (ENSG00000142156)
    Fold Change: 2.91
    Ensembl ID: ENSG00000142156
  • Gene Symbol: NFKBIA (ENSG00000100906)
    Fold Change: 2.86
    Ensembl ID: ENSG00000100906
  • Gene Symbol: MT2A (ENSG00000125148)
    Fold Change: 2.85
    Ensembl ID: ENSG00000125148
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 2.85
    Ensembl ID: ENSG00000047648

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in skeletal muscle fibroblast cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in skeletal muscle fibroblast cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** The skeletal muscle fibroblast (CL0011027) has several key characteristics that distinguish it from other cell types: 1. **Cell adhesion**: The cell expresses integrins, which are transmembrane receptors that mediate cell adhesion to the extracellular matrix. 2. **Extracellular matrix organization**: The cell interacts with the extracellular matrix, particularly with laminin, which is a key component of the basement membrane. 3. **Cell migration**: The cell is capable of migrating in response to various signals, including chemokines and growth factors. 4. **Differentiation**: The cell can differentiate into various cell types, including myoblasts and chondrocytes. 5. **Signaling pathways**: The cell is involved in various signaling pathways, including the Met/PTK2 pathway, which regulates cell migration and differentiation. **Clinical Significance** The skeletal muscle fibroblast (CL0011027) has several clinical significance: 1. **Muscle development and repair**: The cell plays a crucial role in the development and repair of skeletal muscles. 2. **Muscle disorders**: Mutations in the LAMA2 gene have been associated with muscle disorders such as muscular dystrophy and myositis. 3. **Cancer**: The cell's ability to migrate and differentiate makes it a potential target for cancer therapy. 4. **Wound healing**: The cell's ability to interact with the extracellular matrix and migrate makes it a potential target for wound healing therapies. **Gene Symbol and Ensembl ID** The gene symbol for the skeletal muscle fibroblast (CL0011027) is LAMA2, and its Ensembl ID is ENSG00000196569. **Pathways and Ontologies** The skeletal muscle fibroblast (CL0011027) is involved in various cellular processes and signaling pathways, including: 1. **Axon guidance** 2. **Basement membrane** 3. **Cell adhesion** 4. **Collagen-containing extracellular matrix** 5. **Dendritic spine** 6. **Developmental biology** 7. **Ecm proteoglycans** 8. **Egr2 and sox10-mediated initiation of schwann cell myelination** 9. **Extracellular matrix organization** 10. **Extracellular matrix structural constituent** 11. **Laminin interactions** 12. **Maintenance of blood-brain barrier** 13. **Met activates ptk2 signaling** 14. **Met promotes cell motility** 15. **Muscle organ development** 16. **Nervous system development** 17. **Neuromuscular junction** 18. **Non-integrin membrane-ecm interactions** 19. **Positive regulation of cell adhesion** 20. **Positive regulation of integrin-mediated signaling pathway** 21. **Positive regulation of muscle cell differentiation** 22. **Positive regulation of synaptic transmission** 23. **Protein complex involved in cell-matrix adhesion** 24. **Regulation of basement membrane organization** 25. **Regulation of cell migration** 26. **Regulation of embryonic development** 27. **Sarcolemma** 28. **Schwann cell differentiation** 29. **Signaling by met** 30. **Signaling by receptor tyrosine kinases** 31. **Signaling receptor binding** 32. **Signal transduction** 33. **Structural molecule activity** 34. **Synaptic cleft** The cell also interacts with various molecules and pathways, including: 1. **DCN (decorin)** 2. **PTPRG (protein tyrosine phosphatase receptor gamma)** 3. **RORA (retinoic acid receptor alpha)** 4. **ZBTB16 (zinc finger and BTB domain containing 16)** **Gene Symbol and Ensembl ID** The gene symbols for the skeletal muscle fibroblast (CL0011027) are: 1. **LAMA2** 2. **DCN** 3. **PTPRG** 4. **RORA** 5. **ZBTB16** The Ensembl IDs for the skeletal muscle fibroblast (CL0011027) are: 1. **ENSG00000196569** 2. **ENSG00000011465** 3. **ENSG00000044724** 