Details for: CL0011101

Cell ID: CL0011101

Cell Name: chorionic trophoblast cell

Marker Score Threshold: 388
(Derived using integrated single-cell and genomic data)

Description: Cells of the uterine chorion that acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.93
    Ensembl ID: ENSG00000075624
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 2.88
    Ensembl ID: ENSG00000156508
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.63
    Ensembl ID: ENSG00000166710
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.48
    Ensembl ID: ENSG00000131143
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.43
    Ensembl ID: ENSG00000169100
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 2.42
    Ensembl ID: ENSG00000127184
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.42
    Ensembl ID: ENSG00000172757
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 2.38
    Ensembl ID: ENSG00000104529
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 2.37
    Ensembl ID: ENSG00000167658
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.35
    Ensembl ID: ENSG00000099622
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.26
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.22
    Ensembl ID: ENSG00000198668
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 2.11
    Ensembl ID: ENSG00000164919
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 2.09
    Ensembl ID: ENSG00000114942
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.09
    Ensembl ID: ENSG00000133639
  • Gene Symbol: EIF4A2 (ENSG00000156976)
    Fold Change: 2.09
    Ensembl ID: ENSG00000156976
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.99
    Ensembl ID: ENSG00000126267
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 1.95
    Ensembl ID: ENSG00000112695
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.95
    Ensembl ID: ENSG00000070831
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.91
    Ensembl ID: ENSG00000067560
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.9
    Ensembl ID: ENSG00000135940
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.84
    Ensembl ID: ENSG00000143933
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.82
    Ensembl ID: ENSG00000111775
  • Gene Symbol: EIF4G2 (ENSG00000110321)
    Fold Change: 1.8
    Ensembl ID: ENSG00000110321
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.78
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.77
    Ensembl ID: ENSG00000077549
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 1.71
    Ensembl ID: ENSG00000176340
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.68
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.67
    Ensembl ID: ENSG00000143761
  • Gene Symbol: DUSP1 (ENSG00000120129)
    Fold Change: 1.67
    Ensembl ID: ENSG00000120129
  • Gene Symbol: EIF4B (ENSG00000063046)
    Fold Change: 1.66
    Ensembl ID: ENSG00000063046
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.66
    Ensembl ID: ENSG00000152518
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.63
    Ensembl ID: ENSG00000067082
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.61
    Ensembl ID: ENSG00000005022
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.61
    Ensembl ID: ENSG00000134825
  • Gene Symbol: EIF5 (ENSG00000100664)
    Fold Change: 1.61
    Ensembl ID: ENSG00000100664
  • Gene Symbol: DBI (ENSG00000155368)
    Fold Change: 1.55
    Ensembl ID: ENSG00000155368
  • Gene Symbol: CYBA (ENSG00000051523)
    Fold Change: 1.52
    Ensembl ID: ENSG00000051523
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 1.51
    Ensembl ID: ENSG00000160213
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.51
    Ensembl ID: ENSG00000185650
  • Gene Symbol: DAD1 (ENSG00000129562)
    Fold Change: 1.5
    Ensembl ID: ENSG00000129562
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.48
    Ensembl ID: ENSG00000172270
  • Gene Symbol: DDX3X (ENSG00000215301)
    Fold Change: 1.47
    Ensembl ID: ENSG00000215301
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.42
    Ensembl ID: ENSG00000122705
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.42
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.41
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.41
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.41
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.4
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.39
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 1.39
    Ensembl ID: ENSG00000113712
  • Gene Symbol: EIF1AX (ENSG00000173674)
    Fold Change: 1.36
    Ensembl ID: ENSG00000173674
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.35
    Ensembl ID: ENSG00000013441
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.35
    Ensembl ID: ENSG00000161203
  • Gene Symbol: EIF5A (ENSG00000132507)
    Fold Change: 1.33
    Ensembl ID: ENSG00000132507
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.32
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.3
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.28
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.28
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.27
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.25
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.24
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.22
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.21
    Ensembl ID: ENSG00000168374
  • Gene Symbol: EIF2S3 (ENSG00000130741)
    Fold Change: 1.2
    Ensembl ID: ENSG00000130741
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.19
    Ensembl ID: ENSG00000069849
  • Gene Symbol: CTNNB1 (ENSG00000168036)
    Fold Change: 1.19
    Ensembl ID: ENSG00000168036
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.19
    Ensembl ID: ENSG00000042753
  • Gene Symbol: DUT (ENSG00000128951)
    Fold Change: 1.16
    Ensembl ID: ENSG00000128951
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.16
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 1.16
    Ensembl ID: ENSG00000101439
  • Gene Symbol: CTSD (ENSG00000117984)
    Fold Change: 1.15
    Ensembl ID: ENSG00000117984
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.15
    Ensembl ID: ENSG00000149925
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.15
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.14
    Ensembl ID: ENSG00000122359
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.14
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.12
    Ensembl ID: ENSG00000173575
  • Gene Symbol: DYNC1H1 (ENSG00000197102)
    Fold Change: 1.12
    Ensembl ID: ENSG00000197102
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.11
    Ensembl ID: ENSG00000053254
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.11
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.11
    Ensembl ID: ENSG00000146731
  • Gene Symbol: EIF4A1 (ENSG00000161960)
    Fold Change: 1.11
    Ensembl ID: ENSG00000161960
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.11
    Ensembl ID: ENSG00000072778
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.1
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ECH1 (ENSG00000104823)
    Fold Change: 1.09
    Ensembl ID: ENSG00000104823
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.08
    Ensembl ID: ENSG00000130402
  • Gene Symbol: AP3S1 (ENSG00000177879)
    Fold Change: 1.08
    Ensembl ID: ENSG00000177879
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.07
    Ensembl ID: ENSG00000070961
  • Gene Symbol: DDX6 (ENSG00000110367)
    Fold Change: 1.07
    Ensembl ID: ENSG00000110367
  • Gene Symbol: CYC1 (ENSG00000179091)
    Fold Change: 1.06
    Ensembl ID: ENSG00000179091
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.06
    Ensembl ID: ENSG00000084234
  • Gene Symbol: DDT (ENSG00000099977)
    Fold Change: 1.06
    Ensembl ID: ENSG00000099977
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.05
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.05
    Ensembl ID: ENSG00000138279
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.04
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.04
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.04
    Ensembl ID: ENSG00000153922
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.03
    Ensembl ID: ENSG00000115307
  • Gene Symbol: DGUOK (ENSG00000114956)
    Fold Change: 1.02
    Ensembl ID: ENSG00000114956
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1
    Ensembl ID: ENSG00000112576
Hovered Details