4. **ENSG00000069667** 5. **ENSG00000109906** **Pathways and Ontologies** The skeletal muscle fibroblast (CL0011027) is involved in various cellular processes and signaling pathways, including: 1. **Actin binding** 2. **Actin cap** 3. **Actin cytoskeleton** 4. **Adaptive immune system** 5. **Anterior/posterior pattern specification** 6. **Apoptotic process** 7. **Animal organ morphogenesis** 8. **Cartilage development** 9. **Cell population proliferation** 10. **Central nervous system development** 11. **Chondroitin sulfate/dermatan sulfate metabolism** 12. **Chondroitin sulfate biosynthesis** 13. **Chondroitin sulfate degradation** 14. **Circadian clock** 15. **Circadian regulation of gene expression** 16. **Cytokine signaling in immune system** 17. **Dna-binding transcription factor activity** 18. **Dna binding** 19. **Embryonic digit morphogenesis** 20. **Embryonic hindlimb morphogenesis** 21. **Embryonic pattern specification** 22. **Forelimb morphogenesis** 23. **Golgi lumen** 24. **Glycosaminoglycan binding** 25. **Glycosaminoglycan metabolism** 26. **Heme signaling** 27. **Heparan sulfate/heparin (hs-gag) metabolism** 28. **Hepatocyte nuclear factor 3 (HNF3) signaling pathway** 29. **Identical protein binding** 30. **Immune system** 31. **Intracellular receptor signaling pathway** 32. **Lysosomal lumen** 33. **Metabolism** 34. **Metabolism of carbohydrates** 35. **Metabolism of lipids** 36. **Metabolism of proteins** 37. **Metal ion binding** 38. **Neddylation** 39. **Negative regulation of angiogenesis** 40. **Negative regulation of endothelial cell migration** 41. **Negative regulation of inflammatory response** 42. **Negative regulation of nf-kappab signal transduction** 43. **Negative regulation of nf-kappab signaling pathway** 44. **Negative regulation of vascular endothelial growth factor signaling pathway** 45. **Nervous system development** 46. **Non-integrin membrane-ecm interactions** 47. **Nucleolus** 48. **Nucleoplasm** 49. **Nucleus** 50. **Ossification involved in bone maturation** 51. **Pml body** 52. **Peptidyl-prolyl cis-trans isomerase activity** 53. **Positive regulation of apoptotic process** 54. **Positive regulation of autophagy** 55. **Positive regulation of circadian rhythm** 56. **Positive regulation of dna-templated transcription** 57. **Positive regulation of fat cell differentiation** 58. **Positive regulation of glucose metabolic process** 59. **Positive regulation of lipid metabolism by pparalpha** 60. **Positive regulation of macrophage activation** 61. **Positive regulation of mitochondrial fission** 62. **Positive regulation of mitochondrial depolarization** 63. **Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction** 64. **Positive regulation of rna polymerase ii transcription** 65. **Positive regulation of smoothened signaling pathway** 66. **Positive regulation of steroid metabolic process** 67. **Positive regulation of transcription by rna polymerase ii** 68. **Post-translational protein modification** 69. **Protein binding** 70. **Protein complex involved in cell-matrix adhesion** 71. **Protein dephosphorylation** 72. **Protein homodimerization activity** 73. **Protein localization to nucleus** 74. **Protein ubiquitination** 75. **Regulation of dna-templated transcription** 76. **Regulation of embryonic development** 77. **Regulation of glucose metabolic process** 78. **Regulation of lipid metabolism** 79. **Regulation of lipid metabolism by pparalpha** 80. **Regulation of macrophage activation** 81. **Regulation of smoothened signaling pathway** 82. **Regulation of steroid metabolic process** 83. **Regulation of transcription by rna polymerase ii** 84. **Rna binding** 85. **Rna polymerase ii cis-regulatory region sequence-specific dna binding** 86. **Rna polymerase ii transcription** 87. **Rna polymerase ii transcription regulatory region sequence-specific dna binding** 88. **Sequence-specific dna binding** 89. **Signaling by interleukins** 90. **Signaling by nuclear receptors** 91. **Signal transduction** 92. **Sumo e3 ligases sumoylate target proteins** 93. **Sumoylation** 94. **Sumoylation of intracellular receptors** 95. **T-helper 17 cell differentiation** 96. **Tr