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Hovered Details

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**Key Characteristics** * Specialized structural and functional features that enable invasion of the uterine lining and fusion with the spongiotrophoblast layer * Expression of genes involved in cell-cell communication, adhesion, and motility * Actin cytoskeleton organization and regulation * Cell cycle regulation and DNA repair * Interaction with various signaling pathways, including immune responses, cell differentiation, and cancer * Expression of genes related to immune system, infectious disease, and innate immune system * Ability to migrate and invade the uterine lining **Clinical Significance** * Chorionic trophoblast cells play a crucial role in the development of the placenta and fetal growth during pregnancy * Abnormalities in chorionic trophoblast cell function or structure have been implicated in various pregnancy-related complications, including preeclampsia, placental abruption, and gestational diabetes * Understanding the role of chorionic trophoblast cells in immune responses and cell differentiation may provide insights into the development of novel therapeutic strategies for pregnancy-related disorders * The expression of genes involved in cell-cell communication and adhesion in chorionic trophoblast cells may also be relevant to the study of cancer and immune system disorders **Pathways and Ontologies** * Actin cytoskeleton, Actin filament, Adherens junction, Adherens junction assembly, Adherens junctions interactions, Apical junction complex, Apical protein localization, Atp binding, Axon, Axon guidance, Axonogenesis * Autophagy, Cellular responses to stimuli, Cellular responses to stress, Cellular response to epidermal growth factor stimulus, Cellular response to heat stress, Chaperone mediated autophagy * Adaptive immune system, Amyloid fiber formation, Amyloid fibril formation, Antigen presentation: folding, assembly and peptide loading of class i mhc, Antigen processing-cross presentation * Bacterial infection pathways, Cellular response to iron(iii) ion, Cellular response to iron ion, Cellular response to nicotine, Class i mhc mediated antigen processing & presentation * Cortical actin cytoskeleton, Cytoplasm, Cytoplasmic side of lysosomal membrane, Cytosol, Cytosolic ribosome, Disease, Eukaryotic translation elongation, Eukaryotic translation elongation factor 1 complex * Extracellular exosome, Extracellular region, Extracellular space, Ficolin-1-rich granule lumen, Gtpase activity, Gtp binding, Hsf1 activation, Immune system, Infectious disease, Innate immune system * Kinase binding, Membrane, Metabolism of proteins, Molecular adaptor activity, Neutrophil degranulation, Nucleolus, Nucleus, Peptide chain elongation, Plasma membrane, Positive regulation by host of viral genome replication * Post-translational protein modification, Protein binding, Protein kinase binding, Protein methylation, Regulation of chaperone-mediated autophagy, Regulation of d-erythro-sphingosine kinase activity, Ribosome, Rna binding, Ruffle membrane, Sars-cov-1 infection, Sars-cov-1 modulates host translation machinery, Sars-cov-1-host interactions, Sars-cov infections, Secretory granule lumen, Translation, Translational elongation, Translation elongation factor activity, Trna binding, Viral infection pathways